Jonathan Chernoff

Jonathan Chernoff

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Jonathan Chernoff

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How to get and keep your lab funded.

Mol Biol Cell 2018 10;29(21):2519-2521

Fox Chase Cancer Center, Philadelphia, PA 19111.

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https://www.molbiolcell.org/doi/10.1091/mbc.E18-07-0416
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http://dx.doi.org/10.1091/mbc.E18-07-0416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254575PMC
October 2018

Hras helps hippo heterodimerize to evade tumor suppression.

Small GTPases 2018 07 20;9(4):327-331. Epub 2016 Sep 20.

a Fox Chase Cancer Center , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/21541248.2016.1228794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997136PMC
July 2018

A new concept in NF2 pharmacotherapy: targeting fatty acid synthesis.

Oncoscience 2018 May 23;5(5-6):126-127. Epub 2018 Jun 23.

Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.

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http://dx.doi.org/10.18632/oncoscience.417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049319PMC
May 2018

The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin.

Small GTPases 2017 10 18;8(4):193-198. Epub 2016 Jul 18.

a Cancer Biology Program, Fox Chase Cancer Center , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/21541248.2016.1213089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680705PMC
October 2017

An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis.

Cancer Res 2017 09 20;77(18):5026-5038. Epub 2017 Jul 20.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600854PMC
September 2017

Targeting MYC sensitizes malignant mesothelioma cells to PAK blockage-induced cytotoxicity.

Am J Cancer Res 2017 1;7(8):1724-1737. Epub 2017 Aug 1.

Cancer Biology Program, Fox Chase Cancer CenterPhiladelphia, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574944PMC
August 2017

Recent advances in methods to assess the activity of the kinome.

F1000Res 2017 26;6:1004. Epub 2017 Jun 26.

Cancer Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111-2497, USA.

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https://f1000research.com/articles/6-1004/v1
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http://dx.doi.org/10.12688/f1000research.10962.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490475PMC
June 2017

Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro.

Mol Cell Biol 2017 02 1;37(4). Epub 2017 Feb 1.

Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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http://dx.doi.org/10.1128/MCB.00222-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288579PMC
February 2017

Alfred G. Knudson Jr, MD, PhD: In Memoriam (1922-2016).

Cancer Res 2017 02;77(4):815-816

Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-3547DOI Listing
February 2017

Targeting PAK1.

Biochem Soc Trans 2017 02;45(1):79-88

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA

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http://dx.doi.org/10.1042/BST20160134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973817PMC
February 2017

Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP.

PLoS Genet 2016 09 1;12(9):e1006290. Epub 2016 Sep 1.

Department of Neurology, Center for Human Genetics Research, Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008806PMC
September 2016

H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization.

Curr Biol 2016 06 26;26(12):1556-1563. Epub 2016 May 26.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2016.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915977PMC
June 2016

p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix.

Blood 2016 Apr 1;127(16):1967-75. Epub 2016 Mar 1.

Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Harvard Stem Cell Institute, Harvard University, Boston, MA.

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http://dx.doi.org/10.1182/blood-2016-01-693572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841040PMC
April 2016

Potential compensation among group I PAK members in hindlimb ischemia and wound healing.

PLoS One 2014 7;9(11):e112239. Epub 2014 Nov 7.

Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112239PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224450PMC
December 2015

p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway.

Mol Cell Biol 2015 Dec 21;35(23):3990-4005. Epub 2015 Sep 21.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/MCB.00630-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628059PMC
December 2015

Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.

J Immunol 2015 Aug 8;195(4):1564-77. Epub 2015 Jul 8.

Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611; and

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http://dx.doi.org/10.4049/jimmunol.1500843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530067PMC
August 2015

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.

Blood 2015 Aug 13;126(9):1118-27. Epub 2015 Jul 13.

Departments of Cell Biology and of Medicine, Division of Hemato-Oncology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY;

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http://dx.doi.org/10.1182/blood-2014-12-618801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551362PMC
August 2015

Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.

Nat Commun 2015 Jun 24;6:7450. Epub 2015 Jun 24.

Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, Tennessee 38163, USA.

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http://www.nature.com/articles/ncomms8450
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http://dx.doi.org/10.1038/ncomms8450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480433PMC
June 2015

Regulation of mammalian Ste20 (Mst) kinases.

Trends Biochem Sci 2015 Mar 6;40(3):149-56. Epub 2015 Feb 6.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2015.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340714PMC
March 2015

Molecular pathways: targeting the kinase effectors of RHO-family GTPases.

Clin Cancer Res 2015 Jan 21;21(1):24-9. Epub 2014 Oct 21.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286478PMC
January 2015

Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers.

Clin Cancer Res 2014 Sep;20(18):4740-6

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166583PMC
September 2014

p21-activated kinase inhibitors.

Enzymes 2013 7;34 Pt. B:157-80. Epub 2013 Nov 7.

Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-420146-0.00007-XDOI Listing
August 2014

Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice.

Endocrinology 2014 Jun 31;155(6):2122-32. Epub 2014 Mar 31.

Division of Advanced Diagnostics (Y.-t.A.C., W.I., W.S., Z.E.S., T.J.), Toronto General Research Institute, University Health Network, Toronto, Canada M5G 1L7; Department of Physiology (Y.-t.A.C., T.J.), University of Toronto, Toronto, Canada M5S 1A8; and Institute of Medical Science (W.I., T.J.), University of Toronto, Canada; and Fox Chase Cancer Center (J.C.), Philadelphia, Pennsylvania 19111.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2013-1743DOI Listing
June 2014

A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish.

Dev Cell 2014 May;29(3):350-9

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073496PMC
May 2014

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.

Elife 2014 May 13;3:e02270. Epub 2014 May 13.

Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, United States Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017645PMC
http://dx.doi.org/10.7554/eLife.02270DOI Listing
May 2014

Analysis of PTP1B sumoylation.

Methods 2014 Jan 25;65(2):201-6. Epub 2013 Sep 25.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2013.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946832PMC
January 2014

Role of p21-activated kinases in cardiovascular development and function.

Cell Mol Life Sci 2013 Nov 4;70(22):4223-8. Epub 2013 May 4.

Department of Biochemistry, Drexel University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00018-013-1347-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775977PMC
November 2013

Targeting Cdc42 in cancer.

Expert Opin Ther Targets 2013 Nov 19;17(11):1263-73. Epub 2013 Aug 19.

Cancer Biology Program, Fox Chase Cancer Center , Philadelphia, PA , USA +1 215 728 5319 ; +1 215 728 3616 ;

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http://dx.doi.org/10.1517/14728222.2013.828037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937847PMC
November 2013

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation.

Am J Physiol Cell Physiol 2013 Sep 19;305(5):C519-28. Epub 2013 Jun 19.

Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1152/ajpcell.00418.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761148PMC
September 2013

p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear.

Arterioscler Thromb Vasc Biol 2013 Jul 2;33(7):1544-51. Epub 2013 May 2.

Department of Biomedical Engineering, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.301165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938029PMC
July 2013

ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling.

J Biol Chem 2013 Jul 11;288(29):21117-25. Epub 2013 Jun 11.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M113.459719
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http://dx.doi.org/10.1074/jbc.M113.459719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774378PMC
July 2013

Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells.

Cancer Res 2013 Jun 10;73(12):3671-82. Epub 2013 Apr 10.

Cancer Biology Program and Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687032PMC
June 2013

p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways.

Am J Physiol Gastrointest Liver Physiol 2013 Mar 10;304(6):G561-7. Epub 2013 Jan 10.

Department of Surgery, University of Melbourne, Austin Health, Victoria, Australia.

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http://www.physiology.org/doi/10.1152/ajpgi.00218.2012
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http://dx.doi.org/10.1152/ajpgi.00218.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602683PMC
March 2013

The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein.

J Biol Chem 2013 Mar 5;288(12):8762-71. Epub 2013 Feb 5.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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http://dx.doi.org/10.1074/jbc.M112.414524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605693PMC
March 2013

An in vivo assay to test blood vessel permeability.

J Vis Exp 2013 Mar 16(73):e50062. Epub 2013 Mar 16.

Fox Chase Cancer Center, USA.

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http://dx.doi.org/10.3791/50062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639515PMC
March 2013

Mouse models of PAK function.

Cell Logist 2012 Apr;2(2):84-88

Cancer Biology Program; Fox Chase Cancer Center; Philadelphia, PA USA.

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http://dx.doi.org/10.4161/cl.21381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490966PMC
April 2012

PKM2 enters the morpheein academy.

Mol Cell 2012 Mar;45(5):583-4

Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.02.014DOI Listing
March 2012

p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation.

Am J Physiol Heart Circ Physiol 2012 Jan 28;302(1):H224-30. Epub 2011 Oct 28.

Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 60612-7342, USA.

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http://dx.doi.org/10.1152/ajpheart.00612.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334232PMC
January 2012

Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin.

J Cell Sci 2012 Jan 20;125(Pt 2):310-6. Epub 2012 Jan 20.

Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1242/jcs.086256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283870PMC
January 2012

Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.

J Biol Chem 2011 Dec 3;286(48):41359-67. Epub 2011 Oct 3.

Basic Diabetes Group, Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1074/jbc.M111.291500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308848PMC
December 2011

Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A.

J Mol Cell Cardiol 2011 Dec 24;51(6):988-96. Epub 2011 Sep 24.

Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 835 S. Wolcott Ave, M/C 901, Chicago, IL 60612-7342, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2011.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208757PMC
December 2011

Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

EMBO J 2011 Jul 1;30(15):3160-72. Epub 2011 Jul 1.

Rappaport Family Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

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http://dx.doi.org/10.1038/emboj.2011.213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160187PMC
July 2011

Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity.

J Biol Chem 2011 Apr 11;286(15):13603-11. Epub 2011 Feb 11.

Division of Biology and Molecular, Cellular, and Developmental Biology Program, Kansas State University, Manhattan, Kansas 66506, USA.

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http://dx.doi.org/10.1074/jbc.M110.181743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075705PMC
April 2011

Getting smart about p21-activated kinases.

Mol Cell Biol 2011 Feb 29;31(3):386-7. Epub 2010 Nov 29.

Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1128/MCB.01267-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028629PMC
February 2011

Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation.

Small GTPases 2011 Jan;2(1):17-26

Laboratory of Molecular Oncogenetics; Institute of Gene Biology; Russian Academy of Sciences; Moscow, Russia.

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http://dx.doi.org/10.4161/sgtp.2.1.15229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116612PMC
January 2011

p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2.

PLoS One 2010 Nov 2;5(11):e13791. Epub 2010 Nov 2.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013791PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970553PMC
November 2010

p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target?

Small GTPases 2010 Sep;1(2):124-128

Fox Chase Cancer Center; Philadelphia, PA USA.

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http://dx.doi.org/10.4161/sgtp.1.2.14109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116598PMC
September 2010

PTP1B: a double agent in metabolism and oncogenesis.

Trends Biochem Sci 2010 Aug 8;35(8):442-9. Epub 2010 Apr 8.

Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09680004100004
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http://dx.doi.org/10.1016/j.tibs.2010.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917533PMC
August 2010

Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.

J Cell Biol 2010 Jul 5;190(1):101-14. Epub 2010 Jul 5.

Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC 20037, USA.

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http://dx.doi.org/10.1083/jcb.200908050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911675PMC
July 2010

LOV conquers (sm)All GTPases.

F1000 Biol Rep 2010 Apr 12;2. Epub 2010 Apr 12.

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http://dx.doi.org/10.3410/B2-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948368PMC
April 2010

An emerging role for p21-activated kinases (Paks) in viral infections.

Trends Cell Biol 2010 Mar 12;20(3):160-9. Epub 2010 Jan 12.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

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http://dx.doi.org/10.1016/j.tcb.2009.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489496PMC
March 2010

Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis.

Int J Biochem Cell Biol 2010 Jan 9;42(1):13-6. Epub 2009 Sep 9.

Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1016/j.biocel.2009.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787825PMC
January 2010

PAK kinase regulates Rac GTPase and is a potential target in human schwannomas.

Exp Neurol 2009 Jul 3;218(1):137-44. Epub 2009 May 3.

Clinical Neurobiology, Peninsula College for Medicine and Dentistry, The John Bull Building, Tamar Science Park, Research Way, Plymouth PL6 8BU, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760977PMC
http://dx.doi.org/10.1016/j.expneurol.2009.04.019DOI Listing
July 2009

Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases.

Proc Natl Acad Sci U S A 2009 May 12;106(21):8707-12. Epub 2009 May 12.

Department of Virology, Parasitology, and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

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http://dx.doi.org/10.1073/pnas.0900436106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688975PMC
May 2009

The DeMSTification of mammalian Ste20 kinases.

Curr Biol 2009 May;19(10):R421-5

Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1016/j.cub.2009.04.022DOI Listing
May 2009

Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells.

Blood 2008 Dec 2;112(12):4646-54. Epub 2008 Sep 2.

Department of Microbiology and Immunology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA.

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http://dx.doi.org/10.1182/blood-2008-04-155085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597131PMC
December 2008

PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics.

J Cell Sci 2008 Nov 21;121(Pt 22):3729-36. Epub 2008 Oct 21.

Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702775PMC
November 2008

Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes.

J Mol Cell Cardiol 2008 Feb 3;44(2):429-34. Epub 2007 Dec 3.

Cardiovascular Research Center, Sanford Research/USD, University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278035PMC
February 2008

A tale of two Paks.

Biol Cell 2008 Feb;100(2):97-108

Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111, U.S.A.

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February 2008

alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini.

J Cell Sci 2007 Oct 2;120(Pt 20):3700-12. Epub 2007 Oct 2.

Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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October 2007

Specificity profiling of Pak kinases allows identification of novel phosphorylation sites.

J Biol Chem 2007 May 28;282(21):15667-78. Epub 2007 Mar 28.

Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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May 2007

Regulation of protein tyrosine phosphatase 1B by sumoylation.

Nat Cell Biol 2007 Jan 10;9(1):80-5. Epub 2006 Dec 10.

Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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January 2007

Src transforms in a Cool way.

Nat Cell Biol 2006 Sep;8(9):905-7

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September 2006

A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases.

J Mol Biol 2006 Aug 27;361(2):312-26. Epub 2006 Jun 27.

Howard Hughes Medical Institute, Department of Molecular and Cell Biology, Department of Chemistry, University of California, Berkeley, CA 94720, USA.

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August 2006