Jon B Toledo

Jon B Toledo

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Jon B Toledo

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Inflammatory markers and imaging patterns of advanced brain aging in the general population.

Brain Imaging Behav 2019 Mar 1. Epub 2019 Mar 1.

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany.

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http://dx.doi.org/10.1007/s11682-019-00058-yDOI Listing
March 2019

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.

Alzheimers Dement 2019 01 12;15(1):55-64. Epub 2018 Oct 12.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333489PMC
January 2019

APOE Effect on Amyloid-β PET Spatial Distribution, Deposition Rate, and Cut-Points.

J Alzheimers Dis 2019 ;69(3):783-793

Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.3233/JAD-181282DOI Listing
January 2019

White matter lesions: Spatial heterogeneity, links to risk factors, cognition, genetics, and atrophy.

Neurology 2018 09 3;91(10):e964-e975. Epub 2018 Aug 3.

From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.

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http://dx.doi.org/10.1212/WNL.0000000000006116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139818PMC
September 2018

Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease.

Alzheimers Dement 2018 08 28;14(8):1052-1062. Epub 2018 Mar 28.

Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA; Department of Pathology, Peking University Health Science Centre and Third Hospital, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097943PMC
August 2018

Publisher Correction: Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease.

Nat Neurosci 2018 Jul;21(7):1018

Epigenetics Program, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41593-018-0124-2DOI Listing
July 2018

Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease.

Nat Neurosci 2018 04 5;21(4):497-505. Epub 2018 Mar 5.

Epigenetics Program, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41593-018-0101-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124498PMC
April 2018

Milder Alzheimer's disease pathology in heart failure and atrial fibrillation.

Alzheimers Dement 2017 Jul 5;13(7):770-777. Epub 2017 Feb 5.

Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jalz.2016.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592781PMC
July 2017

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

J Neuropathol Exp Neurol 2017 Jul;76(7):605-619

Institute of Neurology, Medical University of Vienna, Vienna, Austria; Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania; and Department of Biostatistics and Epidemiology; and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK; Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida; Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois; Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland; University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California; Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France; Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain; Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia; Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain; Department of Medicine, Imperial College London, London, UK; IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California; Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil; Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuropathology, John Radcliffe Hospital, Oxford, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland; Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic; Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic; Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia; Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky; Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil; Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil; Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan; Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan; Department of Neuroscience, Katholieke Universiteit-Leuven; and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium; Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK; and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1093/jnen/nlx041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251511PMC
July 2017

Patterns of coordinated cortical remodeling during adolescence and their associations with functional specialization and evolutionary expansion.

Proc Natl Acad Sci U S A 2017 03 13;114(13):3527-3532. Epub 2017 Mar 13.

Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

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http://dx.doi.org/10.1073/pnas.1620928114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380071PMC
March 2017

Poly(GP) proteins are a useful pharmacodynamic marker for -associated amyotrophic lateral sclerosis.

Sci Transl Med 2017 03;9(383)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1126/scitranslmed.aai7866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576451PMC
March 2017

Stimulation sites in the subthalamic nucleus and clinical improvement in Parkinson's disease: a new approach for active contact localization.

J Neurosurg 2016 11 5;125(5):1068-1079. Epub 2016 Feb 5.

Neurosciences Area, CIMA, Department of Neurology and Neurosurgery, Clínica Universidad de Navarra Medical School, Pamplona.

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http://dx.doi.org/10.3171/2015.9.JNS15868DOI Listing
November 2016

Impaired functional default mode network in patients with mild neurological Wilson's disease.

Parkinsonism Relat Disord 2016 09 23;30:46-51. Epub 2016 Jun 23.

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2016.06.018DOI Listing
September 2016

Multimodal imaging evidence of pathology-mediated disease distribution in corticobasal syndrome.

Neurology 2016 Sep 19;87(12):1227-34. Epub 2016 Aug 19.

From the Department of Neurology (C.T.M., C.B., R.G.G., J.W., K.F., K.R., D.A.W., D.J.I., M.G.) and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine (J.B.T., L.S., D.J.I., E.B.L., J.Q.T.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035978PMC
http://dx.doi.org/10.1212/WNL.0000000000003119DOI Listing
September 2016

Olfactory impairment predicts cognitive decline in early Parkinson's disease.

Parkinsonism Relat Disord 2016 Apr 19;25:45-51. Epub 2016 Feb 19.

Parkinson's Disease Research, Education, and Clinical Center (PADRECC), Philadelphia VA Medical Center, 3900 Woodland Ave, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.parkreldis.2016.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825674PMC
April 2016

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.

Acta Neuropathol 2016 Jan 10;131(1):87-102. Epub 2015 Dec 10.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-015-1509-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879001PMC
January 2016

Semi-automated quantification of C9orf72 expansion size reveals inverse correlation between hexanucleotide repeat number and disease duration in frontotemporal degeneration.

Acta Neuropathol 2015 Sep 29;130(3):363-72. Epub 2015 May 29.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA, 19104-4283, USA,

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http://dx.doi.org/10.1007/s00401-015-1445-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545720PMC
September 2015

Memory, executive, and multidomain subtle cognitive impairment: clinical and biomarker findings.

Neurology 2015 Jul 17;85(2):144-53. Epub 2015 Jun 17.

From the Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research (J.B.T., M.B., L.M.S., J.Q.T.), and Department of Psychiatry (S.E.A.), University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Banner Alzheimer's Institute (K.C., E.M.R.), Phoenix, AZ; Center for Biomedical Image Computing and Analytics (M.R., C.D.), Philadelphia, PA; Mayo Clinic College of Medicine (C.R.J.), Rochester, MN; and Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Radiology, San Francisco VA Medical Center/University of California San Francisco.

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http://www.neurology.org/content/85/2/144.full.pdf
Web Search
http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000173
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000001738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515043PMC
July 2015

The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans.

Alzheimers Dement 2015 Jul;11(7):772-91

Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Neurodegenerative Disease Research, Institute on Aging, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127404PMC
July 2015

Erratum to: Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD).

Acta Neuropathol 2015 Jun;129(6):929

Center for Neurodegenerative Disease Research (CNDR), Perelman School of Medicine at the University of Pennsylvania, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA, 19104, USA,

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http://dx.doi.org/10.1007/s00401-015-1428-xDOI Listing
June 2015

Qualification of a surrogate matrix-based absolute quantification method for amyloid-β₄₂ in human cerebrospinal fluid using 2D UPLC-tandem mass spectrometry.

J Alzheimers Dis 2014 ;41(2):441-51

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.3233/JAD-132489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159707PMC
February 2015

Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment.

Alzheimers Res Ther 2014 23;6(3):36. Epub 2014 Jun 23.

Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA 98104, USA.

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http://alzres.biomedcentral.com/articles/10.1186/alzrt266
Publisher Site
http://dx.doi.org/10.1186/alzrt266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255518PMC
December 2014

A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis.

Acta Neuropathol 2014 Oct 12;128(4):543-50. Epub 2014 Jun 12.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00401-014-1308-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399383PMC
October 2014

TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord.

Acta Neuropathol 2014 Sep 12;128(3):423-37. Epub 2014 Jun 12.

Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA, 19104, USA,

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http://link.springer.com/10.1007/s00401-014-1299-6
Publisher Site
http://dx.doi.org/10.1007/s00401-014-1299-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384652PMC
September 2014

Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia.

Neurology 2014 Aug 3;83(6):502-9. Epub 2014 Jul 3.

From the Penn Frontotemporal Degeneration Center, Department of Neurology (D.J.I., C.T.M., J.P., K.R., E.M.W., M.G.); Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging, Alzheimer's Disease Core Center (D.J.I., C.T.M., E.S., E.M.W., J.B.T., S.E.A., V.M.-Y.L., V.M.V.D., J.Q.T., M.G.); Penn Memory Center, Department of Neurology (S.E.A.); and Brain-Behavior Laboratory, Departments of Psychiatry, Perelman School of Medicine (S.E.A.), University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1212/WNL.0000000000000668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141997PMC
August 2014

Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker.

Alzheimers Res Ther 2013 8;5(2). Epub 2013 Mar 8.

Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1186/alzrt162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706955PMC
June 2014

Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration.

Neurobiol Aging 2014 Jun 2;35(6):1473-82. Epub 2013 Dec 2.

Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.11.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961542PMC
June 2014

CSF Apo-E levels associate with cognitive decline and MRI changes.

Acta Neuropathol 2014 May 3;127(5):621-32. Epub 2014 Jan 3.

Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP, Maloney 3rd, 36th and Spruce Streets, Philadelphia, PA, 19104-4283, USA.

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http://dx.doi.org/10.1007/s00401-013-1236-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988233PMC
May 2014

High beta activity in the subthalamic nucleus and freezing of gait in Parkinson's disease.

Neurobiol Dis 2014 Apr 17;64:60-5. Epub 2013 Dec 17.

Neurosciences Area, CIMA, University of Navarra, Av Pio XII 55, 31008 Pamplona, Spain; Neurology and Neurosurgery, Clinica Universidad de Navarra, Av. Pio XII 36, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2013.12.005DOI Listing
April 2014

Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD).

Acta Neuropathol 2014 Mar 10;127(3):423-439. Epub 2014 Jan 10.

Center for Neurodegenerative Disease research (CNDR), Perelman School of Medicine at the University of Pennsylvania, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00401-013-1238-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971993PMC
March 2014

Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition.

Acta Neuropathol Commun 2014 Mar 6;2:26. Epub 2014 Mar 6.

Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1186/2051-5960-2-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008258PMC
March 2014

Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases.

J Comp Neurol 2013 Dec;521(18):4339-55

Penn Memory Center, Departments of Psychiatry and Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, 19104.

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http://dx.doi.org/10.1002/cne.23430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872132PMC
December 2013

CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer's disease.

Acta Neuropathol 2013 Nov 29;126(5):683-97. Epub 2013 Jun 29.

Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00401-013-1148-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812407PMC
November 2013

Longitudinal change in CSF Tau and Aβ biomarkers for up to 48 months in ADNI.

Acta Neuropathol 2013 Nov 29;126(5):659-70. Epub 2013 Jun 29.

Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00401-013-1151-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875373PMC
November 2013

Clinical and multimodal biomarker correlates of ADNI neuropathological findings.

Acta Neuropathol Commun 2013 Oct 9;1:65. Epub 2013 Oct 9.

Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1186/2051-5960-1-65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893373PMC
October 2013

Relationship between plasma analytes and SPARE-AD defined brain atrophy patterns in ADNI.

PLoS One 2013 8;8(2):e55531. Epub 2013 Feb 8.

Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055531PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568142PMC
September 2013

White matter imaging helps dissociate tau from TDP-43 in frontotemporal lobar degeneration.

J Neurol Neurosurg Psychiatry 2013 Sep 9;84(9):949-55. Epub 2013 Mar 9.

Department of Neurology, Perelman School of Medicine, Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://jnnp.bmj.com/cgi/doi/10.1136/jnnp-2012-304418
Publisher Site
http://dx.doi.org/10.1136/jnnp-2012-304418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737288PMC
September 2013

Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre.

Brain 2013 Sep 10;136(Pt 9):2697-706. Epub 2013 Jul 10.

Department of Pathology and Laboratory Medicine, Institute on Ageing, Centre for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1093/brain/awt188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858112PMC
September 2013

Stages of pTDP-43 pathology in amyotrophic lateral sclerosis.

Ann Neurol 2013 Jul 19;74(1):20-38. Epub 2013 Jun 19.

Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://doi.wiley.com/10.1002/ana.23937
Publisher Site
http://dx.doi.org/10.1002/ana.23937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785076PMC
July 2013

Clinical utility and analytical challenges in measurement of cerebrospinal fluid amyloid-β(1-42) and τ proteins as Alzheimer disease biomarkers.

Clin Chem 2013 Jun 21;59(6):903-16. Epub 2013 Mar 21.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1373/clinchem.2013.202937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159709PMC
June 2013

Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis.

PLoS One 2012 14;7(6):e39216. Epub 2012 Jun 14.

Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039216PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375234PMC
December 2012

Cardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement 2012 Nov;8(6):483-9

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2011.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668456PMC
November 2012

Neuropathologic substrates of Parkinson disease dementia.

Ann Neurol 2012 Oct 4;72(4):587-98. Epub 2012 Oct 4.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Morris K. Udall Parkinson's Disease Center of Excellence, Institute on Aging, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/ana.23659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484250PMC
October 2012

CSF biomarkers cutoffs: the importance of coincident neuropathological diseases.

Acta Neuropathol 2012 Jul 22;124(1):23-35. Epub 2012 Apr 22.

Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, CNDR, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00401-012-0983-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551449PMC
July 2012

Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.

Acta Neuropathol 2012 Jun 18;123(6):825-39. Epub 2012 Mar 18.

Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00401-012-0970-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521561PMC
June 2012

Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis.

Acta Neuropathol 2012 Mar 1;123(3):395-407. Epub 2012 Jan 1.

Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00401-011-0932-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595560PMC
March 2012

Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI.

Acta Neuropathol 2011 Oct 30;122(4):401-13. Epub 2011 Jul 30.

Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP, Maloney 3rd (JQT) or 7th (LMS) Floor, 36th and Spruce Streets, Philadelphia, PA, 19104-4283, USA.

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http://dx.doi.org/10.1007/s00401-011-0861-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299300PMC
October 2011