Publications by authors named "John Ziebuhr"

79Publications

The rocaglate CR-31-B (-) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo.

Antiviral Res 2021 Jan 8;186:105012. Epub 2021 Jan 8.

Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany; German Center for Infection Research (DZIF) at the Partner Site Giessen-Marburg-Langen, Germany.

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January 2021

ICTV Virus Taxonomy Profile: .

J Gen Virol 2020 Oct 27. Epub 2020 Oct 27.

Institute of Medical Virology, Justus Liebig University Gießen, Gießen, Hesse 35390, Germany.

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October 2020

Call for Papers: The Pathophysiology of COVID-19 and SARS-CoV-2 Infection.

Am J Physiol Lung Cell Mol Physiol 2020 05 8;318(5):L1016-L1019. Epub 2020 Apr 8.

Institute of Medical Virology, Justus Liebig University Giessen, member of the German Center for Infection Research, Giessen, Germany.

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May 2020

Direct RNA nanopore sequencing of full-length coronavirus genomes provides novel insights into structural variants and enables modification analysis.

Genome Res 2019 09 22;29(9):1545-1554. Epub 2019 Aug 22.

RNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University Jena, 07743 Jena, Germany.

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September 2019

Structural basis for catalysis and substrate specificity of a 3C-like cysteine protease from a mosquito mesonivirus.

Virology 2019 07 2;533:21-33. Epub 2019 May 2.

Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany; Institute of Pharmaceutical Chemistry, Philipps University, Marburg, Germany. Electronic address:

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July 2019

Characterization of a bafinivirus exoribonuclease activity.

J Gen Virol 2018 09 30;99(9):1253-1260. Epub 2018 Jul 30.

2​Institute of Medical Virology, Justus Liebig University, Giessen, Germany.

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September 2018

A Single-Center Study of Viral Respiratory Tract Infections in Hospitalized Children From the Kurdistan Region of Iraq.

Glob Pediatr Health 2018 10;5:2333794X18784996. Epub 2018 Jul 10.

Institute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany.

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July 2018

Antiviral activity of K22 against members of the order Nidovirales.

Virus Res 2018 02 11;246:28-34. Epub 2018 Jan 11.

Institute for Virology and Immunology IVI, Mittelhäusern and Bern, Switzerland; Department of Infectious Diseases and Pathobiology, University of Bern, Switzerland. Electronic address:

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February 2018

Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses.

Antiviral Res 2018 02 16;150:123-129. Epub 2017 Dec 16.

Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35037 Marburg, Germany. Electronic address:

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February 2018

Structural and functional conservation of cis-acting RNA elements in coronavirus 5'-terminal genome regions.

Virology 2018 04 6;517:44-55. Epub 2017 Dec 6.

Institute of Medical Virology, Justus Liebig University, Giessen, Germany; European Virus Bioinformatics Center, Jena, Germany. Electronic address:

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April 2018

Inhibition of Cytosolic Phospholipase Aα Impairs an Early Step of Coronavirus Replication in Cell Culture.

J Virol 2018 02 30;92(4). Epub 2018 Jan 30.

Institute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany

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February 2018

Preface.

Authors:
John Ziebuhr

Adv Virus Res 2016 ;96:xiii-xiv

Giessen, Germany.

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January 2017

Characterization of the 3rd International Standard for hepatitis B virus surface antigen (HBsAg).

J Clin Virol 2016 09 3;82:166-172. Epub 2016 Jun 3.

Institute of Medical Virology, Justus Liebig University Giessen, National Reference Centre for Hepatitis B and D Viruses, German Center for Infection Research, Biomedical Research Center Seltersberg, Schubertstr. 81, 35392 Giessen, Germany. Electronic address:

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September 2016

Proteolytic processing of mesonivirus replicase polyproteins by the viral 3C-like protease.

J Gen Virol 2016 06 15;97(6):1439-1445. Epub 2016 Mar 15.

Institute of Medical Virology, Justus Liebig University, Giessen, Germany.

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June 2016

Characterization of monoclonal antibodies against feline coronavirus accessory protein 7b.

Vet Microbiol 2016 Feb 31;184:11-9. Epub 2015 Dec 31.

Institute of Virology, Justus Liebig University Giessen, Germany. Electronic address:

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February 2016

The PB1 segment of an influenza A virus H1N1 2009pdm isolate enhances the replication efficiency of specific influenza vaccine strains in cell culture and embryonated eggs.

J Gen Virol 2016 Mar 7;97(3):620-631. Epub 2016 Jan 7.

Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392 Giessen, Germany.

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March 2016

Studies of nosocomial outbreaks of hepatitis B in nursing homes in Germany suggest a major role of hepatitis B e antigen expression in disease severity and progression.

Int J Med Microbiol 2015 Oct 21;305(7):663-72. Epub 2015 Aug 21.

Institute of Medical Virology, Justus Liebig University Giessen, National Reference Center for Hepatitis B and D Viruses, German Center for Infection Research, Biomedical Research Center Seltersberg, Schubertstr. 81, 35392 Giessen, Germany.

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October 2015

RNA structure analysis of alphacoronavirus terminal genome regions.

Virus Res 2014 Dec 13;194:76-89. Epub 2014 Oct 13.

Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392 Giessen, Germany. Electronic address:

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December 2014

Characterization of an alphamesonivirus 3C-like protease defines a special group of nidovirus main proteases.

J Virol 2014 Dec 17;88(23):13747-58. Epub 2014 Sep 17.

Institute of Medical Virology, Justus Liebig University, Giessen, Germany

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December 2014

Evidence for substrate binding-induced zwitterion formation in the catalytic Cys-His dyad of the SARS-CoV main protease.

Biochemistry 2014 Sep 7;53(37):5930-46. Epub 2014 Sep 7.

Institut für Physikalische und Theoretische Chemie, Universität Würzburg , Emil-Fischer-Straße 42, 97074 Würzburg, Germany.

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September 2014

Development and evaluation of reverse transcription loop-mediated isothermal amplification assay for the detection of the fathead minnow nidovirus.

J Virol Methods 2014 Jun 1;202:39-45. Epub 2014 Mar 1.

Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA; Department of Fisheries and Wildlife, College of Agriculture and Natural Resources, Michigan State University, East Lansing, MI 48824, USA. Electronic address:

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June 2014

Improved dual promotor-driven reverse genetics system for influenza viruses.

J Virol Methods 2013 Nov 22;193(2):603-10. Epub 2013 Jul 22.

Institute of Medical Virology, Justus Liebig University Giessen, BFS, Schubertstrasse 81, 35392 Giessen, Germany; Virology Laboratory, Environmental Research Division, National Research Center, 12311 Dokki, Giza, Egypt. Electronic address:

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November 2013

Mesoniviridae: a proposed new family in the order Nidovirales formed by a single species of mosquito-borne viruses.

Arch Virol 2012 Aug 24;157(8):1623-8. Epub 2012 Apr 24.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands.

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August 2012

Nidovirus ribonucleases: Structures and functions in viral replication.

RNA Biol 2011 Mar-Apr;8(2):295-304. Epub 2011 Mar 1.

Centre for Infection and Immunity, The Queen's University of Belfast, Belfast, UK.

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November 2011

Characterization of Bafinivirus main protease autoprocessing activities.

J Virol 2011 Feb 10;85(3):1348-59. Epub 2010 Nov 10.

Centre for Infection and Immunity, The Queen's University of Belfast, Belfast, United Kingdom.

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February 2011

Biochemical characterization of arterivirus nonstructural protein 11 reveals the nidovirus-wide conservation of a replicative endoribonuclease.

J Virol 2009 Jun 18;83(11):5671-82. Epub 2009 Mar 18.

Department of Medical Microbiology, Molecular Virology Laboratory, Leiden University Medical Center, RC Leiden, The Netherlands.

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June 2009

Human coronavirus 229E papain-like proteases have overlapping specificities but distinct functions in viral replication.

J Virol 2007 Apr 24;81(8):3922-32. Epub 2007 Jan 24.

Centre for Cancer Research and Cell Biology, School of Biomedical Sciences, The Queen's University of Belfast, UK, and Kantonal Hospital St. Gallen, Research Department, 9007 St. Gallen, Switzerland.

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April 2007

The coronavirus replicase: insights into a sophisticated enzyme machinery.

Authors:
John Ziebuhr

Adv Exp Med Biol 2006 ;581:3-11

University of Würzburg, Germany.

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December 2006

Characterization of White bream virus reveals a novel genetic cluster of nidoviruses.

J Virol 2006 Dec 20;80(23):11598-609. Epub 2006 Sep 20.

The Queen's University of Belfast, School of Biomedical Sciences, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom.

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December 2006

Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains.

J Virol 2006 Sep;80(17):8493-502

Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'Ingénieurs de Luminy-Case 925, France.

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September 2006

Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family.

Proc Natl Acad Sci U S A 2006 Aug 1;103(32):11892-7. Epub 2006 Aug 1.

Case 925, Ecole d'Ingénieurs de Luminy, Architecture et Fonction des Macromolécules Biologiques, Unité Mixte de Recherche 6098, Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, 13288 Marseille Cedex 9, France.

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August 2006

Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis.

Proc Natl Acad Sci U S A 2006 Mar 20;103(13):5108-13. Epub 2006 Mar 20.

Institute of Virology and Immunology, University of Würzburg, 97078 Würzburg, Germany.

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March 2006

Nidovirales: evolving the largest RNA virus genome.

Virus Res 2006 Apr 28;117(1):17-37. Epub 2006 Feb 28.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, LUMC E4-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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April 2006

Identification of protease and ADP-ribose 1''-monophosphatase activities associated with transmissible gastroenteritis virus non-structural protein 3.

J Gen Virol 2006 Mar;87(Pt 3):651-656

Institute of Virology and Immunology, University of Würzburg, Versbacher Straße 7, 97078 Würzburg, Germany.

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March 2006

A complex zinc finger controls the enzymatic activities of nidovirus helicases.

J Virol 2005 Jan;79(2):696-704

Institute of Virology and Immunology, University of Würzburg, Versbacher Str. 7, 97078 Würzburg, Germany.

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January 2005

Molecular biology of severe acute respiratory syndrome coronavirus.

Authors:
John Ziebuhr

Curr Opin Microbiol 2004 Aug;7(4):412-9

Institute of Virology and Immunology, University of Würzburg, Versbacher Str. 7, 97078 Würzburg, Germany.

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August 2004

Major genetic marker of nidoviruses encodes a replicative endoribonuclease.

Proc Natl Acad Sci U S A 2004 Aug 10;101(34):12694-9. Epub 2004 Aug 10.

Institute of Virology and Immunology, University of Würzburg, Versbacher Strasse 7, 97078 Würzburg, Germany.

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August 2004

Rapid identification of coronavirus replicase inhibitors using a selectable replicon RNA.

J Gen Virol 2004 Jun;85(Pt 6):1717-1725

Research Department, Cantonal Hospital St Gallen, CH-9007 St Gallen, Switzerland.

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June 2004

[Basically SARS is not a surprise. Coronaviruses lie in wait almost everywhere].

Authors:
John Ziebuhr

Krankenpfl J 2003 ;41(4-6):114-5

Institut für Virologie und Immunbiologie, Universität Würzburg.

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January 2004

Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage.

J Mol Biol 2003 Aug;331(5):991-1004

Department of Medical Microbiology, Leiden University Medical Center, Room L4-34, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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August 2003

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs.

Science 2003 Jun 13;300(5626):1763-7. Epub 2003 May 13.

Institute of Biochemistry, University of Lübeck, D-23538 Lübeck, Germany.

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June 2003

The 3C-like proteinase of an invertebrate nidovirus links coronavirus and potyvirus homologs.

J Virol 2003 Jan;77(2):1415-26

Institute of Virology and Immunology, University of Würzburg, Germany.

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January 2003

Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain.

EMBO J 2002 Jul;21(13):3213-24

Department of Structural Biology and Crystallography, Institute of Molecular Biotechnology, D-07745 Jena , Germany.

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July 2002

Conservation of substrate specificities among coronavirus main proteases.

J Gen Virol 2002 Mar;83(Pt 3):595-599

Institute of Virology and Immunology, University of Würzburg, Versbacher Straße 7, 97078 Würzburg, Germany1.

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March 2002

Mutational analysis of the active centre of coronavirus 3C-like proteases.

J Gen Virol 2002 Mar;83(Pt 3):581-593

Institute of Virology and Immunology, University of Würzburg, Versbacher Straße 7, 97078 Würzburg, Germany1.

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March 2002