Johnson Agniswamy

Johnson Agniswamy

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Johnson Agniswamy

Publications by authors named "Johnson Agniswamy"

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Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.

FEBS J 2020 Jan 9. Epub 2020 Jan 9.

Department of Biology, Georgia State University, Atlanta, GA, USA.

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http://dx.doi.org/10.1111/febs.15207DOI Listing
January 2020

Potent antiviral HIV-1 protease inhibitor combats highly drug resistant mutant PR20.

Biochem Biophys Res Commun 2019 Oct 29;519(1):61-66. Epub 2019 Aug 29.

Department of Biology, Georgia State University, Atlanta, GA, 30303, USA; Department of Chemistry, Georgia State University, Atlanta, GA, 30303, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.08.126DOI Listing
October 2019

Structural studies of antiviral inhibitor with HIV-1 protease bearing drug resistant substitutions of V32I, I47V and V82I.

Biochem Biophys Res Commun 2019 Jun 12;514(3):974-978. Epub 2019 May 12.

Department of Biology, Georgia State University, Atlanta, GA, 30303, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.05.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601333PMC
June 2019

Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues.

ACS Omega 2019 May 17;4(5):8707-8719. Epub 2019 May 17.

Department of Biology, Georgia State University, P.O. Box 4010, Atlanta, Georgia 30302, United States.

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http://dx.doi.org/10.1021/acsomega.9b00683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545544PMC
May 2019

Steric hindrance controls pyridine nucleotide specificity of a flavin-dependent NADH:quinone oxidoreductase.

Protein Sci 2019 01 31;28(1):167-175. Epub 2018 Oct 31.

Department of Chemistry, Georgia State University, Atlanta, Georgia, 30302-3965.

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http://dx.doi.org/10.1002/pro.3514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295900PMC
January 2019

Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.

Eur J Med Chem 2018 Dec 18;160:171-182. Epub 2018 Sep 18.

Department of Refractory Viral Infections, National Center for Global Health & Medicine Research Institute, Tokyo, 162-8655, Japan; Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Kumamoto, 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183081
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http://dx.doi.org/10.1016/j.ejmech.2018.09.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237192PMC
December 2018

Crystal structure of yeast nitronate monooxygenase from Cyberlindnera saturnus.

Proteins 2018 05 6;86(5):599-605. Epub 2018 Feb 6.

Department of Biology, Georgia State University, Atlanta, Georgia, 30302-3965.

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http://dx.doi.org/10.1002/prot.25470DOI Listing
May 2018

Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2' Ligands of Darunavir.

ChemMedChem 2017 12 24;12(23):1942-1952. Epub 2017 Nov 24.

Departments of Hematology and Infectious Diseases, Kumamoto University School of Medicine, Kumamoto, 860-8556, Japan.

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http://dx.doi.org/10.1002/cmdc.201700614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896574PMC
December 2017

Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands.

Bioorg Med Chem Lett 2017 11 6;27(21):4925-4931. Epub 2017 Sep 6.

Departments of Hematology and Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch National Cancer Institute, Bethesda, MD 20892, USA; Center for Clinical Sciences, National Center for Global Health and Medicine, Shinjuku, Tokyo 162-8655, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647257PMC
November 2017

Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

Bioorg Med Chem 2017 10 9;25(19):5114-5127. Epub 2017 Apr 9.

Department of Hematology, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Department of Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch National Cancer Institute, Bethesda, MD 20892, USA; Department of Refractory Viral Infection, National Center for Global Health and Medicine Research Institute, Shinjuku, Tokyo 162-8655, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896173073
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http://dx.doi.org/10.1016/j.bmc.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617771PMC
October 2017

In vitro heme biotransformation by the HupZ enzyme from Group A streptococcus.

Biometals 2016 08 6;29(4):593-609. Epub 2016 May 6.

Department of Biology, College of Arts and Sciences, Georgia State University, P.O. Box 4010, Atlanta, GA, 30302-4010, USA.

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http://dx.doi.org/10.1007/s10534-016-9937-1DOI Listing
August 2016

Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands.

Bioorg Med Chem Lett 2015 Nov 30;25(21):4903-4909. Epub 2015 May 30.

Departments of Hematology and Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892, USA; Center for Clinical Sciences, National Center for Global Health and Medicine, Shinjuku, Tokyo 162-8655, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2015.05.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607586PMC
November 2015

Conformational variation of an extreme drug resistant mutant of HIV protease.

J Mol Graph Model 2015 Nov 8;62:87-96. Epub 2015 Sep 8.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA; Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2015.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695280PMC
November 2015

Structure-based design of potent HIV-1 protease inhibitors with modified P1-biphenyl ligands: synthesis, biological evaluation, and enzyme-inhibitor X-ray structural studies.

J Med Chem 2015 Jul 24;58(13):5334-43. Epub 2015 Jun 24.

§Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765733PMC
July 2015

Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20.

J Med Chem 2015 Jun 4;58(12):5088-95. Epub 2015 Jun 4.

†Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia 30303, United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.5b00474
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http://dx.doi.org/10.1021/acs.jmedchem.5b00474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522690PMC
June 2015

The combined structural and kinetic characterization of a bacterial nitronate monooxygenase from Pseudomonas aeruginosa PAO1 establishes NMO class I and II.

J Biol Chem 2014 Aug 7;289(34):23764-75. Epub 2014 Jul 7.

From the Departments of Chemistry, Biology, Center for Biotechnology and Drug Design, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30302,

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http://dx.doi.org/10.1074/jbc.M114.577791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156069PMC
August 2014

Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.

J Med Chem 2013 Sep 15;56(17):6792-802. Epub 2013 Aug 15.

Department of Chemistry and Department of Medicinal Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/jm400768fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800042PMC
September 2013

Reaction intermediates discovered in crystal structures of enzymes.

Adv Protein Chem Struct Biol 2012 ;87:57-86

Department of Biology, Georgia State University, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1016/B978-0-12-398312-1.00003-2DOI Listing
November 2012

HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.

Biochemistry 2012 Apr 20;51(13):2819-28. Epub 2012 Mar 20.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia 30303, United States.

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http://pubs.acs.org/doi/10.1021/bi2018317
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http://dx.doi.org/10.1021/bi2018317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328860PMC
April 2012

Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease.

Biochemistry 2012 Feb 24;51(5):1041-50. Epub 2012 Jan 24.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia 30303, United States.

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http://dx.doi.org/10.1021/bi201809sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287067PMC
February 2012

Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: relevance to drug resistance.

Protein Sci 2010 Nov;19(11):2055-72

Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892-0520, USA.

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http://doi.wiley.com/10.1002/pro.486
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http://dx.doi.org/10.1002/pro.486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005778PMC
November 2010

Role of valine 464 in the flavin oxidation reaction catalyzed by choline oxidase.

Biochemistry 2010 Apr;49(13):2952-61

Department of Chemistry, Georgia State University, Atlanta, Georgia 30302-4098, USA.

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http://dx.doi.org/10.1021/bi902048cDOI Listing
April 2010

HIV-1 Protease: Structural Perspectives on Drug Resistance.

Viruses 2009 12 3;1(3):1110-36. Epub 2009 Dec 3.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA 30303, USA; E-Mail:

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http://dx.doi.org/10.3390/v1031110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185505PMC
December 2009

A case of structure determination using pseudosymmetry.

Acta Crystallogr D Biol Crystallogr 2009 Dec 17;65(Pt 12):1334-40. Epub 2009 Nov 17.

Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA.

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http://scripts.iucr.org/cgi-bin/paper?S0907444909039912
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http://dx.doi.org/10.1107/S0907444909039912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789005PMC
December 2009

Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7.

Apoptosis 2009 Oct;14(10):1135-44

Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1007/s10495-009-0388-9DOI Listing
October 2009

Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling.

Apoptosis 2009 May;14(5):741-52

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1007/s10495-009-0333-yDOI Listing
May 2009

Structural basis for executioner caspase recognition of P5 position in substrates.

Apoptosis 2008 Nov;13(11):1291-302

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1007/s10495-008-0259-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782447PMC
November 2008

Caspases: structure-guided design of drugs to control cell death.

Mini Rev Med Chem 2008 Oct;8(11):1154-62

Department of Biology, Georgia State University, P.O. Box 4010, Atlanta, GA 30302, USA.

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http://dx.doi.org/10.2174/138955708785909899DOI Listing
October 2008

Towards a rational approach for heavy-atom derivative screening in protein crystallography.

Acta Crystallogr D Biol Crystallogr 2008 Apr 19;64(Pt 4):354-67. Epub 2008 Mar 19.

Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA.

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http://dx.doi.org/10.1107/S0907444907068849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725783PMC
April 2008

Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis.

FEBS J 2007 Sep 14;274(18):4752-65. Epub 2007 Aug 14.

Department of Biology, Molecular Basis of Disease, Georgia State University, Atlanta, GA 30302, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2007.05994.xDOI Listing
September 2007

Crystal structure of group A streptococcus Mac-1: insight into dimer-mediated specificity for recognition of human IgG.

Structure 2006 Feb;14(2):225-35

Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096921260600048
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http://dx.doi.org/10.1016/j.str.2005.10.012DOI Listing
February 2006

Insight of host immune evasion mediated by two variants of group a Streptococcus Mac protein.

J Biol Chem 2004 Dec 4;279(50):52789-96. Epub 2004 Oct 4.

Structural Immunology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA.

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http://dx.doi.org/10.1074/jbc.M410698200DOI Listing
December 2004