Jonas Eriksson, PhD - Uppsala University Hospital

Jonas Eriksson

PhD

Uppsala University Hospital

Sweden

Jonas Eriksson, PhD - Uppsala University Hospital

Jonas Eriksson

PhD

Introduction

Primary Affiliation: Uppsala University Hospital - Sweden

Publications

26Publications

417Reads

-Profile Views

251PubMed Central Citations

A comparative study of the hypoxia PET tracers [¹⁸F]HX4, [¹⁸F]FAZA, and [¹⁸F]FMISO in a preclinical tumor model.

Int J Radiat Oncol Biol Phys 2015 Feb 6;91(2):351-9. Epub 2014 Dec 6.

Department of Radiation Oncology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2014.09.045DOI Listing
February 2015
22 Reads
23 Citations
4.260 Impact Factor

In vivo quantification of hypoxic and metabolic status of NSCLC tumors using [18F]HX4 and [18F]FDG-PET/CT imaging.

Clin Cancer Res 2014 Dec 14;20(24):6389-97. Epub 2014 Oct 14.

Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-14-1524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228298PMC
December 2014
48 Reads
14 Citations
8.722 Impact Factor

Strategy to develop a MAO-A-resistant 5-hydroxy-l-[β-11C]tryptophan isotopologue based on deuterium kinetic isotope effects

EJNMMI Research 2014, 4:62

EJNMMI Research

Background The serotonin precursor 5-hydroxy-L-[β-11C]tryptophan ([11C]HTP) is in clinical use for localization of neuroendocrine tumors and has been suggested as a proxy marker for pancreatic islet cells. However, degradation by monoamine oxidase-A (MAO-A) reduces retention and the contrast to non-endocrine tissue. Methods A synthesis method was developed for 5-hydroxy-L-[β-11C2H]tryptophan ([11C]DHTP), an isotopologue of [11C]HTP, labeled with 11C and 2H at the β-position adjacent to the carbon involved in MAO-A decarboxylation. MAO-A-mediated degradation of [11C]DHTP was evaluated and compared to non-deuterated [11C]HTP. Results [11C]DHTP was synthesized with a radiochemical purity of >98%, radioactivity of 620 ± 190 MBq, and deuterium (2H or 2H2) incorporation at the β-position of 22% ±5%. Retention and resistance to MAO-A-mediated degradation of [11C]DHTP were increased in cells but not in non-human primate pancreas. Conclusions Partial deuteration of the β-position yields improved resistance to MAO-A-mediated degradation in vitro but not in vivo.

View Article
November 2014
8 Reads

(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.

Neuropharmacology 2014 Oct 28;85:104-12. Epub 2014 May 28.

Institute of Pharmacology, Toxicology & Pharmacy, Ludwig-Maximilians-University, Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2014.05.002DOI Listing
October 2014
20 Reads
4 Citations
5.110 Impact Factor

Radiation dose of the P-glycoprotein tracer 11C-laniquidar.

J Nucl Med 2013 Dec 3;54(12):2101-3. Epub 2013 Oct 3.

Departments of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://jnm.snmjournals.org/content/early/2013/09/30/jnumed.1
Web Search
http://jnm.snmjournals.org/cgi/doi/10.2967/jnumed.113.120857
Publisher Site
http://dx.doi.org/10.2967/jnumed.113.120857DOI Listing
December 2013
21 Reads
6.160 Impact Factor

Hypoxia imaging with [¹⁸F]HX4 PET in NSCLC patients: defining optimal imaging parameters.

Radiother Oncol 2013 Oct 14;109(1):58-64. Epub 2013 Sep 14.

Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2013.08.031DOI Listing
October 2013
23 Reads
17 Citations
4.363 Impact Factor

[¹¹C]Sorafenib: radiosynthesis and preclinical evaluation in tumor-bearing mice of a new TKI-PET tracer.

Nucl Med Biol 2013 May 20;40(4):488-97. Epub 2013 Mar 20.

Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nucmedbio.2013.02.002DOI Listing
May 2013
19 Reads
5 Citations
2.412 Impact Factor

Advances in PET imaging of P-glycoprotein function at the blood-brain barrier.

ACS Chem Neurosci 2013 Feb 4;4(2):225-37. Epub 2012 Dec 4.

Department of Public Health and Caring Sciences, Uppsala University, Rudbecklaboratoriet, 751 85 Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cn3001729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582299PMC
February 2013
3 Reads
13 Citations
4.362 Impact Factor

Blood-brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene.

EJNMMI Res 2012 Oct 16;2(1):57. Epub 2012 Oct 16.

Department of Neurology and Alzheimer Center, VU University Medical Center, P,O, Box 7057, Amsterdam, 1007 MB, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/2191-219X-2-57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483228PMC
October 2012
62 Reads
10 Citations

[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats.

EJNMMI Res 2012 Jul 2;2(1):36. Epub 2012 Jul 2.

Department of Nuclear Medicine & PET Research, Radionuclide Centre, VU University Medical Center, P,O, box 7057, Amsterdam 1081, HV, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/2191-219X-2-36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506555PMC
July 2012
15 Reads
4 Citations

Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil.

Nucl Med Biol 2012 May 5;39(4):530-9. Epub 2012 Jan 5.

Department of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nucmedbio.2011.10.017DOI Listing
May 2012
5 Reads
6 Citations
2.412 Impact Factor

Transition metal mediated synthesis using [11C]CO at low pressure – a simplified method for 11C-carbonylation

J Label Compd Radiopharm, 55: 223–228

Journal of Labelled Compounds and Radiopharmaceuticals

Transition metal mediated carbonylation with [11C]CO has proven a useful method to label a wide array of compounds in the carbonyl position. However, the general use in radiopharmaceutical synthesis has been hampered by the low solubility of carbon monoxide in most solvents and the resulting challenge to confine [11C]CO in low volume reaction vessels. This paper introduces a method that utilises xenon to transfer pre-concentrated [11C]CO to a sealed disposable glass vial containing carbonylation reagents. The high solubility of xenon in the organic solvent made it possible to confine the [11C]CO without utilising a pressure autoclave or chemical trapping additives. The utility of the method in 11C-carbonylation was investigated by conducting three model reactions, where [11C-carbonyl]N-benzylbenzamide, [11C-carbonyl]triclocarban and [11C-carbonyl]methyl nicotinate were afforded in decay corrected radiochemical yields of 71 ± 6%, 42 ± 15% and 29 ± 10%, respectively. These promising results and the straight forward technical implementation suggest that 11C-cabonylation can become a viable mean to provide labelled carbonyl functionalities in routine radiopharmaceutical synthesis. Compounds labelled with short lived positron emitters are used in Positron Emission Tomography, a molecular imaging technology with applications in clinical diagnostics, clinical research and basic biomedical research

View Article
May 2012
9 Reads

Synthesis of [11C]/[13C]Acrylamides by Palladium-Mediated Carbonylation

Eur. J. Org. Chem., 2007: 455–461

European Journal of Organic Chemistry

Two methods are presented for the synthesis of acrylamides labelled with 11C (β+, t1/2 = 20.4 min) and 13C in the carbonyl position. In the first method, [1-11C]acrylic acid is synthesised from [11C]carbon monoxide by palladium-mediated hydroxycarbonylation of acetylene. The labelled carboxylic acid is converted into the acyl chloride and subsequently treated with amine to yield N-benzyl[carbonyl-11C]acrylamide. The second method utilizes [11C]carbon monoxide in a palladium-mediated carbonylative cross-coupling of vinyl halides and amines. A higher radiochemical yield is achieved with the latter method and the amount of amine needed is decreased to 1/20. The 11C-labelled acrylamides were isolated in up to 81 % decay-corrected radiochemical yield. Starting from 10 ± 0.5 GBq of [11C]carbon monoxide, N-benzyl[carbonyl-11C]acrylamide was obtained in 4 min with a specific radioactivity of 330 ± 4 GBq μmol–1. Co-labelling with 11C and 13C enabled confirmation of the labelled position by 13C NMR spectroscopy. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

View Article
January 2007
6 Reads

[11C]methyl iodide from [11C]methane and iodine using a non-thermal plasma method

J Label Compd Radiopharm, 49: 1177–1186

Journal of Labelled Compounds and Radiopharmaceuticals

A method and an apparatus for preparing [11C]methyl iodide from [11C]methane and iodine in a single pass through a non-thermal plasma reactor has been developed. The plasma was created by applying high voltage (400 V/31 kHz) to electrodes in a stream of helium gas at reduced pressure. The [11C]methane used in the experiments was produced from [11C]carbon dioxide via reduction with hydrogen over nickel. [11C]methyl iodide was obtained with a specific radioactivity of 412 ± 32 GBq/µmol within 6 min from approximately 24 GBq of [11C]carbon dioxide. The decay corrected radiochemical yield was 13 ± 3% based on [11C]carbon dioxide at start of synthesis. [11C]Flumazenil was synthesized via a N-alkylation with the prepared [11C]methyl iodide. Copyright © 2006 John Wiley & Sons, Ltd.

View Article
November 2006
2 Reads

Synthesis of [1-11C]propyl and [1-11C]butyl iodide from [11C]carbon monoxide and their use in alkylation reactions

J Label Compd Radiopharm, 49: 1105–1116

Journal of Labelled Compounds and Radiopharmaceuticals

A method to prepare [1-11C]propyl iodide and [1-11C]butyl iodide from [11C]carbon monoxide via a three step reaction sequence is presented. Palladium mediated formylation of ethene with [11C]carbon monoxide and hydrogen gave [1-11C]propionaldehyde and [1-11C]propionic acid. The carbonylation products were reduced and subsequently converted to [1-11C]propyl iodide. Labelled propyl iodide was obtained in 58±4% decay corrected radiochemical yield and with a specific radioactivity of 270±33 GBq/µmol within 15 min from approximately 12 GBq of [11C]carbon monoxide. The position of the label was confirmed by 13C-labelling and 13C-NMR analysis. [1-11C]Butyl iodide was obtained correspondingly from propene and approximately 8 GBq of [11C]carbon monoxide, in 34±2% decay corrected radiochemical yield and with a specific radioactivity of 146±20 GBq/µmol. The alkyl iodides were used in model reactions to synthesize [O-propyl-1-11C]propyl and [O-butyl-1-11C]butyl benzoate. Propyl and butyl analogues of etomidate, a β-11-hydroxylase inhibitor, were also synthesized. Copyright © 2006 John Wiley & Sons, Ltd.

View Article
October 2006
7 Reads

Synthesis of [1-11C]ethyl iodide from [11C]carbon monoxide and its application in alkylation reactions

J Label Compd Radiopharm, 47: 723–731

Journal of Labelled Compounds and Radiopharmaceuticals

A method is presented for preparing [1-11C]ethyl iodide from [11C]carbon monoxide. The method utilizes methyl iodide and [11C]carbon monoxide in a palladium-mediated carbonylation reaction to form a mixture of [1-11C]acetic acid and [1-11C]methyl acetate. The acetates are reduced to [1-11C]ethanol and subsequently converted to [1-11C]ethyl iodide. The synthesis time was 20 min and the decay-corrected radiochemical yield of [1-11C]ethyl iodide was 55 ± 5%. The position of the label was confirmed by 13C-labelling and 13C-NMR analysis. [1-11C]Ethyl iodide was used in two model reactions, an O-alkylation and an N-alkylation. Starting with approximately 2.5 GBq of [11C]carbon monoxide, the isolated decay-corrected radiochemical yields for the ester and the amine derivatives were 45 ± 0.5% and 25 ± 2%, respectively, based on [11C]carbon monoxide. Starting with 10 GBq of [11C]carbon monoxide, 0.55 GBq of the labelled ester was isolated within 40 min with a specific radioactivity of 36 GBq/µmol. Copyright © 2004 John Wiley & Sons, Ltd.

View Article
October 2004
19 Reads