Publications by authors named "Jon Frampton"

61Publications

Dependence on Myb expression is attenuated in myeloid leukaemia with N-terminal CEBPA mutations.

Life Sci Alliance 2019 04 15;2(2). Epub 2019 Mar 15.

Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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http://dx.doi.org/10.26508/lsa.201800207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421631PMC
April 2019

Harnessing genomics to improve outcomes for women with cancer in India: key priorities for research.

Lancet Oncol 2018 02;19(2):e102-e112

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1016/S1470-2045(17)30726-XDOI Listing
February 2018

Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature.

Sci Rep 2017 09 11;7(1):11148. Epub 2017 Sep 11.

Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1038/s41598-017-11718-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593973PMC
September 2017

Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.

Gastroenterology 2017 07 28;153(1):233-248.e16. Epub 2017 Mar 28.

Birmingham Liver Biomedical Research Unit, National Institute for Health Research, Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511862PMC
July 2017

Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1.

J Biol Chem 2017 03 4;292(11):4755-4763. Epub 2017 Jan 4.

From the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China, and Guangzhou Medical University, Guangzhou 511436, China,

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http://dx.doi.org/10.1074/jbc.M116.764787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377789PMC
March 2017

Targeting the transcription factor Myb by small-molecule inhibitors.

Exp Hematol 2017 03 23;47:31-35. Epub 2016 Dec 23.

Institute for Biochemistry, Westfälische-Wilhelms-Universität, Münster, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.12.003DOI Listing
March 2017

Fibrin activates GPVI in human and mouse platelets.

Blood 2015 Sep 17;126(13):1601-8. Epub 2015 Aug 17.

Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; and.

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http://dx.doi.org/10.1182/blood-2015-04-641654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582337PMC
September 2015

Pretreatment of Mesenchymal Stem Cells Manipulates Their Vasculoprotective Potential While Not Altering Their Homing Within the Injured Gut.

Stem Cells 2015 Sep 29;33(9):2785-97. Epub 2015 Jun 29.

Centre for Cardiovascular Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1002/stem.2061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737111PMC
September 2015

Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development.

Blood 2015 Jun 23;125(24):3769-77. Epub 2015 Apr 23.

Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom;

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http://dx.doi.org/10.1182/blood-2014-09-603803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463737PMC
June 2015

The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters.

Cell Res 2015 Jan 16;25(1):80-92. Epub 2014 Dec 16.

1] Laboratory of Chromatin and Human Disease, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China [2] Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China [3] Hong Kong - Guangdong Joint Laboratory of Stem Cells and Regenerative Medicine, the University of Hong Kong and Guangzhou Institutes of Biomedicine and Health, Guangzhou, Guangdong 510530, China.

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http://dx.doi.org/10.1038/cr.2014.165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650593PMC
January 2015

Generation of knockout rabbits using transcription activator-like effector nucleases.

Cell Regen 2014 5;3(1). Epub 2014 Feb 5.

Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Guangzhou, 510530 China.

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http://dx.doi.org/10.1186/2045-9769-3-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230510PMC
November 2014

Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes.

Stem Cells 2015 Feb;33(2):479-90

Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto City, Japan.

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http://dx.doi.org/10.1002/stem.1855DOI Listing
February 2015

Transcriptional pause release is a rate-limiting step for somatic cell reprogramming.

Cell Stem Cell 2014 Nov 9;15(5):574-88. Epub 2014 Oct 9.

Laboratory of Chromatin and Human Disease, Chinese Academy of Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Guangzhou 510530, China; Key Laboratory of Regenerative Biology, Chinese Academy of Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Guangzhou 510530, China; Hong Kong-Guangdong Joint Laboratory on Stem Cell and Regenerative Medicine, the University of Hong Kong and Guangzhou Institutes of Biomedicine and Health, China. Electronic address:

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http://www.cell.com/cms/attachment/2022533874/2042574651/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S193459091400450
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http://dx.doi.org/10.1016/j.stem.2014.09.018DOI Listing
November 2014

RAG1/2 knockout pigs with severe combined immunodeficiency.

J Immunol 2014 Aug 27;193(3):1496-503. Epub 2014 Jun 27.

Laboratory of Animal Cloning, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China;

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1400915
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http://dx.doi.org/10.4049/jimmunol.1400915DOI Listing
August 2014

Crosstalk between mesenchymal stem cells and endothelial cells leads to downregulation of cytokine-induced leukocyte recruitment.

Stem Cells 2013 Dec;31(12):2690-702

Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1002/stem.1511DOI Listing
December 2013

Mechanisms of adhesion and subsequent actions of a haematopoietic stem cell line, HPC-7, in the injured murine intestinal microcirculation in vivo.

PLoS One 2013 12;8(3):e59150. Epub 2013 Mar 12.

Centre for Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059150PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595270PMC
September 2013

Multi-modal molecular diffuse optical tomography system for small animal imaging.

Meas Sci Technol 2013 ;24(10):105405

Physical Science of Imaging in the Biomedical Sciences Doctoral Training Centre, College of Engineering and Physical Sciences, University of Birmingham, UK ; School of Computer Science, College of Engineering and Physical Sciences, University of Birmingham, UK.

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http://dx.doi.org/10.1088/0957-0233/24/10/105405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061700PMC
January 2013

Enhancing the adhesion of hematopoietic precursor cell integrins with hydrogen peroxide increases recruitment within murine gut.

Cell Transplant 2013 10;22(8):1485-99. Epub 2012 Aug 10.

Centre for Cardiovascular Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.3727/096368912X653192DOI Listing
April 2014

A lineage of myeloid cells independent of Myb and hematopoietic stem cells.

Science 2012 Apr 22;336(6077):86-90. Epub 2012 Mar 22.

Centre for Molecular and Cellular Biology of Inflammation, New Hunt's House, King's College London, Great Maze Pond, London SE1 1UL, UK.

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http://dx.doi.org/10.1126/science.1219179DOI Listing
April 2012

Human mesenchymal stem cells are recruited to injured liver in a β1-integrin and CD44 dependent manner.

Hepatology 2012 Sep 12;56(3):1063-73. Epub 2012 Jul 12.

National Institute for Health Research Biomedical Research Unit and Centre for Liver Research, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1002/hep.25716DOI Listing
September 2012

Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region.

J Exp Med 2011 Jun 30;208(6):1305-15. Epub 2011 May 30.

Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH9 3JQ, Scotland, UK.

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http://www.jem.org/lookup/doi/10.1084/jem.20102419
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http://dx.doi.org/10.1084/jem.20102419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173253PMC
June 2011

B-Myb is critical for proper DNA duplication during an unperturbed S phase in mouse embryonic stem cells.

Stem Cells 2010 Oct;28(10):1751-9

Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1002/stem.496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214134PMC
October 2010

Critical roles for c-Myb in lymphoid priming and early B-cell development.

Blood 2010 Apr 3;115(14):2796-805. Epub 2010 Feb 3.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1182/blood-2009-08-239210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854426PMC
April 2010

Evidence that integrin alpha IIb beta 3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation.

J Biol Chem 2009 Nov 15;284(45):31463-72. Epub 2009 Sep 15.

Division of Cellular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1074/jbc.M109.030213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781542PMC
November 2009

Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis.

EMBO J 2009 May 9;28(10):1492-504. Epub 2009 Apr 9.

College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK. or

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http://dx.doi.org/10.1038/emboj.2009.97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688541PMC
May 2009

RCAS/SCL-TVA animal model allows targeted delivery of polyoma middle T oncogene to vascular endothelial progenitors in vivo and results in hemangioma development.

Clin Cancer Res 2008 Jun;14(12):3948-55

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-5152DOI Listing
June 2008

Hematopoietic lineage commitment: miRNAs add specificity to a widely expressed transcription factor.

Dev Cell 2008 Jun;14(6):815-6

Institute of Biomedical Research, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1016/j.devcel.2008.05.011DOI Listing
June 2008

c-Myb-dependent smooth muscle cell differentiation.

Circ Res 2008 Mar 10;102(5):554-61. Epub 2008 Jan 10.

Heart & Stroke Richard Lewar Center of Excellence in Cardiovascular Research, Department of Medicine, University of Toronto, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.105.162628DOI Listing
March 2008

c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain.

Stem Cells 2008 Jan 27;26(1):173-81. Epub 2007 Sep 27.

Differentiation and Transcription Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1634/stemcells.2007-0293DOI Listing
January 2008

Glycoprotein VI oligomerization in cell lines and platelets.

J Thromb Haemost 2007 May 15;5(5):1026-1033. Epub 2007 Mar 15.

Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1111/j.1538-7836.2007.02449.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1869045PMC
May 2007

c-Myb is required for progenitor cell homeostasis in colonic crypts.

Proc Natl Acad Sci U S A 2007 Mar 26;104(10):3829-34. Epub 2007 Feb 26.

Peter MacCallum Cancer Centre and Pathology Department, University of Melbourne, Melbourne VIC 8006, Australia.

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http://dx.doi.org/10.1073/pnas.0610055104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820669PMC
March 2007

Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development.

Blood 2006 Aug 4;108(3):896-903. Epub 2006 Apr 4.

Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

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http://dx.doi.org/10.1182/blood-2005-09-3846DOI Listing
August 2006

The transcription factor B-Myb is essential for S-phase progression and genomic stability in diploid and polyploid megakaryocytes.

J Cell Sci 2006 Apr 21;119(Pt 8):1483-93. Epub 2006 Mar 21.

Institute for Biomedical Research, Birmingham University Medical School, Edgbaston, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1242/jcs.02870DOI Listing
April 2006

c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells.

Blood 2006 Jul 28;108(1):297-304. Epub 2006 Feb 28.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1182/blood-2005-12-5014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895838PMC
July 2006

Coordination of erythropoiesis by the transcription factor c-Myb.

Blood 2006 Jun 16;107(12):4703-10. Epub 2006 Feb 16.

Institute of Biomedical Research, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1182/blood-2005-07-2968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895806PMC
June 2006

Generation of a conditional allele of the B-myb gene.

Genesis 2005 Dec;43(4):189-95

Institute for Biomedical Research, Birmingham University Medical School, Edgbaston, United Kingdom.

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http://dx.doi.org/10.1002/gene.20170DOI Listing
December 2005

GPIIb (CD41) integrin is expressed on mast cells and influences their adhesion properties.

Exp Hematol 2005 Apr;33(4):403-12

Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/j.exphem.2005.01.011DOI Listing
April 2005

Selective impairment of platelet activation to collagen in the absence of GATA1.

Blood 2005 Jun 8;105(11):4369-76. Epub 2005 Feb 8.

Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.

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http://www.bloodjournal.org/content/bloodjournal/105/11/4369
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http://www.bloodjournal.org/content/early/2005/02/08/blood-2
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2004-10-40
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http://dx.doi.org/10.1182/blood-2004-10-4098DOI Listing
June 2005

Functional delivery of large genomic DNA to human cells with a peptide-lipid vector.

J Gene Med 2003 Oct;5(10):883-892

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1002/jgm.420DOI Listing
October 2003

Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.

EMBO J 2003 Sep;22(17):4478-88

Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1093/emboj/cdg434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC202376PMC
September 2003

Manipulation of mouse hematopoietic progenitors by specific retroviral infection.

J Biol Chem 2003 Oct 18;278(44):43556-63. Epub 2003 Aug 18.

Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M302717200DOI Listing
October 2003

Murine GPVI stimulates weak integrin activation in PLCgamma2-/- platelets: involvement of PLCgamma1 and PI3-kinase.

Blood 2003 Aug 1;102(4):1367-73. Epub 2003 May 1.

Department of Pharmacology, University of Oxford, United Kingdom.

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http://dx.doi.org/10.1182/blood-2003-01-0029DOI Listing
August 2003

Characterization of the c-Myb-responsive region and regulation of the human type I collagen alpha 2 chain gene by c-Myb.

J Biol Chem 2003 Jan 6;278(3):1533-41. Epub 2002 Nov 6.

Laboratorio di Medicina Molecolare, Istituto di Clinica Medica, Ematologia ed Immunologia Clinica, Università di Ancona, 60020 Ancona, Italy.

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http://dx.doi.org/10.1074/jbc.M204392200DOI Listing
January 2003

Direct regulation of BCL-2 by FLI-1 is involved in the survival of FLI-1-transformed erythroblasts.

EMBO J 2002 Feb;21(4):694-703

CNRS UMR146, Institut Curie-Section de Recherche, Centre Universitaire, Bat. 110, 91405 Orsay, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125347PMC
http://dx.doi.org/10.1093/emboj/21.4.694DOI Listing
February 2002