Publications by authors named "John W Eikelboom"

100Publications

The Indirect Consequences of the Response to the COVID-19 Pandemic.

J Am Coll Cardiol 2021 Jan;77(2):186-188

Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.

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January 2021

Direct oral anticoagulants: evidence and unresolved issues.

Lancet 2020 11;396(10264):1767-1776

Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada; Population Health Research Institute, Hamilton, ON, Canada; Hamilton General Hospital and McMaster University, Hamilton, ON, Canada.

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November 2020

Direct Oral Anticoagulant Dosing in Extremes of Body Weight: Time to Revisit the Guidelines?

Thromb Haemost 2020 Sep 17. Epub 2020 Sep 17.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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September 2020

Colchicine in Patients with Chronic Coronary Disease.

N Engl J Med 2020 11 31;383(19):1838-1847. Epub 2020 Aug 31.

From GenesisCare Western Australia (S.M.N., X.-F.X., M.A.I., D.L., A.W., R.H., P.S., I.T., A.G.T., A. Morton, P.L.T.), the Heart and Vascular Research Institute (S.M.N., P.L.T.) and the Department of Neurology (G.J.H.), Sir Charles Gairdner Hospital, and the Faculty of Health and Medical Sciences (G.J.H., P.L.T.) and the School of Population and Global Health (C.A.B.), University of Western Australia, Perth, the Department of Cardiology, Fiona Stanley Hospital, Murdoch, WA (C.J.), and the Harry Perkins Institute of Medical Research, Nedlands, WA (P.L.T.) - all in Australia; the Dutch Network for Cardiovascular Research (A.T.L.F., A. Mosterd, A.S., S.H.K.T., T.L., P.H., A.J., P.N., H.S., J.S., A.F.M.K., M.W.J.H., M.D., M.A., J.H.C.), the Netherlands Heart Institute (A.T.L.F.), and the Department of Cardiology (A.T.L.F.) and the Julius Center for Health Sciences and Primary Care (A. Mosterd, M.A.), University Medical Center Utrecht, Utrecht, the Department of Cardiology, Meander Medical Center, Amersfoort (A. Mosterd), the Departments of Cardiology (T.S.J.O., M.D., J.H.C.) and Internal Medicine (W.A.B.), Northwest Clinics, Alkmaar, the Department of Cardiology, Radboud University Medical Center, Nijmegen (T.S.J.O., J.H.C.), the Department of Cardiology, Treant Zorggroep, Hoogeveen, Emmen, and Stadskanaal (S.H.K.T.), the Department of Cardiology, Zuyderland Medical Center, Heerlen and Sittard (T.L.), the Department of Cardiology, Isala Diaconessenhuis, Meppel (P.H.), the Department of Cardiology, Gelre Hospitals, Apeldoorn (A.J.), the Department of Cardiology, Franciscus Hospital (P.N.), and Cardialysis (J.G.P.T.), Rotterdam, the Department of Cardiology, D&A Research and Genetics, Sneek (H.S.), the Department of Cardiology, Amphia and Breda (J.S., M.A.), the Department of Cardiology, Spaarne Hospital, Haarlem and Hoofddorp (A.F.M.K.), the Department of Cardiology, Green Heart Hospital, Gouda (M.W.J.H.), and the Department of Cardiology, Amsterdam UMC, Amsterdam (J.G.P.T.) - all in the Netherlands; and the Department of Medicine, McMaster University, Hamilton, ON, Canada (J.W.E.).

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November 2020

Is aspirin safer than a direct oral anticoagulant for patients with atrial fibrillation at high risk of bleeding?

Eur J Intern Med 2020 Sep 6;79:25-26. Epub 2020 Aug 6.

Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, L8L 2×2, Canada.

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September 2020

Cardiac Tamponade During Uninterrupted Oral Anticoagulant Therapy for Catheter Ablation for Atrial Fibrillation.

JACC Clin Electrophysiol 2020 07;6(7):796-798

Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.

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July 2020

Oral factor Xa inhibitors and risk of subdural hematoma: COMPASS trial results and meta-analysis.

Neurology 2020 08 10;95(5):e480-e487. Epub 2020 Jul 10.

From the Department of Medicine (Neurology) (L.C., K.N., S.N., K.S.P., A.S., M.S., R.G.H.), Department of Medicine (Division of Hematology & Thromboembolism) (J.W.E.), and School of Rehabilitation Science (J.B.), McMaster University/Hamilton Health Sciences/Population Health Research Institute (O.S.), Hamilton, Canada.

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August 2020

Prothrombin Complex Concentrates for Intracranial Hemorrhage on Factor Xa Inhibitors.

Circulation 2020 May 26;141(21):1690-1692. Epub 2020 May 26.

Population Health Research Institute, Hamilton Health Sciences and McMaster University Hamilton, Ontario, Canada.

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May 2020

Plasma Levels of Protein Z in Ischemic Stroke: A Systematic Review and Meta-Analysis.

Thromb Haemost 2020 May 5;120(5):815-822. Epub 2020 May 5.

Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada.

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May 2020

Efficacy and safety of rivaroxaban plus aspirin in women and men with chronic coronary or peripheral artery disease.

Cardiovasc Res 2020 04 14. Epub 2020 Apr 14.

Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Center for Cardiovascular Diseases, #167 Beilishi Road, Xicheng District, Beijing, China.

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April 2020

Anticoagulation for Stroke Prevention in Patients With Atrial Fibrillation and End-Stage Renal Disease-First, Do No Harm.

JAMA Netw Open 2020 04 1;3(4):e202237. Epub 2020 Apr 1.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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April 2020

Oral Anticoagulant Treatment in Patients with Atrial Fibrillation and Cancer.

Thromb Haemost 2020 02 2;120(2):194-196. Epub 2020 Feb 2.

Population Health Research Institute, Hamilton Health Sciences and McMaster University, Ontario, Canada.

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February 2020

How Did We Get Here?: A Historical Review and Critical Analysis of Anticoagulation Therapy Following Mechanical Valve Replacement.

Circulation 2019 12 2;140(23):1933-1942. Epub 2019 Dec 2.

Population Health Research Institute, Hamilton, Canada (S.M., I.H.J., E.P.B.-C., G.R.M., J.W.E., R.P.W.).

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December 2019

Applying contemporary antithrombotic therapy in the secondary prevention of chronic atherosclerotic cardiovascular disease.

Am Heart J 2019 12 23;218:100-109. Epub 2019 Oct 23.

Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada.

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December 2019

Reply.

Gastroenterology 2020 01 5;158(1):285-286. Epub 2019 Nov 5.

Population Health Research Institute, McMaster University and, Hamilton Health Sciences, Hamilton, Ontario, Canada.

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January 2020

Fifty years of research on antithrombotic therapy: Achievements and disappointments.

Eur J Intern Med 2019 Dec 1;70:1-7. Epub 2019 Nov 1.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada; Population Health Research Institute, Hamilton, Ontario, Canada. Electronic address:

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December 2019

Andexanet alfa for reversal of factor Xa inhibitors: a critical review of the evidence.

Future Cardiol 2019 11 31;15(6):395-404. Epub 2019 Oct 31.

Division of Hematology & Thromboembolism, Department of Medicine, McMaster University, Hamilton, ON, L8S 4L8, Canada.

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November 2019

Dabigatran Reversal With Idarucizumab in Patients With Renal Impairment.

J Am Coll Cardiol 2019 10;74(14):1760-1768

Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.

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October 2019

Rivaroxaban Plus Aspirin Versus Aspirin in Relation to Vascular Risk in the COMPASS Trial.

J Am Coll Cardiol 2019 07;73(25):3271-3280

Department of Medicine, Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada.

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July 2019

Pulmonary embolism: update on diagnosis and management.

Med J Aust 2019 07 19;211(2):82-87. Epub 2019 Jun 19.

University of Western Australia, Perth, WA.

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July 2019

Rivaroxaban With or Without Aspirin in Patients With Heart Failure and Chronic Coronary or Peripheral Artery Disease.

Circulation 2019 08 5;140(7):529-537. Epub 2019 Jun 5.

Population Health Research Institute, McMaster University and Hamilton Health Sciences, ON, Canada (J.W.E., J.B., S.J.C., O.S., S.Y.).

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August 2019

Deep vein thrombosis: update on diagnosis and management.

Med J Aust 2019 06 2;210(11):516-524. Epub 2019 Jun 2.

University of Western Australia, Perth, WA.

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June 2019

Monitoring Emerging Data From the COMPASS Trial of an Antithrombotic Agent.

J Am Coll Cardiol 2019 06;73(21):2769-2772

Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin.

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June 2019

How can the results of the COMPASS trial benefit patients with coronary or peripheral artery disease in Poland?

Kardiol Pol 2019 Aug 30;77(7-8):661-669. Epub 2019 May 30.

Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada

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August 2019

Rivaroxaban Plus Aspirin in Patients With Vascular Disease and Renal Dysfunction: From the COMPASS Trial.

J Am Coll Cardiol 2019 05;73(18):2243-2250

Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Population Health Research Institute, Hamilton, Ontario, Canada.

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May 2019

Individual Treatment Effect Estimation of 2 Doses of Dabigatran on Stroke and Major Bleeding in Atrial Fibrillation.

Circulation 2019 06 3;139(25):2846-2856. Epub 2019 May 3.

Department of Vascular Medicine, University Medical Center Utrecht, The Netherlands (M.C.S.-S., J.v.d.L., J.A.N.D., F.L.J.V.).

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June 2019

How I manage anticoagulant therapy in older individuals with atrial fibrillation or venous thromboembolism.

Blood 2019 05 29;133(21):2269-2278. Epub 2019 Mar 29.

Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada; Population Health Research Institute, Hamilton, ON, Canada; and Department of Medicine, McMaster University, Hamilton, ON, Canada.

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May 2019

External applicability of the COMPASS trial: the Western Denmark Heart Registry.

Eur Heart J Cardiovasc Pharmacother 2019 10;5(4):192-199

Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK Aarhus, Denmark.

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October 2019

Reversal of the antiplatelet effect of ticagrelor by simulated platelet transfusion.

Transfusion 2019 05 25;59(5):1850-1856. Epub 2019 Feb 25.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

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May 2019

Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors.

N Engl J Med 2019 04 7;380(14):1326-1335. Epub 2019 Feb 7.

From the Population Health Research Institute (S.J.C., J.W.E., D.M.S., E.Z., B.M., S.A., J.N.) and the Department of Medicine (M. Crowther), McMaster University, Hamilton, ON, and the University of Calgary, Calgary, AB (A.M.D.) - all in Canada; Harvard Medical School (C.M.G.) and Brigham and Women's Hospital (D.J.P.) - both in Boston; Portola Pharmaceuticals, South San Francisco, CA (J.T.C., J.H.L., P.Y., M.D.B., G.L., P.B.C., S.G., J.L., S.S.); University of Leuven, Leuven, Belgium (P.V.); Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand (J.S.), and Grenoble-Alpes University Hospital, Grenoble (P.A.) - both in France; Academic Medical Center, Amsterdam (S.M.); Guy's and St. Thomas' Hospitals, King's College London, London (A.T.C.); University Hospital Carl Gustav Carus Dresden, Dresden, Germany (J.B.-W.); Instituto de Investigación Hospital Universitario La Paz, Madrid (J.L.-S.); Sarasota Memorial Hospital, Sarasota, FL (M. Concha); and Seton Dell Medical School Stroke Institute, Austin, TX (T.J.M.).

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April 2019

Synergy of Dual Pathway Inhibition in Chronic Cardiovascular Disease.

Circ Res 2019 02;124(3):416-425

McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada (J.I.W., J.W.A.E.).

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February 2019

Blood Disorders in Patients Undergoing Transcatheter Aortic Valve Replacement: A Review.

JACC Cardiovasc Interv 2019 01;12(1):1-11

Department of Cardiology, Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada. Electronic address:

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January 2019

Stroke prevention in AF: Of Asians and non-Asians.

Eur Heart J 2019 05;40(19):1528-1530

Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada.

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May 2019

Low-dose rivaroxaban plus aspirin for the prevention of cardiovascular events: an evaluation of COMPASS.

Future Cardiol 2018 11 12;14(6):443-453. Epub 2018 Nov 12.

Department of Medicine, McMaster University, Hamilton, ON, L8S 4K1, Canada.

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November 2018

In Vitro Reversal of the Anti-Aggregant Effect of Ticagrelor Using Untreated Platelets.

Thromb Haemost 2018 Nov 17;118(11):1895-1901. Epub 2018 Oct 17.

Population Health Research Institute, Hamilton, Ontario, Canada.

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November 2018

Patients with Peripheral Artery Disease in the COMPASS Trial.

Eur J Vasc Endovasc Surg 2018 12 10;56(6):772-773. Epub 2018 Sep 10.

Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada. Electronic address:

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December 2018

Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation.

J Am Coll Cardiol 2018 07 9;72(3):255-267. Epub 2018 Jul 9.

Sidney Kimmel Medical College at Thomas Jefferson University and Lankenau and Bryn Mawr Hospitals, Philadelphia, Pennsylvania. Electronic address:

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July 2018

Direct Oral Anticoagulants and Myocardial Infarction: The Dust Is Settling.

J Am Coll Cardiol 2018 07;72(1):27-28

McMaster University, Hamilton, Ontario, Canada.

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July 2018

Reduced-Intensity Anticoagulation for Mechanical Aortic Valve Prostheses.

J Am Coll Cardiol 2018 06;71(24):2727-2730

Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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June 2018

Efficacy and safety of dabigatran compared with warfarin in patients with atrial fibrillation in relation to renal function over time-A RE-LY trial analysis.

Am Heart J 2018 04 5;198:169-177. Epub 2018 Jan 5.

Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.

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April 2018

NOACs only for those who cannot tolerate a VKA: where is the evidence?

Acta Cardiol 2019 Feb 23;74(1):17-20. Epub 2018 Feb 23.

a Department of Medicine , McMaster University , Hamilton , Canada.

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February 2019

Rivaroxaban in Stable Cardiovascular Disease.

N Engl J Med 2018 01;378(4):397-398

Population Health Research Institute, Hamilton, ON, Canada

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January 2018

Rivaroxaban with or without aspirin for prevention of cardiovascular disease.

Coron Artery Dis 2018 08;29(5):361-365

Department of Medicine, Division of Hematology and Thromboembolism, Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada.

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August 2018

The value of novel oral anticoagulants in rural Australia.

Med J Aust 2018 01;208(1):15-16

Population Health Research Institute, Hamilton, ON, Canada.

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January 2018

A Test in Context: D-Dimer.

J Am Coll Cardiol 2017 Nov;70(19):2411-2420

Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

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November 2017

Aortic valve replacement in younger patients.

Eur Heart J 2017 12;38(45):3378-3381

Population Health Research Institute, Hamilton, Ontario, Canada.

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December 2017

Bleeding impacting mortality after noncardiac surgery: a protocol to establish diagnostic criteria, estimate prognostic importance, and develop and validate a prediction guide in an international prospective cohort study.

CMAJ Open 2017 Aug;5(3):E594-E603

Affiliations: Lilibeth Caberto Kidney Clinical Research Unit (Roshanov, Garg), London Health Sciences Centre, London, Ont.; Department of Medicine (Eikelboom, Tandon, Borges, Kearon, Panju, Sheth, Mizera, Ribas, Devereaux), Department of Surgery (Lamy, Whitlock, de Beer, Winemaker, Pinthus, Simunovic), Department of Health Research Methods, Evidence, and Impact (Lamy, Guyatt, Le Manach, Thabane, Simunovic, Devereaux), Department of Pathology and Molecular Medicine (Crowther, Kavsak), Department of Anesthesia (Spence, VanHelder, Le Manach), Thrombosis and Atherosclerosis Research Institute (Kearon) and School of Nursing (McGillion), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; Population Health Research Institute (Eikelboom, Borges, Lamy, Whitlock, Spence, McGillion, Le Manach, Devereaux), Hamilton, Ont.; Department of Anaesthesia and Perioperative Medicine (Biccard), Groote Schuur Hospital, Observatory, South Africa, and University of Cape Town, South Africa; Department of Intensive Care and Perioperative Medicine (Szczeklik), Jagiellonian University Medical College, Krakow, Poland; Institute for Clinical Evaluative Sciences at Western (Garg), London, Ont.; Faculty of Health and Life Sciences (McGillion), Coventry University, Coventry, United Kingdom; Department of Outcomes Research (Sessler), Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio.; Biostatistics Unit (Thabane), St. Joseph's Healthcare, Hamilton, Ont.

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August 2017

Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease.

N Engl J Med 2017 10 27;377(14):1319-1330. Epub 2017 Aug 27.

From the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON (J.W.E., S.J.C., J.B., R.G.H., O.S., E.M.L., S.S.A., D.L., S.Y.), and Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, QC (G.R.D.) - both in Canada; Estudios Clínicos Latino América and Instituto Cardiovascular de Rosario, Rosario, Argentina (R.D.); Amphia Ziekenhuis and Werkgroep Cardiologische Centra Nederland (WCN), Utrecht, the Netherlands (M.A.); Cardiocenter, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W.); Osaka International Cancer Institute, Osaka, Japan (M.H.); Instituto Dante Pazzanese de Cardiologia (A.A.), and Hospital do Coração (L.S.P.), São Paulo; University of Washington Medical Center (K.R.H.B.) and University of Washington (J.P.), Seattle; Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston (D.L.B.); FuWai Hospital, Beijing (J.Z., Y.L.); National Association of Hospital Cardiologists Research Center (ANMCO), Florence, Italy (A.P.M.); Research Institute, Fundación Oftalmológica de Santander (FOSCAL)-Bucaramanga, Bucaramanga, Colombia (P.L.-J.); National University of Ireland, Galway (M.O.); Thrombosis Research Institute and University College London, London (A.K.K.), Centre for Cardiovascular Science, University of Edinburgh, Edinburgh (K.A.A.F.), and University of Glasgow, Glasgow (T.J.G.) - all in the United Kingdom; Collegium Medicum Jagiellonian University, Krakow, Poland (T.J.G); Institute of Cardiology, Kiev, Ukraine (A.N.P.); University of Würzburg and University Hospital, Würzburg (G.E., S.S.), and Bayer, Leverkusen (N.C.B., F.M., E.C.) - all in Germany; Semmelweis University, Budapest, Hungary (M.K.); Karolinska Institutet, Stockholm (L.R.); National Research Center for Preventative Medicine, Moscow (N.P.); University of Philippines, Manila (A.L.D.); Universidad de La Frontera, Temuco, Chile (F.L.); University of Cape Town, Cape Town, South Africa (P.J.C.); University of Aalborg, Copenhagen (C.T.-P.); University of Leuven, Leuven, Belgium (P.B.V.); University of Medicine and Pharmacology, Carol Davila University and Emergency Hospital, Bucharest, Romania (D.V.); Catholic University of Korea, Seoul, South Korea (J.-H.K.); Monash University, Melbourne, VIC, Australia (A.M.T.); Lady Davis Carmel Medical Center, Haifa, Israel (B.S.L.); Facultad de Ciencias de la Salud Eugenio Espejo-Universidad Tecnológica Equinoccial, Quito, Ecuador (C.F.); Universiti Teknologi Mara, Selangor, Malaysia (K.Y.); Université Paris Diderot, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris (P.G.S.); and Turku University Central Hospital and Turku University, Turku, Finland (K.P.M.).

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October 2017

Platelet Transfusion for Ticagrelor Reversal.

Circ Cardiovasc Interv 2017 08;10(8)

From the Population Health Research Institute (P.K., J.W.E.); Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada (N.C., J.W.E.); and Hamilton Health Science Corporation and McMaster University, Ontario, Canada (P.K., N.C., J.W.E.).

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August 2017