Jonathan Chernoff

Jonathan Chernoff

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Jonathan Chernoff

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Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1.

Authors:
Mara Sannai Valentina Doneddu Veda Giri Steven Seeholzer Emmanuelle Nicolas Shu-Chin Yip Maria Rosaria Bassi Pietro Mancuso Salvatore Cortellino Antonio Cigliano Rebecca Lurie Hua Ding Jonathan Chernoff Robert W Sobol Timothy J Yen Luigi Bagella Alfonso Bellacosa

DNA Repair (Amst) 2019 Oct 8;82:102687. Epub 2019 Aug 8.

Cancer Epigenetics and Cancer Biology Programs, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.102687DOI Listing
October 2019

Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer.

Authors:
Vladislav Korobeynikov Michelle Borakove Yayi Feng William M Wuest Alex B Koval Anna S Nikonova Ilya Serebriiskii Jonathan Chernoff Virginia F Borges Erica A Golemis Elena Shagisultanova

Breast Cancer Res Treat 2019 Sep 28;177(2):369-382. Epub 2019 Jun 28.

University of Colorado Denver, Young Women's Breast Cancer Translational Program, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1007/s10549-019-05329-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661032PMC
September 2019

Intrinsic Resistance to MEK Inhibition through BET Protein-Mediated Kinome Reprogramming in NF1-Deficient Ovarian Cancer.

Authors:
Alison M Kurimchak Claude Shelton Carlos Herrera-Montávez Kelly E Duncan Jonathan Chernoff James S Duncan

Mol Cancer Res 2019 Aug 1;17(8):1721-1734. Epub 2019 May 1.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-1332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679760PMC
August 2019

Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response.

Authors:
Pablo Binder Shunyao Wang Maria Radu Min Zin Lucy Collins Saba Khan Yatong Li Karolina Sekeres Neil Humphreys Eileithyia Swanton Adam Reid Fay Pu Delvac Oceandy Kaomei Guan Susanne S Hille Norbert Frey Oliver J Müller Elizabeth J Cartwright Jonathan Chernoff Xin Wang Wei Liu

Circ Res 2019 Mar;124(5):696-711

From the Faculty of Biology, Medicine and Health, The University of Manchester, United Kingdom (P.B., S.W., M.Z., L.C., S.K., Y.L., N.H., E.S., A.R., D.O., E.J.C., X.W., W.L.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31282
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http://dx.doi.org/10.1161/CIRCRESAHA.118.312829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407830PMC
March 2019

Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas.

Authors:
Hezhe Lu Shujing Liu Gao Zhang Bin Wu Yueyao Zhu Dennie T Frederick Yi Hu Wenqun Zhong Sergio Randell Norah Sadek Wei Zhang Gang Chen Chaoran Cheng Jingwen Zeng Lawrence W Wu Jie Zhang Xiaoming Liu Wei Xu Clemens Krepler Katrin Sproesser Min Xiao Benchun Miao Jianglan Liu Claire D Song Jephrey Y Liu Giorgos C Karakousis Lynn M Schuchter Yiling Lu Gordon Mills Yusheng Cong Jonathan Chernoff Jun Guo Genevieve M Boland Ryan J Sullivan Zhi Wei Jeffrey Field Ravi K Amaravadi Keith T Flaherty Meenhard Herlyn Xiaowei Xu Wei Guo

Nature 2019 01;565(7738):E4

Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.

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http://www.nature.com/articles/s41586-018-0814-7
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http://dx.doi.org/10.1038/s41586-018-0814-7DOI Listing
January 2019

How to get and keep your lab funded.

Authors:
Jonathan Chernoff

Mol Biol Cell 2018 10;29(21):2519-2521

Fox Chase Cancer Center, Philadelphia, PA 19111.

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https://www.molbiolcell.org/doi/10.1091/mbc.E18-07-0416
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http://dx.doi.org/10.1091/mbc.E18-07-0416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254575PMC
October 2018

Detection of Heterodimerization of Protein Isoforms Using an in Situ Proximity Ligation Assay.

Authors:
Sofiia Karchugina Jonathan Chernoff

J Vis Exp 2018 10 20(140). Epub 2018 Oct 20.

Fox Chase Cancer Center;

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https://www.jove.com/video/57755/detection-heterodimerizatio
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http://dx.doi.org/10.3791/57755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235567PMC
October 2018

Hras helps hippo heterodimerize to evade tumor suppression.

Authors:
Daniela Araiza-Olivera Jonathan Chernoff

Small GTPases 2018 07 20;9(4):327-331. Epub 2016 Sep 20.

a Fox Chase Cancer Center , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/21541248.2016.1228794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997136PMC
July 2018

PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.

Authors:
Seong M Kim Tricia T Nguyen Archna Ravi Peter Kubiniok Brendan T Finicle Vaishali Jayashankar Leonel Malacrida Jue Hou Jane Robertson Dong Gao Jonathan Chernoff Michelle A Digman Eric O Potma Bruce J Tromberg Pierre Thibault Aimee L Edinger

Cancer Discov 2018 07 23;8(7):866-883. Epub 2018 Mar 23.

Department of Developmental and Cell Biology, University of California, Irvine, California.

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http://dx.doi.org/10.1158/2159-8290.CD-17-1215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030497PMC
July 2018

A new concept in NF2 pharmacotherapy: targeting fatty acid synthesis.

Authors:
Dina S Stepanova Lanita Braun Jonathan Chernoff

Oncoscience 2018 May 23;5(5-6):126-127. Epub 2018 Jun 23.

Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.

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http://dx.doi.org/10.18632/oncoscience.417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049319PMC
May 2018

The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin.

Authors:
Tatiana Y Prudnikova Jonathan Chernoff

Small GTPases 2017 10 18;8(4):193-198. Epub 2016 Jul 18.

a Cancer Biology Program, Fox Chase Cancer Center , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/21541248.2016.1213089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680705PMC
October 2017

PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas.

Authors:
Hezhe Lu Shujing Liu Gao Zhang Bin Wu Yueyao Zhu Dennie T Frederick Yi Hu Wenqun Zhong Sergio Randell Norah Sadek Wei Zhang Gang Chen Chaoran Cheng Jingwen Zeng Lawrence W Wu Jie Zhang Xiaoming Liu Wei Xu Clemens Krepler Katrin Sproesser Min Xiao Benchun Miao Jianglan Liu Claire D Song Jephrey Y Liu Giorgos C Karakousis Lynn M Schuchter Yiling Lu Gordon Mills Yusheng Cong Jonathan Chernoff Jun Guo Genevieve M Boland Ryan J Sullivan Zhi Wei Jeffrey Field Ravi K Amaravadi Keith T Flaherty Meenhard Herlyn Xiaowei Xu Wei Guo

Nature 2017 10 27;550(7674):133-136. Epub 2017 Sep 27.

Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nature24040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891348PMC
October 2017

Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression.

Authors:
Kejing Zeng Lili Tian Adam Sirek Weijuan Shao Ling Liu Yu-Ting Chiang Jonathan Chernoff Dominic S Ng Jianping Weng Tianru Jin

J Mol Cell Biol 2017 10;9(5):384-394

Toronto General Research Institutes, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1093/jmcb/mjx031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907843PMC
October 2017

Pak2 regulates myeloid-derived suppressor cell development in mice.

Authors:
Yi Zeng Seongmin Hahn Jessica Stokes Emely A Hoffman Monika Schmelz Maria Proytcheva Jonathan Chernoff Emmanuel Katsanis

Blood Adv 2017 Oct 10;1(22):1923-1933. Epub 2017 Oct 10.

Department of Pediatrics, Steele Children's Research Center.

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http://dx.doi.org/10.1182/bloodadvances.2017007435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728145PMC
October 2017

An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis.

Authors:
Dina S Stepanova Galina Semenova Yin-Ming Kuo Andrew J Andrews Sylwia Ammoun C Oliver Hanemann Jonathan Chernoff

Cancer Res 2017 09 20;77(18):5026-5038. Epub 2017 Jul 20.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600854PMC
September 2017

Targeting MYC sensitizes malignant mesothelioma cells to PAK blockage-induced cytotoxicity.

Authors:
Yinfei Tan Eleonora Sementino Jonathan Chernoff Joseph R Testa

Am J Cancer Res 2017 1;7(8):1724-1737. Epub 2017 Aug 1.

Cancer Biology Program, Fox Chase Cancer CenterPhiladelphia, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574944PMC
August 2017

Recent advances in methods to assess the activity of the kinome.

Authors:
Maria Radu Jonathan Chernoff

F1000Res 2017 26;6:1004. Epub 2017 Jun 26.

Cancer Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111-2497, USA.

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https://f1000research.com/articles/6-1004/v1
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http://dx.doi.org/10.12688/f1000research.10962.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490475PMC
June 2017

Medium throughput biochemical compound screening identifies novel agents for pharmacotherapy of neurofibromatosis type 1.

Authors:
Galina Semenova Dina S Stepanova Sergey M Deyev Jonathan Chernoff

Biochimie 2017 Apr 6;135:1-5. Epub 2017 Jan 6.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S03009084173000
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http://dx.doi.org/10.1016/j.biochi.2017.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405558PMC
April 2017

Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro.

Authors:
Giselle A Joseph Min Lu Maria Radu Jennifer K Lee Steven J Burden Jonathan Chernoff Robert S Krauss

Mol Cell Biol 2017 02 1;37(4). Epub 2017 Feb 1.

Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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http://dx.doi.org/10.1128/MCB.00222-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288579PMC
February 2017

Alfred G. Knudson Jr, MD, PhD: In Memoriam (1922-2016).

Authors:
Jonathan Chernoff

Cancer Res 2017 02;77(4):815-816

Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-3547DOI Listing
February 2017

Targeting PAK1.

Authors:
Galina Semenova Jonathan Chernoff

Biochem Soc Trans 2017 02;45(1):79-88

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA

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http://dx.doi.org/10.1042/BST20160134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973817PMC
February 2017

Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition.

Authors:
Olga Villamar Cruz Tatiana Y Prudnikova Daniela Araiza-Olivera Carlos Perez-Plasencia Neil Johnson Andrea J Bernhardy Michael Slifker Catherine Renner Jonathan Chernoff Luis E Arias-Romero

Oncotarget 2016 11;7(47):76590-76603

UBIMED, Facultad de Estudios Superiores-Iztacala, UNAM, Tlalnepantla, Estado de México, Mexico.

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http://dx.doi.org/10.18632/oncotarget.12576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363532PMC
November 2016

Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP.

Authors:
Bo Hu Sezgi Arpag Xuebao Zhang Wiebke Möbius Hauke Werner Gina Sosinsky Mark Ellisman Yang Zhang Audra Hamilton Jonathan Chernoff Jun Li

PLoS Genet 2016 09 1;12(9):e1006290. Epub 2016 Sep 1.

Department of Neurology, Center for Human Genetics Research, Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008806PMC
September 2016

Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer.

Authors:
Alison M Kurimchak Claude Shelton Kelly E Duncan Katherine J Johnson Jennifer Brown Shane O'Brien Rashid Gabbasov Lauren S Fink Yuesheng Li Nicole Lounsbury Magid Abou-Gharbia Wayne E Childers Denise C Connolly Jonathan Chernoff Jeffrey R Peterson James S Duncan

Cell Rep 2016 08 21;16(5):1273-1286. Epub 2016 Jul 21.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972668PMC
August 2016

H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization.

Authors:
Sonali J Rawat Daniela Araiza-Olivera Luis E Arias-Romero Olga Villamar-Cruz Tatiana Y Prudnikova Heinrich Roder Jonathan Chernoff

Curr Biol 2016 06 26;26(12):1556-1563. Epub 2016 May 26.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2016.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915977PMC
June 2016

p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix.

Authors:
Pavankumar N G Reddy Maria Radu Ke Xu Jenna Wood Chad E Harris Jonathan Chernoff David A Williams

Blood 2016 Apr 1;127(16):1967-75. Epub 2016 Mar 1.

Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Harvard Stem Cell Institute, Harvard University, Boston, MA.

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http://dx.doi.org/10.1182/blood-2016-01-693572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841040PMC
April 2016

Potential compensation among group I PAK members in hindlimb ischemia and wound healing.

Authors:
Laila Elsherif Mehmet Ozler Mohamed A Zayed Jessica H Shen Jonathan Chernoff James E Faber Leslie V Parise

PLoS One 2014 7;9(11):e112239. Epub 2014 Nov 7.

Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112239PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224450PMC
December 2015

p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway.

Authors:
Maria Radu Karen Lyle Klaus P Hoeflich Olga Villamar-Cruz Hartmut Koeppen Jonathan Chernoff

Mol Cell Biol 2015 Dec 21;35(23):3990-4005. Epub 2015 Sep 21.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/MCB.00630-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628059PMC
December 2015

Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.

Authors:
Kyle Leonard O'Hagan Jinyong Choi Olga Pryshchep Jonathan Chernoff Hyewon Phee

J Immunol 2015 Aug 8;195(4):1564-77. Epub 2015 Jul 8.

Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611; and

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http://dx.doi.org/10.4049/jimmunol.1500843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530067PMC
August 2015

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.

Authors:
Ashley Pandolfi Robert F Stanley Yiting Yu Boris Bartholdy Gopichand Pendurti Kira Gritsman Jacqueline Boultwood Jonathan Chernoff Amit Verma Ulrich Steidl

Blood 2015 Aug 13;126(9):1118-27. Epub 2015 Jul 13.

Departments of Cell Biology and of Medicine, Division of Hemato-Oncology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY;

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http://dx.doi.org/10.1182/blood-2014-12-618801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551362PMC
August 2015

Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.

Authors:
Nikhlesh K Singh Sivareddy Kotla Elena Dyukova James G Traylor A Wayne Orr Jonathan Chernoff Tony N Marion Gadiparthi N Rao

Nat Commun 2015 Jun 24;6:7450. Epub 2015 Jun 24.

Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, Tennessee 38163, USA.

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http://www.nature.com/articles/ncomms8450
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http://dx.doi.org/10.1038/ncomms8450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480433PMC
June 2015

Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.

Authors:
Yi Zeng Hal E Broxmeyer Karl Staser Brahmananda Reddy Chitteti Su-Jung Park Seongmin Hahn Scott Cooper Zejin Sun Li Jiang XianLin Yang Jin Yuan Rachelle Kosoff George Sandusky Edward F Srour Jonathan Chernoff D Wade Clapp

Stem Cells 2015 May;33(5):1630-41

Department of Pediatrics, Steele Children's Research Center, University of Arizona School of Medicine, Tucson, Arizona, USA.

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http://dx.doi.org/10.1002/stem.1951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409559PMC
May 2015

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.

Authors:
Rachelle E Kosoff Joseph E Aslan John C Kostyak Essel Dulaimi Hoi Yee Chow Tatiana Y Prudnikova Maria Radu Satya P Kunapuli Owen J T McCarty Jonathan Chernoff

Blood 2015 May 30;125(19):2995-3005. Epub 2015 Mar 30.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA;

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http://www.bloodjournal.org/content/early/2015/03/30/blood-2
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http://www.bloodjournal.org/content/125/19/2995.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-10-60
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http://dx.doi.org/10.1182/blood-2014-10-604504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424419PMC
May 2015

Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.

Authors:
Christy C Ong Sarah Gierke Cameron Pitt Meredith Sagolla Christine K Cheng Wei Zhou Adrian M Jubb Laura Strickland Maike Schmidt Sergio G Duron David A Campbell Wei Zheng Seameen Dehdashti Min Shen Nora Yang Mark L Behnke Wenwei Huang John C McKew Jonathan Chernoff William F Forrest Peter M Haverty Suet-Feung Chin Emad A Rakha Andrew R Green Ian O Ellis Carlos Caldas Thomas O'Brien Lori S Friedman Hartmut Koeppen Joachim Rudolph Klaus P Hoeflich

Breast Cancer Res 2015 Apr 23;17:59. Epub 2015 Apr 23.

Department of Translational Oncology, Genentech, Inc., South San Francisco, CA, USA.

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http://dx.doi.org/10.1186/s13058-015-0564-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445529PMC
April 2015

Regulation of mammalian Ste20 (Mst) kinases.

Authors:
Sonali J Rawat Jonathan Chernoff

Trends Biochem Sci 2015 Mar 6;40(3):149-56. Epub 2015 Feb 6.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2015.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340714PMC
March 2015

Group I Paks as therapeutic targets in NF2-deficient meningioma.

Authors:
Hoi-Yee Chow Biao Dong Sergio G Duron David A Campbell Christy C Ong Klaus P Hoeflich Long-Sheng Chang D Bradley Welling Zeng-Jie Yang Jonathan Chernoff

Oncotarget 2015 Feb;6(4):1981-94

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385830PMC
http://dx.doi.org/10.18632/oncotarget.2810DOI Listing
February 2015

Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets.

Authors:
Rachit Badolia Bhanu Kanth Manne Carol Dangelmaier Jonathan Chernoff Satya P Kunapuli

Blood 2015 Jan 20;125(1):175-84. Epub 2014 Oct 20.

Department of Physiology, Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA; and.

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http://www.bloodjournal.org/content/early/2014/10/20/blood-2
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http://www.bloodjournal.org/content/125/1/175.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-05-57
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http://dx.doi.org/10.1182/blood-2014-05-576306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281826PMC
January 2015

Molecular pathways: targeting the kinase effectors of RHO-family GTPases.

Authors:
Tatiana Y Prudnikova Sonali J Rawat Jonathan Chernoff

Clin Cancer Res 2015 Jan 21;21(1):24-9. Epub 2014 Oct 21.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286478PMC
January 2015

Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers.

Authors:
Nicole M Baker Hoi Yee Chow Jonathan Chernoff Channing J Der

Clin Cancer Res 2014 Sep;20(18):4740-6

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166583PMC
September 2014

p21-activated kinase inhibitors.

Authors:
Joachim Rudolph James J Crawford Klaus P Hoeflich Jonathan Chernoff

Enzymes 2013 7;34 Pt. B:157-80. Epub 2013 Nov 7.

Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-420146-0.00007-XDOI Listing
August 2014

Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice.

Authors:
Yu-Ting Alex Chiang Wilfred Ip Weijuan Shao Zhuolun Eric Song Jonathan Chernoff Tianru Jin

Endocrinology 2014 Jun 31;155(6):2122-32. Epub 2014 Mar 31.

Division of Advanced Diagnostics (Y.-t.A.C., W.I., W.S., Z.E.S., T.J.), Toronto General Research Institute, University Health Network, Toronto, Canada M5G 1L7; Department of Physiology (Y.-t.A.C., T.J.), University of Toronto, Toronto, Canada M5S 1A8; and Institute of Medical Science (W.I., T.J.), University of Toronto, Canada; and Fox Chase Cancer Center (J.C.), Philadelphia, Pennsylvania 19111.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2013-1743DOI Listing
June 2014

p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils.

Authors:
Asako Itakura Joseph E Aslan Branden T Kusanto Kevin G Phillips Juliana E Porter Paul K Newton Xiaolin Nan Robert H Insall Jonathan Chernoff Owen J T McCarty

PLoS One 2013 3;8(9):e73063. Epub 2013 Sep 3.

Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, Oregon, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760889PMC
May 2014

A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish.

Authors:
Mollie L Kelly Artyom Astsaturov Jennifer Rhodes Jonathan Chernoff

Dev Cell 2014 May;29(3):350-9

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073496PMC
May 2014

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.

Authors:
Hyewon Phee Byron B Au-Yeung Olga Pryshchep Kyle Leonard O'Hagan Stephanie Grace Fairbairn Maria Radu Rachelle Kosoff Marianne Mollenauer Debra Cheng Jonathan Chernoff Arthur Weiss

Elife 2014 May 13;3:e02270. Epub 2014 May 13.

Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, United States Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017645PMC
http://dx.doi.org/10.7554/eLife.02270DOI Listing
May 2014

Analysis of PTP1B sumoylation.

Authors:
Sayanti Saha Jonathan Chernoff

Methods 2014 Jan 25;65(2):201-6. Epub 2013 Sep 25.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2013.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946832PMC
January 2014

PAK signalling during the development and progression of cancer.

Authors:
Maria Radu Galina Semenova Rachelle Kosoff Jonathan Chernoff

Nat Rev Cancer 2014 Jan;14(1):13-25

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115244PMC
January 2014

Role of p21-activated kinases in cardiovascular development and function.

Authors:
Mollie L Kelly Artyom Astsaturov Jonathan Chernoff

Cell Mol Life Sci 2013 Nov 4;70(22):4223-8. Epub 2013 May 4.

Department of Biochemistry, Drexel University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00018-013-1347-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775977PMC
November 2013

Targeting Cdc42 in cancer.

Authors:
Luis E Arias-Romero Jonathan Chernoff

Expert Opin Ther Targets 2013 Nov 19;17(11):1263-73. Epub 2013 Aug 19.

Cancer Biology Program, Fox Chase Cancer Center , Philadelphia, PA , USA +1 215 728 5319 ; +1 215 728 3616 ;

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http://dx.doi.org/10.1517/14728222.2013.828037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937847PMC
November 2013

FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas.

Authors:
Silvia Licciulli Jasna Maksimoska Chun Zhou Scott Troutman Smitha Kota Qin Liu Sergio Duron David Campbell Jonathan Chernoff Jeffrey Field Ronen Marmorstein Joseph L Kissil

J Biol Chem 2013 Oct 19;288(40):29105-14. Epub 2013 Aug 19.

From the Department of Cancer Biology, The Scripps Research Institute, Jupiter, Florida 33458.

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http://dx.doi.org/10.1074/jbc.M113.510933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790009PMC
October 2013

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation.

Authors:
Joseph E Aslan Sandra M Baker Cassandra P Loren Kristina M Haley Asako Itakura Jiaqing Pang Daniel L Greenberg Larry L David Ed Manser Jonathan Chernoff Owen J T McCarty

Am J Physiol Cell Physiol 2013 Sep 19;305(5):C519-28. Epub 2013 Jun 19.

Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1152/ajpcell.00418.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761148PMC
September 2013

p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear.

Authors:
Joseph E Aslan Asako Itakura Kristina M Haley Garth W Tormoen Cassandra P Loren Sandra M Baker Jiaqing Pang Jonathan Chernoff Owen J T McCarty

Arterioscler Thromb Vasc Biol 2013 Jul 2;33(7):1544-51. Epub 2013 May 2.

Department of Biomedical Engineering, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.301165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938029PMC
July 2013

ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling.

Authors:
Maria Radu Sonali J Rawat Alexander Beeser Anton Iliuk Weiguo Andy Tao Jonathan Chernoff

J Biol Chem 2013 Jul 11;288(29):21117-25. Epub 2013 Jun 11.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M113.459719
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http://dx.doi.org/10.1074/jbc.M113.459719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774378PMC
July 2013

Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells.

Authors:
Luis E Arias-Romero Olga Villamar-Cruz Min Huang Klaus P Hoeflich Jonathan Chernoff

Cancer Res 2013 Jun 10;73(12):3671-82. Epub 2013 Apr 10.

Cancer Biology Program and Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687032PMC
June 2013

Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways.

Authors:
Wyn C Hoover Wenwu Zhang Zhidong Xue Huanling Gao Jonathan Chernoff D Wade Clapp Susan J Gunst Robert S Tepper

PLoS One 2012 10;7(8):e42601. Epub 2012 Aug 10.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042601PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416806PMC
March 2013

p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways.

Authors:
Nhi Huynh Mildred Yim Jonathan Chernoff Arthur Shulkes Graham S Baldwin Hong He

Am J Physiol Gastrointest Liver Physiol 2013 Mar 10;304(6):G561-7. Epub 2013 Jan 10.

Department of Surgery, University of Melbourne, Austin Health, Victoria, Australia.

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http://www.physiology.org/doi/10.1152/ajpgi.00218.2012
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http://dx.doi.org/10.1152/ajpgi.00218.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602683PMC
March 2013

The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.

Authors:
Adrienne M Dorrance Serena De Vita Maria Radu Pavankumar N G Reddy Meaghan K McGuinness Chad E Harris Ronald Mathieu Steven W Lane Rachelle Kosoff Michael D Milsom Jonathan Chernoff David A Williams

Blood 2013 Mar 18;121(13):2474-82. Epub 2013 Jan 18.

Division of Hematology/Oncology, Children's Hospital Boston, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2012-10-460709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612857PMC
March 2013

The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein.

Authors:
Sonali Jalan Rawat Caretha L Creasy Jeffrey R Peterson Jonathan Chernoff

J Biol Chem 2013 Mar 5;288(12):8762-71. Epub 2013 Feb 5.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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http://dx.doi.org/10.1074/jbc.M112.414524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605693PMC
March 2013

An in vivo assay to test blood vessel permeability.

Authors:
Maria Radu Jonathan Chernoff

J Vis Exp 2013 Mar 16(73):e50062. Epub 2013 Mar 16.

Fox Chase Cancer Center, USA.

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http://dx.doi.org/10.3791/50062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639515PMC
March 2013

P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice.

Authors:
Yuting Alex Chiang Weijuan Shao Xiao Xue Xu Jonathan Chernoff Tianru Jin

Endocrinology 2013 Jan 26;154(1):77-88. Epub 2012 Nov 26.

Departments of Physiology, University of Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1210/en.2012-1781DOI Listing
January 2013

Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity.

Authors:
Rachelle Kosoff Hoi Yee Chow Maria Radu Jonathan Chernoff

J Biol Chem 2013 Jan 30;288(2):974-83. Epub 2012 Nov 30.

Cancer Biology Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.422295
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http://dx.doi.org/10.1074/jbc.M112.422295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543047PMC
January 2013

p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.

Authors:
Hoi Yee Chow Adrian M Jubb Jennifer N Koch Zahara M Jaffer Dina Stepanova David A Campbell Sergio G Duron Marie O'Farrell Kathy Q Cai Andres J P Klein-Szanto J Silvio Gutkind Klaus P Hoeflich Jonathan Chernoff

Cancer Res 2012 Nov 14;72(22):5966-75. Epub 2012 Sep 14.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-2246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500416PMC
November 2012

Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways.

Authors:
Craig W Menges Eleonora Sementino Jacqueline Talarchek Jinfei Xu Jonathan Chernoff Jeffrey R Peterson Joseph R Testa

Mol Cancer Res 2012 Sep 12;10(9):1178-88. Epub 2012 Jul 12.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-12
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http://dx.doi.org/10.1158/1541-7786.MCR-12-0082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447107PMC
September 2012

Mouse models of PAK function.

Authors:
Mollie L Kelly Jonathan Chernoff

Cell Logist 2012 Apr;2(2):84-88

Cancer Biology Program; Fox Chase Cancer Center; Philadelphia, PA USA.

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http://dx.doi.org/10.4161/cl.21381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490966PMC
April 2012

PKM2 enters the morpheein academy.

Authors:
Galina Semenova Jonathan Chernoff

Mol Cell 2012 Mar;45(5):583-4

Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.02.014DOI Listing
March 2012

p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation.

Authors:
Michelle M Monasky Domenico M Taglieri Bindiya G Patel Jonathan Chernoff Beata M Wolska Yunbo Ke R John Solaro

Am J Physiol Heart Circ Physiol 2012 Jan 28;302(1):H224-30. Epub 2011 Oct 28.

Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 60612-7342, USA.

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http://dx.doi.org/10.1152/ajpheart.00612.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334232PMC
January 2012

Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin.

Authors:
Shu-Chin Yip Sophie Cotteret Jonathan Chernoff

J Cell Sci 2012 Jan 20;125(Pt 2):310-6. Epub 2012 Jan 20.

Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1242/jcs.086256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283870PMC
January 2012

Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.

Authors:
Zhanxiang Wang Eunjin Oh D Wade Clapp Jonathan Chernoff Debbie C Thurmond

J Biol Chem 2011 Dec 3;286(48):41359-67. Epub 2011 Oct 3.

Basic Diabetes Group, Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1074/jbc.M111.291500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308848PMC
December 2011

Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A.

Authors:
Domenico M Taglieri Michelle M Monasky Ivana Knezevic Katherine A Sheehan Ming Lei Xin Wang Jonathan Chernoff Beata M Wolska Yunbo Ke R John Solaro

J Mol Cell Cardiol 2011 Dec 24;51(6):988-96. Epub 2011 Sep 24.

Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 835 S. Wolcott Ave, M/C 901, Chicago, IL 60612-7342, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2011.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208757PMC
December 2011

Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.

Authors:
Ang Li Yafeng Ma Xinzi Yu Richard L Mort Colin R Lindsay David Stevenson Douglas Strathdee Robert H Insall Jonathan Chernoff Scott B Snapper Ian J Jackson Lionel Larue Owen J Sansom Laura M Machesky

Dev Cell 2011 Oct 15;21(4):722-34. Epub 2011 Sep 15.

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S153458071100300
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http://dx.doi.org/10.1016/j.devcel.2011.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464460PMC
October 2011

The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers.

Authors:
Igor Makhlin Jiaru Zhang Christopher J Long Karthik Devarajan Yan Zhou Andres J Klein-Szanto Min Huang Jonathan Chernoff Stephen A Boorjian

BJU Int 2011 Jul 2;108(2 Pt 2):E84-90. Epub 2010 Nov 2.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/j.1464-410X.2010.09844.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116980PMC
July 2011

Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

Authors:
Meirav Sela Yaron Bogin Dvora Beach Thomas Oellerich Johanna Lehne Jennifer E Smith-Garvin Mariko Okumura Elina Starosvetsky Rachelle Kosoff Evgeny Libman Gary Koretzky Taku Kambayashi Henning Urlaub Jürgen Wienands Jonathan Chernoff Deborah Yablonski

EMBO J 2011 Jul 1;30(15):3160-72. Epub 2011 Jul 1.

Rappaport Family Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

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http://dx.doi.org/10.1038/emboj.2011.213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160187PMC
July 2011

Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.

Authors:
Violaine D Delorme-Walker Jeffrey R Peterson Jonathan Chernoff Clare M Waterman Gaudenz Danuser Céline DerMardirossian Gary M Bokoch

J Cell Biol 2011 Jun;193(7):1289-303

Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1083/jcb.201010059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216326PMC
June 2011

Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity.

Authors:
Alina De la Mota-Peynado Jonathan Chernoff Alexander Beeser

J Biol Chem 2011 Apr 11;286(15):13603-11. Epub 2011 Feb 11.

Division of Biology and Molecular, Cellular, and Developmental Biology Program, Kansas State University, Manhattan, Kansas 66506, USA.

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http://dx.doi.org/10.1074/jbc.M110.181743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075705PMC
April 2011

Getting smart about p21-activated kinases.

Authors:
Mollie L Kelly Jonathan Chernoff

Mol Cell Biol 2011 Feb 29;31(3):386-7. Epub 2010 Nov 29.

Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1128/MCB.01267-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028629PMC
February 2011

Back to the future: proceedings from the 2010 NF Conference.

Authors:
Susan M Huson Maria T Acosta Allan J Belzberg Andre Bernards Jonathan Chernoff Karen Cichowski D Gareth Evans Rosalie E Ferner Marco Giovannini Bruce R Korf Robert Listernick Kathryn N North Roger J Packer Luis F Parada Juha Peltonen Vijaya Ramesh Karlyne M Reilly John W Risner Elizabeth K Schorry Meena Upadhyaya David H Viskochil Yuan Zhu Kim Hunter-Schaedle Filippo G Giancotti

Am J Med Genet A 2011 Feb 22;155A(2):307-21. Epub 2010 Dec 22.

St. Mary's Hospital, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/ajmg.a.33804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079924PMC
February 2011

Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation.

Authors:
Mikhail V Shepelev Jonathan Chernoff Igor V Korobko

Small GTPases 2011 Jan;2(1):17-26

Laboratory of Molecular Oncogenetics; Institute of Gene Biology; Russian Academy of Sciences; Moscow, Russia.

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http://dx.doi.org/10.4161/sgtp.2.1.15229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116612PMC
January 2011

p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2.

Authors:
Hoi Yee Chow Dina Stepanova Jennifer Koch Jonathan Chernoff

PLoS One 2010 Nov 2;5(11):e13791. Epub 2010 Nov 2.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013791PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970553PMC
November 2010

p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target?

Authors:
Luis E Arias-Romero Jonathan Chernoff

Small GTPases 2010 Sep;1(2):124-128

Fox Chase Cancer Center; Philadelphia, PA USA.

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http://dx.doi.org/10.4161/sgtp.1.2.14109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116598PMC
September 2010

PTP1B: a double agent in metabolism and oncogenesis.

Authors:
Shu-Chin Yip Sayanti Saha Jonathan Chernoff

Trends Biochem Sci 2010 Aug 8;35(8):442-9. Epub 2010 Apr 8.

Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09680004100004
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http://dx.doi.org/10.1016/j.tibs.2010.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917533PMC
August 2010

Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.

Authors:
Poonam R Molli Da-Qiang Li Rozita Bagheri-Yarmand Suresh B Pakala Hiroshi Katayama Subrata Sen Jyoti Iyer Jonathan Chernoff Ming-Ying Tsai Sujit S Nair Rakesh Kumar

J Cell Biol 2010 Jul 5;190(1):101-14. Epub 2010 Jul 5.

Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC 20037, USA.

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http://dx.doi.org/10.1083/jcb.200908050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911675PMC
July 2010

A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma.

Authors:
Craig W Menges Yibai Chen Brooke T Mossman Jonathan Chernoff Anthony T Yeung Joseph R Testa

Genes Cancer 2010 May;1(5):493-505

Cancer Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111.

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http://dx.doi.org/10.1177/1947601910375273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909631PMC
May 2010

LOV conquers (sm)All GTPases.

Authors:
Rachelle Kosoff Jonathan Chernoff

F1000 Biol Rep 2010 Apr 12;2. Epub 2010 Apr 12.

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http://dx.doi.org/10.3410/B2-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948368PMC
April 2010

An emerging role for p21-activated kinases (Paks) in viral infections.

Authors:
Celine Van den Broeke Maria Radu Jonathan Chernoff Herman W Favoreel

Trends Cell Biol 2010 Mar 12;20(3):160-9. Epub 2010 Jan 12.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

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http://dx.doi.org/10.1016/j.tcb.2009.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489496PMC
March 2010

Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis.

Authors:
Almudena Pacheco Jonathan Chernoff

Int J Biochem Cell Biol 2010 Jan 9;42(1):13-6. Epub 2009 Sep 9.

Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1016/j.biocel.2009.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787825PMC
January 2010

PAK kinase regulates Rac GTPase and is a potential target in human schwannomas.

Authors:
Christine Flaiz Jonathan Chernoff Sylwia Ammoun Jeffrey R Peterson Clemens O Hanemann

Exp Neurol 2009 Jul 3;218(1):137-44. Epub 2009 May 3.

Clinical Neurobiology, Peninsula College for Medicine and Dentistry, The John Bull Building, Tamar Science Park, Research Way, Plymouth PL6 8BU, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760977PMC
http://dx.doi.org/10.1016/j.expneurol.2009.04.019DOI Listing
July 2009

Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells.

Authors:
Luis E Arias-Romero Sayanti Saha Olga Villamar-Cruz Shu-Chin Yip Stephen P Ethier Zhong-Yin Zhang Jonathan Chernoff

Cancer Res 2009 Jun 12;69(11):4582-8. Epub 2009 May 12.

Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692630PMC
June 2009

Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development.

Authors:
Christine M Lightcap Gabor Kari Luis E Arias-Romero Jonathan Chernoff Ulrich Rodeck John C Williams

PLoS One 2009 Jun 26;4(6):e6025. Epub 2009 Jun 26.

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006025PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698211PMC
June 2009

Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases.

Authors:
Céline Van den Broeke Maria Radu Matthias Deruelle Hans Nauwynck Clemens Hofmann Zahara M Jaffer Jonathan Chernoff Herman W Favoreel

Proc Natl Acad Sci U S A 2009 May 12;106(21):8707-12. Epub 2009 May 12.

Department of Virology, Parasitology, and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

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http://dx.doi.org/10.1073/pnas.0900436106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688975PMC
May 2009

The DeMSTification of mammalian Ste20 kinases.

Authors:
Maria Radu Jonathan Chernoff

Curr Biol 2009 May;19(10):R421-5

Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1016/j.cub.2009.04.022DOI Listing
May 2009

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.

Authors:
Jayme D Allen Zahara M Jaffer Su-Jung Park Sarah Burgin Clemens Hofmann Mary Ann Sells Shi Chen Ethel Derr-Yellin Elizabeth G Michels Andrew McDaniel Waylan K Bessler David A Ingram Simon J Atkinson Jeffrey B Travers Jonathan Chernoff D Wade Clapp

Blood 2009 Mar 5;113(12):2695-705. Epub 2009 Jan 5.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1182/blood-2008-06-160861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661857PMC
March 2009

Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells.

Authors:
Andrew S McDaniel Jayme D Allen Su-Jung Park Zahara M Jaffer Elizabeth G Michels Sarah J Burgin Shi Chen Waylan K Bessler Clemens Hofmann David A Ingram Jonathan Chernoff D Wade Clapp

Blood 2008 Dec 2;112(12):4646-54. Epub 2008 Sep 2.

Department of Microbiology and Immunology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA.

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http://dx.doi.org/10.1182/blood-2008-04-155085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597131PMC
December 2008

PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics.

Authors:
Stephen D Smith Zahara M Jaffer Jonathan Chernoff Anne J Ridley

J Cell Sci 2008 Nov 21;121(Pt 22):3729-36. Epub 2008 Oct 21.

Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK.

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http://dx.doi.org/10.1242/jcs.027680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702775PMC
November 2008

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.

Authors:
Sean W Deacon Alexander Beeser Jami A Fukui Ulrike E E Rennefahrt Cynthia Myers Jonathan Chernoff Jeffrey R Peterson

Chem Biol 2008 Apr;15(4):322-31

Basic Sciences Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1016/j.chembiol.2008.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353635PMC
April 2008

Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes.

Authors:
Kai Mao Satoru Kobayashi Zahara M Jaffer Yuan Huang Paul Volden Jonathan Chernoff Qiangrong Liang

J Mol Cell Cardiol 2008 Feb 3;44(2):429-34. Epub 2007 Dec 3.

Cardiovascular Research Center, Sanford Research/USD, University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2007.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278035PMC
February 2008

A tale of two Paks.

Authors:
Luis E Arias-Romero Jonathan Chernoff

Biol Cell 2008 Feb;100(2):97-108

Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111, U.S.A.

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http://dx.doi.org/10.1042/BC20070109DOI Listing
February 2008

alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini.

Authors:
Julie C Friedland Johnathon N Lakins Marcelo G Kazanietz Jonathan Chernoff David Boettiger Valerie M Weaver

J Cell Sci 2007 Oct 2;120(Pt 20):3700-12. Epub 2007 Oct 2.

Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.03484
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http://dx.doi.org/10.1242/jcs.03484DOI Listing
October 2007

Specificity profiling of Pak kinases allows identification of novel phosphorylation sites.

Authors:
Ulrike E E Rennefahrt Sean W Deacon Sirlester A Parker Karthik Devarajan Alexander Beeser Jonathan Chernoff Stefan Knapp Benjamin E Turk Jeffrey R Peterson

J Biol Chem 2007 May 28;282(21):15667-78. Epub 2007 Mar 28.

Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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http://dx.doi.org/10.1074/jbc.M700253200DOI Listing
May 2007

Regulation of protein tyrosine phosphatase 1B by sumoylation.

Authors:
Shrikrishna Dadke Sophie Cotteret Shu-Chin Yip Zahara M Jaffer Fawaz Haj Alexey Ivanov Frank Rauscher Ke Shuai Tony Ng Benjamin G Neel Jonathan Chernoff

Nat Cell Biol 2007 Jan 10;9(1):80-5. Epub 2006 Dec 10.

Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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http://www.nature.com/articles/ncb1522
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http://dx.doi.org/10.1038/ncb1522DOI Listing
January 2007

Src transforms in a Cool way.

Authors:
Jeffrey R Peterson Jonathan Chernoff

Nat Cell Biol 2006 Sep;8(9):905-7

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http://dx.doi.org/10.1038/ncb0906-905DOI Listing
September 2006

A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases.

Authors:
Michelle Pirruccello Holger Sondermann Jeffrey G Pelton Patricia Pellicena André Hoelz Jonathan Chernoff David E Wemmer John Kuriyan

J Mol Biol 2006 Aug 27;361(2):312-26. Epub 2006 Jun 27.

Howard Hughes Medical Institute, Department of Molecular and Cell Biology, Department of Chemistry, University of California, Berkeley, CA 94720, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360600728
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http://dx.doi.org/10.1016/j.jmb.2006.06.017DOI Listing
August 2006