Jon Beck

Jon Beck

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Jon Beck

Jon Beck

Publications by authors named "Jon Beck"

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Design and synthesis of fluorescent activity probes for protein phosphatases.

Methods Enzymol 2019 8;622:29-53. Epub 2019 Mar 8.

Department of Chemistry and Nebraska Center for Integrated Biomolecular Communication, University of Nebraska-Lincoln, Lincoln, NE, United States; Cancer Genes and Molecular Recognition Program, Fred & Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567983PMC
March 2019

Quantification of Cell Signaling Networks Using Kinase Activity Chemosensors.

Methods Mol Biol 2017 ;1636:61-70

Department of Chemistry, University of Nebraska - Lincoln, 409D Hamilton Hall, 639 N. 12th Street, Lincoln, NE, 68588, USA.

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http://dx.doi.org/10.1007/978-1-4939-7154-1_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6623968PMC
April 2018

Chemoselective Alteration of Fluorophore Scaffolds as a Strategy for the Development of Ratiometric Chemodosimeters.

Angew Chem Int Ed Engl 2017 04 20;56(15):4197-4200. Epub 2017 Mar 20.

Department of Chemistry, University of Nebraska - Lincoln, Lincoln, NE, 68588, USA.

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http://dx.doi.org/10.1002/anie.201612628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453638PMC
April 2017

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.

Lancet Neurol 2016 Dec 21;15(13):1326-1335. Epub 2016 Oct 21.

Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(16)30193-4DOI Listing
December 2016

Temporal Analysis of PP2A Phosphatase Activity During Insulin Stimulation Using a Direct Activity Probe.

ACS Chem Biol 2016 12 7;11(12):3284-3288. Epub 2016 Nov 7.

Department of Chemistry, University of Nebraska-Lincoln , Lincoln, Nebraska 68588, United States.

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http://dx.doi.org/10.1021/acschembio.6b00697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161680PMC
December 2016

Nebraska Red: a phosphinate-based near-infrared fluorophore scaffold for chemical biology applications.

Chem Commun (Camb) 2016 Oct;52(83):12290-12293

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.

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http://dx.doi.org/10.1039/c6cc05717aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108567PMC
October 2016

Interrogating Endogenous Protein Phosphatase Activity with Rationally Designed Chemosensors.

ACS Chem Biol 2016 Jan 3;11(1):284-90. Epub 2015 Dec 3.

Department of Chemistry, University of Nebraska-Lincoln , Lincoln, Nebraska 68588, United States.

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http://dx.doi.org/10.1021/acschembio.5b00506DOI Listing
January 2016

Design and evaluation of a real-time activity probe for focal adhesion kinase.

Anal Chim Acta 2015 Oct 29;897:62-8. Epub 2015 Sep 29.

Department of Chemistry, University of Nebraska - Lincoln, Lincoln, NE 68588, United States. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2015.09.025DOI Listing
October 2015

A real-time, fluorescence-based assay for Rho-associated protein kinase activity.

Anal Chim Acta 2015 Sep 12;891:284-90. Epub 2015 Aug 12.

Department of Chemistry, University of Nebraska - Lincoln, Lincoln, NE 68588, United States. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2015.07.058DOI Listing
September 2015

Predictive testing for inherited prion disease: report of 22 years experience.

Eur J Hum Genet 2014 Dec 9;22(12):1351-6. Epub 2014 Apr 9.

1] NHS National Prion Clinic, National Hospital for Neurology and Neurosurgery, University College Hospitals NHS Trust, London, UK [2] MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.

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http://dx.doi.org/10.1038/ejhg.2014.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091984PMC
December 2014

Design, synthesis, and evaluation of a selective chemosensor for leucine-rich repeat kinase 2.

Bioorg Med Chem Lett 2014 Dec 30;24(24):5648-5651. Epub 2014 Oct 30.

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.10.079DOI Listing
December 2014

Quantification of protein kinase enzymatic activity in unfractionated cell lysates using CSox-based sensors.

Curr Protoc Chem Biol 2014 Sep 9;6(3):135-56. Epub 2014 Sep 9.

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska.

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http://doi.wiley.com/10.1002/9780470559277.ch140106
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http://dx.doi.org/10.1002/9780470559277.ch140106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174361PMC
September 2014

A pathogenic progranulin mutation and C9orf72 repeat expansion in a family with frontotemporal dementia.

Neuropathol Appl Neurobiol 2014 Jun;40(4):502-13

Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.

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http://dx.doi.org/10.1111/nan.12100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260146PMC
June 2014

C9orf72 expansions are the most common genetic cause of Huntington disease phenocopies.

Neurology 2014 Jan 20;82(4):292-9. Epub 2013 Dec 20.

From the Departments of Neurodegenerative Disease (D.J.H.M., P.M., E.J.W., S.M., S.J.T.) and Molecular Neuroscience (H.H.), UCL Institute of Neurology, London; MRC Prion Unit (M.P., J.B., T.C., G.A.), London; and Neurogenetics Unit (J.H., J.M.P., E.M., A.H., M.G.S., H.H.), National Hospital for Neurology and Neurosurgery, University College London Hospitals, UK.

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http://www.neurology.org/content/82/4/292.full.pdf
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000006
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000000061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929197PMC
January 2014

A novel prion disease associated with diarrhea and autonomic neuropathy.

N Engl J Med 2013 Nov;369(20):1904-14

Medical Research Council (MRC) Prion Unit (S.M., J.B., C.C., S.J., J.M.L., H.A.-D., B.S., M.K.S., S.B., J.D.F.W., J.C.), Department of Molecular Neuroscience (S.G., N.W.W.), and Dementia Research Centre, Department of Neurodegenerative Disease (J.D.W.), and MRC Centre for Neuromuscular Diseases (M.M.R.), University College London (UCL) Institute of Neurology; the National Prion Clinic (S.M., D.C., D.G., H.H., P.R., J.C.), National Hospital for Neurology and Neurosurgery (M.K.), UCL Hospitals National Health Service Trust (A.F.); and the Queen Square Brain Bank (H.A., T.L., T.R., J.L.H.) - all in London.

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http://dx.doi.org/10.1056/NEJMoa1214747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863770PMC
November 2013

PRNP allelic series from 19 years of prion protein gene sequencing at the MRC Prion Unit.

Hum Mutat 2010 Jul;31(7):E1551-63

MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1002/humu.21281DOI Listing
July 2010

A novel protective prion protein variant that colocalizes with kuru exposure.

N Engl J Med 2009 Nov;361(21):2056-65

Medical Research Council Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, United Kingdom.

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http://www.nejm.org/doi/abs/10.1056/NEJMoa0809716
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http://dx.doi.org/10.1056/NEJMoa0809716DOI Listing
November 2009

First report of Creutzfeldt-Jakob disease occurring in 2 siblings unexplained by PRNP mutation.

J Neuropathol Exp Neurol 2008 Sep;67(9):838-41

National Prion Clinic, National Hospital for Neurology and Neurosurgery, UCLH Hospitals Trust, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1097/NEN.0b013e318182f36eDOI Listing
September 2008

Huntington's disease phenocopies are clinically and genetically heterogeneous.

Mov Disord 2008 Apr;23(5):716-20

Department of Neurodegenerative Disease, UCL Institute of Neurology/National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1002/mds.21915DOI Listing
April 2008

Inherited prion disease with six octapeptide repeat insertional mutation--molecular analysis of phenotypic heterogeneity.

Brain 2006 Sep;129(Pt 9):2297-317

MRC Prion Unit, Department of Neurodegenerative Diseases, Institute of Neurology, King's College Hospital, London, UK.

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http://dx.doi.org/10.1093/brain/awl226DOI Listing
September 2006