Publications by authors named "Jonathan Chernoff"

100Publications

RAC1 as a Therapeutic Target in Malignant Melanoma.

Trends Cancer 2020 06 18;6(6):478-488. Epub 2020 Mar 18.

Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA. Electronic address:

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June 2020

Targeting effector pathways in RAC1-driven malignant melanoma.

Small GTPases 2020 Feb 17:1-9. Epub 2020 Feb 17.

Instituto De Química, Universidad Nacional Autónoma De México, México City, México.

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February 2020

A New Rho(d) Map to Diffuse Gastric Cancer.

Cancer Discov 2020 02;10(2):182-184

Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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February 2020

Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2).

BMC Pharmacol Toxicol 2019 11 15;20(1):67. Epub 2019 Nov 15.

Department of Cell and Developmental Biology, 3029 BSRB, University of Michigan Medical School, Ann Arbor, Michigan, 48109-2200, USA.

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November 2019

How much is my paper worth?

Mol Biol Cell 2019 11;30(23):2878-2879

Fox Chase Cancer Center, Philadelphia, PA 19111.

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November 2019

Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer.

Breast Cancer Res Treat 2019 Sep 28;177(2):369-382. Epub 2019 Jun 28.

University of Colorado Denver, Young Women's Breast Cancer Translational Program, Aurora, CO, 80045, USA.

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September 2019

How to get and keep your lab funded.

Mol Biol Cell 2018 10;29(21):2519-2521

Fox Chase Cancer Center, Philadelphia, PA 19111.

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October 2018

A new concept in NF2 pharmacotherapy: targeting fatty acid synthesis.

Oncoscience 2018 May 23;5(5-6):126-127. Epub 2018 Jun 23.

Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.

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May 2018

Pak2 regulates myeloid-derived suppressor cell development in mice.

Blood Adv 2017 Oct 10;1(22):1923-1933. Epub 2017 Oct 10.

Department of Pediatrics, Steele Children's Research Center.

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October 2017

Targeting MYC sensitizes malignant mesothelioma cells to PAK blockage-induced cytotoxicity.

Am J Cancer Res 2017 1;7(8):1724-1737. Epub 2017 Aug 1.

Cancer Biology Program, Fox Chase Cancer CenterPhiladelphia, Pennsylvania, USA.

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August 2017

An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis.

Cancer Res 2017 09 20;77(18):5026-5038. Epub 2017 Jul 20.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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September 2017

Recent advances in methods to assess the activity of the kinome.

F1000Res 2017 26;6:1004. Epub 2017 Jun 26.

Cancer Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111-2497, USA.

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June 2017

Targeting PAK1.

Biochem Soc Trans 2017 02;45(1):79-88

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA

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February 2017

Alfred G. Knudson Jr, MD, PhD: In Memoriam (1922-2016).

Cancer Res 2017 02;77(4):815-816

Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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February 2017

Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro.

Mol Cell Biol 2017 02 1;37(4). Epub 2017 Feb 1.

Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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February 2017

Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP.

PLoS Genet 2016 09 1;12(9):e1006290. Epub 2016 Sep 1.

Department of Neurology, Center for Human Genetics Research, Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

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September 2016

Hras helps hippo heterodimerize to evade tumor suppression.

Small GTPases 2018 07 20;9(4):327-331. Epub 2016 Sep 20.

a Fox Chase Cancer Center , Philadelphia , PA , USA.

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July 2018

The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin.

Small GTPases 2017 10 18;8(4):193-198. Epub 2016 Jul 18.

a Cancer Biology Program, Fox Chase Cancer Center , Philadelphia , PA , USA.

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October 2017

H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization.

Curr Biol 2016 06 26;26(12):1556-1563. Epub 2016 May 26.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address:

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June 2016

p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix.

Blood 2016 Apr 1;127(16):1967-75. Epub 2016 Mar 1.

Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Harvard Stem Cell Institute, Harvard University, Boston, MA.

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April 2016

p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway.

Mol Cell Biol 2015 Dec 21;35(23):3990-4005. Epub 2015 Sep 21.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

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December 2015

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.

Blood 2015 Aug 13;126(9):1118-27. Epub 2015 Jul 13.

Departments of Cell Biology and of Medicine, Division of Hemato-Oncology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY;

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August 2015

Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.

J Immunol 2015 Aug 8;195(4):1564-77. Epub 2015 Jul 8.

Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611; and

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August 2015

Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.

Nat Commun 2015 Jun 24;6:7450. Epub 2015 Jun 24.

Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, Tennessee 38163, USA.

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June 2015

Regulation of mammalian Ste20 (Mst) kinases.

Trends Biochem Sci 2015 Mar 6;40(3):149-56. Epub 2015 Feb 6.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA. Electronic address:

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March 2015

Potential compensation among group I PAK members in hindlimb ischemia and wound healing.

PLoS One 2014 7;9(11):e112239. Epub 2014 Nov 7.

Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.

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December 2015

Molecular pathways: targeting the kinase effectors of RHO-family GTPases.

Clin Cancer Res 2015 Jan 21;21(1):24-9. Epub 2014 Oct 21.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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January 2015

Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets.

Blood 2015 Jan 20;125(1):175-84. Epub 2014 Oct 20.

Department of Physiology, Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA; and.

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January 2015

Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers.

Clin Cancer Res 2014 Sep;20(18):4740-6

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.

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September 2014

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.

Elife 2014 May 13;3:e02270. Epub 2014 May 13.

Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, United States Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.

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May 2014

A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish.

Dev Cell 2014 May;29(3):350-9

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address:

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May 2014

Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice.

Endocrinology 2014 Jun 31;155(6):2122-32. Epub 2014 Mar 31.

Division of Advanced Diagnostics (Y.-t.A.C., W.I., W.S., Z.E.S., T.J.), Toronto General Research Institute, University Health Network, Toronto, Canada M5G 1L7; Department of Physiology (Y.-t.A.C., T.J.), University of Toronto, Toronto, Canada M5S 1A8; and Institute of Medical Science (W.I., T.J.), University of Toronto, Canada; and Fox Chase Cancer Center (J.C.), Philadelphia, Pennsylvania 19111.

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June 2014

Analysis of PTP1B sumoylation.

Methods 2014 Jan 25;65(2):201-6. Epub 2013 Sep 25.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, United States. Electronic address:

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January 2014

p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils.

PLoS One 2013 3;8(9):e73063. Epub 2013 Sep 3.

Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, Oregon, United States of America.

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May 2014

Targeting Cdc42 in cancer.

Expert Opin Ther Targets 2013 Nov 19;17(11):1263-73. Epub 2013 Aug 19.

Cancer Biology Program, Fox Chase Cancer Center , Philadelphia, PA , USA +1 215 728 5319 ; +1 215 728 3616 ;

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November 2013

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation.

Am J Physiol Cell Physiol 2013 Sep 19;305(5):C519-28. Epub 2013 Jun 19.

Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.

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September 2013

ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling.

J Biol Chem 2013 Jul 11;288(29):21117-25. Epub 2013 Jun 11.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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July 2013

Role of p21-activated kinases in cardiovascular development and function.

Cell Mol Life Sci 2013 Nov 4;70(22):4223-8. Epub 2013 May 4.

Department of Biochemistry, Drexel University School of Medicine, Philadelphia, PA, USA.

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November 2013

p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear.

Arterioscler Thromb Vasc Biol 2013 Jul 2;33(7):1544-51. Epub 2013 May 2.

Department of Biomedical Engineering, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR 97239, USA.

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July 2013

Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells.

Cancer Res 2013 Jun 10;73(12):3671-82. Epub 2013 Apr 10.

Cancer Biology Program and Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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June 2013

An in vivo assay to test blood vessel permeability.

J Vis Exp 2013 Mar 16(73):e50062. Epub 2013 Mar 16.

Fox Chase Cancer Center, USA.

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March 2013

The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein.

J Biol Chem 2013 Mar 5;288(12):8762-71. Epub 2013 Feb 5.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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March 2013

p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways.

Am J Physiol Gastrointest Liver Physiol 2013 Mar 10;304(6):G561-7. Epub 2013 Jan 10.

Department of Surgery, University of Melbourne, Austin Health, Victoria, Australia.

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March 2013

p21-activated kinase inhibitors.

Enzymes 2013 7;34 Pt. B:157-80. Epub 2013 Nov 7.

Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA. Electronic address:

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August 2014

Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity.

J Biol Chem 2013 Jan 30;288(2):974-83. Epub 2012 Nov 30.

Cancer Biology Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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January 2013

Mouse models of PAK function.

Cell Logist 2012 Apr;2(2):84-88

Cancer Biology Program; Fox Chase Cancer Center; Philadelphia, PA USA.

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April 2012

Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways.

PLoS One 2012 10;7(8):e42601. Epub 2012 Aug 10.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

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March 2013

Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways.

Mol Cancer Res 2012 Sep 12;10(9):1178-88. Epub 2012 Jul 12.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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September 2012

PKM2 enters the morpheein academy.

Mol Cell 2012 Mar;45(5):583-4

Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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March 2012

Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin.

J Cell Sci 2012 Jan 20;125(Pt 2):310-6. Epub 2012 Jan 20.

Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA.

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January 2012

p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation.

Am J Physiol Heart Circ Physiol 2012 Jan 28;302(1):H224-30. Epub 2011 Oct 28.

Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 60612-7342, USA.

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January 2012

Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A.

J Mol Cell Cardiol 2011 Dec 24;51(6):988-96. Epub 2011 Sep 24.

Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 835 S. Wolcott Ave, M/C 901, Chicago, IL 60612-7342, USA.

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December 2011

Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.

J Biol Chem 2011 Dec 3;286(48):41359-67. Epub 2011 Oct 3.

Basic Diabetes Group, Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA.

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December 2011

Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

EMBO J 2011 Jul 1;30(15):3160-72. Epub 2011 Jul 1.

Rappaport Family Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

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July 2011

Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation.

Small GTPases 2011 Jan;2(1):17-26

Laboratory of Molecular Oncogenetics; Institute of Gene Biology; Russian Academy of Sciences; Moscow, Russia.

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January 2011

p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target?

Small GTPases 2010 Sep;1(2):124-128

Fox Chase Cancer Center; Philadelphia, PA USA.

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September 2010

Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity.

J Biol Chem 2011 Apr 11;286(15):13603-11. Epub 2011 Feb 11.

Division of Biology and Molecular, Cellular, and Developmental Biology Program, Kansas State University, Manhattan, Kansas 66506, USA.

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April 2011

Getting smart about p21-activated kinases.

Mol Cell Biol 2011 Feb 29;31(3):386-7. Epub 2010 Nov 29.

Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111, USA.

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February 2011

p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2.

PLoS One 2010 Nov 2;5(11):e13791. Epub 2010 Nov 2.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.

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November 2010

LOV conquers (sm)All GTPases.

F1000 Biol Rep 2010 Apr 12;2. Epub 2010 Apr 12.

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April 2010

Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.

J Cell Biol 2010 Jul 5;190(1):101-14. Epub 2010 Jul 5.

Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC 20037, USA.

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July 2010

PTP1B: a double agent in metabolism and oncogenesis.

Trends Biochem Sci 2010 Aug 8;35(8):442-9. Epub 2010 Apr 8.

Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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August 2010

An emerging role for p21-activated kinases (Paks) in viral infections.

Trends Cell Biol 2010 Mar 12;20(3):160-9. Epub 2010 Jan 12.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

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March 2010

Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis.

Int J Biochem Cell Biol 2010 Jan 9;42(1):13-6. Epub 2009 Sep 9.

Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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January 2010

Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development.

PLoS One 2009 Jun 26;4(6):e6025. Epub 2009 Jun 26.

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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June 2009

The DeMSTification of mammalian Ste20 kinases.

Curr Biol 2009 May;19(10):R421-5

Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA.

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May 2009

Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases.

Proc Natl Acad Sci U S A 2009 May 12;106(21):8707-12. Epub 2009 May 12.

Department of Virology, Parasitology, and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

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May 2009

PAK kinase regulates Rac GTPase and is a potential target in human schwannomas.

Exp Neurol 2009 Jul 3;218(1):137-44. Epub 2009 May 3.

Clinical Neurobiology, Peninsula College for Medicine and Dentistry, The John Bull Building, Tamar Science Park, Research Way, Plymouth PL6 8BU, UK.

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July 2009

PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics.

J Cell Sci 2008 Nov 21;121(Pt 22):3729-36. Epub 2008 Oct 21.

Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK.

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November 2008

Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells.

Blood 2008 Dec 2;112(12):4646-54. Epub 2008 Sep 2.

Department of Microbiology and Immunology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA.

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December 2008

A tale of two Paks.

Biol Cell 2008 Feb;100(2):97-108

Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111, U.S.A.

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February 2008