Publications by authors named "John V Heymach"

100Publications

Female Gender Predicts Augmented Immune Infiltration in Lung Adenocarcinoma.

Clin Lung Cancer 2020 Jun 14. Epub 2020 Jun 14.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1016/j.cllc.2020.06.003DOI Listing
June 2020

A Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma.

Oncologist 2020 Jul 1. Epub 2020 Jul 1.

Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1634/theoncologist.2020-0610DOI Listing
July 2020

An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis.

Neoplasia 2020 Aug 13;22(8):294-310. Epub 2020 May 13.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2020.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281309PMC
August 2020

Tepotinib in Non-Small-Cell Lung Cancer with Exon 14 Skipping Mutations.

N Engl J Med 2020 09 29;383(10):931-943. Epub 2020 May 29.

From Memorial Sloan Kettering Cancer Center, New York (P.K.P.); the Oncology Department, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (E.F.), and Dr. Rosell Oncology Institute, Dexeus University Hospital, Quirónsalud Group (S.V.), Barcelona; Centre Hospitaliere Universitaire (CHU) Bordeaux, Service des Maladies Respiratoires, Bordeaux (R.V.), Université de Lille, CHU Lille, Thoracic Oncology Department, Centre National de la Recherche Scientifique, INSERM, Institut Pasteur de Lille, UMR9020-UMR-S 1277-Canther, Lille (A.B.C.), CHU de Toulouse, Institut Universitaire du Cancer de Toulouse, Université Paul Sabatier, Toulouse (J.M.), and Institut de Cancérologie de l'Ouest Rene Gauducheau Centre, Saint-Herblain (H. Senellart) - all in France; Saitama Cancer Center, Saitama (H. Sakai), and the Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama (T.K.) - both in Japan; the Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan (M.C.G.), and the Department of Surgery, Oncology and Gastroenterology, University of Padua and Oncologia Medica 2, Istituto Oncologico Veneto, IRCCS, Padua (P.C.) - both in Italy; Antwerp University Hospital, Edegem, Belgium (J.V.M., J.R.); Asklepios Lung Clinic, Munich-Gauting (N.R.), Pius Hospital Oldenburg, University Medicine Oldenburg, Oldenburg (F.G.), Translational Medicine, Department of Bioinformatics (D.J.), Translational Innovation Platform, Oncology (C.S.), the Department of Biostatistics (R.B.), Translational Medicine, Department of Clinical Biomarkers and Companion Diagnostics (J. Straub), and Global Clinical Development (A.J., J. Scheele), Merck, Darmstadt - all in Germany; the Department of Lung Cancer and Thoracic Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland (D.K.); Yonsei Cancer Center, Yonsei University College of Medicine, Seoul (B.C.C.), the Center for Lung Cancer, National Cancer Center, Goyang (J.-Y.H.), and Chonnam National University Medical School and Hwasun Hospital, Hwasun (Y.-C.K.) - all in South Korea; Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (J.D.P.); the Department of Medicine, Vanderbilt Ingram Cancer Center, Nashville (L.H.); the Faculty of Medicine, School of Medicine, National Yang-Ming University (G.-C.C.), the Division of Chest Medicine, Department of Internal Medicine, Tri-service General Hospital, National Defense Medical Center (C.-L.T.), National Taiwan University Hospital (J.C.-H.Y.), and the Department of Chest Medicine, Taipei Veterans General Hospital, and School of Medicine, National Yang-Ming University (Y.-M.C.), Taipei, and the Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung (G.-C.C.) - both in Taiwan; the Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam (E.F.S.), and the Department of Pulmonology, University of Groningen and University Medical Center Groningen, Groningen (A.J.W.) - both in the Netherlands; and M.D. Anderson Cancer Center, University of Texas, Houston (J.V.H., X.L.).

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http://dx.doi.org/10.1056/NEJMoa2004407DOI Listing
September 2020

Phase I/II Trial of Immunotherapy With Durvalumab and Tremelimumab With Continuous or Intermittent MEK Inhibitor Selumetinib in NSCLC: Early Trial Report.

Clin Lung Cancer 2020 Jul 4;21(4):384-388. Epub 2020 Mar 4.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2020.02.019DOI Listing
July 2020

Definitive Management of Presumed Synchronous Early Stage Non-Small Cell Lung Cancers: Outcomes and Utility of Stereotactic Ablative Radiation Therapy.

Int J Radiat Oncol Biol Phys 2020 Jun 7;107(2):261-269. Epub 2020 Feb 7.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2020.02.001DOI Listing
June 2020

β-Adrenergic Signaling in Lung Cancer: A Potential Role for Beta-Blockers.

J Neuroimmune Pharmacol 2020 03 11;15(1):27-36. Epub 2019 Dec 11.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s11481-019-09891-wDOI Listing
March 2020

Immune and Circulating Tumor DNA Profiling After Radiation Treatment for Oligometastatic Non-Small Cell Lung Cancer: Translational Correlatives from a Mature Randomized Phase II Trial.

Int J Radiat Oncol Biol Phys 2020 02 31;106(2):349-357. Epub 2019 Oct 31.

Department of Genomic Medicine, MD Anderson Cancer Center, Houston, Texas; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2019.10.038DOI Listing
February 2020

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.

Mol Cell 2019 12 26;76(5):838-851.e5. Epub 2019 Sep 26.

Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.08.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898782PMC
December 2019

Improved Overall Survival With Comprehensive Local Consolidative Therapy in Synchronous Oligometastatic Non-Small-Cell Lung Cancer.

Clin Lung Cancer 2020 01 1;21(1):37-46.e7. Epub 2019 Aug 1.

Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2019.07.007DOI Listing
January 2020

Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy.

Nat Rev Cancer 2019 09 12;19(9):495-509. Epub 2019 Aug 12.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41568-019-0179-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043073PMC
September 2019

miR-125a-5p Functions as Tumor Suppressor microRNA And Is a Marker of Locoregional Recurrence And Poor prognosis in Head And Neck Cancer.

Neoplasia 2019 09 18;21(9):849-862. Epub 2019 Jul 18.

Department of Radiation Oncology, Division of Molecular Radiation Biology, UT Southwestern Medical Center, Dallas, TX 75390. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2019.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642270PMC
September 2019

Impact of Corticosteroid Administration on Outcomes Following Stereotactic Ablative Radiotherapy for Non-small-cell Lung Cancer.

Clin Lung Cancer 2019 07 15;20(4):e480-e488. Epub 2019 Mar 15.

Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2019.03.001DOI Listing
July 2019

Stereotactic ablative body radiation for oligometastatic and oligoprogressive disease.

Transl Lung Cancer Res 2019 Feb;8(1):97-106

Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.21037/tlcr.2018.09.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351406PMC
February 2019

Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer.

J Transl Med 2018 11 26;16(1):328. Epub 2018 Nov 26.

Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s12967-018-1704-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260563PMC
November 2018

Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers.

Clin Cancer Res 2019 01 26;25(1):346-357. Epub 2018 Sep 26.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320267PMC
January 2019

Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer.

J Clin Oncol 2018 08 15;36(23):2386-2394. Epub 2018 Jun 15.

M. Catherine Pietanza, Lee M. Krug, Mark G. Kris, and Charles M. Rudin, Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College; Kaitlin M. Woo, Yevgeniva Bensman, Brenda Hurtado, and Martin Fleisher, Memorial Sloan Kettering Cancer Center, New York, NY; Saiama N. Waqar, Washington University School of Medicine in St. Louis, St Louis, MO; Afshin Dowlati, Case Western Reserve University and University Hospitals Seidman Cancer Center, Cleveland, OH; Christine L. Hann, Johns Hopkins University, Baltimore; Alice Chen, National Institutes of Health, Bethesda, MD; Alberto Chiappori, H. Lee Moffitt Cancer Center, Tampa, FL; Taofeek K. Owonikoko, Emory University, Atlanta, GA; and Robert J. Cardnell, Junya Fujimoto, Lihong Long, Lixia Diao, Jing Wang, Patricia de Groot, Erik P. Sulman, Ignacio I. Wistuba, John V. Heymach, and Lauren Averett Byers, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2018.77.7672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085179PMC
August 2018

Mutations and PD-1 Inhibitor Resistance in -Mutant Lung Adenocarcinoma.

Cancer Discov 2018 07 17;8(7):822-835. Epub 2018 May 17.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030433PMC
July 2018

Antitumor activity of CD56-chimeric antigen receptor T cells in neuroblastoma and SCLC models.

Oncogene 2018 07 6;37(27):3686-3697. Epub 2018 Apr 6.

Thoracic Head and Neck Medical Oncology, UT MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41388-018-0187-2DOI Listing
July 2018

Prognostic Value of PD-L1 mRNA Sequencing Expression Profile in Non-Small Cell Lung Cancer.

Ann Thorac Surg 2018 06 3;105(6):1621-1626. Epub 2018 Mar 3.

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1016/j.athoracsur.2018.01.081DOI Listing
June 2018

Bayesian Adaptive Randomization Trial of Passive Scattering Proton Therapy and Intensity-Modulated Photon Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer.

J Clin Oncol 2018 06 2;36(18):1813-1822. Epub 2018 Jan 2.

Zhongxing Liao, J. Jack Lee, Ritsuko Komaki, Daniel R. Gomez, Michael S. O'Reilly, Frank V. Fossella, George R. Blumenschein Jr, John V. Heymach, Ara A. Vaporciyan, Stephen G. Swisher, Pamela K. Allen, Stephen M. Hahn, James D. Cox, Charles S. Lu, and Radhe Mohan, The University of Texas MD Anderson Cancer Center, Houston, TX; and Noah Chan Choi and Thomas F. DeLaney, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://ascopubs.org/doi/10.1200/JCO.2017.74.0720
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http://dx.doi.org/10.1200/JCO.2017.74.0720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008104PMC
June 2018

Induction Cisplatin Docetaxel Followed by Surgery and Erlotinib in Non-Small Cell Lung Cancer.

Ann Thorac Surg 2018 Feb 6;105(2):418-424. Epub 2017 Dec 6.

Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2017.08.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783769PMC
February 2018

Response rates to single-agent chemotherapy after exposure to immune checkpoint inhibitors in advanced non-small cell lung cancer.

Lung Cancer 2017 10 3;112:90-95. Epub 2017 Aug 3.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 432, Houston, TX, 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.07.034DOI Listing
October 2017

Circulating metabolite profiles to predict overall survival in advanced non-small cell lung cancer patients receiving first-line chemotherapy.

Lung Cancer 2017 12 2;114:70-78. Epub 2017 Nov 2.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1016/j.lungcan.2017.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715727PMC
December 2017

Taking it up a NOTCH: a novel subgroup of ACC is identified.

Oncotarget 2017 Oct 14;8(47):81725-81726. Epub 2017 Sep 14.

Renata Ferrarotto: Thoracic and Head and Neck Medical Oncology Department, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.20879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669839PMC
October 2017

BAP1 Is a Novel Target in HPV-Negative Head and Neck Cancer.

Clin Cancer Res 2018 02 7;24(3):600-607. Epub 2017 Nov 7.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446178PMC
February 2018

RAD50 Expression Is Associated with Poor Clinical Outcomes after Radiotherapy for Resected Non-small Cell Lung Cancer.

Clin Cancer Res 2018 01 13;24(2):341-350. Epub 2017 Oct 13.

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1455DOI Listing
January 2018

PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions.

Cancer Prev Res (Phila) 2017 Dec 10;10(12):684-693. Epub 2017 Oct 10.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://cancerpreventionresearch.aacrjournals.org/lookup/doi/
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http://dx.doi.org/10.1158/1940-6207.CAPR-17-0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716880PMC
December 2017

Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer.

J Am Soc Mass Spectrom 2017 10 27;28(10):2078-2089. Epub 2017 Jul 27.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1007/s13361-017-1706-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693617PMC
October 2017

Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer.

Clin Cancer Res 2017 Oct 11;23(20):6239-6253. Epub 2017 Jul 11.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882197PMC
October 2017