John Wharton

John Wharton

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John Wharton

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Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Authors:
Christopher J Rhodes Ken Batai Marta Bleda Matthias Haimel Laura Southgate Marine Germain Michael W Pauciulo Charaka Hadinnapola Jurjan Aman Barbara Girerd Amit Arora Jo Knight Ken B Hanscombe Jason H Karnes Marika Kaakinen Henning Gall Anna Ulrich Lars Harbaum Inês Cebola Jorge Ferrer Katie Lutz Emilia M Swietlik Ferhaan Ahmad Philippe Amouyel Stephen L Archer Rahul Argula Eric D Austin David Badesch Sahil Bakshi Christopher Barnett Raymond Benza Nitin Bhatt Harm J Bogaard Charles D Burger Murali Chakinala Colin Church John G Coghlan Robin Condliffe Paul A Corris Cesare Danesino Stéphanie Debette C Gregory Elliott Jean Elwing Melanie Eyries Terry Fortin Andre Franke Robert P Frantz Adaani Frost Joe G N Garcia Stefano Ghio Hossein-Ardeschir Ghofrani J Simon R Gibbs John Harley Hua He Nicholas S Hill Russel Hirsch Arjan C Houweling Luke S Howard Dunbar Ivy David G Kiely James Klinger Gabor Kovacs Tim Lahm Matthias Laudes Rajiv D Machado Robert V MacKenzie Ross Keith Marsolo Lisa J Martin Shahin Moledina David Montani Steven D Nathan Michael Newnham Andrea Olschewski Horst Olschewski Ronald J Oudiz Willem H Ouwehand Andrew J Peacock Joanna Pepke-Zaba Zia Rehman Ivan Robbins Dan M Roden Erika B Rosenzweig Ghulam Saydain Laura Scelsi Robert Schilz Werner Seeger Christian M Shaffer Robert W Simms Marc Simon Olivier Sitbon Jay Suntharalingam Haiyang Tang Alexander Y Tchourbanov Thenappan Thenappan Fernando Torres Mark R Toshner Carmen M Treacy Anton Vonk Noordegraaf Quinten Waisfisz Anna K Walsworth Robert E Walter John Wharton R James White Jeffrey Wilt Stephen J Wort Delphine Yung Allan Lawrie Marc Humbert Florent Soubrier David-Alexandre Trégouët Inga Prokopenko Richard Kittles Stefan Gräf William C Nichols Richard C Trembath Ankit A Desai Nicholas W Morrell Martin R Wilkins

Lancet Respir Med 2019 Mar 5;7(3):227-238. Epub 2018 Dec 5.

Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30409-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391516PMC
March 2019

Fractal Analysis of Right Ventricular Trabeculae in Pulmonary Hypertension.

Radiology 2018 08 5;288(2):386-395. Epub 2018 Jun 5.

From the MRC London Institute of Medical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Rd, London W12 0HS, England (T.J.W.D., M.Q., A.d.M., P.J.O., P.F.T., S.A.C., D.P.O.); National Heart and Lung Institute (T.J.W.D., J.S.R.G., S.A.C.), and Division of Experimental Medicine, Department of Medicine (G.M.J.W., J.W., M.R.W.), Imperial College London, London, England; National Heart Centre Singapore, Singapore, and Duke-NUS Graduate Medical School, Singapore (J.C., S.A.C.); and Department of Cardiology, National Pulmonary Hypertension Service, Imperial College Healthcare NHS Trust, London, England (L.S.G.E.H., J.S.R.G.).

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http://dx.doi.org/10.1148/radiol.2018172821DOI Listing
August 2018

Recent advances in pulmonary arterial hypertension.

F1000Res 2018 24;7. Epub 2018 Jul 24.

Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.12688/f1000research.14984.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058465PMC
July 2018

Machine Learning of Three-dimensional Right Ventricular Motion Enables Outcome Prediction in Pulmonary Hypertension: A Cardiac MR Imaging Study.

Radiology 2017 05 16;283(2):381-390. Epub 2017 Jan 16.

From the MRC Clinical Sciences Centre, Du Cane Rd, London W12 0NN, England (T.J.W.D., A.d.M., W.S., T.F., S.A.C., D.P.O.); Division of Experimental Medicine, Department of Medicine (T.J.W.D, T.F., G.M.J.W., J.W., C.J.R., M.R.W.), Department of Computing (W.S., D.R.), and National Heart and Lung Institute (J.S.R.G.), Imperial College London, London, England; National Heart Centre Singapore, Singapore and Duke-NUS Graduate Medical School, Singapore (S.A.C.); and Department of Cardiology, National Pulmonary Hypertension Service, Imperial College Healthcare NHS Trust, London, England (L.S.G.E.H., J.S.R.G.).

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http://dx.doi.org/10.1148/radiol.2016161315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398374PMC
May 2017

Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension.

Circulation 2017 01 21;135(5):460-475. Epub 2016 Nov 21.

From the Department of Medicine, Imperial College London, Hammersmith Campus, United Kingdom (C.J.R., P.G., J.W., K.C.R.-A., G.W., M.R.W.); Department of Medicine, University of Cambridge School of Clinical Medicine, United Kingdom (C.H., M.B., M.H., M.R.T., S.G., N.W.M.); Cardiology Department, Royal Free Hospital, London, United Kingdom (G.C.); Institute of Cellular Medicine, Newcastle University and the Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom (P.A.C.); National Pulmonary Hypertension Service, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom (L.S.H., J.S.R.G.); National Heart and Lung Institute, Imperial College London, Hammersmith Campus, United Kingdom (L.S.H., J.S.R.G.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, United Kingdom (D.G.K.); Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, United Kingdom (D.G.K., A.L.); Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, United Kingdom (A.J.P.); Pulmonary Vascular Disease Unit, Papworth Hospital, Cambridge, United Kingdom (J.P.Z., M.R.T.); Pulmonary Hypertension Service, Royal Brompton Hospital, London, United Kingdom (S.J.W.); and Department of Haematology, University of Cambridge, United Kingdom (S.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287439PMC
January 2017

Why drugs fail in clinical trials in pulmonary arterial hypertension, and strategies to succeed in the future.

Pharmacol Ther 2016 08 29;164:195-203. Epub 2016 Apr 29.

Department of Medicine, Imperial College London, W12 0NN, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2016.04.012DOI Listing
August 2016

Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α.

Circulation 2016 Jun 25;133(24):2447-58. Epub 2016 Apr 25.

From Department of Pharmacology (Z.D., M.L., M.M.Z., Y.-Y.Z.) and Center for Lung and Vascular Biology (Z.D., M.L., M.M.Z., Y.-Y.Z.), University of Illinois College of Medicine, Chicago; and Centre for Pharmacology and Therapeutics, Department of Medicine, Imperial College of London, Hammersmith Hospital, UK (J.W.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.021494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907810PMC
June 2016

Sotalol.

Card Electrophysiol Clin 2016 Jun;8(2):437-52

Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Tourville Arrhythmia Center, Medical University of South Carolina, 114 Doughty Street, BM 216, MSC 592, Charleston, SC 29425-5920, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccep.2016.02.007DOI Listing
June 2016

Endothelium-derived microparticles from chronically thromboembolic pulmonary hypertensive patients facilitate endothelial angiogenesis.

J Biomed Sci 2016 Jan 19;23. Epub 2016 Jan 19.

Centre for Pharmacology and Therapeutics, Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1186/s12929-016-0224-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717540PMC
January 2016

Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.

Circ Res 2015 May 12;116(10):1680-90. Epub 2015 Mar 12.

From the Centre for Pharmacology and Therapeutics, Department of Medicine (E.C., A.A., L.W., J.W., O.D., S.B., M.R.W., L.Z.) and Division of Brain Sciences, Department of Medicine (K.N.A.), Imperial College London, Hammersmith Hospital, London, United Kingdom; and Clinical Biochemistry, Imperial College Healthcare NHS Trust, London, United Kingdom (M.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.305265DOI Listing
May 2015

α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.

Circ Cardiovasc Genet 2014 Dec 4;7(6):920-9. Epub 2014 Nov 4.

From the Department of Medicine, Imperial College London, London, United Kingdom (M.R.W., J.W., C.J.R., S.R.); National Academy of Sciences of Kyrgyz Republic, Bishkek, Kyrgyz Republic (A.A.A.); Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, London, United Kingdom (J.V., T.J.A.); NIHR BRC Clinical Genome Informatics Facility, Imperial College London, London, United Kingdom (D.K., S.G.B., M.M.); Cardiology Research, Bayer Pharma AG, Wuppertal, Germany (S.G., J.-P.S.); Department of Pharmacology, The School of Pharmacy, Martin-Luther-University, Halle, Germany (J.-P.S.); Department of Pulmonary Pharmacotherapy, University of Giessen and Marburg Lung Center, Giessen, Germany (B.K.); Department of Medicine, University of Cambridge, Cambridge, United Kingdom (N.W.M.); Department of Pharmacology, Toxicology, and Clinical Pharmacy, University of Braunschweig-Center of Pharmaceutical Engineering, Braunschweig, Germany (I.N., S.B.); and Department of Chemistry, The Scripps Research Institute, La Jolla, CA (N.B.S., M.A.M.).

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000763DOI Listing
December 2014

miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.

Biochem J 2014 Aug;462(1):103-12

*Centre for Pharmacology and Therapeutics, Experimental Medicine, Imperial College London, Du Cane Road, London W12 0NN, U.K.

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http://dx.doi.org/10.1042/BJ20140486DOI Listing
August 2014

Pulmonary hypertension: biomarkers.

Handb Exp Pharmacol 2013 ;218:77-103

Imperial College London, Hammersmith Hospital, London, W12 0NN, UK.

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http://dx.doi.org/10.1007/978-3-642-38664-0_4DOI Listing
July 2014

Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.

Circulation 2014 Apr 6;129(17):1770-80. Epub 2014 Feb 6.

Centre for Pharmacology and Therapeutics, Department of Medicine, Imperial College London, London, UK (B.W.-S., V.B.A.-S., K.H.L., H.T., R.J.E., C.J.R., J.W., L.Z., M.R.W.); Cardiovascular Pulmonary Research Group, University of Colorado Denver Health Sciences Center, Aurora (D.C.I., C.L., Z.L., K.R.S.); Division of Nephrology, Department of Internal Medicine, St. Louis University, St. Louis MO (J.C.E.); Laboratory of Cancer Biology & Genetics, Centre for Cancer Research, Bethesda, MD (S.H.Y.); and National Pulmonary Hypertension Service and National Heart & Lung Institute, Imperial College Healthcare NHS Trust, London, UK (L.S.H., J.S.R.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.006797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033409PMC
April 2014

Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension.

Rheumatology (Oxford) 2014 Feb 22;53(2):285-92. Epub 2013 Oct 22.

Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/ket331DOI Listing
February 2014

Update in pulmonary vascular diseases 2012.

Am J Respir Crit Care Med 2013 Jul;188(1):23-8

Department of Medicine, Imperial College London, UK.

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http://dx.doi.org/10.1164/rccm.201303-0470UPDOI Listing
July 2013

Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells.

Respir Res 2011 Oct 14;12:137. Epub 2011 Oct 14.

Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK.

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http://dx.doi.org/10.1186/1465-9921-12-137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213146PMC
October 2011

Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension.

Heart 2011 Jul 10;97(13):1054-60. Epub 2011 May 10.

Centre for Pharmacology and Therapeutics, Hammersmith Hospital, Imperial College London, UK.

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http://dx.doi.org/10.1136/hrt.2011.224857DOI Listing
July 2011

Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights.

J Am Coll Cardiol 2011 Jul;58(3):300-9

Centre for Pharmacology and Therapeutics, Experimental Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.jacc.2011.02.057DOI Listing
July 2011

Proteomic analysis of lung tissues from patients with pulmonary arterial hypertension.

Circulation 2010 Nov 1;122(20):2058-67. Epub 2010 Nov 1.

Centre for Pharmacology and Therapeutics, Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.972745DOI Listing
November 2010

Simvastatin as a treatment for pulmonary hypertension trial.

Am J Respir Crit Care Med 2010 May;181(10):1106-13

Experimental Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, United Kingdom.

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http://dx.doi.org/10.1164/rccm.200911-1699OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874452PMC
May 2010

Endothelial progenitor cells in pulmonary arterial hypertension.

Trends Cardiovasc Med 2010 Jan;20(1):22-9

Adult Congenital Heart Center and Center for Pulmonary Hypertension, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College of Science and Medicine, SW3 6NP London, UK.

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http://dx.doi.org/10.1016/j.tcm.2010.03.003DOI Listing
January 2010

Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration.

J Clin Invest 2009 Jul;119(7):2009-18

Department of Pharmacology and 2Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1172/JCI33338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701851PMC
July 2009

Therapeutic targets in pulmonary arterial hypertension.

Pharmacol Ther 2009 Jan 28;121(1):69-88. Epub 2008 Oct 28.

Department of Experimental Medicine and Toxicology, Imperial College London, and National Pulmonary Hypertension Service, Hammersmith Hospital, United Kingdom.

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http://dx.doi.org/10.1016/j.pharmthera.2008.10.002DOI Listing
January 2009

Template synthesis of carbon nanotubes with diamond-shaped cross sections.

Small 2007 Oct;3(10):1718-22

Department of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, FL 32611-7200, USA.

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http://dx.doi.org/10.1002/smll.200700306DOI Listing
October 2007

A method for reproducibly preparing synthetic nanopores for resistive-pulse biosensors.

Small 2007 Aug;3(8):1424-30

Department of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, FL 32611-7200, USA.

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http://dx.doi.org/10.1002/smll.200700106DOI Listing
August 2007

Emerging therapies for pulmonary arterial hypertension.

Expert Opin Investig Drugs 2007 Jun;16(6):803-18

Imperial College London, Experimental Medicine & Toxicology, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1517/13543784.16.6.803DOI Listing
June 2007

Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells.

Respir Res 2006 Jan 19;7. Epub 2006 Jan 19.

Section on Experimental Medicine and Toxicology, Imperial College London, Hammersmith Campus, London W12 0NN, UK.

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http://dx.doi.org/10.1186/1465-9921-7-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1386664PMC
January 2006

Hypoxia amplifies the proliferative capacity of distal human pulmonary artery smooth-muscle cells.

Chest 2005 Dec;128(6 Suppl):600S-601S

Experimental Medicine and Toxicology, Imperial College London, Hammersmith Campus, London W12 0NN, UK.

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http://dx.doi.org/10.1378/chest.128.6_suppl.600SDOI Listing
December 2005

Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells.

Am J Respir Crit Care Med 2005 Jul 7;172(1):105-13. Epub 2005 Apr 7.

Section on Experimental Medicine and Toxicology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, UK.

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http://dx.doi.org/10.1164/rccm.200411-1587OCDOI Listing
July 2005

Autoradiography of enzymes, second messenger systems, and ion channels.

Methods Mol Biol 2005 ;306:139-54

Section on Experimental Medicine and Toxicology, Imperial College London, London, UK.

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http://dx.doi.org/10.1385/1-59259-927-3:139DOI Listing
June 2005

Profibrotic effects of endothelin-1 via the ETA receptor in cultured human cardiac fibroblasts.

Cell Physiol Biochem 2004 ;14(4-6):285-92

Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College School of Medicine at Harefield Hospital, Middlesex.

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https://www.karger.com/Article/FullText/80338
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http://dx.doi.org/10.1159/000080338DOI Listing
February 2005

Template synthesis of gold nanotubes in an anodic alumina membrane.

J Nanosci Nanotechnol 2004 Jul;4(6):605-10

Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA.

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http://dx.doi.org/10.1166/jnn.2004.015DOI Listing
July 2004

Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension.

Circulation 2003 Jul 9;107(25):3230-5. Epub 2003 Jun 9.

Section on Clinical Pharmacology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom.

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http://dx.doi.org/10.1161/01.CIR.0000074226.20466.B1DOI Listing
July 2003

Hypoxic induction of cox-2 regulates proliferation of human pulmonary artery smooth muscle cells.

Am J Respir Cell Mol Biol 2002 Dec;27(6):688-96

Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospitals, Cambridge, UK.

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http://dx.doi.org/10.1165/rcmb.2002-0067OCDOI Listing
December 2002

Recent insights into the pathogenesis and therapeutics of pulmonary hypertension.

Clin Sci (Lond) 2002 Mar;102(3):253-68

Section on Clinical Pharmacology, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK.

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March 2002

ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells.

Am J Respir Crit Care Med 2002 Feb;165(3):398-405

Section on Clinical Pharmacology, Department of Histochemistry, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1164/ajrccm.165.3.2104059DOI Listing
February 2002