Jon C Aster

Jon C Aster

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A Distinctive Genomic and Immunohistochemical Profile for NOTCH3 and PDGFRB in Myofibroma With Diagnostic and Therapeutic Implications.

Authors:
Selene C Koo Katherine A Janeway Marian H Harris Christy J Fryer Jon C Aster Alyaa Al-Ibraheemi Alanna J Church

Int J Surg Pathol 2020 Apr 29;28(2):128-137. Epub 2019 Sep 29.

Boston Children's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1177/1066896919876703DOI Listing
April 2020

Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia.

Authors:
Anica M Wandler Benjamin J Huang Jeffrey W Craig Kathryn Hayes Hannah Yan Lauren K Meyer Alessandro Scacchetti Gabriela Monsalve Monique Dail Qing Li Jasmine C Wong Olga Weinberg Robert P Hasserjian Scott C Kogan Philip Jonsson Keith Yamamoto Deepak Sampath Joy Nakitandwe James R Downing Jinghui Zhang Jon C Aster Barry S Taylor Kevin Shannon

Leukemia 2020 Feb 17. Epub 2020 Feb 17.

Department of Pediatrics, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41375-020-0748-6DOI Listing
February 2020

Gene expression profiling distinguishes prefibrotic from overtly fibrotic myeloproliferative neoplasms and identifies disease subsets with distinct inflammatory signatures.

Authors:
Waihay J Wong Michele Baltay Annaliese Getz Kit Fuhrman Jon C Aster Robert P Hasserjian Olga Pozdnyakova

PLoS One 2019 9;14(5):e0216810. Epub 2019 May 9.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216810PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534080PMC
January 2020

Detection of the KIT mutation in myelodysplastic and/or myeloproliferative neoplasms and acute myeloid leukemia with myelodysplasia-related changes predicts concurrent systemic mastocytosis.

Authors:
Jeffrey W Craig Robert P Hasserjian Annette S Kim Jon C Aster Geraldine S Pinkus Jason L Hornick David P Steensma R Coleman Lindsley Daniel J DeAngelo Elizabeth A Morgan

Mod Pathol 2020 Jan 2. Epub 2020 Jan 2.

Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41379-019-0447-xDOI Listing
January 2020

DNA methyltransferase inhibition overcomes diphthamide pathway deficiencies underlying CD123-targeted treatment resistance.

Authors:
Katsuhiro Togami Timothy Pastika Jason Stephansky Mahmoud Ghandi Amanda L Christie Kristen L Jones Carl A Johnson Ross W Lindsay Christopher L Brooks Anthony Letai Jeffrey W Craig Olga Pozdnyakova David M Weinstock Joan Montero Jon C Aster Cory M Johannessen Andrew A Lane

J Clin Invest 2019 Nov;129(11):5005-5019

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI128571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819120PMC
November 2019

Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.

Authors:
Sanchez M Jarrett Tom C M Seegar Mark Andrews Guillaume Adelmant Jarrod A Marto Jon C Aster Stephen C Blacklow

Sci Signal 2019 Nov 5;12(606). Epub 2019 Nov 5.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.aay2369DOI Listing
November 2019

Targeted inhibition of CD47-SIRPα requires Fc-FcγR interactions to maximize activity in T-cell lymphomas.

Authors:
Salvia Jain Alexandria Van Scoyk Elizabeth A Morgan Andrew Matthews Kristen Stevenson Gail Newton Foster Powers Anu Autio Abner Louissaint Guillemette Pontini Jon C Aster Francis W Luscinskas David M Weinstock

Blood 2019 10;134(17):1430-1440

Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1182/blood.2019001744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839960PMC
October 2019

Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging.

Authors:
Ziming Du Jia-Ren Lin Rumana Rashid Zoltan Maliga Shu Wang Jon C Aster Benjamin Izar Peter K Sorger Sandro Santagata

Nat Protoc 2019 10 18;14(10):2900-2930. Epub 2019 Sep 18.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41596-019-0206-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959005PMC
October 2019

Concomitant classic Hodgkin lymphoma and schistosomiasis.

Authors:
Waihay J Wong Deogratias Ruhangaza Alexis Manirakiza Jack Omondi Marcellin C Mugabe Izimukwiye Isabelle Elizabeth A Morgan Jon C Aster

Am J Hematol 2019 Jul 25;94(7):840-841. Epub 2018 Nov 25.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://doi.wiley.com/10.1002/ajh.25316
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http://dx.doi.org/10.1002/ajh.25316DOI Listing
July 2019

Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents.

Authors:
Chen Lossos Yunpeng Liu Kellie E Kolb Amanda L Christie Alexandria Van Scoyk Sanjay M Prakadan Kay Shigemori Kristen E Stevenson Sara Morrow Olivia D Plana Cameron Fraser Kristen L Jones Huiyun Liu Christian P Pallasch Rebecca Modiste Quang-De Nguyen Jeffrey W Craig Elizabeth A Morgan Francisco Vega Jon C Aster Kristopher A Sarosiek Alex K Shalek Michael T Hemann David M Weinstock

Cancer Discov 2019 Jul 30;9(7):944-961. Epub 2019 Apr 30.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-18-1393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606344PMC
July 2019

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies.

Authors:
Felix Oppel Ting Tao Hui Shi Kenneth N Ross Mark W Zimmerman Shuning He Guangxiang Tong Jon C Aster A Thomas Look

PLoS Genet 2019 04 10;15(4):e1008039. Epub 2019 Apr 10.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476535PMC
April 2019

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.

Authors:
Jelena Petrovic Yeqiao Zhou Maria Fasolino Naomi Goldman Gregory W Schwartz Maxwell R Mumbach Son C Nguyen Kelly S Rome Yogev Sela Zachary Zapataro Stephen C Blacklow Michael J Kruhlak Junwei Shi Jon C Aster Eric F Joyce Shawn C Little Golnaz Vahedi Warren S Pear Robert B Faryabi

Mol Cell 2019 03 7;73(6):1174-1190.e12. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765193000
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http://dx.doi.org/10.1016/j.molcel.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485942PMC
March 2019

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.

Authors:
Peter van Galen Volker Hovestadt Marc H Wadsworth Ii Travis K Hughes Gabriel K Griffin Sofia Battaglia Julia A Verga Jason Stephansky Timothy J Pastika Jennifer Lombardi Story Geraldine S Pinkus Olga Pozdnyakova Ilene Galinsky Richard M Stone Timothy A Graubert Alex K Shalek Jon C Aster Andrew A Lane Bradley E Bernstein

Cell 2019 03 28;176(6):1265-1281.e24. Epub 2019 Feb 28.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Ludwig Center at Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193009
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http://dx.doi.org/10.1016/j.cell.2019.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515904PMC
March 2019

Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling.

Authors:
Toshiaki Nakano Shunsuke Katsuki Mingxian Chen Julius L Decano Arda Halu Lang Ho Lee Diego V S Pestana Angelo S T Kum Rodrigo K Kuromoto Whitney S Golden Mario S Boff Gabriel C Guimaraes Hideyuki Higashi Kevin J Kauffman Takashi Maejima Takehiro Suzuki Hiroshi Iwata Albert-László Barabási Jon C Aster Daniel G Anderson Amitabh Sharma Sasha A Singh Elena Aikawa Masanori Aikawa

Circulation 2019 01;139(1):78-96

Center for Excellence in Vascular Biology (T.N., S.K., M.C., D.V.S.P., A.S.T.K., R.K.K., W.S.G., M.S.B., G.C.G., E.A., M.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311723PMC
January 2019

Genomic and clinical characterization of B/T mixed phenotype acute leukemia reveals recurrent features and T-ALL like mutations.

Authors:
Xiaoli Mi Gabriel Griffin Winston Lee Sanjay Patel Robert Ohgami Chi Young Ok Sa Wang Julia T Geyer Wenbin Xiao Mikhail Roshal Jacqueline S Garcia Lewis B Silverman Stephen E Sallan Jon C Aster Marian H Harris Olga K Weinberg

Am J Hematol 2018 11 26;93(11):1358-1367. Epub 2018 Sep 26.

Department of Pathology, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/ajh.25256DOI Listing
November 2018

Pre-diagnosis plasma immune markers and risk of non-Hodgkin lymphoma in two prospective cohort studies.

Authors:
Mara M Epstein Bernard Rosner Elizabeth C Breen Julie L Batista Edward L Giovannucci Larry Magpantay Jon C Aster Scott J Rodig Kimberly A Bertrand Francine Laden Otoniel Martínez-Maza Brenda M Birmann

Haematologica 2018 10 21;103(10):1679-1687. Epub 2018 Jun 21.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.3324/haematol.2017.183236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165815PMC
October 2018

Anti-CD37 chimeric antigen receptor T cells are active against B- and T-cell lymphomas.

Authors:
Irene Scarfò Maria Ormhøj Matthew J Frigault Ana P Castano Selena Lorrey Amanda A Bouffard Alexandria van Scoyk Scott J Rodig Alexandra J Shay Jon C Aster Frederic I Preffer David M Weinstock Marcela V Maus

Blood 2018 10 8;132(14):1495-1506. Epub 2018 Aug 8.

Cellular Immunotherapy Program, Massachusetts General Hospital Cancer Center, Charlestown, MA.

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http://dx.doi.org/10.1182/blood-2018-04-842708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172564PMC
October 2018

RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice.

Authors:
Samuel Y Ng Leon Brown Kristen Stevenson Tiffany deSouza Jon C Aster Abner Louissaint David M Weinstock

Blood 2018 08 16;132(9):935-947. Epub 2018 May 16.

Department of Medical Oncology and.

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http://dx.doi.org/10.1182/blood-2017-11-818617DOI Listing
August 2018

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.

Authors:
Samuel Y Ng Noriaki Yoshida Amanda L Christie Mahmoud Ghandi Neekesh V Dharia Joshua Dempster Mark Murakami Kay Shigemori Sara N Morrow Alexandria Van Scoyk Nicolas A Cordero Kristen E Stevenson Maneka Puligandla Brian Haas Christopher Lo Robin Meyers Galen Gao Andrew Cherniack Abner Louissaint Valentina Nardi Aaron R Thorner Henry Long Xintao Qiu Elizabeth A Morgan David M Dorfman Danilo Fiore Julie Jang Alan L Epstein Ahmet Dogan Yanming Zhang Steven M Horwitz Eric D Jacobsen Solimar Santiago Jian-Guo Ren Vincent Guerlavais D Allen Annis Manuel Aivado Mansoor N Saleh Amitkumar Mehta Aviad Tsherniak David Root Francisca Vazquez William C Hahn Giorgio Inghirami Jon C Aster David M Weinstock Raphael Koch

Nat Commun 2018 05 22;9(1):2024. Epub 2018 May 22.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.

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http://www.nature.com/articles/s41467-018-04356-9
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http://dx.doi.org/10.1038/s41467-018-04356-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964252PMC
May 2018

Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma.

Authors:
Patrick A Ott Zhuting Hu Derin B Keskin Sachet A Shukla Jing Sun David J Bozym Wandi Zhang Adrienne Luoma Anita Giobbie-Hurder Lauren Peter Christina Chen Oriol Olive Todd A Carter Shuqiang Li David J Lieb Thomas Eisenhaure Evisa Gjini Jonathan Stevens William J Lane Indu Javeri Kaliappanadar Nellaiappan Andres M Salazar Heather Daley Michael Seaman Elizabeth I Buchbinder Charles H Yoon Maegan Harden Niall Lennon Stacey Gabriel Scott J Rodig Dan H Barouch Jon C Aster Gad Getz Kai Wucherpfennig Donna Neuberg Jerome Ritz Eric S Lander Edward F Fritsch Nir Hacohen Catherine J Wu

Nature 2018 03;555(7696):402

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http://dx.doi.org/10.1038/nature25145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064631PMC
March 2018

Activity of the PI3K-δ,γ inhibitor duvelisib in a phase 1 trial and preclinical models of T-cell lymphoma.

Authors:
Steven M Horwitz Raphael Koch Pierluigi Porcu Yasuhiro Oki Alison Moskowitz Megan Perez Patricia Myskowski Adam Officer Jacob D Jaffe Sara N Morrow Kerstin Allen Mark Douglas Howard Stern Jennifer Sweeney Patrick Kelly Virginia Kelly Jon C Aster David Weaver Francine M Foss David M Weinstock

Blood 2018 02 12;131(8):888-898. Epub 2017 Dec 12.

Dana-Farber Cancer Institute, Boston, MA.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2017-08
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http://dx.doi.org/10.1182/blood-2017-08-802470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824337PMC
February 2018

Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma.

Authors:
Dipti P Sajed William C Faquin Chris Carey Eric A Severson Amir H Afrogheh Carl A Johnson Stephen C Blacklow Nicole G Chau Derrick T Lin Jeffrey F Krane Vickie Y Jo Joaquín J Garcia Lynette M Sholl Jon C Aster

Am J Surg Pathol 2017 Nov;41(11):1473-1482

*Department of Pathology, Massachusetts General Hospital ¶Department of Surgery, Massachusetts General Hospital ‡Department of Pathology, Brigham and Women's Hospital §Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School ∥Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA #Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN †Northern Institute for Cancer Research, University of Newcastle, Newcastle on Tyne, UK.

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http://Insights.ovid.com/crossref?an=00000478-201711000-0000
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http://dx.doi.org/10.1097/PAS.0000000000000945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657508PMC
November 2017

Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry.

Authors:
Michael J Kluk Todd Ashworth Hongfang Wang Birgit Knoechel Emily F Mason Elizabeth A Morgan David Dorfman Geraldine Pinkus Oliver Weigert Jason L Hornick Lucian R Chirieac Michelle Hirsch David J Oh Andrew P South Irene M Leigh Celine Pourreyron Andrew J Cassidy Daniel J Deangelo David M Weinstock Ian E Krop Deborah Dillon Jane E Brock Alexander J F Lazar Myron Peto Raymond J Cho Alexander Stoeck Brian B Haines Sriram Sathayanrayanan Scott Rodig Jon C Aster

PLoS One 2013 18;8(6):e67306. Epub 2013 Jun 18.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067306PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688991PMC
October 2017

Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia.

Authors:
Zuzana Tothova John M Krill-Burger Katerina D Popova Catherine C Landers Quinlan L Sievers David Yudovich Roger Belizaire Jon C Aster Elizabeth A Morgan Aviad Tsherniak Benjamin L Ebert

Cell Stem Cell 2017 10;21(4):547-555.e8

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA; Division of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679060PMC
October 2017

The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.

Authors:
Sung Hee Choi Eric Severson Warren S Pear Xiaole S Liu Jon C Aster Stephen C Blacklow

PLoS One 2017 12;12(10):e0185762. Epub 2017 Oct 12.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185762PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638296PMC
October 2017

A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas.

Authors:
Russell J H Ryan Jelena Petrovic Dylan M Rausch Yeqiao Zhou Caleb A Lareau Michael J Kluk Amanda L Christie Winston Y Lee Daniel R Tarjan Bingqian Guo Laura K H Donohue Shawn M Gillespie Valentina Nardi Ephraim P Hochberg Stephen C Blacklow David M Weinstock Robert B Faryabi Bradley E Bernstein Jon C Aster Warren S Pear

Cell Rep 2017 Oct;21(3):784-797

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.09.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687286PMC
October 2017

Similar outcomes after haploidentical transplantation with post-transplant cyclophosphamide versus HLA-matched transplantation: a meta-analysis of case-control studies.

Authors:
Zhenyang Gu Li Wang Lei Yuan Wenrong Huang Meng Li Lixun Guan Qingyi Wang Zhe Gao Shasha Zhao Lan Luo Feiyan Wang Nan Yang Daihong Liu Jon C Aster Chunji Gao

Oncotarget 2017 Sep 29;8(38):63574-63586. Epub 2017 Jun 29.

Department of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.

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http://www.oncotarget.com/fulltext/18862
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http://dx.doi.org/10.18632/oncotarget.18862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609944PMC
September 2017

Systematic sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia.

Authors:
Elizabeth A Morgan Mark N Lee Daniel J DeAngelo David P Steensma Richard M Stone Frank C Kuo Jon C Aster Christopher J Gibson R Coleman Lindsley

Blood Adv 2017 Sep 13;1(21):1786-1789. Epub 2017 Sep 13.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1182/bloodadvances.2017011197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728102PMC
September 2017

An immunogenic personal neoantigen vaccine for patients with melanoma.

Authors:
Patrick A Ott Zhuting Hu Derin B Keskin Sachet A Shukla Jing Sun David J Bozym Wandi Zhang Adrienne Luoma Anita Giobbie-Hurder Lauren Peter Christina Chen Oriol Olive Todd A Carter Shuqiang Li David J Lieb Thomas Eisenhaure Evisa Gjini Jonathan Stevens William J Lane Indu Javeri Kaliappanadar Nellaiappan Andres M Salazar Heather Daley Michael Seaman Elizabeth I Buchbinder Charles H Yoon Maegan Harden Niall Lennon Stacey Gabriel Scott J Rodig Dan H Barouch Jon C Aster Gad Getz Kai Wucherpfennig Donna Neuberg Jerome Ritz Eric S Lander Edward F Fritsch Nir Hacohen Catherine J Wu

Nature 2017 07 5;547(7662):217-221. Epub 2017 Jul 5.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature22991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577644PMC
July 2017

Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset.

Authors:
Sathish K R Padi Libia A Luevano Ningfei An Ritu Pandey Neha Singh Jin H Song Jon C Aster Xue-Zhong Yu Shikhar Mehrotra Andrew S Kraft

Oncotarget 2017 May;8(18):30199-30216

University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.

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http://dx.doi.org/10.18632/oncotarget.16320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444737PMC
May 2017

Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells.

Authors:
Eric Severson Kelly L Arnett Hongfang Wang Chongzhi Zang Len Taing Hudan Liu Warren S Pear X Shirley Liu Stephen C Blacklow Jon C Aster

Sci Signal 2017 May 2;10(477). Epub 2017 May 2.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aag1
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http://dx.doi.org/10.1126/scisignal.aag1598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931361PMC
May 2017

Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax.

Authors:
Joan Montero Jason Stephansky Tianyu Cai Gabriel K Griffin Lucia Cabal-Hierro Katsuhiro Togami Leah J Hogdal Ilene Galinsky Elizabeth A Morgan Jon C Aster Matthew S Davids Nicole R LeBoeuf Richard M Stone Marina Konopleva Naveen Pemmaraju Anthony Letai Andrew A Lane

Cancer Discov 2017 02 16;7(2):156-164. Epub 2016 Dec 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296248PMC
February 2017

Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.

Authors:
Brian B Liau Cem Sievers Laura K Donohue Shawn M Gillespie William A Flavahan Tyler E Miller Andrew S Venteicher Christine H Hebert Christopher D Carey Scott J Rodig Sarah J Shareef Fadi J Najm Peter van Galen Hiroaki Wakimoto Daniel P Cahill Jeremy N Rich Jon C Aster Mario L Suvà Anoop P Patel Bradley E Bernstein

Cell Stem Cell 2017 02 15;20(2):233-246.e7. Epub 2016 Dec 15.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291795PMC
February 2017

Detection of activating MAP2K1 mutations in atypical hairy cell leukemia and hairy cell leukemia variant.

Authors:
Emily F Mason Ronald D Brown David P Szeto Christopher J Gibson Yonghui Jia Elizabeth P Garcia Caron A Jacobson Paola Dal Cin Frank C Kuo Geraldine S Pinkus Neal I Lindeman Lynette M Sholl Jon C Aster Elizabeth A Morgan

Leuk Lymphoma 2017 01 31;58(1):233-236. Epub 2016 May 31.

a Department of Pathology, Brigham & Women's Hospital , Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/10428194.2016.1185786DOI Listing
January 2017

The Varied Roles of Notch in Cancer.

Authors:
Jon C Aster Warren S Pear Stephen C Blacklow

Annu Rev Pathol 2017 Jan 5;12:245-275. Epub 2016 Dec 5.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1146/annurev-pathol-052016-100127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933931PMC
January 2017

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia.

Authors:
Mark Y Chiang Qing Wang Anna C Gormley Sarah J Stein Lanwei Xu Olga Shestova Jon C Aster Warren S Pear

Blood 2016 11 26;128(18):2229-2240. Epub 2016 Sep 26.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute of Medicine and Engineering, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; and.

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http://dx.doi.org/10.1182/blood-2016-01-692855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095757PMC
November 2016

Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia.

Authors:
Lili Wang Angela N Brooks Jean Fan Youzhong Wan Rutendo Gambe Shuqiang Li Sarah Hergert Shanye Yin Samuel S Freeman Joshua Z Levin Lin Fan Michael Seiler Silvia Buonamici Peter G Smith Kevin F Chau Carrie L Cibulskis Wandi Zhang Laura Z Rassenti Emanuela M Ghia Thomas J Kipps Stacey Fernandes Donald B Bloch Dylan Kotliar Dan A Landau Sachet A Shukla Jon C Aster Robin Reed David S DeLuca Jennifer R Brown Donna Neuberg Gad Getz Kenneth J Livak Matthew M Meyerson Peter V Kharchenko Catherine J Wu

Cancer Cell 2016 Nov 3;30(5):750-763. Epub 2016 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Dana 540, 44 Binney Street, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127278PMC
November 2016

Comprehensive analyses of tumor immunity: implications for cancer immunotherapy.

Authors:
Bo Li Eric Severson Jean-Christophe Pignon Haoquan Zhao Taiwen Li Jesse Novak Peng Jiang Hui Shen Jon C Aster Scott Rodig Sabina Signoretti Jun S Liu X Shirley Liu

Genome Biol 2016 08 22;17(1):174. Epub 2016 Aug 22.

Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, 450 Brookline Ave., Boston, MA, 02215, USA.

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http://dx.doi.org/10.1186/s13059-016-1028-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993001PMC
August 2016

Validation and Implementation of a Custom Next-Generation Sequencing Clinical Assay for Hematologic Malignancies.

Authors:
Michael J Kluk R Coleman Lindsley Jon C Aster Neal I Lindeman David Szeto Dimity Hall Frank C Kuo

J Mol Diagn 2016 07;18(4):507-15

Center for Advanced Molecular Diagnostics, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707186PMC
July 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

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July 2016

Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease.

Authors:
Bjoern Chapuy Hongwei Cheng Akira Watahiki Matthew D Ducar Yuxiang Tan Linfeng Chen Margaretha G M Roemer Jing Ouyang Amanda L Christie Liye Zhang Daniel Gusenleitner Ryan P Abo Pedro Farinha Frederike von Bonin Aaron R Thorner Heather H Sun Randy D Gascoyne Geraldine S Pinkus Paul van Hummelen Gerald G Wulf Jon C Aster David M Weinstock Stefano Monti Scott J Rodig Yuzhuo Wang Margaret A Shipp

Blood 2016 05 15;127(18):2203-13. Epub 2016 Jan 15.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859195PMC
May 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma.

Authors:
Yotam Drier Matthew J Cotton Kaylyn E Williamson Shawn M Gillespie Russell J H Ryan Michael J Kluk Christopher D Carey Scott J Rodig Lynette M Sholl Amir H Afrogheh William C Faquin Lurdes Queimado Jun Qi Michael J Wick Adel K El-Naggar James E Bradner Christopher A Moskaluk Jon C Aster Birgit Knoechel Bradley E Bernstein

Nat Genet 2016 Mar 1;48(3):265-72. Epub 2016 Feb 1.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767593PMC
March 2016

Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure.

Authors:
Jun-Ichiro Koga Toshiaki Nakano James E Dahlman Jose-Luiz Figueiredo Hengmin Zhang Julius Decano Omar F Khan Tomiharu Niida Hiroshi Iwata Jon C Aster Hideo Yagita Daniel G Anderson C Keith Ozaki Masanori Aikawa

Arterioscler Thromb Vasc Biol 2015 Nov 24;35(11):2343-2353. Epub 2015 Sep 24.

The Center for Excellence in Vascular Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/ATVBAHA.115.305516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003117PMC
November 2015

Metabolic Mechanisms of Drug Resistance in Leukemia.

Authors:
Birgit Knoechel Jon C Aster

Cell Metab 2015 Nov;22(5):759-60

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

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November 2015

Network analysis of gene essentiality in functional genomics experiments.

Authors:
Peng Jiang Hongfang Wang Wei Li Chongzhi Zang Bo Li Yinling J Wong Cliff Meyer Jun S Liu Jon C Aster X Shirley Liu

Genome Biol 2015 Oct 30;16:239. Epub 2015 Oct 30.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1186/s13059-015-0808-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627418PMC
October 2015

Myeloid neoplasm demonstrating a STAT5B-RARA rearrangement and genetic alterations associated with all-trans retinoic acid resistance identified by a custom next-generation sequencing assay.

Authors:
Michael J Kluk Ryan P Abo Ronald D Brown Frank C Kuo Paola Dal Cin Olga Pozdnyakova Elizabeth A Morgan Neal I Lindeman Daniel J DeAngelo Jon C Aster

Cold Spring Harb Mol Case Stud 2015 Oct;1(1):a000307

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA;

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http://dx.doi.org/10.1101/mcs.a000307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850893PMC
October 2015

Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case.

Authors:
Birgit Knoechel Ami Bhatt Li Pan Chandra S Pedamallu Eric Severson Alejandro Gutierrez David M Dorfman Frank C Kuo Michael Kluk Andrew L Kung Patrick Zweidler-McKay Matthew Meyerson Stephen C Blacklow Daniel J DeAngelo Jon C Aster

Cold Spring Harb Mol Case Stud 2015 Oct;1(1):a000539

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA;

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http://dx.doi.org/10.1101/mcs.a000539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850884PMC
October 2015

Dicing up T-ALL.

Authors:
Jon C Aster

Blood 2015 Aug;126(8):929-30

BRIGHAM AND WOMEN'S HOSPITAL.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-06-64
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August 2015

Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region.

Authors:
Xiang Xu Sung Hee Choi Tiancen Hu Kittichoat Tiyanont Roger Habets Arjan J Groot Marc Vooijs Jon C Aster Rajiv Chopra Christy Fryer Stephen C Blacklow

Structure 2015 Jul 4;23(7):1227-35. Epub 2015 Jun 4.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497832PMC
July 2015

A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors.

Authors:
Ankur Sharma Rupali A Gadkari Satthenapalli V Ramakanth Krishnanand Padmanabhan Davanam S Madhumathi Lakshmi Devi Lingappa Appaji Jon C Aster Annapoorni Rangarajan Rajan R Dighe

Sci Rep 2015 Jun 5;5:11012. Epub 2015 Jun 5.

Department of Molecular Reproduction Development and Genetics, Indian Institute of Science Bangalore, Karnataka, India.

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http://dx.doi.org/10.1038/srep11012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457015PMC
June 2015

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.

Authors:
Wendy R Gordon Brandon Zimmerman Li He Laura J Miles Jiuhong Huang Kittichoat Tiyanont Debbie G McArthur Jon C Aster Norbert Perrimon Joseph J Loparo Stephen C Blacklow

Dev Cell 2015 Jun 4;33(6):729-36. Epub 2015 Jun 4.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Dana Farber Cancer Institute, Boston, MA 02215, USA; Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481192PMC
June 2015

The role of Notch receptors in transcriptional regulation.

Authors:
Hongfang Wang Chongzhi Zang X Shirley Liu Jon C Aster

J Cell Physiol 2015 May;230(5):982-8

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jcp.24872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442318PMC
May 2015

Ibrutinib in previously treated Waldenström's macroglobulinemia.

Authors:
Steven P Treon Christina K Tripsas Kirsten Meid Diane Warren Gaurav Varma Rebecca Green Kimon V Argyropoulos Guang Yang Yang Cao Lian Xu Christopher J Patterson Scott Rodig James L Zehnder Jon C Aster Nancy Lee Harris Sandra Kanan Irene Ghobrial Jorge J Castillo Jacob P Laubach Zachary R Hunter Zeena Salman Jianling Li Mei Cheng Fong Clow Thorsten Graef M Lia Palomba Ranjana H Advani

N Engl J Med 2015 Apr;372(15):1430-40

From the Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute (S.P.T., C.K.T., K.M., D.W., G.Y., Y.C., L.X., C.J.P., S.K., I.G., J.J.C., J.P.L., Z.R.H.), Harvard Medical School (S.P.T., G.Y., Y.C., S.R., J.C.A., N.L.H., I.G., J.J.C., J.P.L.), Department of Pathology, Brigham and Women's Hospital (S.R., J.C.A.), Department of Pathology, Massachusetts General Hospital (N.L.H.), and Department of Pathology, Boston University Medical Center (Z.R.H.) - all in Boston; Memorial Sloan Kettering Cancer Center, New York (R.G., K.V.A., M.L.P.); and Stanford University Medical Center, Stanford (G.V., J.L.Z., R.H.A.), and Pharmacyclics, Sunnyvale (Z.S., J.L., M.C., F.C., T.G.) - both in California.

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http://dx.doi.org/10.1056/NEJMoa1501548DOI Listing
April 2015

Application and evaluation of anti-Notch antibodies to modulate Notch signaling.

Authors:
Wendy R Gordon Jon C Aster

Methods Mol Biol 2014 ;1187:323-33

Department of Biochemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/978-1-4939-1139-4_24DOI Listing
March 2015

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling.

Authors:
Michelle I Lin Emily N Price Sonja Boatman Elliott J Hagedorn Eirini Trompouki Sruthi Satishchandran Charles W Carspecken Audrey Uong Anthony DiBiase Song Yang Matthew C Canver Ann Dahlberg Zhigang Lu Cheng Cheng Zhang Stuart H Orkin Irwin D Bernstein Jon C Aster Richard M White Leonard I Zon

Elife 2015 Feb 25;4. Epub 2015 Feb 25.

Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States.

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https://elifesciences.org/articles/05544
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http://dx.doi.org/10.7554/eLife.05544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371382PMC
February 2015

Cyclin C is a haploinsufficient tumour suppressor.

Authors:
Na Li Anne Fassl Joel Chick Hiroyuki Inuzuka Xiaoyu Li Marc R Mansour Lijun Liu Haizhen Wang Bryan King Shavali Shaik Alejandro Gutierrez Alban Ordureau Tobias Otto Taras Kreslavsky Lukas Baitsch Leah Bury Clifford A Meyer Nan Ke Kristin A Mulry Michael J Kluk Moni Roy Sunkyu Kim Xiaowu Zhang Yan Geng Agnieszka Zagozdzon Sarah Jenkinson Rosemary E Gale David C Linch Jean J Zhao Charles G Mullighan J Wade Harper Jon C Aster Iannis Aifantis Harald von Boehmer Steven P Gygi Wenyi Wei A Thomas Look Piotr Sicinski

Nat Cell Biol 2014 Nov 26;16(11):1080-91. Epub 2014 Oct 26.

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncb3046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235773PMC
November 2014

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.

Authors:
Yumi Yashiro-Ohtani Hongfang Wang Chongzhi Zang Kelly L Arnett Will Bailis Yugong Ho Birgit Knoechel Claudia Lanauze Lumena Louis Katherine S Forsyth Sujun Chen Yoonjie Chung Jonathan Schug Gerd A Blobel Stephen A Liebhaber Bradley E Bernstein Stephen C Blacklow Xiaole Shirley Liu Jon C Aster Warren S Pear

Proc Natl Acad Sci U S A 2014 Nov 4;111(46):E4946-53. Epub 2014 Nov 4.

Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, and

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246292PMC
November 2014

NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis.

Authors:
Andrew P South Karin J Purdie Stephen A Watt Sam Haldenby Nicoline den Breems Michelle Dimon Sarah T Arron Michael J Kluk Jon C Aster Angela McHugh Dylan J Xue Jasbani Hs Dayal Kim S Robinson Sm Hasan Rizvi Charlotte M Proby Catherine A Harwood Irene M Leigh

J Invest Dermatol 2014 Oct 24;134(10):2630-2638. Epub 2014 Mar 24.

Division of Cancer Research, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/jid.2014.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753672PMC
October 2014

Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.

Authors:
Alexander Stoeck Serguei Lejnine Andrew Truong Li Pan Hongfang Wang Chongzhi Zang Jing Yuan Chris Ware John MacLean Philip W Garrett-Engele Michael Kluk Jason Laskey Brian B Haines Christopher Moskaluk Leigh Zawel Stephen Fawell Gary Gilliland Theresa Zhang Brandon E Kremer Birgit Knoechel Bradley E Bernstein Warren S Pear X Shirley Liu Jon C Aster Sriram Sathyanarayanan

Cancer Discov 2014 Oct 7;4(10):1154-67. Epub 2014 Aug 7.

Merck Research Laboratory, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184927PMC
October 2014

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.

Authors:
Dirk Heckl Monika S Kowalczyk David Yudovich Roger Belizaire Rishi V Puram Marie E McConkey Anne Thielke Jon C Aster Aviv Regev Benjamin L Ebert

Nat Biotechnol 2014 Sep 22;32(9):941-6. Epub 2014 Jun 22.

1] Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160386PMC
September 2014

Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.

Authors:
Monique Dail Jason Wong Jessica Lawrence Daniel O'Connor Joy Nakitandwe Shann-Ching Chen Jin Xu Leslie B Lee Keiko Akagi Qing Li Jon C Aster Warren S Pear James R Downing Deepak Sampath Kevin Shannon

Nature 2014 Sep 20;513(7519):512-6. Epub 2014 Jul 20.

Department of Pediatrics and Benniof Children's Hospital, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nature13495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213126PMC
September 2014

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

Authors:
Birgit Knoechel Justine E Roderick Kaylyn E Williamson Jiang Zhu Jens G Lohr Matthew J Cotton Shawn M Gillespie Daniel Fernandez Manching Ku Hongfang Wang Federica Piccioni Serena J Silver Mohit Jain Daniel Pearson Michael J Kluk Christopher J Ott Leonard D Shultz Michael A Brehm Dale L Greiner Alejandro Gutierrez Kimberly Stegmaier Andrew L Kung David E Root James E Bradner Jon C Aster Michelle A Kelliher Bradley E Bernstein

Nat Genet 2014 Apr 2;46(4):364-70. Epub 2014 Mar 2.

1] Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [3] Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [4] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.

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http://www.nature.com/articles/ng.2913
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086945PMC
April 2014

MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma.

Authors:
Adlai R Grayson Erica M Walsh Michael J Cameron Jernej Godec Todd Ashworth Jessica M Ambrose Alexandra B Aserlind Hongfang Wang Gerard Evan Michael J Kluk James E Bradner Jon C Aster Christopher A French

Oncogene 2014 Mar 22;33(13):1736-1742. Epub 2013 Apr 22.

Department of Pathology, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1038/onc.2013.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942361PMC
March 2014

The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.

Authors:
Dawson M Gerhardt Kostandin V Pajcini Teresa D'altri Lili Tu Rajan Jain Lanwei Xu Michael J Chen Stacey Rentschler Olga Shestova Gerald B Wertheim John W Tobias Michael Kluk Antony W Wood Jon C Aster Phyllis A Gimotty Jonathan A Epstein Nancy Speck Anna Bigas Warren S Pear

Genes Dev 2014 Mar;28(6):576-93

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

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http://dx.doi.org/10.1101/gad.227496.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967047PMC
March 2014

Targeted imaging of Ewing sarcoma in preclinical models using a 64Cu-labeled anti-CD99 antibody.

Authors:
Allison F O'Neill Jason L J Dearling Yuchuan Wang Tanya Tupper Yanping Sun Jon C Aster Monica L Calicchio Antonio R Perez-Atayde Alan B Packard Andrew L Kung

Clin Cancer Res 2014 Feb 11;20(3):678-87. Epub 2013 Nov 11.

Authors' Affiliations: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital, and Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, and Harvard Medical School; Lurie Family Imaging Center, Dana-Farber Cancer Institute; Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School; Department of Pathology, Boston Children's Hospital, and Harvard Medical School, Boston, Massachusetts; and Department of Pediatrics, Columbia University Medical Center, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946397PMC
February 2014

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

Authors:
Alejandro Gutierrez Li Pan Richard W J Groen Frederic Baleydier Alex Kentsis Jason Marineau Ruta Grebliunaite Elena Kozakewich Casie Reed Francoise Pflumio Sandrine Poglio Benjamin Uzan Paul Clemons Lynn VerPlank Frank An Jason Burbank Stephanie Norton Nicola Tolliday Hanno Steen Andrew P Weng Huipin Yuan James E Bradner Constantine Mitsiades A Thomas Look Jon C Aster

J Clin Invest 2014 Feb 9;124(2):644-55. Epub 2014 Jan 9.

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http://www.jci.org/articles/view/65093
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904599PMC
February 2014

SYK is a critical regulator of FLT3 in acute myeloid leukemia.

Authors:
Alexandre Puissant Nina Fenouille Gabriela Alexe Yana Pikman Christopher F Bassil Swapnil Mehta Jinyan Du Julhash U Kazi Frédéric Luciano Lars Rönnstrand Andrew L Kung Jon C Aster Ilene Galinsky Richard M Stone Daniel J DeAngelo Michael T Hemann Kimberly Stegmaier

Cancer Cell 2014 Feb;25(2):226-42

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA; The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106711PMC
February 2014

In brief: Notch signalling in health and disease.

Authors:
Jon C Aster

J Pathol 2014 Jan;232(1):1-3

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1002/path.4291DOI Listing
January 2014

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.

Authors:
Hongfang Wang Chongzhi Zang Len Taing Kelly L Arnett Yinling Joey Wong Warren S Pear Stephen C Blacklow X Shirley Liu Jon C Aster

Proc Natl Acad Sci U S A 2014 Jan 27;111(2):705-10. Epub 2013 Dec 27.

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1315023111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896193PMC
January 2014

Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.

Authors:
Marie Blanke Andrawes Xiang Xu Hong Liu Scott B Ficarro Jarrod A Marto Jon C Aster Stephen C Blacklow

J Biol Chem 2013 Aug 9;288(35):25477-89. Epub 2013 Jul 9.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M113.454850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757209PMC
August 2013

Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11.

Authors:
Richard Patryk Ngondo-Mbongo Evelyne Myslinski Jon C Aster Philippe Carbon

Nucleic Acids Res 2013 Apr 13;41(7):4000-14. Epub 2013 Feb 13.

Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 15 rue René Descartes, 67084 Strasbourg, France.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkt088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627581PMC
April 2013

Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.

Authors:
Giovanni Roti Anne Carlton Kenneth N Ross Michele Markstein Kostandin Pajcini Angela H Su Norbert Perrimon Warren S Pear Andrew L Kung Stephen C Blacklow Jon C Aster Kimberly Stegmaier

Cancer Cell 2013 Mar 21;23(3):390-405. Epub 2013 Feb 21.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709972PMC
March 2013

Resistance revealed in acute lymphoblastic leukemia.

Authors:
Jon C Aster Daniel J DeAngelo

Nat Med 2013 Mar;19(3):264-5

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http://www.nature.com/articles/nm.3119
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http://dx.doi.org/10.1038/nm.3119DOI Listing
March 2013

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells.

Authors:
Mark Y Chiang Olga Shestova Lanwei Xu Jon C Aster Warren S Pear

Blood 2013 Feb 31;121(6):905-17. Epub 2012 Oct 31.

Division of Hematology-Oncology and the University of Michigan Cancer Center, University of Michigan, Ann Arbor, MI, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-03-41
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http://dx.doi.org/10.1182/blood-2012-03-416503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567338PMC
February 2013

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.

Authors:
Vincenzo Giambra Christopher R Jenkins Hongfang Wang Sonya H Lam Olena O Shevchuk Oksana Nemirovsky Carol Wai Sam Gusscott Mark Y Chiang Jon C Aster R Keith Humphries Connie Eaves Andrew P Weng

Nat Med 2012 Nov 21;18(11):1693-8. Epub 2012 Oct 21.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/nm.2960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738873PMC
November 2012

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy.

Authors:
Shannon M McAuliffe Stefanie L Morgan Gregory A Wyant Lieu T Tran Katherine W Muto Yu Sarah Chen Kenneth T Chin Justin C Partridge Barish B Poole Kuang-Hung Cheng John Daggett Kristen Cullen Emily Kantoff Kathleen Hasselbatt Julia Berkowitz Michael G Muto Ross S Berkowitz Jon C Aster Ursula A Matulonis Daniela M Dinulescu

Proc Natl Acad Sci U S A 2012 Oct 27;109(43):E2939-48. Epub 2012 Sep 27.

Department of Pathology and Obstetrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1206400109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491453PMC
October 2012

Targeting the Notch pathway: twists and turns on the road to rational therapeutics.

Authors:
Jon C Aster Stephen C Blacklow

J Clin Oncol 2012 Jul 14;30(19):2418-20. Epub 2012 May 14.

Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1200/JCO.2012.42.0992DOI Listing
July 2012

Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.

Authors:
Daiju Fukuda Elena Aikawa Filip K Swirski Tatiana I Novobrantseva Victor Kotelianski Cem Z Gorgun Aleksey Chudnovskiy Hiroyuki Yamazaki Kevin Croce Ralph Weissleder Jon C Aster Gökhan S Hotamisligil Hideo Yagita Masanori Aikawa

Proc Natl Acad Sci U S A 2012 Jul 13;109(27):E1868-77. Epub 2012 Jun 13.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1116889109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390871PMC
July 2012

The double-edged sword of Notch signaling in cancer.

Authors:
Andrew P South Raymond J Cho Jon C Aster

Semin Cell Dev Biol 2012 Jun 30;23(4):458-64. Epub 2012 Jan 30.

Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1016/j.semcdb.2012.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360804PMC
June 2012

Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling.

Authors:
Min Jie Alvin Tan Elizabeth A White Mathew E Sowa J Wade Harper Jon C Aster Peter M Howley

Proc Natl Acad Sci U S A 2012 Jun 30;109(23):E1473-80. Epub 2012 Apr 30.

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1205991109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384212PMC
June 2012

The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia.

Authors:
Versha Banerji Stacey M Frumm Kenneth N Ross Loretta S Li Anna C Schinzel Cynthia K Hahn Rose M Kakoza Kwan T Chow Linda Ross Gabriela Alexe Nicola Tolliday Haig Inguilizian Ilene Galinsky Richard M Stone Daniel J DeAngelo Giovanni Roti Jon C Aster William C Hahn Andrew L Kung Kimberly Stegmaier

J Clin Invest 2012 Mar 13;122(3):935-47. Epub 2012 Feb 13.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children’s Hospital Boston, Boston 02215, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI46465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287215PMC
March 2012

Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.

Authors:
Jon C Aster Nick Bodnar Lanwei Xu Fredrick Karnell John M Milholland Ivan Maillard Gavin Histen Yunsun Nam Stephen C Blacklow Warren S Pear

PLoS One 2011 13;6(10):e25645. Epub 2011 Oct 13.

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025645PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192765PMC
February 2012

T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.

Authors:
Kristine Germar Marei Dose Tassos Konstantinou Jiangwen Zhang Hongfang Wang Camille Lobry Kelly L Arnett Stephen C Blacklow Iannis Aifantis Jon C Aster Fotini Gounari

Proc Natl Acad Sci U S A 2011 Dec 22;108(50):20060-5. Epub 2011 Nov 22.

Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.1110230108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250146PMC
December 2011

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.

Authors:
Nicholas J Wang Zachary Sanborn Kelly L Arnett Laura J Bayston Wilson Liao Charlotte M Proby Irene M Leigh Eric A Collisson Patricia B Gordon Lakshmi Jakkula Sally Pennypacker Yong Zou Mimansa Sharma Jeffrey P North Swapna S Vemula Theodora M Mauro Isaac M Neuhaus Philip E Leboit Joe S Hur Kyunghee Park Nam Huh Pui-Yan Kwok Sarah T Arron Pierre P Massion Allen E Bale David Haussler James E Cleaver Joe W Gray Paul T Spellman Andrew P South Jon C Aster Stephen C Blacklow Raymond J Cho

Proc Natl Acad Sci U S A 2011 Oct 17;108(43):17761-6. Epub 2011 Oct 17.

Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1073/pnas.1114669108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203814PMC
October 2011

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.

Authors:
Hongfang Wang James Zou Bo Zhao Eric Johannsen Todd Ashworth Hoifung Wong Warren S Pear Jonathan Schug Stephen C Blacklow Kelly L Arnett Bradley E Bernstein Elliott Kieff Jon C Aster

Proc Natl Acad Sci U S A 2011 Sep 7;108(36):14908-13. Epub 2011 Jul 7.

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1109023108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169118PMC
September 2011

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth.

Authors:
Bo Zhao James Zou Hongfang Wang Eric Johannsen Chih-wen Peng John Quackenbush Jessica C Mar Cynthia Casson Morton Matthew L Freedman Stephen C Blacklow Jon C Aster Bradley E Bernstein Elliott Kieff

Proc Natl Acad Sci U S A 2011 Sep 11;108(36):14902-7. Epub 2011 Jul 11.

Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1108892108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169132PMC
September 2011

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.

Authors:
Melanie G Cornejo Vinciane Mabialah Stephen M Sykes Tulasi Khandan Cristina Lo Celso Cécile K Lopez Paola Rivera-Muñoz Philippe Rameau Zuzana Tothova Jon C Aster Ronald A DePinho David T Scadden D Gary Gilliland Thomas Mercher

Blood 2011 Aug 7;118(5):1264-73. Epub 2011 Jun 7.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1182/blood-2011-01-328567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152494PMC
August 2011

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.

Authors:
Jessica Tatarek Kathleen Cullion Todd Ashworth Rachel Gerstein Jon C Aster Michelle A Kelliher

Blood 2011 Aug 13;118(6):1579-90. Epub 2011 Jun 13.

Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.1182/blood-2010-08-300343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156046PMC
August 2011

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.

Authors:
Hind Medyouf Samuel Gusscott Hongfang Wang Jen-Chieh Tseng Carol Wai Oksana Nemirovsky Andreas Trumpp Francoise Pflumio Joan Carboni Marco Gottardis Michael Pollak Andrew L Kung Jon C Aster Martin Holzenberger Andrew P Weng

J Exp Med 2011 Aug 1;208(9):1809-22. Epub 2011 Aug 1.

Terry Fox Laboratory/Department of Pathology, BC Cancer Agency, Vancouver, BC, V52 1L3 Canada.

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http://dx.doi.org/10.1084/jem.20110121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171095PMC
August 2011

Temporal dissection of tumorigenesis in primary cancers.

Authors:
Steffen Durinck Christine Ho Nicholas J Wang Wilson Liao Lakshmi R Jakkula Eric A Collisson Jennifer Pons Sai-Wing Chan Ernest T Lam Catherine Chu Kyunghee Park Sung-woo Hong Joe S Hur Nam Huh Isaac M Neuhaus Siegrid S Yu Roy C Grekin Theodora M Mauro James E Cleaver Pui-Yan Kwok Philip E LeBoit Gad Getz Kristian Cibulskis Jon C Aster Haiyan Huang Elizabeth Purdom Jian Li Lars Bolund Sarah T Arron Joe W Gray Paul T Spellman Raymond J Cho

Cancer Discov 2011 Jul 29;1(2):137-43. Epub 2011 Jun 29.

Life Sciences Division, Lawrence Berkeley National Laboratories, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187561PMC
July 2011

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.

Authors:
Inge Van de Walle Greet De Smet Martina Gärtner Magda De Smedt Els Waegemans Bart Vandekerckhove Georges Leclercq Jean Plum Jon C Aster Irwin D Bernstein Cynthia J Guidos Bruno Kyewski Tom Taghon

Blood 2011 Apr 3;117(17):4449-59. Epub 2011 Mar 3.

Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent University Hospital, Ghent, Belgium.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-06-29
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http://dx.doi.org/10.1182/blood-2010-06-290049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673751PMC
April 2011

Differentiation of NUT midline carcinoma by epigenomic reprogramming.

Authors:
Brian E Schwartz Matthias D Hofer Madeleine E Lemieux Daniel E Bauer Michael J Cameron Nathan H West Elin S Agoston Nicolas Reynoird Saadi Khochbin Tan A Ince Amanda Christie Katherine A Janeway Sara O Vargas Antonio R Perez-Atayde Jon C Aster Stephen E Sallan Andrew L Kung James E Bradner Christopher A French

Cancer Res 2011 Apr 29;71(7):2686-96. Epub 2011 Mar 29.

Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070805PMC
April 2011

Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation.

Authors:
Kittichoat Tiyanont Thomas E Wales Miguel Aste-Amezaga Jon C Aster John R Engen Stephen C Blacklow

Structure 2011 Apr;19(4):546-54

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.str.2011.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075624PMC
April 2011

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.

Authors:
Jon C Aster Stephen C Blacklow Warren S Pear

J Pathol 2011 Jan 21;223(2):262-73. Epub 2010 Oct 21.

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://doi.wiley.com/10.1002/path.2789
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http://dx.doi.org/10.1002/path.2789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996483PMC
January 2011

An asymptomatic 61-year-old man with BCR-ABL-positive bone marrow following autologous transplantation for multiple myeloma.

Authors:
Nitin Roper Daniel J DeAngelo Frank Kuo Paola Dal Cin Irene Ghobrial Jon C Aster

Am J Hematol 2010 Dec;85(12):944-6

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/ajh.21809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992107PMC
December 2010

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.

Authors:
Robin Jeannet Jérôme Mastio Alejandra Macias-Garcia Attila Oravecz Todd Ashworth Anne-Solen Geimer Le Lay Bernard Jost Stéphanie Le Gras Jacques Ghysdael Thomas Gridley Tasuku Honjo Freddy Radtke Jon C Aster Susan Chan Philippe Kastner

Blood 2010 Dec 9;116(25):5443-54. Epub 2010 Sep 9.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.

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http://dx.doi.org/10.1182/blood-2010-05-286658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100247PMC
December 2010

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.

Authors:
Todd D Ashworth Warren S Pear Mark Y Chiang Stephen C Blacklow Jérôme Mastio Lanwei Xu Michelle Kelliher Philippe Kastner Susan Chan Jon C Aster

Blood 2010 Dec 17;116(25):5455-64. Epub 2010 Sep 17.

Department of Pathology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1182/blood-2010-05-286328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031398PMC
December 2010

Notch dimerization is required for leukemogenesis and T-cell development.

Authors:
Hudan Liu Anthony W S Chi Kelly L Arnett Mark Y Chiang Lanwei Xu Olga Shestova Hongfang Wang Yue-Ming Li Avinash Bhandoola Jon C Aster Stephen C Blacklow Warren S Pear

Genes Dev 2010 Nov 8;24(21):2395-407. Epub 2010 Oct 8.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.1975210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964750PMC
November 2010

Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.

Authors:
Kelly L Arnett Matthew Hass Debbie G McArthur Ma Xenia G Ilagan Jon C Aster Raphael Kopan Stephen C Blacklow

Nat Struct Mol Biol 2010 Nov 24;17(11):1312-7. Epub 2010 Oct 24.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.1938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024583PMC
November 2010