Jonas Lategahn

Jonas Lategahn

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Jonas Lategahn

Jonas Lategahn

Publications by authors named "Jonas Lategahn"

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18Publications

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Structure Defines Function: Clinically Relevant Mutations in ErbB Kinases.

J Med Chem 2019 Aug 28. Epub 2019 Aug 28.

Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , ( Germany ).

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http://dx.doi.org/10.1021/acs.jmedchem.9b00964DOI Listing
August 2019

Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7).

J Med Chem 2019 Jun 31;62(11):5541-5546. Epub 2019 May 31.

Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00472DOI Listing
June 2019

Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.

J Med Chem 2019 Mar 21;62(5):2843-2848. Epub 2019 Feb 21.

Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00102DOI Listing
March 2019

A novel scaffold for EGFR inhibition: Introducing N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives.

Sci Rep 2019 01 9;9(1):14. Epub 2019 Jan 9.

Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos (INCT-INOFAR; http://www.inct-inofar.ccs.ufrj.br/), Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio®, http://www.lassbio.icb.ufrj.br) Universidade Federal do Rio de Janeiro, CCS, Cidade Universitária, Rio de Janeiro, RJ, Brazil.

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http://www.nature.com/articles/s41598-018-36846-7
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http://dx.doi.org/10.1038/s41598-018-36846-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327040PMC
January 2019

RASPELD to Perform High-End Screening in an Academic Environment toward the Development of Cancer Therapeutics.

ChemMedChem 2018 10 23;13(19):2065-2072. Epub 2018 Aug 23.

Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany.

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http://dx.doi.org/10.1002/cmdc.201800477DOI Listing
October 2018

Insights into the Kinetics of the Resistance Formation of Bacteria against Ciprofloxacin Poly(2-methyl-2-oxazoline) Conjugates.

Bioconjug Chem 2018 08 11;29(8):2671-2678. Epub 2018 Jul 11.

Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany.

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http://dx.doi.org/10.1021/acs.bioconjchem.8b00361DOI Listing
August 2018

C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?

ACS Med Chem Lett 2018 Aug 23;9(8):779-782. Epub 2018 Jul 23.

Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00314
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http://dx.doi.org/10.1021/acsmedchemlett.8b00314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088362PMC
August 2018

Lessons To Be Learned: The Molecular Basis of Kinase-Targeted Therapies and Drug Resistance in Non-Small Cell Lung Cancer.

Angew Chem Int Ed Engl 2018 02 12;57(9):2307-2313. Epub 2018 Jan 12.

Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany.

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http://dx.doi.org/10.1002/anie.201710398DOI Listing
February 2018

Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.

J Med Chem 2017 07 21;60(13):5613-5637. Epub 2017 Jun 21.

Institute of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry, Eberhard Karls University Tübingen , Auf der Morgenstelle 8, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00316DOI Listing
July 2017

Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.

J Med Chem 2017 03 10;60(6):2361-2372. Epub 2017 Mar 10.

Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, Dortmund D-44227, Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01626DOI Listing
March 2017

Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR.

Angew Chem Int Ed Engl 2016 08 5;55(36):10909-12. Epub 2016 Aug 5.

Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie, Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany.

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http://dx.doi.org/10.1002/anie.201605011DOI Listing
August 2016

Hope and Disappointment: Covalent Inhibitors to Overcome Drug Resistance in Non-Small Cell Lung Cancer.

ACS Med Chem Lett 2016 Jan 18;7(1):2-5. Epub 2015 Dec 18.

Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, D-44227 Dortmund, Germany.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716607PMC
January 2016

Metal-free direct oxidative intermolecular diarylation of anilides at ambient temperature assisted by cascade selective formation of C-C and C-N bonds.

Chem Commun (Camb) 2012 Mar 13;48(26):3194-6. Epub 2012 Feb 13.

Max-Planck Institute of Molecular Physiology, Otto-Hahn Strasse 11, Dortmund 44227, Germany.

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http://dx.doi.org/10.1039/c2cc30324hDOI Listing
March 2012

Organocatalytic, oxidative, intramolecular C-H bond amination and metal-free cross-amination of unactivated arenes at ambient temperature.

Angew Chem Int Ed Engl 2011 Sep 26;50(37):8605-8. Epub 2011 Jul 26.

Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1002/anie.201102984DOI Listing
September 2011