Publications by authors named "John T Chang"

78Publications

Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population.

Proc Natl Acad Sci U S A 2020 Oct 25;117(41):25667-25678. Epub 2020 Sep 25.

Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093;

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http://dx.doi.org/10.1073/pnas.2008571117DOI Listing
October 2020

Should We Divide Crohn's Disease Into Ileum-Dominant and Isolated Colonic Diseases?

Clin Gastroenterol Hepatol 2019 12 19;17(13):2634-2643. Epub 2019 Apr 19.

Division of Gastroenterology, University of California San Diego, La Jolla, California.

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http://dx.doi.org/10.1016/j.cgh.2019.04.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885453PMC
December 2019

USP11 Enhances TGFβ-Induced Epithelial-Mesenchymal Plasticity and Human Breast Cancer Metastasis.

Mol Cancer Res 2018 07 3;16(7):1172-1184. Epub 2018 May 3.

Department of Medicine, University of California San Diego, La Jolla, California.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030438PMC
July 2018

Hyperbaric oxygen therapy is well tolerated and effective for ulcerative colitis patients hospitalized for moderate-severe flares: a phase 2A pilot multi-center, randomized, double-blind, sham-controlled trial.

Am J Gastroenterol 2018 10 16;113(10):1516-1523. Epub 2018 Feb 16.

University of California at San Diego, La Jolla, CA, USA. Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. Mayo Clinic, Rochester, MN, USA. University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1038/s41395-018-0005-zDOI Listing
October 2018

Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool.

J Immunol 2017 06 17;198(12):4639-4651. Epub 2017 May 17.

Department of Medicine, University of California San Diego, La Jolla, CA 92093;

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http://dx.doi.org/10.4049/jimmunol.1601165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507362PMC
June 2017

The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation.

J Immunol 2016 05 30;196(10):4237-45. Epub 2016 Mar 30.

Department of Medicine, University of California San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.4049/jimmunol.1502410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868634PMC
May 2016

Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates.

Sci Rep 2016 Jan 14;6:19182. Epub 2016 Jan 14.

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1038/srep19182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725917PMC
January 2016

Ubiquitylation of CD98 limits cell proliferation and clonal expansion.

J Cell Sci 2015 Dec 22;128(23):4273-8. Epub 2015 Oct 22.

Department of Medicine, University of California San Diego, La Jolla, CA 92093-0726, USA

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http://dx.doi.org/10.1242/jcs.178129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712820PMC
December 2015

Asymmetric Cell Division in T Lymphocyte Fate Diversification.

Trends Immunol 2015 Nov 20;36(11):670-683. Epub 2015 Oct 20.

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714906150022
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http://dx.doi.org/10.1016/j.it.2015.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640954PMC
November 2015

Reply to: "CD8(+) T cell diversification by asymmetric cell division".

Nat Immunol 2015 Sep;16(9):893-4

Department of Medicine, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/ni.3234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758127PMC
September 2015

A gp130-Src-YAP module links inflammation to epithelial regeneration.

Nature 2015 Mar 25;519(7541):57-62. Epub 2015 Feb 25.

1] Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, La Jolla, California 92093, USA [2] Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, California 92093, USA [3] Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nature14228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447318PMC
March 2015

Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease.

Inflamm Bowel Dis 2015 Feb;21(2):323-30

*Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, California; †San Diego Digestive Disease Research Center, University of California San Diego, La Jolla, California; ‡Department of Medicine, Division of Gastroenterology, University of California San Diego, La Jolla, California; §Clinical and Translational Research Institute, University of California San Diego, La Jolla, California; ‖Department of Medicine, Division of Rheumatology, University of California San Diego, La Jolla, California; ¶Department of Pathology, University of California San Diego, La Jolla, California; **Division of Gastroenterology & Hepatology, Kaiser Permanente, San Diego, California; and ††Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.

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http://dx.doi.org/10.1097/MIB.0000000000000264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404151PMC
February 2015

Molecular regulation of effector and memory T cell differentiation.

Nat Immunol 2014 Dec;15(12):1104-15

Division of Biological Sciences, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/ni.3031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386685PMC
December 2014

Algal chloroplast produced camelid VH H antitoxins are capable of neutralizing botulinum neurotoxin.

Plant Biotechnol J 2015 Jan 17;13(1):117-24. Epub 2014 Sep 17.

Division of Biological Sciences, The California Center for Algae Biotechnology, UC-San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/pbi.12244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620920PMC
January 2015

Update on Janus kinase antagonists in inflammatory bowel disease.

Gastroenterol Clin North Am 2014 Sep 24;43(3):603-17. Epub 2014 Jun 24.

Division of Gastroenterology, Department of Medicine, Inflammatory Bowel Disease Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Digestive Diseases Research Development Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://ac.els-cdn.com/S0889855314000685/1-s2.0-S088985531400
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http://dx.doi.org/10.1016/j.gtc.2014.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129380PMC
September 2014

Studies in human intestinal tissues: is it time to reemphasize research in human immunology?

Gastroenterology 2014 Jul 27;147(1):26-30. Epub 2014 May 27.

Department of Pathology, Division of Comparative Pathology and Medicine, University of California, San Diego, California.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085140067
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http://dx.doi.org/10.1053/j.gastro.2014.05.025DOI Listing
July 2014

Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays.

PLoS One 2014 14;9(3):e91926. Epub 2014 Mar 14.

School of Interdisciplinary Bioscience and Bioengineering (I-Bio), Pohang University of Science and Technology (POSTECH), Pohang, Korea; Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091926PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954838PMC
November 2014

Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses.

Nat Immunol 2014 Apr 2;15(4):365-372. Epub 2014 Mar 2.

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1038/ni.2842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968536PMC
April 2014

Endoscopic retrieval of ingested nails using a refrigerator magnet.

Clin Gastroenterol Hepatol 2013 Sep 16;11(9):A24. Epub 2013 Jan 16.

Division of Gastroenterology, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1016/j.cgh.2012.12.023DOI Listing
September 2013

Strategies for the care of adults hospitalized for active ulcerative colitis.

Clin Gastroenterol Hepatol 2012 Dec 24;10(12):1315-1325.e4. Epub 2012 Jul 24.

Inflammatory Bowel Disease Center, Division of Gastroenterology, University of California San Diego Health System, La Jolla, CA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15423565120083
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http://dx.doi.org/10.1016/j.cgh.2012.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226798PMC
December 2012

Polarity and lymphocyte fate determination.

Authors:
John T Chang

Curr Opin Cell Biol 2012 Aug 2;24(4):526-33. Epub 2012 Jun 2.

Department of Medicine, University of California San Diego, La Jolla, CA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09550674120006
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http://dx.doi.org/10.1016/j.ceb.2012.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425726PMC
August 2012

Cutting edge: Asymmetric memory T cell division in response to rechallenge.

J Immunol 2012 May 30;188(9):4145-8. Epub 2012 Mar 30.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1200176
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http://dx.doi.org/10.4049/jimmunol.1200176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331961PMC
May 2012

Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity.

J Immunol 2011 Jul 13;187(2):851-60. Epub 2011 Jun 13.

Department of Medicine, University of California San Diego, La Jolla, CA 92093-0726, USA.

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http://dx.doi.org/10.4049/jimmunol.1100002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131465PMC
July 2011

An update on assessing development in the pediatric office: has anything changed after two policy statements?

Acad Pediatr 2010 Nov-Dec;10(6):400-4

UCLA Center for Healthier Children, Families and Communities, Los Angeles, Calif 90024, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S187628591000224
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http://dx.doi.org/10.1016/j.acap.2010.08.008DOI Listing
March 2011

The effectiveness of radioactive iodine for treatment of low-risk thyroid cancer: a systematic analysis of the peer-reviewed literature from 1966 to April 2008.

Thyroid 2010 Nov;20(11):1235-45

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90403, USA.

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http://dx.doi.org/10.1089/thy.2009.0455DOI Listing
November 2010

Relationship between organizational factors and performance among pay-for-performance hospitals.

J Gen Intern Med 2009 Jul 5;24(7):833-40. Epub 2009 May 5.

Zynx Health, 10880 Wilshire Blvd., Los Angeles, CA 90024, USA.

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http://dx.doi.org/10.1007/s11606-009-0997-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695536PMC
July 2009

Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation.

J Immunol 2009 Apr;182(8):4686-95

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.4049/jimmunol.0803180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922395PMC
April 2009

Specifying helper T cell fates during immunity.

J Pediatr Gastroenterol Nutr 2008 Apr;46 Suppl 1:E19-20

University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1097/01.mpg.0000313832.47207.0eDOI Listing
April 2008

Protection one cell thick.

Immunity 2007 Dec;27(6):832-4

Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.immuni.2007.11.009DOI Listing
December 2007

Quality indicators for falls and mobility problems in vulnerable elders.

J Am Geriatr Soc 2007 Oct;55 Suppl 2:S327-34

Division of General Internal Medicine and Health Services Research, and Speciality Training and Advanced Research Program, University of California at Lost Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1111/j.1532-5415.2007.01339.xDOI Listing
October 2007

Asymmetric T lymphocyte division in the initiation of adaptive immune responses.

Science 2007 Mar 1;315(5819):1687-91. Epub 2007 Mar 1.

Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/science.1139393DOI Listing
March 2007

The effect of a quality improvement initiative on the quality of other aspects of health care: the law of unintended consequences?

Med Care 2007 Jan;45(1):8-18

Veterans Affairs Greater Los Angeles Health Care System, David Geffen School of Medicine at UCLA, Los Angeles, California 90024, USA.

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http://dx.doi.org/10.1097/01.mlr.0000241115.31531.15DOI Listing
January 2007

Patients' global ratings of their health care are not associated with the technical quality of their care.

Ann Intern Med 2006 May;144(9):665-72

the David Geffen School of Medicine at UCLA and Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California; RAND Health, Santa Monica, California; and RAND Health, Arlington, Virginia.

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http://dx.doi.org/10.7326/0003-4819-144-9-200605020-00010DOI Listing
May 2006

Quality of osteoarthritis care for community-dwelling older adults.

Arthritis Rheum 2006 Apr;55(2):241-7

Robert Wood Johnson Clinical Scholars Program, V.A. Greater Los Angeles Health Care System, STAR Program, University of California-Los Angeles, 911 Broxton Plaza 3rd Floor, Los Angeles, CA 90024, USA.

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http://dx.doi.org/10.1002/art.21844DOI Listing
April 2006

Drug insight: antagonists of tumor-necrosis factor-alpha in the treatment of inflammatory bowel disease.

Nat Clin Pract Gastroenterol Hepatol 2006 Apr;3(4):220-8

Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104-4283, USA.

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http://www.nature.com/doifinder/10.1038/ncpgasthep0447
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http://dx.doi.org/10.1038/ncpgasthep0447DOI Listing
April 2006

Predictors of overall quality of care provided to vulnerable older people.

J Am Geriatr Soc 2005 Oct;53(10):1705-11

Division of Geriatrics, University of California at Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1111/j.1532-5415.2005.53520.xDOI Listing
October 2005

A non-lensed fiber-optic resonance-enhanced multiphoton ionization probe.

Appl Spectrosc 2004 Sep;58(9):1038-43

University of South Carolina, Columbia, South Carolina 29208, USA.

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http://dx.doi.org/10.1366/0003702041959479DOI Listing
September 2004

Gastroesophageal reflux disease, Barrett esophagus, and esophageal adenocarcinoma.

Arch Intern Med 2004 Jul;164(14):1482-8

Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1001/archinte.164.14.1482DOI Listing
July 2004

The quality of pharmacologic care for vulnerable older patients.

Ann Intern Med 2004 May;140(9):714-20

Division of General Internal Medicine, University of California, Los Angeles, and the Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.7326/0003-4819-140-9-200405040-00011DOI Listing
May 2004

The quality of medical care provided to vulnerable older patients with chronic pain.

J Am Geriatr Soc 2004 May;52(5):756-61

Greater Los Angeles VA Healthcare System, Los Angeles, California, USA.

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http://dx.doi.org/10.1111/j.1532-5415.2004.52214.xDOI Listing
May 2004

Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials.

BMJ 2004 Mar;328(7441):680

Department of Medicine, Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California at Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1136/bmj.328.7441.680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC381224PMC
March 2004

Are high-volume surgeons and hospitals the most important predictors of in-hospital outcome for colon cancer resection?

Surgery 2002 Aug;132(2):268-73

Department of Surgery, UCLA School of Medicine and Public Health, 90095, USA.

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http://dx.doi.org/10.1067/msy.2002.125721DOI Listing
August 2002

Reporting randomized, controlled trials: where quality of reporting may be improved.

Dis Colon Rectum 2002 Apr;45(4):443-7

Department of Medicine, UCLA School of Medicine and Public Health, Los Angeles, California 90095-6904, USA.

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http://dx.doi.org/10.1007/s10350-004-6217-xDOI Listing
April 2002