Publications by authors named "Jonathan A Fletcher"

100Publications

Loss of SFRP1 expression is a key progression event in gastrointestinal stromal tumor pathogenesis.

Hum Pathol 2020 Nov 10. Epub 2020 Nov 10.

Department and Graduate Institute of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, 10002, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2020.10.010DOI Listing
November 2020

AXL Inactivation Inhibits Mesothelioma Growth and Migration via Regulation of p53 Expression.

Cancers (Basel) 2020 Sep 25;12(10). Epub 2020 Sep 25.

Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.

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http://dx.doi.org/10.3390/cancers12102757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601862PMC
September 2020

Resistance to avapritinib in PDGFRA-driven GIST is caused by secondary mutations in the PDGFRA kinase domain.

Cancer Discov 2020 Sep 24. Epub 2020 Sep 24.

Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany; DKTK partner site Essen and German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://dx.doi.org/10.1158/2159-8290.CD-20-0487DOI Listing
September 2020

Preclinical Activity of PI3K Inhibitor Copanlisib in Gastrointestinal Stromal Tumor.

Mol Cancer Ther 2020 06 5;19(6):1289-1297. Epub 2020 May 5.

Sarcoma Translational Research Laboratory, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.

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http://dx.doi.org/10.1158/1535-7163.MCT-19-1069DOI Listing
June 2020

Coordinated targeting of CK2 and KIT in gastrointestinal stromal tumours.

Br J Cancer 2020 02 28;122(3):372-381. Epub 2019 Nov 28.

Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.

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http://dx.doi.org/10.1038/s41416-019-0657-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000686PMC
February 2020

Overcoming heterogenity in imatinib-resistant gastrointestinal stromal tumor.

Oncotarget 2019 Oct 29;10(59):6286-6287. Epub 2019 Oct 29.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.18632/oncotarget.27277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824868PMC
October 2019

Mutational inactivation of mTORC1 repressor gene in human gastrointestinal stromal tumors.

Proc Natl Acad Sci U S A 2019 11 21;116(45):22746-22753. Epub 2019 Oct 21.

Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences-Changzheng Hospital Joint Center for Translational Medicine, Changzheng Hospital, Institutes for Translational Medicine, Chinese Academy of Sciences-Second Military Medical University, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031 Shanghai, China;

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http://dx.doi.org/10.1073/pnas.1914542116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842588PMC
November 2019

Cyclin D1 is a mediator of gastrointestinal stromal tumor KIT-independence.

Oncogene 2019 09 1;38(39):6615-6629. Epub 2019 Aug 1.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41388-019-0894-3DOI Listing
September 2019

Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish.

Cell 2019 06 25;177(7):1903-1914.e14. Epub 2019 Apr 25.

Molecular Pathology Unit, Massachusetts General Hospital Research Institute, Charlestown, MA 02129, USA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570580PMC
June 2019

ZMYM2-FGFR1 fusion as secondary change in acute myeloid leukemia.

Leuk Lymphoma 2019 02 30;60(2):556-558. Epub 2018 Aug 30.

a Department of Pathology, Brigham and Women's Hospital , Harvard Medical School , Boston ( MA) , USA.

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https://www.tandfonline.com/doi/full/10.1080/10428194.2018.1
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http://dx.doi.org/10.1080/10428194.2018.1493733DOI Listing
February 2019

Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors.

Cancer Res 2017 09 31;77(18):5107-5117. Epub 2017 Jul 31.

Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0917DOI Listing
September 2017

What is New in Gastrointestinal Stromal Tumor?

Adv Anat Pathol 2017 Sep;24(5):259-267

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/PAP.0000000000000158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608028PMC
September 2017

KIT Oncogenic Mutations: Biologic Insights, Therapeutic Advances, and Future Directions.

Cancer Res 2016 11;76(21):6140-6142

Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-16-2646DOI Listing
November 2016

Co-targeting of FAK and MDM2 triggers additive anti-proliferative effects in mesothelioma via a coordinated reactivation of p53.

Br J Cancer 2016 Nov 13;115(10):1253-1263. Epub 2016 Oct 13.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/bjc.2016.331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104897PMC
November 2016

Targeting SALL4 by entinostat in lung cancer.

Oncotarget 2016 Nov;7(46):75425-75440

Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.12251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342750PMC
November 2016

Downregulation of cyclin D1 sensitizes cancer cells to MDM2 antagonist Nutlin-3.

Oncotarget 2016 May;7(22):32652-63

Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, China.

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http://dx.doi.org/10.18632/oncotarget.8999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078041PMC
May 2016

Reporting of Diagnostic Cytogenetic Results.

Curr Protoc Hum Genet 2016 Apr 1;89:A.1D.1-A.1D.23. Epub 2016 Apr 1.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/0471142905.hg01ds89DOI Listing
April 2016

Preclinical activity of selinexor, an inhibitor of XPO1, in sarcoma.

Oncotarget 2016 Mar;7(13):16581-92

Ludwig Center at Dana-Farber/Harvard and Center for Sarcoma and Bone Oncology, Department of Medical Oncology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.7667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941336PMC
March 2016

ALK-rearranged renal cell carcinomas in children.

Genes Chromosomes Cancer 2016 May 23;55(5):442-51. Epub 2016 Feb 23.

Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL.

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http://dx.doi.org/10.1002/gcc.22346DOI Listing
May 2016

Alternate PAX3-FOXO1 oncogenic fusion in biphenotypic sinonasal sarcoma.

Genes Chromosomes Cancer 2016 Jan 10;55(1):25-9. Epub 2015 Sep 10.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/gcc.22295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919599PMC
January 2016

Cell cycle and dystrophin dysregulation in GIST.

Cell Cycle 2015 23;14(17):2713-4. Epub 2015 Jun 23.

a Department of Pathology ; Brigham and Women's Hospital ; Boston , MA USA.

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http://dx.doi.org/10.1080/15384101.2015.1064676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613538PMC
November 2015

Key Issues in the Clinical Management of Gastrointestinal Stromal Tumors: An Expert Discussion.

Oncologist 2015 Jul 12;20(7):823-30. Epub 2015 Jun 12.

Tisch Cancer Institute, Mount Sinai Medical Center, New York, New York, USA; Department of Medical Oncology, Centre Léon Bérard, Lyon, France; Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA; Helsinki University Hospital and University of Helsinki, Helsinki, Finland; Servicio de Oncología Médica, Fundación Instituto Valenciano de Oncología, Valencia, Spain; National Cancer Center Hospital East, Department of Surgery, Kashiwa, Japan; HELIOS Klinikum Berlin-Buch, Interdisciplinary Oncology, Berlin, Germany; General Medical Oncology, Leuven Cancer Institute, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium; University of Miami Sylvester Cancer Center, Sarcoma Medical Oncology Program, Miami, Florida, USA.

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http://dx.doi.org/10.1634/theoncologist.2014-0471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492234PMC
July 2015

Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1.

Gastroenterology 2015 Aug 9;149(2):420-32.e16. Epub 2015 Apr 9.

Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota; Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516576PMC
August 2015

Inhibition of KIT-glycosylation by 2-deoxyglucose abrogates KIT-signaling and combination with ABT-263 synergistically induces apoptosis in gastrointestinal stromal tumor.

PLoS One 2015 17;10(3):e0120531. Epub 2015 Mar 17.

Dept. of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Sarcoma Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120531PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364009PMC
February 2016

Ewing sarcoma mimicking atypical carcinoid tumor: detection of unexpected genomic alterations demonstrates the use of next generation sequencing as a diagnostic tool.

Cancer Genet 2014 Jul-Aug;207(7-8):335-9. Epub 2014 Aug 29.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.cancergen.2014.08.004DOI Listing
January 2015

Phosphoinositide 3-kinase inhibitors combined with imatinib in patient-derived xenograft models of gastrointestinal stromal tumors: rationale and efficacy.

Clin Cancer Res 2014 Dec 14;20(23):6071-82. Epub 2014 Oct 14.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium. Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1823DOI Listing
December 2014

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.

Nat Genet 2014 Nov 21;46(11):1227-32. Epub 2014 Sep 21.

1] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [2] Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [3] Department of Medicine, Weill Cornell Medical College, New York, New York, USA.

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http://dx.doi.org/10.1038/ng.3095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249650PMC
November 2014

c-Jun promotes cell migration and drives expression of the motility factor ENPP2 in soft tissue sarcomas.

J Pathol 2014 Oct 1;234(2):190-202. Epub 2014 Aug 1.

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA; Ludwig Center at Dana-Farber/Harvard Cancer Center, Boston, MA, USA.

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http://dx.doi.org/10.1002/path.4379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472460PMC
October 2014

VCL-ALK renal cell carcinoma in children with sickle-cell trait: the eighth sickle-cell nephropathy?

Am J Surg Pathol 2014 Jun;38(6):858-63

Departments of *Pathology ∥Urology ¶Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD †Department of Pathology, University of South Carolina School of Medicine-Greenville, Greenville, SC ‡Department of Pathology, Brigham and Women's Hospital, Boston, MA §Departments of Pathology/Microbiology, Pediatrics and Orthopedic Surgery, University of Nebraska Medical Center, Omaha, NE.

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http://pdfs.journals.lww.com/ajsp/2014/06000/VCL_ALK_Renal_C
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PAS.0000000000000179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352307PMC
June 2014

Thyroid hormone inactivation in gastrointestinal stromal tumors.

N Engl J Med 2014 Apr;370(14):1327-34

From the Thyroid Program of the Division of Endocrinology (M.A.M., C.G., C.D., H.S., R.H.J., S.A.H.) and the Clinical Research Center (H.A.F.), Boston Children's Hospital, the Departments of Pathology (A.M.-E., J.A.F., D.M.D., Y.W.), Surgery (C.P.R.), and Radiology (M.C.F.), and the Thyroid Section of the Division of Endocrinology, Diabetes, and Hypertension (L.Y., P.R.L., S.A.H.), Brigham and Women's Hospital, and the Dana-Farber Cancer Institute (J.A.F., C.P.R., P.R.L., S.A.H.) - all in Boston; the Department of Neurobiology and Anatomy, Kochi Medical School, Nankoku, Japan (T.T.); and the Endocrinology and Diabetes Division, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles (J.M.H.).

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http://dx.doi.org/10.1056/NEJMoa1308893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186889PMC
April 2014

Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways.

PLoS One 2013 7;8(10):e76822. Epub 2013 Oct 7.

Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America ; Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076822PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792098PMC
August 2014

Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin.

J Clin Oncol 2013 Sep 17;31(26):3182-90. Epub 2013 Jun 17.

F. Stephen Hodi, Anita Giobbie-Hurder, Philip Friedlander, Jason J. Luke, Katherine A. Zukotynski, Jeffrey T. Yap, Annick D. Van den Abbeele, and George D. Demetri, Dana-Farber Cancer Institute; Jonathan A. Fletcher, Meijun Zhu, and Adrian Marino-Enriquez, Brigham and Women's Hospital; Donald Lawrence, Keith T. Flaherty, and David E. Fisher, Massachusetts General Hospital, Boston, MA; Christopher L. Corless, Michael C. Heinrich, and Carol Beadling, Portland Veterans Administration Medical Center and Oregon Health & Science University, Portland, OR; Philip Friedlander, Mount Sinai Medical Center, New York, NY; Rene Gonzalez, University of Colorado Cancer Center, Aurora, CO; Jeffrey S. Weber, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Thomas F. Gajewski, University of Chicago, Chicago, IL; Steven J. O'Day, Beverly Hills Cancer Center, Beverly Hills, CA; Kevin B. Kim, The University of Texas MD Anderson Cancer Center, Houston, TX; Frances A. Collichio, The University of North Carolina at Chapel Hill, Chapel Hill, NC; and Marc S. Ernstoff, Geisel School of Medicine and Norris Cotton Cancer Center, Hanover, NH.

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http://dx.doi.org/10.1200/JCO.2012.47.7836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878082PMC
September 2013

Clinical relevance of pharmacogenetics in gastrointestinal stromal tumor treatment in the era of personalized therapy.

Pharmacogenomics 2013 Jun;14(8):941-56

Department of Pharmacy & Biotechnology, Via Irnerio 48, 40126 Alma Mater Studiorum-University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.2217/pgs.13.63DOI Listing
June 2013

DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors.

Cancer Res 2013 Jun 10;73(12):3661-70. Epub 2013 Apr 10.

Sarcoma Center, Departments of Medical Oncology, Pathology and Neuropathology, Trauma and Orthopedic Surgery, Visceral and Transplant Surgery, West German Cancer Center, University Duisburg-Essen, University Hospital Essen, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-3839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694361PMC
June 2013

Anti-KIT designer T cells for the treatment of gastrointestinal stromal tumor.

J Transl Med 2013 Feb 21;11:46. Epub 2013 Feb 21.

Roger Williams Medical Center, Department of Surgery, Providence, RI/Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1186/1479-5876-11-46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599052PMC
February 2013

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

Mod Pathol 2013 May 7;26(5):743-9. Epub 2012 Dec 7.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/modpathol.2012.203DOI Listing
May 2013

Sorafenib inhibits many kinase mutations associated with drug-resistant gastrointestinal stromal tumors.

Mol Cancer Ther 2012 Aug 4;11(8):1770-80. Epub 2012 Jun 4.

Division of Hematology/Oncology, Department of Medicine, Portland VA Medical Center and OHSU Knight Cancer Institute, Oregon Health & Science University, R&D-19 3710 U.S. Veterans Hospital Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-0223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992122PMC
August 2012

Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-κB pathways.

Mol Cancer Ther 2012 Sep 31;11(9):1905-14. Epub 2012 May 31.

Department of Medical Oncology, Melanoma Disease Center, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-0121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992123PMC
September 2012

The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma.

PLoS One 2012 12;7(1):e29622. Epub 2012 Jan 12.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029622PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257235PMC
May 2012

Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma.

Neoplasia 2011 Jan;13(1):12-22

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022424PMC
http://dx.doi.org/10.1593/neo.101156DOI Listing
January 2011

ALK rearrangement in sickle cell trait-associated renal medullary carcinoma.

Genes Chromosomes Cancer 2011 Mar 13;50(3):146-53. Epub 2010 Dec 13.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston 02115, MA, USA.

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http://dx.doi.org/10.1002/gcc.20839DOI Listing
March 2011

Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines.

ACS Med Chem Lett 2010 Oct 1;1(7):306-10. Epub 2010 Jul 1.

The University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom ; School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, United Kingdom ; Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom.

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http://dx.doi.org/10.1021/ml100062zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017300PMC
October 2010

Trisomy 18 is a consistent cytogenetic feature in pilomatricoma.

Mod Pathol 2010 Aug 21;23(8):1147-50. Epub 2010 May 21.

Department of Pathology, Children's Hospital, Boston, MA 02115, USA.

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http://www.nature.com/articles/modpathol201099
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http://dx.doi.org/10.1038/modpathol.2010.99DOI Listing
August 2010

Gastrointestinal stromal tumors.

Virchows Arch 2010 Feb 18;456(2):111-27. Epub 2010 Feb 18.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://link.springer.com/10.1007/s00428-010-0891-y
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http://dx.doi.org/10.1007/s00428-010-0891-yDOI Listing
February 2010

Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification.

Int J Cancer 2010 Dec;127(11):2718-22

Department of Pediatric Hematology-Oncology, Dana Farber Cancer Institute and Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1002/ijc.25247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947557PMC
December 2010