Publications by authors named "Jon C Aster"

194 Publications

Notch activation is pervasive in SMZL and uncommon in DLBCL: implications for Notch signaling in B-cell tumors.

Authors:
Vignesh Shanmugam Jeffrey W Craig Laura K Hilton Matthew H Nguyen Christopher K Rushton Kian Fahimdanesh Scott Lovitch Ben Ferland David W Scott Jon C Aster

Blood Adv 2021 Jan;5(1):71-83

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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January 2021

Single cell RNA-seq reveals developmental plasticity with coexisting oncogenic and immune evasion programs in ETP-ALL.

Authors:
Praveen Anand Amy Guillaumet-Adkins Valeriya Dimitrova Huiyoung Yun Yotam Drier Noori Sotudeh Anna Jollyette Rogers Madhu M Ouseph Monica Nair Sayalee Potdar Randi Isenhart Jake A Kloeber Tushara Vijaykumar Leili Niu Tiffaney Lorraine Vincent Guangwu Guo Julia Frede Marian Harris Andrew Place Lewis B Silverman David T Teachey Andrew A Lane Daniel J DeAngelo Jon C Aster Bradley Bernstein Jens Lohr Birgit Knoechel

Blood 2020 Nov 23. Epub 2020 Nov 23.

Boston Children's Hospital, United States.

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November 2020

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Authors:
Renata Ferrarotto Yoshitsugu Mitani Daniel J McGrail Kaiyi Li Tatiana V Karpinets Diana Bell Steven J Frank Xingzhi Song Michael E Kupferman Bin Liu J Jack Lee Bonnie S Glisson Jianhua Zhang Jon C Aster Shiaw-Yih Lin P Andrew Futreal John V Heymach Adel K El-Naggar

Clin Cancer Res 2021 Feb 10;27(3):852-864. Epub 2020 Nov 10.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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February 2021

Shortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content.

Authors:
Yanyu Zhao Anahita Pilvar Anup Tank Hannah Peterson John Jiang Jon C Aster John Paul Dumas Mark C Pierce Darren Roblyer

Nat Commun 2020 10 23;11(1):5355. Epub 2020 Oct 23.

Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA, 02215, USA.

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October 2020

Contribution of clonal hematopoiesis to adult-onset hemophagocytic lymphohistiocytosis.

Authors:
Peter G Miller Adam S Sperling Christopher J Gibson Kaushik Viswanathan Cecilia Castellano Marie McConkey John Ceremsak Martin S Taylor Sebastian Birndt Florian Perner Jon Arnason Mridul Agrawal Alison M Schram Sarah Nikiforow German Pihan Robert P Hasserjian Jon C Aster Paul La Rosée Elizabeth A Morgan Nancy Berliner Benjamin L Ebert

Blood 2020 Dec;136(26):3051-3055

Department of Medical Oncology, Dana-Farber Cancer Institute.

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December 2020

, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation.

Authors:
Li Pan Madeleine E Lemieux Tom Thomas Julia M Rogers Colin H Lipper Winston Lee Carl Johnson Lynette M Sholl Andrew P South Jarrod A Marto Guillaume O Adelmant Stephen C Blacklow Jon C Aster

Elife 2020 09 16;9. Epub 2020 Sep 16.

Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, United States.

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September 2020

NOTCH SIGNALING IN CONTEXT: BASIC AND TRANSLATIONAL IMPLICATIONS.

Authors:
Jon C Aster

Trans Am Clin Climatol Assoc 2020 ;131:147-156

BOSTON, MASSACHUSETTS.

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January 2020

inactivation in - and -deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types.

Authors:
Felix Oppel Dong H Ki Mark W Zimmerman Kenneth N Ross Ting Tao Hui Shi Shuning He Jon C Aster A Thomas Look

Dis Model Mech 2020 08 27;13(8). Epub 2020 Aug 27.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA

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August 2020

Pharmacological disruption of the Notch transcription factor complex.

Authors:
Rajwinder Lehal Jelena Zaric Michele Vigolo Charlotte Urech Viktoras Frismantas Nadine Zangger Linlin Cao Adeline Berger Irene Chicote Sylvain Loubéry Sung Hee Choi Ute Koch Stephen C Blacklow Hector G Palmer Beat Bornhauser Marcos González-Gaitán Yvan Arsenijevic Vincent Zoete Jon C Aster Jean-Pierre Bourquin Freddy Radtke

Proc Natl Acad Sci U S A 2020 07 29;117(28):16292-16301. Epub 2020 Jun 29.

Swiss Institute for Experimental Cancer Research, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland;

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July 2020

MAML1-Dependent Notch-Responsive Genes Exhibit Differing Cofactor Requirements for Transcriptional Activation.

Authors:
Julia M Rogers Bingqian Guo Emily D Egan Jon C Aster Karen Adelman Stephen C Blacklow

Mol Cell Biol 2020 05 14;40(11). Epub 2020 May 14.

Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA

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May 2020

rearrangement in myeloid neoplasms.

Authors:
Amy W Xiao Yuyan Jia Linda B Baughn Kathryn E Pearce Beth A Pitel Jon C Aster Paola Dal Cin Sheng Xiao

Haematologica 2020 Jun 12;105(6):e315-e317. Epub 2020 Mar 12.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

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June 2020

Identification of germline variants in adults with hemophagocytic lymphohistiocytosis.

Authors:
Peter G Miller Abhishek Niroula John J Ceremsak Christopher J Gibson Martin S Taylor Sebastian Birndt Florian Perner Jon Arnason Adam S Sperling Mridul Agrawal Alison M Schram Sarah Nikiforow German Pihan Robert P Hasserjian Jon C Aster Paul La Rosée Elizabeth A Morgan Nancy Berliner Benjamin L Ebert

Blood Adv 2020 03;4(5):925-929

Department of Medical Oncology, Dana-Farber Cancer Institute, and.

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March 2020

Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia.

Authors:
Anica M Wandler Benjamin J Huang Jeffrey W Craig Kathryn Hayes Hannah Yan Lauren K Meyer Alessandro Scacchetti Gabriela Monsalve Monique Dail Qing Li Jasmine C Wong Olga Weinberg Robert P Hasserjian Scott C Kogan Philip Jonsson Keith Yamamoto Deepak Sampath Joy Nakitandwe James R Downing Jinghui Zhang Jon C Aster Barry S Taylor Kevin Shannon

Leukemia 2020 08 17;34(8):2025-2037. Epub 2020 Feb 17.

Department of Pediatrics, University of California, San Francisco, CA, USA.

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August 2020

Detection of the KIT mutation in myelodysplastic and/or myeloproliferative neoplasms and acute myeloid leukemia with myelodysplasia-related changes predicts concurrent systemic mastocytosis.

Authors:
Jeffrey W Craig Robert P Hasserjian Annette S Kim Jon C Aster Geraldine S Pinkus Jason L Hornick David P Steensma R Coleman Lindsley Daniel J DeAngelo Elizabeth A Morgan

Mod Pathol 2020 06 2;33(6):1135-1145. Epub 2020 Jan 2.

Harvard Medical School, Boston, MA, USA.

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June 2020

Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.

Authors:
Sanchez M Jarrett Tom C M Seegar Mark Andrews Guillaume Adelmant Jarrod A Marto Jon C Aster Stephen C Blacklow

Sci Signal 2019 11 5;12(606). Epub 2019 Nov 5.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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November 2019

A Distinctive Genomic and Immunohistochemical Profile for NOTCH3 and PDGFRB in Myofibroma With Diagnostic and Therapeutic Implications.

Authors:
Selene C Koo Katherine A Janeway Marian H Harris Christy J Fryer Jon C Aster Alyaa Al-Ibraheemi Alanna J Church

Int J Surg Pathol 2020 Apr 29;28(2):128-137. Epub 2019 Sep 29.

Boston Children's Hospital, Boston, MA, USA.

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April 2020

Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging.

Authors:
Ziming Du Jia-Ren Lin Rumana Rashid Zoltan Maliga Shu Wang Jon C Aster Benjamin Izar Peter K Sorger Sandro Santagata

Nat Protoc 2019 10 18;14(10):2900-2930. Epub 2019 Sep 18.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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October 2019

DNA methyltransferase inhibition overcomes diphthamide pathway deficiencies underlying CD123-targeted treatment resistance.

Authors:
Katsuhiro Togami Timothy Pastika Jason Stephansky Mahmoud Ghandi Amanda L Christie Kristen L Jones Carl A Johnson Ross W Lindsay Christopher L Brooks Anthony Letai Jeffrey W Craig Olga Pozdnyakova David M Weinstock Joan Montero Jon C Aster Cory M Johannessen Andrew A Lane

J Clin Invest 2019 11;129(11):5005-5019

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

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November 2019

Targeted inhibition of CD47-SIRPα requires Fc-FcγR interactions to maximize activity in T-cell lymphomas.

Authors:
Salvia Jain Alexandria Van Scoyk Elizabeth A Morgan Andrew Matthews Kristen Stevenson Gail Newton Foster Powers Anu Autio Abner Louissaint Guillemette Pontini Jon C Aster Francis W Luscinskas David M Weinstock

Blood 2019 10;134(17):1430-1440

Harvard Medical School, Boston, MA.

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October 2019

Gene expression profiling distinguishes prefibrotic from overtly fibrotic myeloproliferative neoplasms and identifies disease subsets with distinct inflammatory signatures.

Authors:
Waihay J Wong Michele Baltay Annaliese Getz Kit Fuhrman Jon C Aster Robert P Hasserjian Olga Pozdnyakova

PLoS One 2019 9;14(5):e0216810. Epub 2019 May 9.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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January 2020

Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents.

Authors:
Chen Lossos Yunpeng Liu Kellie E Kolb Amanda L Christie Alexandria Van Scoyk Sanjay M Prakadan Kay Shigemori Kristen E Stevenson Sara Morrow Olivia D Plana Cameron Fraser Kristen L Jones Huiyun Liu Christian P Pallasch Rebecca Modiste Quang-De Nguyen Jeffrey W Craig Elizabeth A Morgan Francisco Vega Jon C Aster Kristopher A Sarosiek Alex K Shalek Michael T Hemann David M Weinstock

Cancer Discov 2019 07 30;9(7):944-961. Epub 2019 Apr 30.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

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July 2019

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies.

Authors:
Felix Oppel Ting Tao Hui Shi Kenneth N Ross Mark W Zimmerman Shuning He Guangxiang Tong Jon C Aster A Thomas Look

PLoS Genet 2019 04 10;15(4):e1008039. Epub 2019 Apr 10.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America.

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April 2019

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.

Authors:
Peter van Galen Volker Hovestadt Marc H Wadsworth Ii Travis K Hughes Gabriel K Griffin Sofia Battaglia Julia A Verga Jason Stephansky Timothy J Pastika Jennifer Lombardi Story Geraldine S Pinkus Olga Pozdnyakova Ilene Galinsky Richard M Stone Timothy A Graubert Alex K Shalek Jon C Aster Andrew A Lane Bradley E Bernstein

Cell 2019 03 28;176(6):1265-1281.e24. Epub 2019 Feb 28.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Ludwig Center at Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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March 2019

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.

Authors:
Jelena Petrovic Yeqiao Zhou Maria Fasolino Naomi Goldman Gregory W Schwartz Maxwell R Mumbach Son C Nguyen Kelly S Rome Yogev Sela Zachary Zapataro Stephen C Blacklow Michael J Kruhlak Junwei Shi Jon C Aster Eric F Joyce Shawn C Little Golnaz Vahedi Warren S Pear Robert B Faryabi

Mol Cell 2019 03 7;73(6):1174-1190.e12. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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March 2019

Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling.

Authors:
Toshiaki Nakano Shunsuke Katsuki Mingxian Chen Julius L Decano Arda Halu Lang Ho Lee Diego V S Pestana Angelo S T Kum Rodrigo K Kuromoto Whitney S Golden Mario S Boff Gabriel C Guimaraes Hideyuki Higashi Kevin J Kauffman Takashi Maejima Takehiro Suzuki Hiroshi Iwata Albert-László Barabási Jon C Aster Daniel G Anderson Amitabh Sharma Sasha A Singh Elena Aikawa Masanori Aikawa

Circulation 2019 01;139(1):78-96

Center for Excellence in Vascular Biology (T.N., S.K., M.C., D.V.S.P., A.S.T.K., R.K.K., W.S.G., M.S.B., G.C.G., E.A., M.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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January 2019

Concomitant classic Hodgkin lymphoma and schistosomiasis.

Authors:
Waihay J Wong Deogratias Ruhangaza Alexis Manirakiza Jack Omondi Marcellin C Mugabe Izimukwiye Isabelle Elizabeth A Morgan Jon C Aster

Am J Hematol 2019 07 25;94(7):840-841. Epub 2018 Nov 25.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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July 2019

Genomic and clinical characterization of B/T mixed phenotype acute leukemia reveals recurrent features and T-ALL like mutations.

Authors:
Xiaoli Mi Gabriel Griffin Winston Lee Sanjay Patel Robert Ohgami Chi Young Ok Sa Wang Julia T Geyer Wenbin Xiao Mikhail Roshal Jacqueline S Garcia Lewis B Silverman Stephen E Sallan Jon C Aster Marian H Harris Olga K Weinberg

Am J Hematol 2018 11 26;93(11):1358-1367. Epub 2018 Sep 26.

Department of Pathology, Boston Children's Hospital, Boston, Massachusetts.

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November 2018

Anti-CD37 chimeric antigen receptor T cells are active against B- and T-cell lymphomas.

Authors:
Irene Scarfò Maria Ormhøj Matthew J Frigault Ana P Castano Selena Lorrey Amanda A Bouffard Alexandria van Scoyk Scott J Rodig Alexandra J Shay Jon C Aster Frederic I Preffer David M Weinstock Marcela V Maus

Blood 2018 10 8;132(14):1495-1506. Epub 2018 Aug 8.

Cellular Immunotherapy Program, Massachusetts General Hospital Cancer Center, Charlestown, MA.

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October 2018

Pre-diagnosis plasma immune markers and risk of non-Hodgkin lymphoma in two prospective cohort studies.

Authors:
Mara M Epstein Bernard Rosner Elizabeth C Breen Julie L Batista Edward L Giovannucci Larry Magpantay Jon C Aster Scott J Rodig Kimberly A Bertrand Francine Laden Otoniel Martínez-Maza Brenda M Birmann

Haematologica 2018 10 21;103(10):1679-1687. Epub 2018 Jun 21.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

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October 2018

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.

Authors:
Samuel Y Ng Noriaki Yoshida Amanda L Christie Mahmoud Ghandi Neekesh V Dharia Joshua Dempster Mark Murakami Kay Shigemori Sara N Morrow Alexandria Van Scoyk Nicolas A Cordero Kristen E Stevenson Maneka Puligandla Brian Haas Christopher Lo Robin Meyers Galen Gao Andrew Cherniack Abner Louissaint Valentina Nardi Aaron R Thorner Henry Long Xintao Qiu Elizabeth A Morgan David M Dorfman Danilo Fiore Julie Jang Alan L Epstein Ahmet Dogan Yanming Zhang Steven M Horwitz Eric D Jacobsen Solimar Santiago Jian-Guo Ren Vincent Guerlavais D Allen Annis Manuel Aivado Mansoor N Saleh Amitkumar Mehta Aviad Tsherniak David Root Francisca Vazquez William C Hahn Giorgio Inghirami Jon C Aster David M Weinstock Raphael Koch

Nat Commun 2018 05 22;9(1):2024. Epub 2018 May 22.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.

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May 2018