John V Reynolds

John V Reynolds

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Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8 T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients.

Front Immunol 2018 13;9:1867. Epub 2018 Aug 13.

Department of Surgery, St. James's Hospital, Trinity College Dublin, Trinity Translational Medicine Institute, Dublin, Ireland.

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http://dx.doi.org/10.3389/fimmu.2018.01867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099201PMC
September 2019

Differential Expression Profiles of Oxidative Stress Levels, 8-oxo-dG and 4-HNE, in Barrett's Esophagus Compared to Esophageal Adenocarcinoma.

Int J Mol Sci 2019 Sep 10;20(18). Epub 2019 Sep 10.

Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James' Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.3390/ijms20184449DOI Listing
September 2019

Physical recovery in the first six months following oesophago-gastric cancer surgery. Identifying rehabilitative needs: a qualitative interview study.

Disabil Rehabil 2019 Sep 16:1-8. Epub 2019 Sep 16.

Discipline of Physiotherapy, School of Medicine, Trinity College Dublin , Dublin , Ireland.

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http://dx.doi.org/10.1080/09638288.2019.1663946DOI Listing
September 2019

Silencing microRNA-330-5p increases MMP1 expression and promotes an invasive phenotype in oesophageal adenocarcinoma.

BMC Cancer 2019 Aug 7;19(1):784. Epub 2019 Aug 7.

Cancer Biology and Therapeutics Lab, School of Life Sciences, University of Hull, Hull, HU6 7RX, UK.

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http://dx.doi.org/10.1186/s12885-019-5996-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686260PMC
August 2019

A pilot study of the impact of Vitamin C supplementation with neoadjuvant chemoradiation on regulators of inflammation and carcinogenesis in esophageal cancer patients.

J Cancer Res Ther 2019 Jan-Mar;15(1):185-191

Department of Clinical Surgery, Trinity Centre for Health Sciences, St. James's Hospital and Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.4103/jcrt.JCRT_763_16DOI Listing
July 2019

Pyrazinib (P3), [(E)-2-(2-Pyrazin-2-yl-vinyl)-phenol], a small molecule pyrazine compound enhances radiosensitivity in oesophageal adenocarcinoma.

Cancer Lett 2019 Apr 19;447:115-129. Epub 2019 Jan 19.

Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Ireland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835193002
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http://dx.doi.org/10.1016/j.canlet.2019.01.009DOI Listing
April 2019

Altered T Cell Migratory Capacity in the Progression from Barrett Oesophagus to Oesophageal Adenocarcinoma.

Cancer Microenviron 2019 Apr 4;12(1):57-66. Epub 2019 Mar 4.

Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1007/s12307-019-00220-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529503PMC
April 2019

Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma.

Int J Med Sci 2019 5;16(4):519-528. Epub 2019 Apr 5.

Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.7150/ijms.29296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535661PMC
April 2019

Attenuation of satiety gut hormones increases appetitive behavior after curative esophagectomy for esophageal cancer.

Am J Clin Nutr 2019 02;109(2):335-344

Metabolic Medicine, Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1093/ajcn/nqy324DOI Listing
February 2019

Risk factors for loss of bone mineral density after curative esophagectomy.

Arch Osteoporos 2019 Jan 9;14(1). Epub 2019 Jan 9.

Metabolic Medicine, University College Dublin, Conway Institute of Biomedical and Biomolecular Research, Dublin 4, Ireland.

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http://link.springer.com/10.1007/s11657-018-0556-z
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http://dx.doi.org/10.1007/s11657-018-0556-zDOI Listing
January 2019

Can the Efficacy of [F]FDG-PET/CT in Clinical Oncology Be Enhanced by Screening Biomolecular Profiles?

Pharmaceuticals (Basel) 2019 Jan 23;12(1). Epub 2019 Jan 23.

Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, D08W9RT Dublin, Ireland.

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http://dx.doi.org/10.3390/ph12010016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469153PMC
January 2019

Obesity and gastrointestinal cancer: the interrelationship of adipose and tumour microenvironments.

Nat Rev Gastroenterol Hepatol 2018 11;15(11):699-714

Trinity Translational Medicine Institute, Trinity College Dublin and St. James's Hospital, Dublin, Ireland.

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http://www.nature.com/articles/s41575-018-0069-7
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http://dx.doi.org/10.1038/s41575-018-0069-7DOI Listing
November 2018

The Mitochondrial Genes , and are Linked with Alterations in Mitochondrial Membrane Potential in Barrett's Esophagus.

Int J Mol Sci 2018 Nov 6;19(11). Epub 2018 Nov 6.

Trinity Translational Medicine Institute, Department of Surgery, St. James's Hospital, D08W9RT Dublin, Ireland.

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http://dx.doi.org/10.3390/ijms19113483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275077PMC
November 2018

Physical decline and its implications in the management of oesophageal and gastric cancer: a systematic review.

J Cancer Surviv 2018 08 23;12(4):601-618. Epub 2018 May 23.

Discipline of Physiotherapy, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1007/s11764-018-0696-6DOI Listing
August 2018

Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma.

Cancer Lett 2018 04 12;418:230-238. Epub 2018 Jan 12.

Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.01.039DOI Listing
April 2018

Deoxycholic acid promotes development of gastroesophageal reflux disease and Barrett's oesophagus by modulating integrin-αv trafficking.

J Cell Mol Med 2017 Dec 22;21(12):3612-3625. Epub 2017 Sep 22.

Cell and Molecular Biology Group, Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1111/jcmm.13271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706496PMC
December 2017

Multidisciplinary rehabilitation across the esophageal cancer journey.

J Thorac Dis 2017 Dec;9(12):E1140-E1142

Discipline of Physiotherapy, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.21037/jtd.2017.11.72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757004PMC
December 2017

Does Prolonged Enteral Feeding With Supplemental Omega-3 Fatty Acids Impact on Recovery Post-esophagectomy: Results of a Randomized Double-Blind Trial.

Ann Surg 2017 11;266(5):720-728

*National Esophageal Center, St James Hospital, Dublin, Ireland †Clinical Nutrition, St James Hospital, Dublin, Ireland ‡School of Food & Nutritional Sciences, University College Cork, Cork, Ireland §School of Biological Sciences, Dublin Institute of Technology, Dublin, Ireland ¶Centre for Support and Training in Analysis and Research (CSTAR), University College Dublin, Dublin, Ireland ||Dept of Surgery, Mercy University Hospital, Cork, Ireland.

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http://dx.doi.org/10.1097/SLA.0000000000002390DOI Listing
November 2017

Sarcopenia: Prevalence, and Impact on Operative and Oncologic Outcomes in the Multimodal Management of Locally Advanced Esophageal Cancer.

Ann Surg 2017 11;266(5):822-830

*Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin, and St. James's Hospital, Dublin, Ireland †School of Biological Sciences, Dublin Institute of Technology, Dublin, Ireland ‡School of Medicine, Trinity College Dublin, Dublin, Ireland §Department of Radiology, St. James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1097/SLA.0000000000002398DOI Listing
November 2017

Weight Loss, Satiety, and the Postprandial Gut Hormone Response After Esophagectomy: A Prospective Study.

Ann Surg 2017 07;266(1):82-90

*Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin and St James's Hospital, Dublin 8, Ireland †Diabetes Complications Research Centre, Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Dublin 4, Ireland ‡Gastrosurgical Laboratory, Sahlgrenska Academy, University of Gothenburg, Sweden.

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http://Insights.ovid.com/crossref?an=00000658-201707000-0001
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http://dx.doi.org/10.1097/SLA.0000000000001918DOI Listing
July 2017

Neoadjuvant treatment of locally advanced esophageal and junctional cancer: the evidence-base, current key questions and clinical trials.

J Thorac Dis 2017 Jul;9(Suppl 8):S697-S704

Department of Surgery, St. James's Hospital and Trinity College Dublin, Ireland.

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http://dx.doi.org/10.21037/jtd.2017.03.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538972PMC
July 2017

Risk Factors for Anastomotic Stricture Post-esophagectomy with a Standardized Sutured Anastomosis.

World J Surg 2017 Feb;41(2):487-497

Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin and St. James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1007/s00268-016-3746-0DOI Listing
February 2017

Metabolic tumor volume provides complementary prognostic information to EUS staging in esophageal and junctional cancer.

Dis Esophagus 2017 Feb;30(3):1-8

Department of Clinical Surgery, St James's Hospital and Trinity College Dublin, Ireland.

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http://dx.doi.org/10.1111/dote.12505DOI Listing
February 2017

Emerging Concepts Linking Obesity with the Hallmarks of Cancer.

Trends Endocrinol Metab 2017 01 12;28(1):46-62. Epub 2016 Sep 12.

Department of Surgery, Trinity Translational Medicine Institute (TTMI), Trinity College Dublin/St James' Hospital, Dublin, Ireland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10432760163010
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http://dx.doi.org/10.1016/j.tem.2016.08.004DOI Listing
January 2017

Home enteral nutrition recipients: patient perspectives on training, complications and satisfaction.

Frontline Gastroenterol 2017 Jan 8;8(1):79-84. Epub 2016 Oct 8.

Department of Nutrition and Dietetics, Beaumont Hospital, Dublin 9, Ireland; Trinity Centre, St James Hospital, Dublin 8, Ireland; Department of Surgery, St James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1136/flgastro-2016-100736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256397PMC
January 2017

Factors regulating nuclear factor-kappa B activation in esophageal cancer cells: Role of bile acids and acid.

J Cancer Res Ther 2016 Jan-Mar;12(1):364-73

Department of Surgery, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.4103/0973-1482.174525DOI Listing
December 2016

The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function.

J Leukoc Biol 2016 12 30;100(6):1435-1442. Epub 2016 Jun 30.

Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Ireland;

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http://dx.doi.org/10.1189/jlb.5AB1115-493RRDOI Listing
December 2016

Can CT-PET and Endoscopic Assessment Post-Neoadjuvant Chemoradiotherapy Predict Residual Disease in Esophageal Cancer?

Ann Surg 2016 Nov;264(5):831-838

Department of Surgery, Trinity Healthcare Sciences Building, St. James's Hospital and Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1097/SLA.0000000000001902DOI Listing
November 2016

Physiology, pathophysiology and therapeutic implications of enteroendocrine control of food intake.

Expert Rev Endocrinol Metab 2016 Nov 20;11(6):475-499. Epub 2016 Oct 20.

a Diabetes Complications Research Centre, Conway Institute of Biomedical and Biomolecular Research , University College Dublin , Dublin , Ireland.

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http://dx.doi.org/10.1080/17446651.2016.1245140DOI Listing
November 2016

Parallel Profiles of Inflammatory and Effector Memory T Cells in Visceral Fat and Liver of Obesity-Associated Cancer Patients.

Inflammation 2016 Oct;39(5):1729-36

Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1007/s10753-016-0407-2DOI Listing
October 2016

Docemur Docemus: Peer-Assisted Learning Improves the Knowledge Gain of Tutors in the Highest Quartile of Achievement but Not Those in the Lowest Quartile.

J Surg Educ 2015 Nov-Dec;72(6):1139-44. Epub 2015 Aug 10.

Department of Surgery, St. James's Hospital and Trinity College Dublin, Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.jsurg.2015.07.001DOI Listing
September 2016

Opposing effects of bile acids deoxycholic acid and ursodeoxycholic acid on signal transduction pathways in oesophageal cancer cells.

Eur J Cancer Prev 2016 09;25(5):368-79

aDepartment of Clinical Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt bDepartment of Pharmacology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan cDepartment of Clinical Surgery, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1097/CEJ.0000000000000198DOI Listing
September 2016

CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer.

Immunol Cell Biol 2016 07 5;94(6):531-7. Epub 2016 Apr 5.

Department of Surgery, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1038/icb.2016.26DOI Listing
July 2016

Does the modified Glasgow Prognostic Score (mGPS) have a prognostic role in esophageal cancer?

J Surg Oncol 2016 Jun 23;113(7):732-7. Epub 2016 Mar 23.

National Centre for Esophageal and Gastric Cancer, St. James's Hospital, Dublin, Ireland.

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http://doi.wiley.com/10.1002/jso.24225
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http://dx.doi.org/10.1002/jso.24225DOI Listing
June 2016

MicroRNA-330-5p as a Putative Modulator of Neoadjuvant Chemoradiotherapy Sensitivity in Oesophageal Adenocarcinoma.

PLoS One 2015 29;10(7):e0134180. Epub 2015 Jul 29.

School of Biological, Biomedical and Environmental Sciences, University of Hull, Hull, United States of America; Department of Surgery, Institute of Molecular Medicine, Trinity College Dublin, St. James Hospital, Dublin, Ireland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134180PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519309PMC
May 2016

Obesity-associated cancer: an immunological perspective.

Proc Nutr Soc 2016 May 16;75(2):125-38. Epub 2015 Nov 16.

Dept. Surgery,Trinity Centre for Health Sciences,St. James's Hospital and Trinity College Dublin,Dublin 8,Ireland.

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http://dx.doi.org/10.1017/S0029665115004176DOI Listing
May 2016

Pancreatic Aetiology for Massive Upper Gastrointestinal Haemorrhage in Pregnancy.

Case Rep Surg 2016 29;2016:5491851. Epub 2016 Feb 29.

Department of Surgery, Trinity Centre, St. James's Hospital, James's Street, Dublin 8, Ireland.

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http://dx.doi.org/10.1155/2016/5491851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789407PMC
April 2016

Letter to the Co-Editors-in-Chief, Radiotherapy and Oncology.

Radiother Oncol 2016 Jan 4;118(1):215. Epub 2016 Jan 4.

Dept. of Surgery, Trinity College Dublin/St James' Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.radonc.2015.12.010DOI Listing
January 2016

Golgi phosphoprotein 2 (GOLPH2) is a novel bile acid-responsive modulator of oesophageal cell migration and invasion.

Br J Cancer 2015 Nov 13;113(9):1332-42. Epub 2015 Oct 13.

Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College, Dublin D08W9RT, Ireland.

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http://dx.doi.org/10.1038/bjc.2015.350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815786PMC
November 2015

Prospective Study of Malabsorption and Malnutrition After Esophageal and Gastric Cancer Surgery.

Ann Surg 2015 Nov;262(5):803-7; discussion 807-8

Department of Surgery, Trinity College Dublin, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1097/SLA.0000000000001445DOI Listing
November 2015

Gut Hormone Suppression Increases Food Intake After Esophagectomy With Gastric Conduit Reconstruction.

Ann Surg 2015 Nov;262(5):824-29; discussion 829-30

*Diabetes Complications Research Centre, Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Dublin, Ireland †Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin and St. James's Hospital, Dublin, Ireland ‡Wellcome Trust and HRB Clinical Research Facility, St. James's Hospital, Dublin, Ireland §Gastrosurgical Laboratory, Sahlgrenska Academy, University of Gothenburg, Gothenberg, Sweden.

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http://dx.doi.org/10.1097/SLA.0000000000001465DOI Listing
November 2015

Diffuse oesophageal leiomyomatosis.

ANZ J Surg 2015 Sep 16;85(9):685-6. Epub 2013 Dec 16.

Department of Surgery, St. James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1111/ans.12492DOI Listing
September 2015

Obesity and increased risk of esophageal adenocarcinoma.

Expert Rev Endocrinol Metab 2015 Sep 9;10(5):511-523. Epub 2015 Aug 9.

a 1 Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin & St. James' Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1586/17446651.2015.1077696DOI Listing
September 2015

International Consensus on Standardization of Data Collection for Complications Associated With Esophagectomy: Esophagectomy Complications Consensus Group (ECCG).

Ann Surg 2015 Aug;262(2):286-94

*Virginia Mason Medical Center, Seattle, WA †University of Birmingham, Birmingham, United Kingdom ‡University of São Paulo, School of Medicine, São Paulo, Brazil §University of Michigan Health System, Ann Arbor, MI ¶Toronto General Hospital, Toronto, Ontario, Canada ‖Sainte Marguerite Hospital, Marseille, France **University of Newcastle upon Tyne, Newcastle, United Kingdom ††University of Cologne, Cologne, Germany ‡‡MD Anderson Cancer Center, Houston, TX §§Allegheny Health Network's Esophageal and Thoracic Institute, Pittsburgh, PA ¶¶Keio University, Tokyo, Japan ‖‖University of Pennsylvania, Philadelphia, PA ***Queen Mary Hospital, Hong Kong SAR, China †††Katholieke Universiteit Leuven, Leuven, Belgium ‡‡‡Oxford Radcliffe Hospitals, Oxford, United Kingdom §§§Hospital Universitario del Mar, Barcelona, Spain ¶¶¶University of Rochester Surgery, Rochester, NY ‖‖‖Tata Hospital, Mumbai, India ****Trinity College Dublin, Dublin, Ireland ††††Princess Alexandra Hospital, The University of Queensland, Brisbane, Australia ‡‡‡‡Erasmus Medical Center, Rotterdam, The Netherlands.

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http://pdfs.journals.lww.com/annalsofsurgery/2015/08000/Inte
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http://dx.doi.org/10.1097/SLA.0000000000001098DOI Listing
August 2015

Oesophageal perforations commentary.

Dig Surg 2013 10;30(1):26-7. Epub 2013 Apr 10.

Department of Surgery, Trinity College Dublin, St James' Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1159/000348671DOI Listing
May 2015

Molecular mechanisms of constitutive and inducible NF-kappaB activation in oesophageal adenocarcinoma.

Eur J Cancer 2015 Mar 14;51(4):464-72. Epub 2015 Jan 14.

Department of Surgery, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049140113
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http://dx.doi.org/10.1016/j.ejca.2014.11.014DOI Listing
March 2015

Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.

Gastroenterology 2015 Feb 5;148(2):367-78. Epub 2014 Nov 5.

University Hospitals Coventry & Warwickshire NHS Trust, Warwickshire, England; Warwick Medical School, University of Warwick, Warwickshire, England. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315134PMC
February 2015

New-onset atrial fibrillation post-surgery for esophageal and junctional cancer: incidence, management, and impact on short- and long-term outcomes.

Ann Surg 2014 Nov;260(5):772-8; discussion 778

From the National Esophageal and Gastric Cancer Center, Trinity College Dublin, and St. James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1097/SLA.0000000000000960DOI Listing
November 2014

The role of inflammation in cancer of the esophagus.

Expert Rev Gastroenterol Hepatol 2014 Sep 23;8(7):749-60. Epub 2014 May 23.

Department of Surgery, Institute of Molecular Medicine, St. James Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1586/17474124.2014.913478DOI Listing
September 2014

Images in clinical medicine. Intermittent facial flushing and diarrhea.

N Engl J Med 2014 Jul;371(3):260

St. James's Hospital, Dublin, Ireland

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http://dx.doi.org/10.1056/NEJMicm1314969DOI Listing
July 2014

Defining a successful esophagectomy.

Ann Surg 2014 May;259(5):e82

Trinity College Dublin, Ireland St James's Hospital Trinity Center for Health Sciences Dublin, Ireland

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http://dx.doi.org/10.1097/SLA.0b013e318248088dDOI Listing
May 2014

Eosinophilic ascites with marked peripheral eosinophilia: a diagnostic challenge.

Eur J Gastroenterol Hepatol 2014 Apr;26(4):478-84

aDepartment of Surgery, Trinity Centre, St James's Hospital and Trinity College bDepartment of Pathology cDepartment of Immunology dDepartment of Gastroenterology, St James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1097/MEG.0000000000000037DOI Listing
April 2014

Could signal transducer and activator of transcription 3 be a therapeutic target in obesity-related gastrointestinal malignancy?

J Gastrointest Cancer 2014 Mar;45(1):1-11

Department of Surgery, Institute of Molecular Medicine, St. James Hospital, Dublin 8, Ireland,

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http://link.springer.com/10.1007/s12029-013-9555-x
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http://dx.doi.org/10.1007/s12029-013-9555-xDOI Listing
March 2014

Identification of potential therapeutic molecular targets preferentially expressed by esophageal cancer cells.

Expert Rev Anticancer Ther 2014 Mar 12;14(3):267-9. Epub 2014 Feb 12.

Department of Histopathology, Waterford Regional Hospital, Waterford, Ireland.

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http://dx.doi.org/10.1586/14737140.2014.889790DOI Listing
March 2014

Severe dysphagia, candidiasis, and an oesophageal mass, but over 50 biopsies negative for malignancy.

Dysphagia 2014 Feb 2;29(1):109-12. Epub 2013 Aug 2.

Department of Surgery, St. James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1007/s00455-013-9483-8DOI Listing
February 2014

The role of obesity in gastrointestinal cancer: evidence and opinion.

Therap Adv Gastroenterol 2014 Jan;7(1):38-50

Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin/ St James' Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1177/1756283X13501786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871278PMC
January 2014

Classification of pathologic response to neoadjuvant therapy in esophageal and junctional cancer: assessment of existing measures and proposal of a novel 3-point standard.

Ann Surg 2013 Nov;258(5):784-92; discussion 792

*Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin, and St James Hospital †Department of Biostatistics, University College Dublin ‡Department of Pathology, St James Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1097/SLA.0b013e3182a66588DOI Listing
November 2013

Spontaneous perforation of the esophagus in a patient with achalasia.

Ann Thorac Surg 2013 Oct;96(4):1456-1457

Department of Surgery, St. James's Hospital and Trinity Center for Health Sciences, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.athoracsur.2013.01.091DOI Listing
October 2013

Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma.

Ann N Y Acad Sci 2013 Oct;1300:187-199

Department of Cellular and Molecular Medicine, Arizona Cancer Center, University of Arizona, Tucson, Arizona.

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http://dx.doi.org/10.1111/nyas.12249DOI Listing
October 2013

Paraneoplastic limbic encephalitis from esophagogastric squamous cell carcinoma successfully managed by radical gastrectomy.

Surgery 2013 Sep 7;154(3):638-40. Epub 2013 Jan 7.

Department of Surgery, St. James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.surg.2012.11.014DOI Listing
September 2013

Appraisal of staging endoscopic ultrasonography in a modern high-volume esophageal program.

World J Surg 2013 Jul;37(7):1666-72

Department of Surgery, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Ireland.

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http://link.springer.com/10.1007/s00268-013-2004-y
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http://dx.doi.org/10.1007/s00268-013-2004-yDOI Listing
July 2013

Severe intractable postprandial chest pain.

JAMA 2013 Jul;310(4):424-7

National Center for Esophageal and Gastric Surgery, St James's Hospital, and Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1001/jama.2013.8567DOI Listing
July 2013

Resolving sclerosing mesenteritis.

Surgery 2013 Jun 7;153(6):879-80. Epub 2012 Jun 7.

Department of Surgery, St. James's Hospital, Dublin, Ireland; Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.surg.2012.03.027DOI Listing
June 2013

Incarcerated thoracic gastric herniation after nephrectomy: a report of two cases.

Case Rep Surg 2013 16;2013:896452. Epub 2013 May 16.

Department of Surgery, St. James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1155/2013/896452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670470PMC
June 2013

Gastric neuroendocrine tumours.

Dig Surg 2012 17;29(4):331-48. Epub 2012 Oct 17.

Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin/St James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1159/000342988DOI Listing
May 2013

Barrett's to oesophageal cancer sequence: a model of inflammatory-driven upper gastrointestinal cancer.

Dig Surg 2012 3;29(3):251-60. Epub 2012 Aug 3.

Department of Surgery, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1159/000341498DOI Listing
March 2013

Establishing computed tomography-defined visceral fat area thresholds for use in obesity-related cancer research.

Nutr Res 2013 Mar 30;33(3):171-9. Epub 2013 Jan 30.

Department of Surgery, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1016/j.nutres.2012.12.007DOI Listing
March 2013

MMP9 expression in oesophageal adenocarcinoma is upregulated with visceral obesity and is associated with poor tumour differentiation.

Mol Carcinog 2013 Feb 28;52(2):144-54. Epub 2011 Nov 28.

Department of Surgery, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1002/mc.21840DOI Listing
February 2013

MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma.

J Mol Med (Berl) 2012 Dec 17;90(12):1449-58. Epub 2012 Jun 17.

Department of Surgery, Trinity College Dublin, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1007/s00109-012-0924-xDOI Listing
December 2012

(18)F-FDG PET-detected synchronous primary neoplasms in the staging of esophageal cancer: incidence, cost, and impact on management.

Clin Nucl Med 2012 Dec;37(12):1152-8

Department of Surgery, St James's Hospital and Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1097/RLU.0b013e31827083baDOI Listing
December 2012

Management of squamous cell cancer of the oesophagus in a patient with a polyglandular endocrinopathy (APECED) and achalasia.

J Gastrointest Surg 2012 Oct 5;16(10):1963-6. Epub 2012 Apr 5.

Department of Surgery, St. James's Hospital, Dublin, and Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1007/s11605-012-1879-5DOI Listing
October 2012

The SGBS cell strain as a model for the in vitro study of obesity and cancer.

Clin Transl Oncol 2012 Oct 2;14(10):774-82. Epub 2012 Aug 2.

Department of Surgery, Trinity Centre for Health Sciences, Institute of Molecular Medicine, St James' Hospital, Trinity College Dublin, Ireland.

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http://dx.doi.org/10.1007/s12094-012-0863-6DOI Listing
October 2012

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.

Authors:
Zhan Su Laura J Gay Amy Strange Claire Palles Gavin Band David C Whiteman Francesco Lescai Cordelia Langford Manoj Nanji Sarah Edkins Anouk van der Winkel David Levine Peter Sasieni Céline Bellenguez Kimberley Howarth Colin Freeman Nigel Trudgill Art T Tucker Matti Pirinen Maikel P Peppelenbosch Luc J W van der Laan Ernst J Kuipers Joost P H Drenth Wilbert H Peters John V Reynolds Dermot P Kelleher Ross McManus Heike Grabsch Hans Prenen Raf Bisschops Kausila Krishnadath Peter D Siersema Jantine W P M van Baal Mark Middleton Russell Petty Richard Gillies Nicola Burch Pradeep Bhandari Stuart Paterson Cathryn Edwards Ian Penman Kishor Vaidya Yeng Ang Iain Murray Praful Patel Weimin Ye Paul Mullins Anna H Wu Nigel C Bird Helen Dallal Nicholas J Shaheen Liam J Murray Konrad Koss Leslie Bernstein Yvonne Romero Laura J Hardie Rui Zhang Helen Winter Douglas A Corley Simon Panter Harvey A Risch Brian J Reid Ian Sargeant Marilie D Gammon Howard Smart Anjan Dhar Hugh McMurtry Haythem Ali Geoffrey Liu Alan G Casson Wong-Ho Chow Matt Rutter Ashref Tawil Danielle Morris Chuka Nwokolo Peter Isaacs Colin Rodgers Krish Ragunath Chris MacDonald Chris Haigh David Monk Gareth Davies Saj Wajed David Johnston Michael Gibbons Sue Cullen Nicholas Church Ruth Langley Michael Griffin Derek Alderson Panos Deloukas Sarah E Hunt Emma Gray Serge Dronov Simon C Potter Avazeh Tashakkori-Ghanbaria Mark Anderson Claire Brooks Jenefer M Blackwell Elvira Bramon Matthew A Brown Juan P Casas Aiden Corvin Audrey Duncanson Hugh S Markus Christopher G Mathew Colin N A Palmer Robert Plomin Anna Rautanen Stephen J Sawcer Richard C Trembath Ananth C Viswanathan Nicholas Wood Gosia Trynka Cisca Wijmenga Jean-Baptiste Cazier Paul Atherfold Anna M Nicholson Nichola L Gellatly Deborah Glancy Sheldon C Cooper David Cunningham Tore Lind Julie Hapeshi David Ferry Barrie Rathbone Julia Brown Sharon Love Stephen Attwood Stuart MacGregor Peter Watson Scott Sanders Weronica Ek Rebecca F Harrison Paul Moayyedi John de Caestecker Hugh Barr Elia Stupka Thomas L Vaughan Leena Peltonen Chris C A Spencer Ian Tomlinson Peter Donnelly Janusz A Z Jankowski

Nat Genet 2012 Oct 9;44(10):1131-6. Epub 2012 Sep 9.

Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://dx.doi.org/10.1038/ng.2408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459818PMC
October 2012

Genes of the interleukin-18 pathway are associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma.

Am J Gastroenterol 2012 Sep 5;107(9):1331-41. Epub 2012 Jun 5.

Department of Surgery, St. James's Hospital and Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1038/ajg.2012.134DOI Listing
September 2012

Evolving progress in oncologic and operative outcomes for esophageal and junctional cancer: lessons from the experience of a high-volume center.

J Thorac Cardiovasc Surg 2012 May 11;143(5):1130-1137.e1. Epub 2012 Jan 11.

Department of Surgery, St James's Hospital and Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.jtcvs.2011.12.003DOI Listing
May 2012

Elevated Tumor Expression of PAI-1 and SNAI2 in Obese Esophageal Adenocarcinoma Patients and Impact on Prognosis.

Clin Transl Gastroenterol 2012 Apr 19;3:e12. Epub 2012 Apr 19.

Department of Surgery, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1038/ctg.2012.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365676PMC
April 2012

Radiation sensitivity of esophageal adenocarcinoma: the contribution of the RNA-binding protein RNPC1 and p21-mediated cell cycle arrest to radioresistance.

Radiat Res 2012 Mar 3;177(3):272-9. Epub 2012 Jan 3.

Department of Surgery, Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St. James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1667/rr2776.1DOI Listing
March 2012

IGF-1 and its receptor in esophageal cancer: association with adenocarcinoma and visceral obesity.

Am J Gastroenterol 2012 Feb 6;107(2):196-204. Epub 2011 Dec 6.

Department of Surgery, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James's Hospital and University of Dublin, Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1038/ajg.2011.417DOI Listing
February 2012

Necrotizing pancreatitis presenting with pneumatosis coli and hepatic portal venous gas.

ANZ J Surg 2011 Jun;81(6):467-8

Department of Clinical Surgery, St James’s Hospital and Trinity College, Dublin, Ireland.

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June 2011