Publications by authors named "Jonathan C Killen"

3 Publications

  • Page 1 of 1

Fusarochromene, a novel tryptophan-derived metabolite from .

Org Biomol Chem 2021 01;19(1):182-187

School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.

Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporation studies with 13C-labelled acetate, glycerol and tryptophans show that fusarochromene is unexpectedly derived via oxidative cleavage of the aromatic amino acid tryptophan. A putative biosynthetic gene cluster has been identified.
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http://dx.doi.org/10.1039/d0ob02031aDOI Listing
January 2021

A reversed sulfonamide series of selective RORc inverse agonists.

Bioorg Med Chem Lett 2014 Dec 25;24(24):5769-5776. Epub 2014 Oct 25.

Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

The identification of a new series of RORc inverse agonists is described. Comprehensive structure-activity relationship studies of this reversed sulfonamide series identified potent RORc inverse agonists in biochemical and cellular assays which were also selective against a panel of nuclear receptors. Our work has contributed a compound that may serve as a useful in vitro tool to delineate the complex biological pathways involved in signalling through RORc. An X-ray co-crystal structure of an analogue with RORc has also provided useful insights into the binding interactions of the new series.
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http://dx.doi.org/10.1016/j.bmcl.2014.10.037DOI Listing
December 2014

Convergent syntheses of 3,6-dihydroxydec-4-enolides.

Org Lett 2012 Aug 31;14(16):4194-7. Epub 2012 Jul 31.

School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.

The total syntheses of the 3,6-dihydroxydecanolide from Cordyceps militaris and the novel C-3 epimer are reported using a diastereoselective Nozaki-Hiyama-Kishi reaction in the key cyclization to generate the 6R stereocenter.
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http://dx.doi.org/10.1021/ol3018566DOI Listing
August 2012
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