Jon C Aster

Jon C Aster

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Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.

Sci Signal 2019 Nov 5;12(606). Epub 2019 Nov 5.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.aay2369DOI Listing
November 2019

Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging.

Nat Protoc 2019 10 18;14(10):2900-2930. Epub 2019 Sep 18.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41596-019-0206-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959005PMC
October 2019

Concomitant classic Hodgkin lymphoma and schistosomiasis.

Am J Hematol 2019 Jul 25;94(7):840-841. Epub 2018 Nov 25.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://doi.wiley.com/10.1002/ajh.25316
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http://dx.doi.org/10.1002/ajh.25316DOI Listing
July 2019

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies.

PLoS Genet 2019 04 10;15(4):e1008039. Epub 2019 Apr 10.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476535PMC
April 2019

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.

Mol Cell 2019 03 7;73(6):1174-1190.e12. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765193000
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http://dx.doi.org/10.1016/j.molcel.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485942PMC
March 2019

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.

Cell 2019 03 28;176(6):1265-1281.e24. Epub 2019 Feb 28.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Ludwig Center at Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193009
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http://dx.doi.org/10.1016/j.cell.2019.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515904PMC
March 2019

Pre-diagnosis plasma immune markers and risk of non-Hodgkin lymphoma in two prospective cohort studies.

Haematologica 2018 10 21;103(10):1679-1687. Epub 2018 Jun 21.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.3324/haematol.2017.183236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165815PMC
October 2018

Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma.

Am J Surg Pathol 2017 Nov;41(11):1473-1482

*Department of Pathology, Massachusetts General Hospital ¶Department of Surgery, Massachusetts General Hospital ‡Department of Pathology, Brigham and Women's Hospital §Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School ∥Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA #Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN †Northern Institute for Cancer Research, University of Newcastle, Newcastle on Tyne, UK.

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http://Insights.ovid.com/crossref?an=00000478-201711000-0000
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http://dx.doi.org/10.1097/PAS.0000000000000945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657508PMC
November 2017

Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia.

Cell Stem Cell 2017 10;21(4):547-555.e8

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA; Division of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679060PMC
October 2017

The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.

PLoS One 2017 12;12(10):e0185762. Epub 2017 Oct 12.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185762PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638296PMC
October 2017

Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.

Cell Stem Cell 2017 02 15;20(2):233-246.e7. Epub 2016 Dec 15.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291795PMC
February 2017

The Varied Roles of Notch in Cancer.

Annu Rev Pathol 2017 Jan 5;12:245-275. Epub 2016 Dec 5.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1146/annurev-pathol-052016-100127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933931PMC
January 2017

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia.

Blood 2016 11 26;128(18):2229-2240. Epub 2016 Sep 26.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute of Medicine and Engineering, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; and.

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http://dx.doi.org/10.1182/blood-2016-01-692855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095757PMC
November 2016

Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia.

Cancer Cell 2016 Nov 3;30(5):750-763. Epub 2016 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Dana 540, 44 Binney Street, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127278PMC
November 2016

Comprehensive analyses of tumor immunity: implications for cancer immunotherapy.

Genome Biol 2016 08 22;17(1):174. Epub 2016 Aug 22.

Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, 450 Brookline Ave., Boston, MA, 02215, USA.

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http://dx.doi.org/10.1186/s13059-016-1028-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993001PMC
August 2016

Validation and Implementation of a Custom Next-Generation Sequencing Clinical Assay for Hematologic Malignancies.

J Mol Diagn 2016 07;18(4):507-15

Center for Advanced Molecular Diagnostics, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707186PMC
July 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

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http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

Metabolic Mechanisms of Drug Resistance in Leukemia.

Cell Metab 2015 Nov;22(5):759-60

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131150052
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http://dx.doi.org/10.1016/j.cmet.2015.10.005DOI Listing
November 2015

Network analysis of gene essentiality in functional genomics experiments.

Genome Biol 2015 Oct 30;16:239. Epub 2015 Oct 30.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1186/s13059-015-0808-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627418PMC
October 2015

Dicing up T-ALL.

Authors:
Jon C Aster

Blood 2015 Aug;126(8):929-30

BRIGHAM AND WOMEN'S HOSPITAL.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-06-64
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http://dx.doi.org/10.1182/blood-2015-06-646653DOI Listing
August 2015

Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region.

Structure 2015 Jul 4;23(7):1227-35. Epub 2015 Jun 4.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497832PMC
July 2015

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.

Dev Cell 2015 Jun 4;33(6):729-36. Epub 2015 Jun 4.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Dana Farber Cancer Institute, Boston, MA 02215, USA; Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481192PMC
June 2015

The role of Notch receptors in transcriptional regulation.

J Cell Physiol 2015 May;230(5):982-8

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jcp.24872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442318PMC
May 2015

Ibrutinib in previously treated Waldenström's macroglobulinemia.

N Engl J Med 2015 Apr;372(15):1430-40

From the Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute (S.P.T., C.K.T., K.M., D.W., G.Y., Y.C., L.X., C.J.P., S.K., I.G., J.J.C., J.P.L., Z.R.H.), Harvard Medical School (S.P.T., G.Y., Y.C., S.R., J.C.A., N.L.H., I.G., J.J.C., J.P.L.), Department of Pathology, Brigham and Women's Hospital (S.R., J.C.A.), Department of Pathology, Massachusetts General Hospital (N.L.H.), and Department of Pathology, Boston University Medical Center (Z.R.H.) - all in Boston; Memorial Sloan Kettering Cancer Center, New York (R.G., K.V.A., M.L.P.); and Stanford University Medical Center, Stanford (G.V., J.L.Z., R.H.A.), and Pharmacyclics, Sunnyvale (Z.S., J.L., M.C., F.C., T.G.) - both in California.

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http://dx.doi.org/10.1056/NEJMoa1501548DOI Listing
April 2015

Application and evaluation of anti-Notch antibodies to modulate Notch signaling.

Methods Mol Biol 2014 ;1187:323-33

Department of Biochemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/978-1-4939-1139-4_24DOI Listing
March 2015

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.

Nat Biotechnol 2014 Sep 22;32(9):941-6. Epub 2014 Jun 22.

1] Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160386PMC
September 2014

Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.

Nature 2014 Sep 20;513(7519):512-6. Epub 2014 Jul 20.

Department of Pediatrics and Benniof Children's Hospital, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nature13495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213126PMC
September 2014

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

Nat Genet 2014 Apr 2;46(4):364-70. Epub 2014 Mar 2.

1] Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [3] Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [4] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.

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http://www.nature.com/articles/ng.2913
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http://dx.doi.org/10.1038/ng.2913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086945PMC
April 2014

Targeted imaging of Ewing sarcoma in preclinical models using a 64Cu-labeled anti-CD99 antibody.

Clin Cancer Res 2014 Feb 11;20(3):678-87. Epub 2013 Nov 11.

Authors' Affiliations: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital, and Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children's Hospital, and Harvard Medical School; Lurie Family Imaging Center, Dana-Farber Cancer Institute; Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School; Department of Pathology, Boston Children's Hospital, and Harvard Medical School, Boston, Massachusetts; and Department of Pediatrics, Columbia University Medical Center, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946397PMC
February 2014

SYK is a critical regulator of FLT3 in acute myeloid leukemia.

Cancer Cell 2014 Feb;25(2):226-42

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA; The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106711PMC
February 2014

In brief: Notch signalling in health and disease.

Authors:
Jon C Aster

J Pathol 2014 Jan;232(1):1-3

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1002/path.4291DOI Listing
January 2014

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.

Proc Natl Acad Sci U S A 2014 Jan 27;111(2):705-10. Epub 2013 Dec 27.

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1315023111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896193PMC
January 2014

Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.

J Biol Chem 2013 Aug 9;288(35):25477-89. Epub 2013 Jul 9.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M113.454850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757209PMC
August 2013

Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11.

Nucleic Acids Res 2013 Apr 13;41(7):4000-14. Epub 2013 Feb 13.

Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 15 rue René Descartes, 67084 Strasbourg, France.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkt088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627581PMC
April 2013

Resistance revealed in acute lymphoblastic leukemia.

Nat Med 2013 Mar;19(3):264-5

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http://www.nature.com/articles/nm.3119
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http://dx.doi.org/10.1038/nm.3119DOI Listing
March 2013

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells.

Blood 2013 Feb 31;121(6):905-17. Epub 2012 Oct 31.

Division of Hematology-Oncology and the University of Michigan Cancer Center, University of Michigan, Ann Arbor, MI, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-03-41
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http://dx.doi.org/10.1182/blood-2012-03-416503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567338PMC
February 2013

Targeting the Notch pathway: twists and turns on the road to rational therapeutics.

J Clin Oncol 2012 Jul 14;30(19):2418-20. Epub 2012 May 14.

Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1200/JCO.2012.42.0992DOI Listing
July 2012

The double-edged sword of Notch signaling in cancer.

Semin Cell Dev Biol 2012 Jun 30;23(4):458-64. Epub 2012 Jan 30.

Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1016/j.semcdb.2012.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360804PMC
June 2012

Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling.

Proc Natl Acad Sci U S A 2012 Jun 30;109(23):E1473-80. Epub 2012 Apr 30.

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1205991109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384212PMC
June 2012

T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.

Proc Natl Acad Sci U S A 2011 Dec 22;108(50):20060-5. Epub 2011 Nov 22.

Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.1110230108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250146PMC
December 2011

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.

Blood 2011 Aug 13;118(6):1579-90. Epub 2011 Jun 13.

Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.1182/blood-2010-08-300343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156046PMC
August 2011

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.

Blood 2011 Apr 3;117(17):4449-59. Epub 2011 Mar 3.

Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent University Hospital, Ghent, Belgium.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-06-29
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http://dx.doi.org/10.1182/blood-2010-06-290049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673751PMC
April 2011

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.

J Pathol 2011 Jan 21;223(2):262-73. Epub 2010 Oct 21.

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://doi.wiley.com/10.1002/path.2789
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http://dx.doi.org/10.1002/path.2789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996483PMC
January 2011

An asymptomatic 61-year-old man with BCR-ABL-positive bone marrow following autologous transplantation for multiple myeloma.

Am J Hematol 2010 Dec;85(12):944-6

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/ajh.21809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992107PMC
December 2010

Notch dimerization is required for leukemogenesis and T-cell development.

Genes Dev 2010 Nov 8;24(21):2395-407. Epub 2010 Oct 8.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.1975210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964750PMC
November 2010

Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.

Nat Struct Mol Biol 2010 Nov 24;17(11):1312-7. Epub 2010 Oct 24.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.1938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024583PMC
November 2010