Publications by authors named "Jon C Aster"

194 Publications

Shortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content.

Nat Commun 2020 10 23;11(1):5355. Epub 2020 Oct 23.

Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA, 02215, USA.

View Article and Find Full Text PDF
October 2020

NOTCH SIGNALING IN CONTEXT: BASIC AND TRANSLATIONAL IMPLICATIONS.

Authors:
Jon C Aster

Trans Am Clin Climatol Assoc 2020 ;131:147-156

BOSTON, MASSACHUSETTS.

View Article and Find Full Text PDF
January 2020

inactivation in - and -deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types.

Dis Model Mech 2020 08 27;13(8). Epub 2020 Aug 27.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA

View Article and Find Full Text PDF
August 2020

MAML1-Dependent Notch-Responsive Genes Exhibit Differing Cofactor Requirements for Transcriptional Activation.

Mol Cell Biol 2020 05 14;40(11). Epub 2020 May 14.

Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA

View Article and Find Full Text PDF
May 2020

rearrangement in myeloid neoplasms.

Haematologica 2020 Jun 12;105(6):e315-e317. Epub 2020 Mar 12.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

View Article and Find Full Text PDF
June 2020

Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.

Sci Signal 2019 11 5;12(606). Epub 2019 Nov 5.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

View Article and Find Full Text PDF
November 2019

Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging.

Nat Protoc 2019 10 18;14(10):2900-2930. Epub 2019 Sep 18.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
October 2019

Gene expression profiling distinguishes prefibrotic from overtly fibrotic myeloproliferative neoplasms and identifies disease subsets with distinct inflammatory signatures.

PLoS One 2019 9;14(5):e0216810. Epub 2019 May 9.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

View Article and Find Full Text PDF
January 2020

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies.

PLoS Genet 2019 04 10;15(4):e1008039. Epub 2019 Apr 10.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America.

View Article and Find Full Text PDF
April 2019

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.

Cell 2019 03 28;176(6):1265-1281.e24. Epub 2019 Feb 28.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Ludwig Center at Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

View Article and Find Full Text PDF
March 2019

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.

Mol Cell 2019 03 7;73(6):1174-1190.e12. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article and Find Full Text PDF
March 2019

Concomitant classic Hodgkin lymphoma and schistosomiasis.

Am J Hematol 2019 07 25;94(7):840-841. Epub 2018 Nov 25.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

View Article and Find Full Text PDF
July 2019

Pre-diagnosis plasma immune markers and risk of non-Hodgkin lymphoma in two prospective cohort studies.

Haematologica 2018 10 21;103(10):1679-1687. Epub 2018 Jun 21.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

View Article and Find Full Text PDF
October 2018