Jon H Tobias

Jon H Tobias

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Jon H Tobias

Jon H Tobias

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A rare mutation in SMAD9 associated with high bone mass identifies the SMAD-dependent BMP signalling pathway as a potential anabolic target for osteoporosis.

J Bone Miner Res 2019 Sep 16. Epub 2019 Sep 16.

Translational Genomics Group, Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology (QUT), Translational Research Institute, Princess Alexandra Hospital, Ipswich Rd, Woolloongabba, QLD, 4102, Australia.

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http://dx.doi.org/10.1002/jbmr.3875DOI Listing
September 2019

Association Between Age at Puberty and Bone Accrual From 10 to 25 Years of Age.

JAMA Netw Open 2019 Aug 2;2(8):e198918. Epub 2019 Aug 2.

Medical Research Council Integrative Epidemiology Unit at University of Bristol, Population Health Sciences, Bristol Medical School, Bristol, United Kingdom.

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http://dx.doi.org/10.1001/jamanetworkopen.2019.8918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692837PMC
August 2019

Day-to-day physical activity producing low gravitational impacts is associated with faster visual processing speed at age 69: cross-sectional study.

Eur Rev Aging Phys Act 2019 25;16. Epub 2019 Jun 25.

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning & Research Building Level 1, Southmead Hospital, Bristol, BS10 5NB UK.

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http://dx.doi.org/10.1186/s11556-019-0216-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593499PMC
June 2019

Association between physical activity and scoliosis: a prospective cohort study.

Int J Epidemiol 2018 Dec 6. Epub 2018 Dec 6.

Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.1093/ije/dyy268DOI Listing
December 2018

Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes.

Bone 2018 09 5;114:62-71. Epub 2018 Jun 5.

Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD, Australia; Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S87563282183022
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http://dx.doi.org/10.1016/j.bone.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086337PMC
September 2018

Sarcopenia Is Negatively Related to High Gravitational Impacts Achieved From Day-to-day Physical Activity.

J Gerontol A Biol Sci Med Sci 2018 04;73(5):652-659

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, UK.

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http://dx.doi.org/10.1093/gerona/glx223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905580PMC
April 2018

Do subjective memory complaints predict falls, fractures and healthcare utilization? A two-year prospective study based on a cohort of older women recruited from primary care.

Int J Geriatr Psychiatry 2017 09 18;32(9):968-976. Epub 2016 Jul 18.

Academic Rheumatology, Musculoskeletal Research Unit, School of Clinical Sciences, Southmead Hospital, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/gps.4555DOI Listing
September 2017

Anxiety at 13 and its effect on pain, pain-related anxiety, and pain-related disability at 17: An ALSPAC cohort longitudinal analysis.

Psychol Health Med 2016 4;21(1):1-9. Epub 2015 Jun 4.

a Centre for Pain Research , University of Bath , Bath , BA2 7AY , UK.

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http://dx.doi.org/10.1080/13548506.2015.1051062DOI Listing
May 2017

Chronic Fatigue Syndrome and Chronic Widespread Pain in Adolescence: Population Birth Cohort Study.

J Pain 2017 03 12;18(3):285-294. Epub 2016 Nov 12.

Centre for Child and Adolescent Health, School of Social and Community Medicine, Bristol, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S15265900163030
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http://dx.doi.org/10.1016/j.jpain.2016.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340566PMC
March 2017

Bone Mineral Density Is Positively Related to Carotid Intima-Media Thickness: Findings From a Population-Based Study in Adolescents and Premenopausal Women.

J Bone Miner Res 2016 12 1;31(12):2139-2148. Epub 2016 Sep 1.

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/jbmr.2903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244498PMC
December 2016

Genetic Studies of Endophenotypes From Spine CT Scans Provide Novel Insights Into the Contribution of Mechanosensory Pathways to Vertebral Fractures and Spinal Curvature.

J Bone Miner Res 2016 12 21;31(12):2073-2076. Epub 2016 Nov 21.

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/jbmr.3032DOI Listing
December 2016

Placental Size Is Associated Differentially With Postnatal Bone Size and Density.

J Bone Miner Res 2016 10 22;31(10):1855-1864. Epub 2016 Apr 22.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1002/jbmr.2840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010780PMC
October 2016

The Impact of Small Spinal Curves in Adolescents Who Have Not Presented to Secondary Care: A Population-Based Cohort Study.

Spine (Phila Pa 1976) 2016 May;41(10):E611-7

*Musculoskeletal Research Unit, School of Clinical Science, University of Bristol, Southmead Hospital, Bristol, UK †Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford, UK.

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http://pdfs.journals.lww.com/spinejournal/9000/00000/The_Imp
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/BRS.0000000000001330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959823PMC
May 2016

Motor Competence in Early Childhood Is Positively Associated With Bone Strength in Late Adolescence.

J Bone Miner Res 2016 05 6;31(5):1089-98. Epub 2016 Feb 6.

School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/jbmr.2775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864944PMC
May 2016

Characterization of Vertical Accelerations Experienced by Older People Attending an Aerobics Class Designed to Produce High Impacts.

J Aging Phys Act 2016 04 30;24(2):268-74. Epub 2015 Sep 30.

Musculoskeletal Research Unit, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1123/japa.2015-0060DOI Listing
April 2016

Maternal Preeclampsia Is Associated With Reduced Adolescent Offspring Hip BMD in a UK Population-Based Birth Cohort.

J Bone Miner Res 2015 Sep 14;30(9):1684-91. Epub 2015 May 14.

Musculoskeletal Research Unit, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/jbmr.2506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540657PMC
September 2015

The effect of vigorous physical activity and body composition on cortical bone mass in adolescence.

J Bone Miner Res 2015 Mar;30(3):584

Musculoskeletal Research Unit, University of Bristol, Learning and Research Southmead Hospital, Westbury on Trym, Bristol, United Kingdom.

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http://dx.doi.org/10.1002/jbmr.2400DOI Listing
March 2015

Osteoarthritis and bone mineral density: are strong bones bad for joints?

Bonekey Rep 2015 21;4:624. Epub 2015 Jan 21.

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol , Bristol, UK.

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http://dx.doi.org/10.1038/bonekey.2014.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303262PMC
January 2015

Birth weight is positively related to bone size in adolescents but inversely related to cortical bone mineral density: findings from a large prospective cohort study.

Bone 2014 Aug 17;65:77-82. Epub 2014 May 17.

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2014.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073227PMC
August 2014

Life-course determinants of bone mass in young adults from a transitional rural community in India: the Andhra Pradesh Children and Parents Study (APCAPS).

Am J Clin Nutr 2014 Jun 2;99(6):1450-9. Epub 2014 Apr 2.

From the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).

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http://dx.doi.org/10.3945/ajcn.113.068791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021785PMC
June 2014

Jump power and force have distinct associations with cortical bone parameters: findings from a population enriched by individuals with high bone mass.

J Clin Endocrinol Metab 2014 Jan 20;99(1):266-75. Epub 2013 Dec 20.

Musculoskeletal Research Unit (S.A.H., C.L.G., J.H.T.), School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, United Kingdom; Institute of Aerospace Medicine (J.R.), German Aerospace Center, D-51147 Cologne, Germany; Institute for Biomedical Research into Human Movement and Health Research Institute (J.R.), Manchester Metropolitan University, Manchester M1 5GD, United Kingdom; Birmingham Children's Hospital (N.C.), Birmingham B4 6NH, United Kingdom; and Nutrition and Bone Health, Medical Research Council Human Nutrition Research, Cambridge CB1 9NL, United Kingdom.

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http://dx.doi.org/10.1210/jc.2013-2837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952022PMC
January 2014

High bone mass is associated with an increased prevalence of joint replacement: a case-control study.

Rheumatology (Oxford) 2013 Jun 28;52(6):1042-51. Epub 2013 Jan 28.

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/rheumatology/kes411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651613PMC
June 2013

Identifying scoliosis in population-based cohorts: development and validation of a novel method based on total-body dual-energy x-ray absorptiometric scans.

Calcif Tissue Int 2013 Jun 28;92(6):539-47. Epub 2013 Feb 28.

Musculoskeletal Research Unit, Avon Orthopaedic Centre, Southmead Hospital, University of Bristol, Westbury-on-Trym, Bristol BS10 5NB, UK.

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http://link.springer.com/10.1007/s00223-013-9713-y
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http://dx.doi.org/10.1007/s00223-013-9713-yDOI Listing
June 2013

Analysis of body composition in individuals with high bone mass reveals a marked increase in fat mass in women but not men.

J Clin Endocrinol Metab 2013 Feb 21;98(2):818-28. Epub 2013 Jan 21.

Musculoskeletal Research Unit, University of Bristol, Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, United Kingdom.

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http://dx.doi.org/10.1210/jc.2012-3342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589712PMC
February 2013

Obesity is a risk factor for musculoskeletal pain in adolescents: findings from a population-based cohort.

Pain 2012 Sep 16;153(9):1932-8. Epub 2012 Jul 16.

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Avon Orthopaedic Centre, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.1016/j.pain.2012.06.006DOI Listing
September 2012

High impact activity is related to lean but not fat mass: findings from a population-based study in adolescents.

Int J Epidemiol 2012 Aug 9;41(4):1124-31. Epub 2012 May 9.

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/ije/dys073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429873PMC
August 2012

Using multiple genetic variants as instrumental variables for modifiable risk factors.

Stat Methods Med Res 2012 Jun 7;21(3):223-42. Epub 2011 Jan 7.

MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1177/0962280210394459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917707PMC
June 2012

The association of fasting insulin, glucose, and lipids with bone mass in adolescents: findings from a cross-sectional study.

J Clin Endocrinol Metab 2012 Jun 6;97(6):2068-76. Epub 2012 Apr 6.

Medical Research Council Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove BS8 2BN, United Kingdom.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2011-2721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387416PMC
June 2012

The association between insulin levels and cortical bone: findings from a cross-sectional analysis of pQCT parameters in adolescents.

J Bone Miner Res 2012 Mar;27(3):610-8

Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1002/jbmr.1467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378703PMC
March 2012

Randomized controlled trial of a primary care-based screening program to identify older women with prevalent osteoporotic vertebral fractures: Cohort for Skeletal Health in Bristol and Avon (COSHIBA).

J Bone Miner Res 2012 Mar;27(3):664-71

Academic Rheumatology, Musculoskeletal Research Unit, University of Bristol, Avon Orthopaedic Centre, Southmead Hospital, Bristol, UK.

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http://dx.doi.org/10.1002/jbmr.1478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378696PMC
March 2012

Fat mass is a positive predictor of bone mass in adolescents.

J Bone Miner Res 2011 Mar;26(3):673; author reply 674-5

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http://dx.doi.org/10.1002/jbmr.332DOI Listing
March 2011

Adiponectin and its association with bone mass accrual in childhood.

J Bone Miner Res 2010 Oct;25(10):2212-20

Academic Rheumatology, School of Clinical Sciences, Bristol, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1002/jbmr.116DOI Listing
October 2010

Relation of maternal prepregnancy body mass index with offspring bone mass in childhood: is there evidence for an intrauterine effect?

Am J Clin Nutr 2010 Oct 28;92(4):872-80. Epub 2010 Jul 28.

MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, United Kingdom.

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https://academic.oup.com/ajcn/article/92/4/872/4597578
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http://dx.doi.org/10.3945/ajcn.2010.29501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937586PMC
October 2010

Predicting ambient ultraviolet from routine meteorological data; its potential use as an instrumental variable for vitamin D status in pregnancy in a longitudinal birth cohort in the UK.

Int J Epidemiol 2009 Dec 29;38(6):1681-8. Epub 2009 Jun 29.

Academic Rheumatology, Department of Clinical Science at North Bristol, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/ije/dyp237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788530PMC
December 2009

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with spinal BMD in 9-year-old children.

J Bone Miner Res 2009 Jan;24(1):117-24

Department of Community Based Medicine, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1359/jbmr.080814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742728PMC
January 2009

Bone fragility contributes to the risk of fracture in children, even after moderate and severe trauma.

J Bone Miner Res 2008 Feb;23(2):173-9

Clinical Science at South Bristol, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1359/jbmr.071010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742712PMC
February 2008

PTHR1 polymorphisms influence BMD variation through effects on the growing skeleton.

Calcif Tissue Int 2007 Oct 21;81(4):270-8. Epub 2007 Sep 21.

Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Headington, Oxford, UK.

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http://dx.doi.org/10.1007/s00223-007-9072-7DOI Listing
October 2007

Intervertebral disc degeneration can predispose to anterior vertebral fractures in the thoracolumbar spine.

J Bone Miner Res 2006 Sep;21(9):1409-16

Department of Anatomy, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1359/jbmr.060609DOI Listing
September 2006

Association between bone mass and fractures in children: a prospective cohort study.

J Bone Miner Res 2006 Sep;21(9):1489-95

Community Based Medicine, University of Bristol, Bristol, United Kingdom.

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http://doi.wiley.com/10.1359/jbmr.060601
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http://dx.doi.org/10.1359/jbmr.060601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742714PMC
September 2006

Social position affects bone mass in childhood through opposing actions on height and weight.

J Bone Miner Res 2005 Dec 8;20(12):2082-9. Epub 2005 Aug 8.

Community Based Medicine, University of Bristol, United Kingdom.

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http://dx.doi.org/10.1359/JBMR.050808DOI Listing
December 2005

Intervertebral disc degeneration can lead to "stress-shielding" of the anterior vertebral body: a cause of osteoporotic vertebral fracture?

Spine (Phila Pa 1976) 2004 Apr;29(7):774-82

Department of Anatomy, Rheumatology Unit, University of Bristol, UK.

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http://dx.doi.org/10.1097/01.brs.0000119401.23006.d2DOI Listing
April 2004