Jonas B Nielsen

Jonas B Nielsen

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Jonas B Nielsen

Jonas B Nielsen

Publications by authors named "Jonas B Nielsen"

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Robust meta-analysis of biobank-based genome-wide association studies with unbalanced binary phenotypes.

Genet Epidemiol 2019 07 22;43(5):462-476. Epub 2019 Feb 22.

Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan.

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http://dx.doi.org/10.1002/gepi.22197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559837PMC
July 2019

Genetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early-onset lone atrial fibrillation.

Ann Noninvasive Electrocardiol 2019 Jun 1:e12661. Epub 2019 Jun 1.

The Center for Integrative Electrocardiology, Arrhythmia Clinic Skåne University Hospital, Lund University (CIEL), Lund, Sweden.

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http://dx.doi.org/10.1111/anec.12661DOI Listing
June 2019

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.

Authors:
Mengzhen Liu Yu Jiang Robbee Wedow Yue Li David M Brazel Fang Chen Gargi Datta Jose Davila-Velderrain Daniel McGuire Chao Tian Xiaowei Zhan Hélène Choquet Anna R Docherty Jessica D Faul Johanna R Foerster Lars G Fritsche Maiken Elvestad Gabrielsen Scott D Gordon Jeffrey Haessler Jouke-Jan Hottenga Hongyan Huang Seon-Kyeong Jang Philip R Jansen Yueh Ling Reedik Mägi Nana Matoba George McMahon Antonella Mulas Valeria Orrù Teemu Palviainen Anita Pandit Gunnar W Reginsson Anne Heidi Skogholt Jennifer A Smith Amy E Taylor Constance Turman Gonneke Willemsen Hannah Young Kendra A Young Gregory J M Zajac Wei Zhao Wei Zhou Gyda Bjornsdottir Jason D Boardman Michael Boehnke Dorret I Boomsma Chu Chen Francesco Cucca Gareth E Davies Charles B Eaton Marissa A Ehringer Tõnu Esko Edoardo Fiorillo Nathan A Gillespie Daniel F Gudbjartsson Toomas Haller Kathleen Mullan Harris Andrew C Heath John K Hewitt Ian B Hickie John E Hokanson Christian J Hopfer David J Hunter William G Iacono Eric O Johnson Yoichiro Kamatani Sharon L R Kardia Matthew C Keller Manolis Kellis Charles Kooperberg Peter Kraft Kenneth S Krauter Markku Laakso Penelope A Lind Anu Loukola Sharon M Lutz Pamela A F Madden Nicholas G Martin Matt McGue Matthew B McQueen Sarah E Medland Andres Metspalu Karen L Mohlke Jonas B Nielsen Yukinori Okada Ulrike Peters Tinca J C Polderman Danielle Posthuma Alexander P Reiner John P Rice Eric Rimm Richard J Rose Valgerdur Runarsdottir Michael C Stallings Alena Stančáková Hreinn Stefansson Khanh K Thai Hilary A Tindle Thorarinn Tyrfingsson Tamara L Wall David R Weir Constance Weisner John B Whitfield Bendik Slagsvold Winsvold Jie Yin Luisa Zuccolo Laura J Bierut Kristian Hveem James J Lee Marcus R Munafò Nancy L Saccone Cristen J Willer Marilyn C Cornelis Sean P David David A Hinds Eric Jorgenson Jaakko Kaprio Jerry A Stitzel Kari Stefansson Thorgeir E Thorgeirsson Gonçalo Abecasis Dajiang J Liu Scott Vrieze

Nat Genet 2019 02 14;51(2):237-244. Epub 2019 Jan 14.

Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.

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http://www.nature.com/articles/s41588-018-0307-5
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http://dx.doi.org/10.1038/s41588-018-0307-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358542PMC
February 2019

Visit-to-Visit Variability of Hemoglobin A in People Without Diabetes and Risk of Major Adverse Cardiovascular Events and All-Cause Mortality.

Diabetes Care 2019 01 23;42(1):134-141. Epub 2018 Oct 23.

Laboratory of Molecular Cardiology, Department of Cardiology, Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-139
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http://dx.doi.org/10.2337/dc18-1396DOI Listing
January 2019

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Nat Commun 2018 06 13;9(1):2252. Epub 2018 Jun 13.

Regeneron Pharmaceuticals, Tarrytown, 10591, NY, USA.

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http://dx.doi.org/10.1038/s41467-018-04611-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997992PMC
June 2018

Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development.

Am J Hum Genet 2018 01 28;102(1):103-115. Epub 2017 Dec 28.

Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim 7491, Norway; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777936PMC
January 2018

Improving power of association tests using multiple sets of imputed genotypes from distributed reference panels.

Genet Epidemiol 2017 12 1;41(8):744-755. Epub 2017 Sep 1.

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://doi.wiley.com/10.1002/gepi.22067
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http://dx.doi.org/10.1002/gepi.22067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324190PMC
December 2017

Exome-wide association study of plasma lipids in >300,000 individuals.

Authors:
Dajiang J Liu Gina M Peloso Haojie Yu Adam S Butterworth Xiao Wang Anubha Mahajan Danish Saleheen Connor Emdin Dewan Alam Alexessander Couto Alves Philippe Amouyel Emanuele Di Angelantonio Dominique Arveiler Themistocles L Assimes Paul L Auer Usman Baber Christie M Ballantyne Lia E Bang Marianne Benn Joshua C Bis Michael Boehnke Eric Boerwinkle Jette Bork-Jensen Erwin P Bottinger Ivan Brandslund Morris Brown Fabio Busonero Mark J Caulfield John C Chambers Daniel I Chasman Y Eugene Chen Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu John M Connell Francesco Cucca L Adrienne Cupples Scott M Damrauer Gail Davies Ian J Deary George Dedoussis Joshua C Denny Anna Dominiczak Marie-Pierre Dubé Tapani Ebeling Gudny Eiriksdottir Tõnu Esko Aliki-Eleni Farmaki Mary F Feitosa Marco Ferrario Jean Ferrieres Ian Ford Myriam Fornage Paul W Franks Timothy M Frayling Ruth Frikke-Schmidt Lars G Fritsche Philippe Frossard Valentin Fuster Santhi K Ganesh Wei Gao Melissa E Garcia Christian Gieger Franco Giulianini Mark O Goodarzi Harald Grallert Niels Grarup Leif Groop Megan L Grove Vilmundur Gudnason Torben Hansen Tamara B Harris Caroline Hayward Joel N Hirschhorn Oddgeir L Holmen Jennifer Huffman Yong Huo Kristian Hveem Sehrish Jabeen Anne U Jackson Johanna Jakobsdottir Marjo-Riitta Jarvelin Gorm B Jensen Marit E Jørgensen J Wouter Jukema Johanne M Justesen Pia R Kamstrup Stavroula Kanoni Fredrik Karpe Frank Kee Amit V Khera Derek Klarin Heikki A Koistinen Jaspal S Kooner Charles Kooperberg Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo Lakka Claudia Langenberg Anne Langsted Lenore J Launer Torsten Lauritzen David C M Liewald Li An Lin Allan Linneberg Ruth J F Loos Yingchang Lu Xiangfeng Lu Reedik Mägi Anders Malarstig Ani Manichaikul Alisa K Manning Pekka Mäntyselkä Eirini Marouli Nicholas G D Masca Andrea Maschio James B Meigs Olle Melander Andres Metspalu Andrew P Morris Alanna C Morrison Antonella Mulas Martina Müller-Nurasyid Patricia B Munroe Matt J Neville Jonas B Nielsen Sune F Nielsen Børge G Nordestgaard Jose M Ordovas Roxana Mehran Christoper J O'Donnell Marju Orho-Melander Cliona M Molony Pieter Muntendam Sandosh Padmanabhan Colin N A Palmer Dorota Pasko Aniruddh P Patel Oluf Pedersen Markus Perola Annette Peters Charlotta Pisinger Giorgio Pistis Ozren Polasek Neil Poulter Bruce M Psaty Daniel J Rader Asif Rasheed Rainer Rauramaa Dermot F Reilly Alex P Reiner Frida Renström Stephen S Rich Paul M Ridker John D Rioux Neil R Robertson Dan M Roden Jerome I Rotter Igor Rudan Veikko Salomaa Nilesh J Samani Serena Sanna Naveed Sattar Ellen M Schmidt Robert A Scott Peter Sever Raquel S Sevilla Christian M Shaffer Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Albert V Smith Blair H Smith Sangeetha Somayajula Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kathleen E Stirrups Nathan Stitziel Konstantin Strauch Heather M Stringham Praveen Surendran Hayato Tada Alan R Tall Hua Tang Jean-Claude Tardif Kent D Taylor Stella Trompet Philip S Tsao Jaakko Tuomilehto Anne Tybjaerg-Hansen Natalie R van Zuydam Anette Varbo Tibor V Varga Jarmo Virtamo Melanie Waldenberger Nan Wang Nick J Wareham Helen R Warren Peter E Weeke Joshua Weinstock Jennifer Wessel James G Wilson Peter W F Wilson Ming Xu Hanieh Yaghootkar Robin Young Eleftheria Zeggini He Zhang Neil S Zheng Weihua Zhang Yan Zhang Wei Zhou Yanhua Zhou Magdalena Zoledziewska Joanna M M Howson John Danesh Mark I McCarthy Chad A Cowan Goncalo Abecasis Panos Deloukas Kiran Musunuru Cristen J Willer Sekar Kathiresan

Nat Genet 2017 Dec 30;49(12):1758-1766. Epub 2017 Oct 30.

Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709146PMC
December 2017

Electrocardiographic Preexcitation and Risk of Cardiovascular Morbidity and Mortality: Results From the Copenhagen ECG Study.

Circ Arrhythm Electrophysiol 2017 Jun;10(6)

From the Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, Copenhagen, Denmark (M.W.S., P.V.R., J.G., M.S.O., S.H., J.H.S., A.G.H., J.B.N.); Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (S.H., L.K., J.H.S.); Department of Health Science and Technology, Aalborg University, Denmark (S.M.H., C.G., C.T.-P.); Copenhagen General Practitioners' Laboratory, Denmark (A.P.); and Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor (J.B.N.).

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http://dx.doi.org/10.1161/CIRCEP.116.004778DOI Listing
June 2017

Association Between Heart Rate at Rest and Incident Atrial Fibrillation (from the Copenhagen Electrocardiographic Study).

Am J Cardiol 2016 09 14;118(5):708-13. Epub 2016 Jun 14.

Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1016/j.amjcard.2016.06.013DOI Listing
September 2016

Electrocardiographic Tpeak-Tend interval and risk of cardiovascular morbidity and mortality: Results from the Copenhagen ECG study.

Heart Rhythm 2016 Apr 18;13(4):915-24. Epub 2015 Dec 18.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark; Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2015.12.027DOI Listing
April 2016

Reply to the Editor--Regarding the Role of Advanced Interatrial Block Pattern as a Predictor of Atrial Fibrillation.

Heart Rhythm 2016 Mar 17;13(3):e87-8. Epub 2015 Nov 17.

Laboratory for Molecular Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.hrthm.2015.11.025DOI Listing
March 2016

P-wave duration and the risk of atrial fibrillation: Results from the Copenhagen ECG Study.

Heart Rhythm 2015 Sep 23;12(9):1887-95. Epub 2015 Apr 23.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark; Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.hrthm.2015.04.026DOI Listing
September 2015

Genetic aspects of lone atrial fibrillation: what do we know?

Curr Pharm Des 2015 ;21(5):667-78

Laboratory for Molecular Cardiology, Rigshospitalet, Juliane Mariesvej 9, 2100 Copenhagen Ø, Denmark.

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http://dx.doi.org/10.2174/1381612820666140825143610DOI Listing
August 2015

Common and rare variants in SCN10A modulate the risk of atrial fibrillation.

Circ Cardiovasc Genet 2015 Feb;8(1):64-73

From the The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Department of Biomedical Sciences (J.J., M.S.O., L.Y., J.B.N., B.L., N.N., M.G., S.H., A.G.H., J.H.S., T.J.), Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet (J.J., M.S.O., J.B.N., S.H., A.G.H., J.H.S.), and Department of Clinical Medicine (S.H., J.H.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA (M.V., P.T.E) and Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E); Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Rud, Norway (I.E.C.); Department of Cardiology, Copenhagen University Hospital of Bispebjerg, Bispebjerg, Denmark (A.S.); and LuCamp, The Lundbeck Foundation Centre for Applied Medical Genomics in Personalized Disease Prediction, Prevention and Care, Copenhagen, Denmark (S.H.).

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http://dx.doi.org/10.1161/HCG.0000000000000022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392342PMC
February 2015

Brugada syndrome risk loci seem protective against atrial fibrillation.

Eur J Hum Genet 2014 Dec 26;22(12):1357-61. Epub 2014 Mar 26.

1] Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark [2] Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/ejhg.2014.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231412PMC
December 2014

Left anterior fascicular block and the risk of cardiovascular outcomes.

JAMA Intern Med 2014 Jun;174(6):1001-3

Department of Cardiology, Laboratory of Molecular Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark2Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark.

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http://dx.doi.org/10.1001/jamainternmed.2014.578DOI Listing
June 2014

New population-based exome data question the pathogenicity of some genetic variants previously associated with Marfan syndrome.

BMC Genet 2014 Jun 18;15:74. Epub 2014 Jun 18.

Laboratory of Molecular Cardiology, Department of Cardiology, the Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1186/1471-2156-15-74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070351PMC
June 2014

Risk prediction of cardiovascular death based on the QTc interval: evaluating age and gender differences in a large primary care population.

Eur Heart J 2014 May 6;35(20):1335-44. Epub 2014 Mar 6.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1093/eurheartj/ehu081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028611PMC
May 2014

Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation.

Heart Rhythm 2014 Feb 18;11(2):246-51. Epub 2013 Oct 18.

Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark; Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S15475271130120
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http://dx.doi.org/10.1016/j.hrthm.2013.10.034DOI Listing
February 2014

Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.

J Mol Cell Cardiol 2014 Feb 27;67:69-76. Epub 2013 Dec 27.

Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia; Faculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia; Cardiology Department, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.yjmcc.2013.12.014DOI Listing
February 2014

Genetic modifier of the QTc interval associated with early-onset atrial fibrillation.

Can J Cardiol 2013 Oct;29(10):1234-40

Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark; Laboratory for Molecular Cardiology, Rigshospitalet, Copenhagen, Denmark; The Ion Channel Group, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.cjca.2013.06.009DOI Listing
October 2013

Cardiac symptoms before sudden cardiac death caused by coronary artery disease: a nationwide study among young Danish people.

Heart 2013 Jul 10;99(13):938-43. Epub 2013 Apr 10.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), University of Copenhagen, Rigshospitalet, Juliane Maries Vej 20, 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1136/heartjnl-2012-303534DOI Listing
July 2013

Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation.

Eur Heart J 2013 May 21;34(20):1517-25. Epub 2012 Dec 21.

Danish National Research Foundation Centre for Cardiac Arrhythmia and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen N, Denmark.

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http://dx.doi.org/10.1093/eurheartj/ehs442DOI Listing
May 2013

High prevalence of genetic variants previously associated with LQT syndrome in new exome data.

Eur J Hum Genet 2012 Aug 29;20(8):905-8. Epub 2012 Feb 29.

The Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark.

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http://www.nature.com/articles/ejhg201223
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http://dx.doi.org/10.1038/ejhg.2012.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400735PMC
August 2012

Genetic loci on chromosomes 4q25, 7p31, and 12p12 are associated with onset of lone atrial fibrillation before the age of 40 years.

Can J Cardiol 2012 Mar-Apr;28(2):191-5. Epub 2012 Feb 14.

The Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.cjca.2011.11.016DOI Listing
July 2012

Common polymorphisms in KCNJ5 [corrected] are associated with early-onset lone atrial fibrillation in Caucasians.

Cardiology 2011 9;118(2):116-20. Epub 2011 May 9.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1159/000323840DOI Listing
December 2011

A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias.

Can J Cardiol 2011 Jul-Aug;27(4):523.e17-23. Epub 2011 May 28.

Department of Cardiology, Laboratory for Molecular Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen Ø, Denmark.

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http://dx.doi.org/10.1016/j.cjca.2011.01.003DOI Listing
September 2011

Screening of KCNN3 in patients with early-onset lone atrial fibrillation.

Europace 2011 Jul 11;13(7):963-7. Epub 2011 Mar 11.

The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1093/europace/eur007DOI Listing
July 2011

Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation.

Cardiovasc Res 2011 Mar 4;89(4):786-93. Epub 2010 Nov 4.

Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark.

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http://dx.doi.org/10.1093/cvr/cvq348DOI Listing
March 2011