John Zajicek

John Zajicek

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John Zajicek

Publications by authors named "John Zajicek"

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Assessment of a home-based standing frame programme in people with progressive multiple sclerosis (SUMS): a pragmatic, multi-centre, randomised, controlled trial and cost-effectiveness analysis.

Lancet Neurol 2019 Aug;18(8):736-747

Medical Statistics Group, Faculty of Medicine and Dentistry, University of Plymouth, Plymouth, UK; Peninsula Clinical Trials Unit, Faculty of Medicine and Dentistry, University of Plymouth, Plymouth, UK.

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http://dx.doi.org/10.1016/S1474-4422(19)30190-5DOI Listing
August 2019

Machine-learning based identification of undiagnosed dementia in primary care: a feasibility study.

BJGP Open 2018 Jul 13;2(2):bjgpopen18X101589. Epub 2018 Jun 13.

Research Professor, School of Computing, Electronics and Mathematics, Faculty of Science and Engineering, Plymouth University, Plymouth, UK.

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http://bjgpopen.org/lookup/doi/10.3399/bjgpopen18X101589
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http://dx.doi.org/10.3399/bjgpopen18X101589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6184101PMC
July 2018

Improving the quality of cognitive screening assessments: ACEmobile, an iPad-based version of the Addenbrooke's Cognitive Examination-III.

Alzheimers Dement (Amst) 2018 29;10:182-187. Epub 2017 Dec 29.

Plymouth Hospitals NHS Trust, Department of Neuropsychology, Level 7, Derriford Hospital, Plymouth, United Kingdom.

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http://dx.doi.org/10.1016/j.dadm.2017.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852320PMC
December 2017

A review of clinical trial designs used to detect a disease-modifying effect of drug therapy in Alzheimer's disease and Parkinson's disease.

BMC Neurol 2016 Jun 16;16:92. Epub 2016 Jun 16.

Division of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK.

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http://dx.doi.org/10.1186/s12883-016-0606-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910262PMC
June 2016

Lending a hand: can DASH items help ABILHAND improve manual ability measurement in multiple sclerosis?

Mult Scler 2015 Apr 12;21(5):612-21. Epub 2015 Jan 12.

Clinical Neurology Research Group, Plymouth University Peninsula Schools of Medicine and Dentistry, UK

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http://dx.doi.org/10.1177/1352458514549396DOI Listing
April 2015

Using 'dead or dependent' as an outcome measure in clinical trials in Parkinson's disease.

J Neurol Neurosurg Psychiatry 2015 Feb 22;86(2):180-5. Epub 2014 May 22.

Division of Applied Health Sciences, University of Aberdeen, Aberdeen, Scotland, UK.

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http://dx.doi.org/10.1136/jnnp-2014-307703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316847PMC
February 2015

A systematic review of biomarkers for disease progression in Alzheimer's disease.

PLoS One 2014 18;9(2):e88854. Epub 2014 Feb 18.

Division of Applied Health Sciences, University of Aberdeen, Aberdeen, Scotland, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088854PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928315PMC
December 2014

Pharmacology: Cannabis in neurology--a potted review.

Nat Rev Neurol 2014 Aug 8;10(8):429-30. Epub 2014 Jul 8.

Clinical Neurology Research Group, Plymouth University Peninsula Schools of Medicine and Dentistry, Room N13, ITTC Building 1, Davy Road, Tamar Science Park, Plymouth PL6 8BX, UK.

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http://dx.doi.org/10.1038/nrneurol.2014.122DOI Listing
August 2014

Future placebo-controlled trials of disease modifying therapy in relapsing multiple sclerosis would be unethical: No.

Authors:
John Zajicek

Mult Scler 2014 08;20(9):1165-6

Peninsula Schools of Medicine and Dentistry, Plymouth University, UK

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http://dx.doi.org/10.1177/1352458514536087DOI Listing
August 2014

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease.

Acta Neuropathol 2014 Feb 17;127(2):235-41. Epub 2013 Nov 17.

Department of Cellular and Anatomical Pathology, Derriford Hospital, Plymouth, PL6 8DH, UK,

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http://dx.doi.org/10.1007/s00401-013-1214-6DOI Listing
February 2014

Achieving valid patient-reported outcomes measurement: a lesson from fatigue in multiple sclerosis.

Mult Scler 2013 Nov 10;19(13):1773-83. Epub 2013 Apr 10.

The Department of Clinical Neuroscience, Plymouth University Peninsula Schools of Medicine and Dentistry, Devon, UK.

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http://dx.doi.org/10.1177/1352458513483378DOI Listing
November 2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:
Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

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http://dx.doi.org/10.1038/ng.2770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895PMC
November 2013

Evaluating change in mobility in people with multiple sclerosis: relative responsiveness of four clinical measures.

Mult Scler 2013 Oct 25;19(12):1632-9. Epub 2013 Mar 25.

School of Health Professions, Plymouth University, UK.

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http://dx.doi.org/10.1177/1352458513482373DOI Listing
October 2013

Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial.

Lancet Neurol 2013 Sep 13;12(9):857-865. Epub 2013 Jul 13.

Peninsula Clinical Trials Unit, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK.

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http://dx.doi.org/10.1016/S1474-4422(13)70159-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744749PMC
September 2013

Bioprofile analysis: a new approach for the analysis of biomedical data in Alzheimer's disease.

J Alzheimers Dis 2012 ;32(4):997-1010

Signal Processing and Multimedia Communications Research Group, School of Computing and Mathematics, Plymouth University, Plymouth, UK.

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http://dx.doi.org/10.3233/JAD-2012-121024DOI Listing
August 2013

Multiple sclerosis.

Authors:
John Zajicek

Handb Clin Neurol 2013 ;110:461-70

Peninsula College of Medicine and Dentistry, Plymouth, UK.

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http://dx.doi.org/10.1016/B978-0-444-52901-5.00039-3DOI Listing
August 2013

A systematic review of biomarkers for disease progression in Parkinson's disease.

BMC Neurol 2013 Apr 12;13:35. Epub 2013 Apr 12.

Division of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK.

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http://dx.doi.org/10.1186/1471-2377-13-35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637496PMC
April 2013

Putting the Alzheimer's cognitive test to the test I: traditional psychometric methods.

Alzheimers Dement 2013 Feb 17;9(1 Suppl):S4-9. Epub 2012 Dec 17.

Clinical Neurology Research Group, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK.

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http://dx.doi.org/10.1016/j.jalz.2012.08.005DOI Listing
February 2013

Putting the Alzheimer's cognitive test to the test II: Rasch Measurement Theory.

Alzheimers Dement 2013 Feb 17;9(1 Suppl):S10-20. Epub 2012 Dec 17.

Clinical Neurology Research Group, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK.

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http://dx.doi.org/10.1016/j.jalz.2012.08.006DOI Listing
February 2013

Machine learning-based method for personalized and cost-effective detection of Alzheimer's disease.

IEEE Trans Biomed Eng 2013 Jan 8;60(1):164-8. Epub 2012 Aug 8.

Signal Processing and Multimedia Communications Research Group, School of Computing and Mathematics, Plymouth University, Plymouth, PL4 8AA, UK.

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http://dx.doi.org/10.1109/TBME.2012.2212278DOI Listing
January 2013

Using the Multiple Sclerosis Impact Scale to estimate health state utility values: mapping from the MSIS-29, version 2, to the EQ-5D and the SF-6D.

Value Health 2012 Dec 4;15(8):1084-91. Epub 2012 Nov 4.

Health Economics Group, PenCLAHRC, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, Devon, UK.

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http://dx.doi.org/10.1016/j.jval.2012.07.007DOI Listing
December 2012

Multiple sclerosis and extract of cannabis: results of the MUSEC trial.

J Neurol Neurosurg Psychiatry 2012 Nov 12;83(11):1125-32. Epub 2012 Jul 12.

Clinical Neurology Research Group, Peninsula College of Medicine and Dentistry, University of Plymouth, Derriford, UK.

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http://dx.doi.org/10.1136/jnnp-2012-302468DOI Listing
November 2012

Early detection and characterization of Alzheimer's disease in clinical scenarios using Bioprofile concepts and K-means.

Conf Proc IEEE Eng Med Biol Soc 2011 ;2011:6470-3

Signal Processing and Multimedia Communications Research Group, School of Computing and Mathematics, University of Plymouth, Plymouth PL4 8AA, UK.

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http://dx.doi.org/10.1109/IEMBS.2011.6091597DOI Listing
August 2012

Analysis and validation of a Parkinson's disease register as a recruitment tool for clinical studies.

Clin Med (Lond) 2012 Jun;12(3):210-5

Dept Clinical Neuroscience, Peninsula College of Medicine and Dentistry, University of Plymouth, Devon, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4953481PMC
http://dx.doi.org/10.7861/clinmedicine.12-3-210DOI Listing
June 2012

Machine Learning classification of MRI features of Alzheimer's disease and mild cognitive impairment subjects to reduce the sample size in clinical trials.

Conf Proc IEEE Eng Med Biol Soc 2011 ;2011:7957-60

Signal Processing and Multimedia Communications Research Group, School of Computing and Mathematics, University of Plymouth, Plymouth PL4 8AA, UK.

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http://dx.doi.org/10.1109/IEMBS.2011.6091962DOI Listing
May 2012

The impact of motor and non motor symptoms on health state values in newly diagnosed idiopathic Parkinson's disease.

J Neurol 2012 Mar 5;259(3):462-8. Epub 2011 Aug 5.

Health Economics Group, Peninsula College of Medicine and Dentistry, University of Exeter, Veysey Building, Salmon Pool Lane, Exeter, EX2 4SG, UK.

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http://dx.doi.org/10.1007/s00415-011-6202-yDOI Listing
March 2012

Health state values for use in the economic evaluation of treatments for Alzheimer's disease.

Drugs Aging 2012 Jan;29(1):31-43

Health Economics Group, Institute of Health Service Research, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.

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http://dx.doi.org/10.2165/11597380-000000000-00000DOI Listing
January 2012

Model-based economic evaluation in Alzheimer's disease: a review of the methods available to model Alzheimer's disease progression.

Value Health 2011 Jul-Aug;14(5):621-30

Health Economics Group, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.

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http://dx.doi.org/10.1016/j.jval.2010.12.008DOI Listing
October 2011

Cannabinoid receptor and N-acyl phosphatidylethanolamine phospholipase D--evidence for altered expression in multiple sclerosis.

Brain Pathol 2011 Sep 22;21(5):544-57. Epub 2011 Feb 22.

Clinical Neurobiology, Peninsula College of Medicine and Dentistry.

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http://dx.doi.org/10.1111/j.1750-3639.2011.00477.xDOI Listing
September 2011

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Authors:
Stephen Sawcer Garrett Hellenthal Matti Pirinen Chris C A Spencer Nikolaos A Patsopoulos Loukas Moutsianas Alexander Dilthey Zhan Su Colin Freeman Sarah E Hunt Sarah Edkins Emma Gray David R Booth Simon C Potter An Goris Gavin Band Annette Bang Oturai Amy Strange Janna Saarela Céline Bellenguez Bertrand Fontaine Matthew Gillman Bernhard Hemmer Rhian Gwilliam Frauke Zipp Alagurevathi Jayakumar Roland Martin Stephen Leslie Stanley Hawkins Eleni Giannoulatou Sandra D'alfonso Hannah Blackburn Filippo Martinelli Boneschi Jennifer Liddle Hanne F Harbo Marc L Perez Anne Spurkland Matthew J Waller Marcin P Mycko Michelle Ricketts Manuel Comabella Naomi Hammond Ingrid Kockum Owen T McCann Maria Ban Pamela Whittaker Anu Kemppinen Paul Weston Clive Hawkins Sara Widaa John Zajicek Serge Dronov Neil Robertson Suzannah J Bumpstead Lisa F Barcellos Rathi Ravindrarajah Roby Abraham Lars Alfredsson Kristin Ardlie Cristin Aubin Amie Baker Katharine Baker Sergio E Baranzini Laura Bergamaschi Roberto Bergamaschi Allan Bernstein Achim Berthele Mike Boggild Jonathan P Bradfield David Brassat Simon A Broadley Dorothea Buck Helmut Butzkueven Ruggero Capra William M Carroll Paola Cavalla Elisabeth G Celius Sabine Cepok Rosetta Chiavacci Françoise Clerget-Darpoux Katleen Clysters Giancarlo Comi Mark Cossburn Isabelle Cournu-Rebeix Mathew B Cox Wendy Cozen Bruce A C Cree Anne H Cross Daniele Cusi Mark J Daly Emma Davis Paul I W de Bakker Marc Debouverie Marie Beatrice D'hooghe Katherine Dixon Rita Dobosi Bénédicte Dubois David Ellinghaus Irina Elovaara Federica Esposito Claire Fontenille Simon Foote Andre Franke Daniela Galimberti Angelo Ghezzi Joseph Glessner Refujia Gomez Olivier Gout Colin Graham Struan F A Grant Franca Rosa Guerini Hakon Hakonarson Per Hall Anders Hamsten Hans-Peter Hartung Rob N Heard Simon Heath Jeremy Hobart Muna Hoshi Carmen Infante-Duarte Gillian Ingram Wendy Ingram Talat Islam Maja Jagodic Michael Kabesch Allan G Kermode Trevor J Kilpatrick Cecilia Kim Norman Klopp Keijo Koivisto Malin Larsson Mark Lathrop Jeannette S Lechner-Scott Maurizio A Leone Virpi Leppä Ulrika Liljedahl Izaura Lima Bomfim Robin R Lincoln Jenny Link Jianjun Liu Aslaug R Lorentzen Sara Lupoli Fabio Macciardi Thomas Mack Mark Marriott Vittorio Martinelli Deborah Mason Jacob L McCauley Frank Mentch Inger-Lise Mero Tania Mihalova Xavier Montalban John Mottershead Kjell-Morten Myhr Paola Naldi William Ollier Alison Page Aarno Palotie Jean Pelletier Laura Piccio Trevor Pickersgill Fredrik Piehl Susan Pobywajlo Hong L Quach Patricia P Ramsay Mauri Reunanen Richard Reynolds John D Rioux Mariaemma Rodegher Sabine Roesner Justin P Rubio Ina-Maria Rückert Marco Salvetti Erika Salvi Adam Santaniello Catherine A Schaefer Stefan Schreiber Christian Schulze Rodney J Scott Finn Sellebjerg Krzysztof W Selmaj David Sexton Ling Shen Brigid Simms-Acuna Sheila Skidmore Patrick M A Sleiman Cathrine Smestad Per Soelberg Sørensen Helle Bach Søndergaard Jim Stankovich Richard C Strange Anna-Maija Sulonen Emilie Sundqvist Ann-Christine Syvänen Francesca Taddeo Bruce Taylor Jenefer M Blackwell Pentti Tienari Elvira Bramon Ayman Tourbah Matthew A Brown Ewa Tronczynska Juan P Casas Niall Tubridy Aiden Corvin Jane Vickery Janusz Jankowski Pablo Villoslada Hugh S Markus Kai Wang Christopher G Mathew James Wason Colin N A Palmer H-Erich Wichmann Robert Plomin Ernest Willoughby Anna Rautanen Juliane Winkelmann Michael Wittig Richard C Trembath Jacqueline Yaouanq Ananth C Viswanathan Haitao Zhang Nicholas W Wood Rebecca Zuvich Panos Deloukas Cordelia Langford Audrey Duncanson Jorge R Oksenberg Margaret A Pericak-Vance Jonathan L Haines Tomas Olsson Jan Hillert Adrian J Ivinson Philip L De Jager Leena Peltonen Graeme J Stewart David A Hafler Stephen L Hauser Gil McVean Peter Donnelly Alastair Compston

Nature 2011 Aug 10;476(7359):214-9. Epub 2011 Aug 10.

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http://dx.doi.org/10.1038/nature10251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182531PMC
August 2011

The use of decision-analytic models in Parkinson's disease: a systematic review and critical appraisal.

Appl Health Econ Health Policy 2011 Jul;9(4):243-58

Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.

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http://dx.doi.org/10.2165/11590160-000000000-00000DOI Listing
July 2011

Role of cannabinoids in multiple sclerosis.

CNS Drugs 2011 Mar;25(3):187-201

Clinical Neurology Research Group, Peninsula College of Medicine and Dentistry, Plymouth, UK.

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http://dx.doi.org/10.2165/11539000-000000000-00000DOI Listing
March 2011

The epidemiology of motor neurone disease in two counties in the southwest of England.

J Neurol 2010 Jun 22;257(6):977-81. Epub 2010 Jan 22.

Neurology Department, Torbay Hospital, Torquay, UK.

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http://dx.doi.org/10.1007/s00415-009-5448-0DOI Listing
June 2010

Clinically isolated syndrome: a protected zone for trials of new therapies?

Mult Scler 2010 Jun 28;16(6):754-5. Epub 2010 Apr 28.

Department of Neurology, St Vincent's University Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1177/1352458510366015DOI Listing
June 2010

The epidemiology of multiple sclerosis.

Authors:
John Zajicek

J Neurol 2007 Dec 15;254(12):1742. Epub 2007 Oct 15.

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http://dx.doi.org/10.1007/s00415-007-0603-yDOI Listing
December 2007

Rating scales as outcome measures for clinical trials in neurology: problems, solutions, and recommendations.

Lancet Neurol 2007 Dec;6(12):1094-105

Neurological Outcome Measures Unit, Peninsula College of Medicine and Dentistry, Plymouth, Devon, UK.

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http://dx.doi.org/10.1016/S1474-4422(07)70290-9DOI Listing
December 2007

The use of cannabinoids in multiple sclerosis.

Expert Opin Investig Drugs 2005 Jul;14(7):859-69

Neurology Research Group, Peninsula Medical School, Plymouth PL6 8BX, UK.

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http://dx.doi.org/10.1517/13543784.14.7.859 DOI Listing
July 2005

Quantifying drug-induced dyskinesias in the arms using digitised spiral-drawing tasks.

J Neurosci Methods 2005 May 28;144(1):47-52. Epub 2004 Nov 28.

Movement Disorders and Neurostimulation Group, Charing Cross Hospital, Division of Neurosciences and Psychological Medicine, Imperial College, London W6 8RF, UK.

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http://dx.doi.org/10.1016/j.jneumeth.2004.10.005DOI Listing
May 2005

Cannabinoids on trial for multiple sclerosis.

Authors:
John Zajicek

Lancet Neurol 2002 Jul;1(3):147

Peninsula Medical School, Derriford Hospital, Plymouth, Devon, PL 8DH, UK.

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July 2002