Jon Mirsalis

Jon Mirsalis

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Jon Mirsalis

Jon Mirsalis

Publications by authors named "Jon Mirsalis"

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Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120.

Eur J Med Chem 2018 Jun 12;154:367-391. Epub 2018 May 12.

Laboratory of Molecular Modeling & Drug Design, Lindsley F. Kimball Research Institute, New York Blood Center, 310 E 67th Street, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.04.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993640PMC
June 2018

Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole: toward first in human studies.

Int J Toxicol 2015 Mar-Apr;34(2):129-37. Epub 2015 Feb 20.

Department of Microbiology, School of Sciences and Center for Global Health-Tumbes, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.

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http://dx.doi.org/10.1177/1091581815569582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409460PMC
April 2016

Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy.

mBio 2015 Nov 3;6(6):e01741-15. Epub 2015 Nov 3.

Department of Medicine, Institute for Therapeutic Innovation, University of Florida, Orlando, Florida, USA.

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http://dx.doi.org/10.1128/mBio.01741-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631805PMC
November 2015

Quantitative proteomics for cardiac biomarker discovery using isoproterenol-treated nonhuman primates.

J Proteome Res 2014 Dec 7;13(12):5909-17. Epub 2014 Nov 7.

Biosciences Division, SRI International , Harrisonburg, Virginia 22802, United States.

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http://dx.doi.org/10.1021/pr500835wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261936PMC
December 2014

Serum biomarkers reveal long-term cardiac injury in isoproterenol-treated African green monkeys.

J Proteome Res 2013 Apr 28;12(4):1830-7. Epub 2013 Mar 28.

Center for Advanced Drug Research, SRI International , Harrisonburg, Virginia 22801, United States.

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http://dx.doi.org/10.1021/pr3011809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812378PMC
April 2013

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.

J Med Chem 2012 May 18;55(9):4205-19. Epub 2012 Apr 18.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/jm201642zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349818PMC
May 2012

Biodistribution, toxicology, and radiation dosimetry of 5-HT1A-receptor agonist positron emission tomography ligand [11C]CUMI-101.

Int J Toxicol 2011 Dec 12;30(6):611-8. Epub 2011 Oct 12.

Department of Psychiatry and Division of Molecular Imaging and Neuropathology, Columbia University Medical Center and New York State Psychiatric Institute (NYSPI), New York, NY 10032, USA.

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http://dx.doi.org/10.1177/1091581811419024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169297PMC
December 2011

Biodistribution, toxicity and radiation dosimetry studies of the serotonin transporter radioligand 4-[18F]-ADAM in rats and monkeys.

Eur J Nucl Med Mol Imaging 2010 Mar 10;37(3):545-55. Epub 2009 Oct 10.

PET Center, Department of Nuclear Medicine, Tri-Service General Hospital, 325 Sec. 2, Cheng-Kung Rd., Neihu 114, Taipei, Taiwan.

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http://link.springer.com/10.1007/s00259-009-1281-z
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http://dx.doi.org/10.1007/s00259-009-1281-zDOI Listing
March 2010

Gene expression analysis reveals new possible mechanisms of vancomycin-induced nephrotoxicity and identifies gene markers candidates.

Toxicol Sci 2009 Jan 16;107(1):258-69. Epub 2008 Oct 16.

Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025-3493, USA.

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http://dx.doi.org/10.1093/toxsci/kfn203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638642PMC
January 2009

Microarray evaluation of the Listeria monocytogenes infection and amoxicillin treatment in mice.

Int J Toxicol 2008 ;27(3):265-72

Biosciences Division, SRI International, Menlo Park, California 94025-3493, USA.

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http://dx.doi.org/10.1080/10915810802152111DOI Listing
August 2008

Evaluation of chemopreventive agents for genotoxic activity.

Mutat Res 2007 May 25;629(2):148-60. Epub 2007 Feb 25.

SRI International, Biosciences Division, Menlo Park, CA 94025, USA.

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http://dx.doi.org/10.1016/j.mrgentox.2007.02.004DOI Listing
May 2007

Preclinical acute toxicity studies and dosimetry estimates of the novel sigma-1 receptor radiotracer, [18F]SFE.

Mol Imaging Biol 2006 Sep-Oct;8(5):284-91

Neurobiology and Imaging Program, Department of Psychiatry, New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1007/s11307-006-0056-1DOI Listing
January 2007

Gene expression profiling of mouse host response to Listeria monocytogenes infection.

Genomics 2005 Dec 15;86(6):657-67. Epub 2005 Aug 15.

Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493, USA.

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http://dx.doi.org/10.1016/j.ygeno.2005.07.005DOI Listing
December 2005

Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice.

Environ Mol Mutagen 2005 ;45(1):17-35

Biopharmaceutical Division, SRI International, Menlo Park, California 94025, USA.

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http://dx.doi.org/10.1002/em.20084DOI Listing
March 2005

Genotoxicity and toxicity of the potential cancer-preventive agent polyphenon E.

Environ Mol Mutagen 2003 ;41(1):43-54

Biopharmaceutical Development Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.

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http://dx.doi.org/10.1002/em.10129DOI Listing
March 2003

Toxicity of a quinocarmycin analog, DX-52-1, in rats and dogs in relation to clinical outcome.

Cancer Chemother Pharmacol 2003 Mar 18;51(3):193-201. Epub 2003 Jan 18.

Toxicology Laboratory, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493, USA.

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http://dx.doi.org/10.1007/s00280-002-0553-0DOI Listing
March 2003