John W Semple - Lund University - Professor of Transfusion Medicine

John W Semple

Lund University

Professor of Transfusion Medicine

Lund, Skane | Sweden

ORCID logohttps://orcid.org/0000-0002-1510-0077

John W Semple - Lund University - Professor of Transfusion Medicine

John W Semple

Introduction

Primary Affiliation: Lund University - Lund, Skane , Sweden

Experience

Sep 2016
Lund University
Professor of Transfusion Medicine
Hematology and LMP

Publications

89Publications

1264Reads

33Profile Views

Osteopontin mediates murine transfusion-related acute lung injury via stimulation of pulmonary neutrophil accumulation.

Blood 2019 Jul 10;134(1):74-84. Epub 2019 May 10.

Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2019000972DOI Listing
July 2019
2 Reads
10.452 Impact Factor

Transfusion-associated circulatory overload and transfusion-related acute lung injury.

Blood 2019 Apr 26;133(17):1840-1853. Epub 2019 Feb 26.

Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-10
Publisher Site
http://dx.doi.org/10.1182/blood-2018-10-860809DOI Listing
April 2019
11 Reads
10.452 Impact Factor

The Ultimate Murine Model of Immune Thrombocytopaenia.

Thromb Haemost 2019 Mar 6;119(3):353-354. Epub 2019 Feb 6.

Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678697
Publisher Site
http://dx.doi.org/10.1055/s-0039-1678697DOI Listing
March 2019
18 Reads
4.984 Impact Factor

A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP).

Br J Haematol 2018 11 19;183(3):501-503. Epub 2017 Oct 19.

Division of Haematology and Transfusion Medicine, Lund University, Lund, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.14985DOI Listing
November 2018
9 Reads
4.711 Impact Factor

The Pathogenic Involvement of Neutrophils in Acute Respiratory Distress Syndrome and Transfusion-Related Acute Lung Injury.

Transfus Med Hemother 2018 Oct 21;45(5):290-298. Epub 2018 Sep 21.

Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257140PMC
October 2018
9 Reads
2.011 Impact Factor

Moving target PF4 directs HIT responses.

Blood 2018 08;132(7):678-679

Lund University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2018-07-859975DOI Listing
August 2018
1 Read
10.452 Impact Factor

Targeting Transfusion-Related Acute Lung Injury: The Journey From Basic Science to Novel Therapies.

Crit Care Med 2018 05;46(5):e452-e458

Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden.

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00003246-201805000-0004
Publisher Site
http://dx.doi.org/10.1097/CCM.0000000000002989DOI Listing
May 2018
16 Reads
6.312 Impact Factor

Intravenous immunoglobulin treatment of spleen cells from patients with immune thrombocytopenia significantly increases the percentage of myeloid-derived suppressor cells.

Br J Haematol 2018 04 6;181(2):262-264. Epub 2017 Feb 6.

Keenan Research Centre for Biomedical Science of St. Michaels Hospital, Rochester, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.14542DOI Listing
April 2018
6 Reads
4.711 Impact Factor

Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets.

Blood Adv 2017 Sep 8;1(20):1773-1785. Epub 2017 Sep 8.

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/bloodadvances.2017007021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728336PMC
September 2017
11 Reads

Low levels of interleukin-10 in patients with transfusion-related acute lung injury.

Ann Transl Med 2017 Aug;5(16):339

Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm.2017.04.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566739PMC
August 2017
2 Reads

Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia.

Platelets 2017 Jul 25;28(5):521-524. Epub 2016 Nov 25.

a The Toronto Platelet Immunobiology Group , Keenan Research Centre for Biomedical Science of St. Michael's Hospital , Toronto , ON , Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09537104.2016.1246718DOI Listing
July 2017
21 Reads
2.627 Impact Factor

Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets.

Am J Physiol Lung Cell Mol Physiol 2017 05 10;312(5):L625-L637. Epub 2017 Mar 10.

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00317.2016DOI Listing
May 2017
76 Reads
4.080 Impact Factor

The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia () mutation.

Dis Model Mech 2017 05 12;10(5):581-595. Epub 2017 Jan 12.

Lunenfeld-Tanenbaum Research Institute, Room 876, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada

View Article

Download full-text PDF

Source
http://dmm.biologists.org/lookup/doi/10.1242/dmm.027433
Publisher Site
http://dx.doi.org/10.1242/dmm.027433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451163PMC
May 2017
34 Reads
4.973 Impact Factor

DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis.

Am J Respir Crit Care Med 2017 04;195(7):889-905

1 The Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201604-0730OCDOI Listing
April 2017
61 Reads
12.996 Impact Factor

Pathogenesis and Therapeutic Mechanisms in  Immune Thrombocytopenia (ITP).

J Clin Med 2017 Feb 9;6(2). Epub 2017 Feb 9.

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm6020016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332920PMC
February 2017
2 Reads

Alleviation of gram-negative bacterial lung inflammation by targeting HECTD2.

Ann Transl Med 2016 Dec;4(24):488

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Canadian Blood Services,; Department of Pharmacology, Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada;; Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm.2016.11.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233488PMC
December 2016
2 Reads

Elevation of C-reactive protein levels in patients with transfusion-related acute lung injury.

Oncotarget 2016 Nov;7(47):78048-78054

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.12872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363642PMC
November 2016
1 Read
6.359 Impact Factor

Platelets as immune-sensing cells.

Blood Adv 2016 Nov 22;1(1):10-14. Epub 2016 Nov 22.

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Canadian Blood Services, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/bloodadvances.2016000067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744049PMC
November 2016
3 Reads

The spleen dictates platelet destruction, anti-platelet antibody production, and lymphocyte distribution patterns in a murine model of immune thrombocytopenia.

Exp Hematol 2016 10 12;44(10):924-930.e1. Epub 2016 Jul 12.

Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Departments of Medicine and Pharmacology, University of Toronto, Toronto, ON, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2016.07.004DOI Listing
October 2016
36 Reads
2.475 Impact Factor

Microparticles as biomarkers of lung disease: enumeration in biological fluids using lipid bilayer microspheres.

Am J Physiol Lung Cell Mol Physiol 2016 05 4;310(9):L802-14. Epub 2016 Mar 4.

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada; Departments of Physiology, Surgery, University of Toronto, Toronto, Ontario, Canada; Institute of Physiology, Charité-Universitätsmedizin Berlin, Germany; and German Heart Institute, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00369.2015DOI Listing
May 2016
5 Reads
4.080 Impact Factor

The nonhemostatic immune functions of platelets.

Semin Hematol 2016 04 6;53 Suppl 1:S2-6. Epub 2016 Apr 6.

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael׳s Hospital, Canadian Blood Services, Toronto, Ontario, Canada; Departments of Pharmacology, Medicine, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.seminhematol.2016.04.002DOI Listing
April 2016
1 Read
3.274 Impact Factor

Splenic lymphocyte subtypes in immune thrombocytopenia: increased presence of a subtype of B-regulatory cells.

Br J Haematol 2016 Apr 24;173(1):159-60. Epub 2015 Jun 24.

Keenan Research Centre for Biomedical Science, St. Michaels Hospital, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/bjh.13567
Publisher Site
http://dx.doi.org/10.1111/bjh.13567DOI Listing
April 2016
11 Reads
4.711 Impact Factor

Move over Tregs, MDSCs are here.

Authors:
John W Semple

Blood 2016 Mar;127(12):1526-8

ST. MICHAEL'S HOSPITAL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-01-692160DOI Listing
March 2016
10.452 Impact Factor

CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia.

Blood 2016 Feb 10;127(6):735-8. Epub 2015 Nov 10.

The Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; and Department of Medicine, Department of Laboratory Medicine and Pathobiology, and Department of Pharmacology, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/content/bloodjournal/127/6/735.f
Web Search
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-06-65
Publisher Site
http://dx.doi.org/10.1182/blood-2015-06-655126DOI Listing
February 2016
19 Reads
10.452 Impact Factor

Acute Lung Injury Causes Asynchronous Alveolar Ventilation That Can Be Corrected by Individual Sighs.

Am J Respir Crit Care Med 2016 Feb;193(4):396-406

1 Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201505-0901OCDOI Listing
February 2016
71 Reads
12.996 Impact Factor

C-reactive protein enhances murine antibody-mediated transfusion-related acute lung injury.

Blood 2015 Dec 9;126(25):2747-51. Epub 2015 Oct 9.

The Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; and Departments of Pharmacology, Medicine, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2015-09-672592DOI Listing
December 2015
13 Reads
10.452 Impact Factor

Nouvelle cuisine: platelets served with inflammation.

J Immunol 2015 Jun;194(12):5579-87

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario M5B 1W8, Canada; Canadian Blood Services, Toronto, Ontario M5B 1W8, Canada; Department of Pharmacology, University of Toronto, Toronto, Ontario M5B 1W8, Canada; Department of Medicine, University of Toronto, Toronto, Ontario M5B 1W8, Canada; and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5B 1W8, Canada

View Article

Download full-text PDF

Source
http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1500259
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1500259DOI Listing
June 2015
5 Reads
4.922 Impact Factor

C-reactive protein boosts antibody-mediated platelet destruction.

Authors:
John W Semple

Blood 2015 Mar;125(11):1690-1

ST. MICHAEL'S HOSPITAL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2015-01-621219DOI Listing
March 2015
3 Reads
10.452 Impact Factor

A comprehensive study of ovine haemostasis to assess suitability to model human coagulation.

Thromb Res 2014 Aug 27;134(2):468-73. Epub 2014 May 27.

Critical Care Research Group, The University of Queensland and The Prince Charles Hospital, Brisbane, QLD, Australia; School of Health and Sports Science, University of Sunshine Coast, Sippy Downs, QLD, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thromres.2014.05.026DOI Listing
August 2014
58 Reads
2.447 Impact Factor

Peripheral blood monocyte-derived chemokine blockade prevents murine transfusion-related acute lung injury (TRALI).

Blood 2014 May 17;123(22):3496-503. Epub 2014 Mar 17.

Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Keenan Center for Biomedical Research, St. Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; and Departments of Medicine, Pharmacology, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-11-53
Publisher Site
http://dx.doi.org/10.1182/blood-2013-11-536755DOI Listing
May 2014
27 Reads
10.452 Impact Factor

Platelet GPIb-IX has suppressive effects on septic inflammation.

Authors:
John W Semple

Arterioscler Thromb Vasc Biol 2014 May;34(5):962-3

From the Keenan Center for Biomedical Research, St. Michael's Hospital, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.114.303367DOI Listing
May 2014
6.000 Impact Factor

Pathogenesis of immune thrombocytopenia.

Presse Med 2014 Apr 12;43(4 Pt 2):e49-59. Epub 2014 Mar 12.

The Keenan Research Centre for Biomedical Science in St. Michael's Hospital, Departments of Laboratory Medicine and Pathobiology, Toronto, ON M5B 1W8, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lpm.2014.01.010DOI Listing
April 2014
19 Reads
1.173 Impact Factor

Allogeneic platelet transfusions prevent murine T-cell-mediated immune thrombocytopenia.

Blood 2014 Jan 20;123(3):422-7. Epub 2013 Nov 20.

The Toronto Platelet Immunobiology Group.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2013-08-523308DOI Listing
January 2014
26 Reads
10.452 Impact Factor

Cellular immune dysfunction in immune thrombocytopenia (ITP).

Br J Haematol 2013 Oct 12;163(1):10-23. Epub 2013 Aug 12.

Toronto Platelet Immunobiology Group, University of Toronto, Toronto, ON, Canada; Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.12480DOI Listing
October 2013
43 Reads
4.711 Impact Factor

Platelets deliver small packages of genetic function.

Authors:
John W Semple

Blood 2013 Jul;122(2):155-6

St. Michael's Hospital.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2013-05-502609DOI Listing
July 2013
8 Reads
10.452 Impact Factor

Innate and adaptive immunity in immune thrombocytopenia.

Semin Hematol 2013 Jan;50 Suppl 1:S68-70

The Canadian Blood Services, Ottawa, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.seminhematol.2013.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691820PMC
January 2013
1 Read
3.274 Impact Factor

Bregging rights in ITP.

Authors:
John W Semple

Blood 2012 Oct;120(16):3169

St Michael's Hospital, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-08-448522DOI Listing
October 2012
10 Reads
10.452 Impact Factor

The immunopathogenesis of immune thrombocytopenia: T cells still take center-stage.

Curr Opin Hematol 2012 Sep;19(5):357-62

Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Department of Pharmacology, University of Toronto, Canadian Blood Services, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOH.0b013e3283567541DOI Listing
September 2012
1 Read
3.970 Impact Factor

Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia.

Blood 2012 Sep 3;120(10):2127-32. Epub 2012 Jul 3.

Toronto Platelet Immunobiology Group, Li Ka Shing Knowledge Institute of St Michael's Hospital, Toronto, ON.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-02-413526DOI Listing
September 2012
60 Reads
10.452 Impact Factor

T granules in human platelets function in TLR9 organization and signaling.

J Cell Biol 2012 Aug;198(4):561-74

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201111136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514030PMC
August 2012
6 Reads
9.834 Impact Factor

Management of immune thrombocytopenic purpura in children: potential role of novel agents.

Paediatr Drugs 2011 Aug;13(4):213-23

Department of Pediatrics, Division of Hematology/Oncology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2165/11591640-000000000-00000DOI Listing
August 2011
2 Reads
1.721 Impact Factor

Platelets and the immune continuum.

Nat Rev Immunol 2011 Apr;11(4):264-74

Toronto Platelet Immunobiology Group, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nri2956DOI Listing
April 2011
25 Reads
34.985 Impact Factor

Current problems and future directions of transfusion-induced alloimmunization: summary of an NHLBI working group.

Transfusion 2011 Feb 20;51(2):435-41. Epub 2011 Jan 20.

Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Children's Healthcare of Atlanta, Division of Pediatric Hematology/Oncology, Emory University School of Medicine, Atlanta, Georgia, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1537-2995.2010.03024.xDOI Listing
February 2011
6 Reads
3.225 Impact Factor

Recent progress in understanding the pathogenesis of immune thrombocytopenia.

Curr Opin Hematol 2010 Nov;17(6):590-5

Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Department of Pharmacology, University of Toronto, Canadian Blood Services, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=00062752-201011000-000
Publisher Site
http://dx.doi.org/10.1097/MOH.0b013e32833eaef3DOI Listing
November 2010
1 Read
3.970 Impact Factor

Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury.

Blood 2010 Oct 8;116(16):3073-9. Epub 2010 Jul 8.

Prince Charles Hospital, University of Queensland, Brisbane, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-05-284570DOI Listing
October 2010
15 Reads
10.452 Impact Factor

Future research in ITP: an ICIS consensus.

Ann Hematol 2010 Jul 23;89 Suppl 1:19-23. Epub 2010 Mar 23.

Department of Pathology, Stanford University School of Medicine, L235, Stanford, CA, 94305, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-010-0917-1DOI Listing
July 2010
32 Reads
2.634 Impact Factor

Animal models of immune thrombocytopenia (ITP).

Authors:
John W Semple

Ann Hematol 2010 Jul 25;89 Suppl 1:37-44. Epub 2010 Mar 25.

Toronto Platelet Immunobiology Group, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Canadian Blood Services, Departments of Pharmacology, Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada,

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00277-009-0882-8
Publisher Site
http://dx.doi.org/10.1007/s00277-009-0882-8DOI Listing
July 2010
29 Reads
2.634 Impact Factor

Platelets and innate immunity.

Cell Mol Life Sci 2010 Feb 18;67(4):499-511. Epub 2009 Dec 18.

Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-009-0205-1DOI Listing
February 2010
21 Reads
5.808 Impact Factor

ITP has elevated BAFF expression.

Authors:
John W Semple

Blood 2009 Dec;114(26):5248-9

Saint Michael's Hospital.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2009-10-247536DOI Listing
December 2009
4 Reads
10.452 Impact Factor

Infections, antigen-presenting cells, T cells, and immune tolerance: their role in the pathogenesis of immune thrombocytopenia.

Authors:
John W Semple

Hematol Oncol Clin North Am 2009 Dec;23(6):1177-92

Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hoc.2009.08.007DOI Listing
December 2009
1 Read
2.295 Impact Factor

Processed platelet HPA1a peptides au naturel.

Authors:
John W Semple

Blood 2009 Aug;114(9):1724-5

St Michael's Hospital.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2009-06-226746DOI Listing
August 2009
6 Reads
10.452 Impact Factor

Platelet antigen-induced regulation in ITP.

Authors:
John W Semple

Blood 2009 Mar;113(11):2373

St Michael's Hospital, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2009-01-197574DOI Listing
March 2009
10.452 Impact Factor

A novel immunosuppressive pathway involving peroxynitrite-mediated [corrected] nitration of platelet antigens within antigen-presenting cells.

Transfusion 2008 Sep 28;48(9):1917-24. Epub 2008 Jun 28.

Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1537-2995.2008.01793.xDOI Listing
September 2008
18 Reads
3.225 Impact Factor

Transfusion-related immunomodulation by platelets is dependent on their expression of MHC Class I molecules and is independent of white cells.

Transfusion 2008 Sep 2;48(9):1778-86. Epub 2008 Jun 2.

Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1537-2995.2008.01791.xDOI Listing
September 2008
31 Reads
3.225 Impact Factor

ITP three R's: regulation, routing, rituximab.

Authors:
John W Semple

Blood 2008 Aug;112(4):927-8

Toronto Platelet Immunobiology Group at Saint Michael's Hospital.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2008-05-155770DOI Listing
August 2008
2 Reads
10.452 Impact Factor

Plasma-derived biological medicines used to promote haemostasis.

Thromb Haemost 2008 May;99(5):851-62

Canadian Blood Services, Department of Pathology & Molecular Medicine, McMaster University, 1200 Main Street West, HSC 3N26, Hamilton, ON, Canada L8N 3Z5.

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1160/TH07-10-0592
Publisher Site
http://dx.doi.org/10.1160/TH07-10-0592DOI Listing
May 2008
18 Reads
4.984 Impact Factor

Evaluation of platelet gel characteristics using thrombin produced by the thrombin processing device: a comparative study.

J Oral Maxillofac Surg 2008 Apr;66(4):632-8

Canadian Blood Services, Research and Development, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.joms.2007.06.623DOI Listing
April 2008
7 Reads
1.280 Impact Factor

Platelets play a direct role in sepsis-associated endothelial cell death.

Authors:
John W Semple

Thromb Haemost 2008 Feb;99(2):249

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1160/TH08-01-0010DOI Listing
February 2008
4.984 Impact Factor

Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells.

Transfusion 2007 Nov;47(11):2161-8

Department of Laboratory Medicine, St Michael's Hospital, the Department of Pharmacology, and the Laboratory of Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1537-2995.2007.01441.x
Publisher Site
http://dx.doi.org/10.1111/j.1537-2995.2007.01441.xDOI Listing
November 2007
25 Reads
3.225 Impact Factor

ITP: a new regulatory issue!

Authors:
John W Semple

Eur J Haematol 2007 Oct;79(4):279-80

The Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1600-0609.2007.00951.xDOI Listing
October 2007
1 Read
2.066 Impact Factor

Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets.

Blood 2007 Aug 24;110(4):1359-61. Epub 2007 Apr 24.

Department of Pediatrics, Aarhus University Hospital, Skejby, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2007-03-079848DOI Listing
August 2007
5 Reads
10.452 Impact Factor

Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets.

Blood 2007 Jun 13;109(11):4803-5. Epub 2007 Feb 13.

Department of Laboratory Medicine, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-12-06
Publisher Site
http://dx.doi.org/10.1182/blood-2006-12-062695DOI Listing
June 2007
12 Reads
10.452 Impact Factor

About the mechanism of action of WinRho SDF.

Transfusion 2007 Feb;47(2):351; author reply 351-2

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1537-2995.2007.01112.xDOI Listing
February 2007
4 Reads
3.225 Impact Factor

A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?

Blood 2007 Jan 5;109(1):155-8. Epub 2006 Sep 5.

Canadian Blood Services, Department of Laboratory Medicine, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada M5B 1W8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2006-05-023796DOI Listing
January 2007
4 Reads
10.452 Impact Factor

A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy.

Blood 2006 Apr 29;107(7):2976-83. Epub 2005 Nov 29.

Canadian Blood Services and Dept of Laboratory Medicine and Pathobiology, St Michael's Hospital, University of Toronto, 30 Bond St Rm 2-006, Bond Wing, Toronto, ON, Canada M5B 1W8.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-06-25
Publisher Site
http://dx.doi.org/10.1182/blood-2005-06-2562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895387PMC
April 2006
18 Reads
10.452 Impact Factor

Intravenous immunoglobulin inhibits anti-glycoprotein IIb-induced platelet apoptosis in a murine model of immune thrombocytopenia.

Br J Haematol 2006 Apr;133(1):78-82

Division of Transfusion Medicine, Department of Laboratory Medicine, St Michael's Hospital, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2141.2006.05981.xDOI Listing
April 2006
31 Reads
4.711 Impact Factor

Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo.

Blood 2006 Jan 22;107(2):637-41. Epub 2005 Sep 22.

Department of Laboratory Medicine and Pathobiology, St Michael's Hospital, 30 Bond St, Toronto, ON, Canada, M5B 1W8.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-06-22
Publisher Site
http://dx.doi.org/10.1182/blood-2005-06-2202DOI Listing
January 2006
35 Reads
10.452 Impact Factor

Autoimmune pathogenesis and autoimmune hemolytic anemia.

Semin Hematol 2005 Jul;42(3):122-30

Department of Laboratory Medicine, St. Micheal's Hospital, University of Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
July 2005
15 Reads
3.274 Impact Factor

Quality of thrombin produced from the patient's own plasma using the TPD, a new Thrombin-processing Device.

J Extra Corpor Technol 2005 Jun;37(2):196-200

Thermogenesis Corp., Rancho Cordova, California, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682536PMC
June 2005
1 Read

Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotype.

Transfusion 2004 Nov;44(11):1572-8

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1537-2995.2004.04197.xDOI Listing
November 2004
24 Reads
3.225 Impact Factor

IgG antiplatelet immunity is dependent on an early innate natural killer cell-derived interferon-gamma response that is regulated by CD8+ T cells.

Blood 2004 Apr 4;103(7):2705-9. Epub 2003 Dec 4.

Department of Laboratory Medicine and Pathobiology, St Michael's Hospital, University of Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2003-10-35
Publisher Site
http://dx.doi.org/10.1182/blood-2003-10-3552DOI Listing
April 2004
8 Reads
10.452 Impact Factor

Inhibition of xenogeneic GVHD by PEN110 treatment of donor human PBMNCs.

Transfusion 2004 Feb;44(2):282-5

Department of Medicine, Rhode Island Hospital-Brown University, Providence 02903, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1537-2995.2004.00639.xDOI Listing
February 2004
3 Reads
3.225 Impact Factor

Pathogenic T-cell responses in patients with autoimmune thrombocytopenic purpura.

Authors:
John W Semple

J Pediatr Hematol Oncol 2003 Dec;25 Suppl 1:S11-3

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, 30 Bond St., Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/00043426-200312001-00003DOI Listing
December 2003
0.956 Impact Factor

Platelets give us many messages.

Authors:
John W Semple

Thromb Haemost 2003 Oct;90(4):562-3

View Article

Download full-text PDF

Source
October 2003
1 Read
4.984 Impact Factor

Anti-D initially stimulates an Fc-dependent leukocyte oxidative burst and subsequently suppresses erythrophagocytosis via interleukin-1 receptor antagonist.

Blood 2003 Oct 26;102(8):2862-7. Epub 2003 Jun 26.

Department of Laboratory Medicine and Pathobiology, St Michael's Hospital, 30 Bond St, Toronto, M5B 1W8 ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2003-04-1029DOI Listing
October 2003
4 Reads
10.452 Impact Factor

T cell and cytokine abnormalities in patients with autoimmune thrombocytopenic purpura.

Authors:
John W Semple

Transfus Apher Sci 2003 Jun;28(3):237-42

Canadian Blood Services and the Toronto Platelet Immunobiology Group, Ont., Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1473-0502(03)00041-7DOI Listing
June 2003
2 Reads
1.072 Impact Factor

IVIG induces dose-dependent amelioration of ITP in rodent models.

Blood 2003 Feb;101(4):1658-9; author reply 1659

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2002-10-3196DOI Listing
February 2003
2 Reads
10.452 Impact Factor

Cellular immune mechanisms in autoimmune thrombocytopenic purpura: An update.

Transfus Med Rev 2003 Jan;17(1):69-80

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, Toronto, Ontario Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/tmrv.2003.50004DOI Listing
January 2003
2 Reads
2.923 Impact Factor

Leukoreduction just doesn't "take away" immunogenic leukcocytes, it creates an immunosuppressive leukocyte dose.

Vox Sang 2002 Aug;83 Suppl 1:425-7

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, The University of Toronto and The Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1423-0410.2002.tb05346.xDOI Listing
August 2002
2.799 Impact Factor

Gamma-globulins prepared from sera of multiparous women bind anti-HLA antibodies and inhibit an established in vivo human alloimmune response.

Blood 2002 Aug;100(3):1055-9

Department of Laboratory Medicine and Pathobiology, St Michael's Hospital, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.v100.3.1055DOI Listing
August 2002
4 Reads
10.452 Impact Factor

Recipient antigen-processing pathways of allogeneic platelet antigens: essential mediators of immunity.

Transfusion 2002 Jul;42(7):958-61

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1537-2995.2002.00127.xDOI Listing
July 2002
3.225 Impact Factor

Top co-authors

John Freedman
John Freedman

University of Toronto

32
Michael Kim
Michael Kim

Northwestern University

26
Rick Kapur
Rick Kapur

University of Amsterdam

21
Rukhsana Aslam
Rukhsana Aslam

St Michael's Hospital

19
Alan H Lazarus
Alan H Lazarus

The Canadian Blood Services

13
Heyu Ni
Heyu Ni

University of Toronto

9
Li Guo
Li Guo

The Second Hospital of Hebei Medical University

8
Wolfgang M Kuebler
Wolfgang M Kuebler

Institute of Physiology

7
Mark J McVey
Mark J McVey

University of Ottawa

6