Publications by authors named "Jonathan A Nowak"

75Publications

HER2 in Colorectal Carcinoma: Are We There yet?

Authors:
Jonathan A Nowak

Surg Pathol Clin 2020 Sep 11;13(3):485-502. Epub 2020 Jul 11.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.path.2020.05.007DOI Listing
September 2020

Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer.

EBioMedicine 2020 Jul 8;57:102860. Epub 2020 Jul 8.

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Cancer Immunology and Cancer Epidemiology Programs, Dana-Farber Harvard Cancer Center, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2020.102860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347996PMC
July 2020

Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy.

Cell 2020 Aug 29;182(3):655-671.e22. Epub 2020 Jun 29.

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA; Department of Neurology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415717PMC
August 2020

ALK rearrangement in a gastrointestinal stromal tumour of the small bowel.

Histopathology 2020 09 2;77(3):513-515. Epub 2020 Jul 2.

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1111/his.14133DOI Listing
September 2020

Calcium intake and colon cancer risk subtypes by tumor molecular characteristics.

Cancer Causes Control 2019 Jun 8;30(6):637-649. Epub 2019 Apr 8.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10552-019-01165-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546870PMC
June 2019

Clinicopathologic Features of Mismatch Repair-Deficient Anaplastic Thyroid Carcinomas.

Thyroid 2019 05 16;29(5):666-673. Epub 2019 Apr 16.

1 Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1089/thy.2018.0716DOI Listing
May 2019

Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial.

Eur J Cancer 2019 04 1;111:82-93. Epub 2019 Mar 1.

Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436990PMC
April 2019

Characteristics of mismatch repair deficiency in sarcomas.

Mod Pathol 2019 07 14;32(7):977-987. Epub 2019 Feb 14.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41379-019-0202-3
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http://dx.doi.org/10.1038/s41379-019-0202-3DOI Listing
July 2019

Integration of microbiology, molecular pathology, and epidemiology: a new paradigm to explore the pathogenesis of microbiome-driven neoplasms.

J Pathol 2019 04 20;247(5):615-628. Epub 2019 Feb 20.

Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, 02215, USA.

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http://doi.wiley.com/10.1002/path.5236
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http://dx.doi.org/10.1002/path.5236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509405PMC
April 2019

The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome.

Am J Pathol 2018 12 20;188(12):2839-2852. Epub 2018 Sep 20.

Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284552PMC
December 2018

Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour.

Eur J Cancer 2018 11 13;103:98-107. Epub 2018 Sep 13.

Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183110
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http://dx.doi.org/10.1016/j.ejca.2018.07.130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195453PMC
November 2018

Insights into Pathogenic Interactions Among Environment, Host, and Tumor at the Crossroads of Molecular Pathology and Epidemiology.

Annu Rev Pathol 2019 01 20;14:83-103. Epub 2018 Aug 20.

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02215, USA; email: , ,

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http://dx.doi.org/10.1146/annurev-pathmechdis-012418-012818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345592PMC
January 2019

Validation of a targeted next-generation sequencing approach to detect mismatch repair deficiency in colorectal adenocarcinoma.

Mod Pathol 2018 12 28;31(12):1882-1890. Epub 2018 Jun 28.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41379-018-0091-xDOI Listing
December 2018

Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum.

Clin Gastroenterol Hepatol 2018 10 24;16(10):1622-1631.e3. Epub 2018 Apr 24.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.cgh.2018.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151288PMC
October 2018

Prediagnosis Use of Statins Associates With Increased Survival Times of Patients With Pancreatic Cancer.

Clin Gastroenterol Hepatol 2018 08 21;16(8):1300-1306.e3. Epub 2018 Feb 21.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2018.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056316PMC
August 2018

Pilot study of serial FLT and FDG-PET/CT imaging to monitor response to neoadjuvant chemoradiotherapy of esophageal adenocarcinoma: correlation with histopathologic response.

Ann Nucl Med 2018 Apr 13;32(3):165-174. Epub 2018 Jan 13.

Department of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1007/s12149-018-1229-0DOI Listing
April 2018

Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor.

Gastroenterology 2017 12 1;153(6):1517-1530.e14. Epub 2017 Sep 1.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.08.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705461PMC
December 2017

PIK3CA mutation and colorectal cancer precision medicine.

Oncotarget 2017 04;8(14):22305-22306

Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.15724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410221PMC
April 2017

Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status.

J Clin Oncol 2017 Jun 13;35(16):1836-1844. Epub 2017 Apr 13.

Tsuyoshi Hamada, Zhi Rong Qian, Yohei Masugi, Juhong Yang, Kosuke Mima, Keisuke Kosumi, Li Liu, Yan Shi, Annacarolina da Silva, Mancang Gu, Wanwan Li, Jeffrey A. Meyerhardt, Marios Giannakis, Scott J. Rodig, Gordon J. Freeman, Charles S. Fuchs, Reiko Nishihara, and Shuji Ogino, Dana-Farber Cancer Institute and Harvard Medical School; Yin Cao, Mingyang Song, and Andrew T. Chan, Massachusetts General Hospital and Harvard Medical School; Yin Cao, Mingyang Song, Li Liu, NaNa Keum, Kana Wu, Edward L. Giovannucci, Daniel Nevo, Molin Wang, Reiko Nishihara, and Shuji Ogino, Harvard T.H. Chan School of Public Health; Jonathan A. Nowak, Xuehong Zhang, Edward L. Giovannucci, Marios Giannakis, Gordon J. Freeman, Molin Wang, Andrew T. Chan, Charles S. Fuchs, and Shuji Ogino, Brigham and Women's Hospital and Harvard Medical School, Boston; Marios Giannakis and Andrew T. Chan, Broad Institute of MIT and Harvard University, Cambridge, MA; Li Liu, Huazhong University of Science and Technology, Wuhan; Yan Shi, Chinese People's Liberation Army General Hospital, Beijing; and Mancang Gu, Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.

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http://dx.doi.org/10.1200/JCO.2016.70.7547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455595PMC
June 2017

Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue.

JAMA Oncol 2017 Jul;3(7):921-927

Division of MPE Molecular Pathological Epidemiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts4Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts7Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts9Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts13Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaoncol.2016.6374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502000PMC
July 2017

Molecular Evaluation of Colorectal Adenocarcinoma: Current Practice and Emerging Concepts.

Surg Pathol Clin 2016 Sep;9(3):427-39

Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.path.2016.04.007DOI Listing
September 2016

Regular Aspirin Use Associates With Lower Risk of Colorectal Cancers With Low Numbers of Tumor-Infiltrating Lymphocytes.

Gastroenterology 2016 11 27;151(5):879-892.e4. Epub 2016 Jul 27.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Division of MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159194PMC
November 2016

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma.

Cell Rep 2016 Apr 14;15(4):857-865. Epub 2016 Apr 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850357PMC
April 2016

Marine ω-3 Polyunsaturated Fatty Acid Intake and Risk of Colorectal Cancer Characterized by Tumor-Infiltrating T Cells.

JAMA Oncol 2016 Sep;2(9):1197-206

Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston2Division of Gastroenterology, Massachusetts General Hospital, Boston12Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts13Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge.

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http://dx.doi.org/10.1001/jamaoncol.2016.0605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016204PMC
September 2016

MicroRNA MIR21 and T Cells in Colorectal Cancer.

Cancer Immunol Res 2016 Jan 29;4(1):33-40. Epub 2015 Sep 29.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703429PMC
January 2016

Fusobacterium nucleatum and T Cells in Colorectal Carcinoma.

JAMA Oncol 2015 Aug;1(5):653-61

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts3Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts5Department of Pathology, Brigham and Women's Hospital.

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http://dx.doi.org/10.1001/jamaoncol.2015.1377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537376PMC
August 2015

Impact of a prospective review program for reference laboratory testing requests.

Am J Clin Pathol 2015 May;143(5):627-34

From the Department of Pathology, Brigham and Women's Hospital, Boston, MA, and Harvard Medical School, Boston, MA.

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https://academic.oup.com/ajcp/article/143/5/627/1760818
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http://dx.doi.org/10.1309/AJCPN1VCZDVD9ZVXDOI Listing
May 2015

Early-stage rectal cancer: clinical and pathologic prognostic markers of time to local recurrence and overall survival after resection.

Dis Colon Rectum 2014 Apr;57(4):449-59

1Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts 2Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 3Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 4Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 5Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts 6Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 7Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/DCR.0b013e3182a70709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954982PMC
April 2014

Isolation and culture of epithelial stem cells.

Methods Mol Biol 2009 ;482:215-32

Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1007/978-1-59745-060-7_14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760227PMC
February 2009

Hair follicle stem cells are specified and function in early skin morphogenesis.

Cell Stem Cell 2008 Jul;3(1):33-43

Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.stem.2008.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877596PMC
July 2008

Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells.

Genes Dev 2005 Jul 16;19(13):1596-611. Epub 2005 Jun 16.

Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA.

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http://dx.doi.org/10.1101/gad.1324905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1172065PMC
July 2005