John Wai

John Wai

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John Wai

John Wai

Publications by authors named "John Wai"

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Design, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugs.

Bioorg Med Chem Lett 2017 12 13;27(23):5300-5304. Epub 2017 Oct 13.

Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.bmcl.2017.10.023DOI Listing
December 2017

Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates.

ACS Med Chem Lett 2016 Nov 26;7(11):988-993. Epub 2016 Aug 26.

Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108036PMC
November 2016

8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.

Bioorg Med Chem Lett 2007 Dec 29;17(23):6511-5. Epub 2007 Sep 29.

Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.09.086DOI Listing
December 2007

Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid.

J Biol Chem 2003 Jan 11;278(5):2777-80. Epub 2002 Dec 11.

Department of Biological Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486-0004, USA.

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http://dx.doi.org/10.1074/jbc.C200621200DOI Listing
January 2003