Publications by authors named "John Silke"

100Publications

Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo.

Viruses 2020 08 17;12(8). Epub 2020 Aug 17.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia.

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August 2020

Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease.

Nat Rev Rheumatol 2020 09 8;16(9):496-513. Epub 2020 Jul 8.

The Walter and Eliza Hall Institute for Medical Research, Parkville, Melbourne, Victoria, Australia.

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September 2020

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling.

F1000Res 2020 29;9. Epub 2020 Jun 29.

The Walter and Eliza Hall Institute, IG Royal Parade, Parkville, Victoria, 3052, Australia.

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October 2020

Loss of NF-kB1 and c-Rel accelerates oral carcinogenesis in mice.

Oral Dis 2021 Mar 9;27(2):168-172. Epub 2020 Jul 9.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic., Australia.

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March 2021

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection.

Cell Rep 2020 03;30(13):4343-4354.e4

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. Electronic address:

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March 2020

Future Therapeutic Directions for Smac-Mimetics.

Cells 2020 02 11;9(2). Epub 2020 Feb 11.

Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia.

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February 2020

Targeting XIAP and PPARγ in Granulosa Cell Tumors Alters Metabolic Signaling.

J Proteome Res 2019 04 4;18(4):1691-1702. Epub 2019 Mar 4.

Department of Molecular and Translational Science , Hudson Institute of Medical Research and the Monash University , Clayton , Victoria 3168 , Australia.

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April 2019

Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors.

Mol Cancer Ther 2019 02 7;18(2):364-375. Epub 2018 Dec 7.

Hudson Institute of Medical Research and the Monash University Department of Molecular and Translational Science, Clayton, Victoria, Australia.

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February 2019

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development.

Cell Death Differ 2019 05 5;26(5):877-889. Epub 2018 Sep 5.

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3050, Australia.

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May 2019

Methods for Studying TNF-Mediated Necroptosis in Cultured Cells.

Methods Mol Biol 2018 ;1857:53-61

Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

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May 2019

The Walrus and the Carpenter: Complex Regulation of Tumor Immunity in Colorectal Cancer.

Cell 2018 06;174(1):14-16

Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia. Electronic address:

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June 2018

IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans.

Cell Rep 2018 02;22(6):1496-1508

Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia. Electronic address:

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February 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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March 2018

The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues.

Cell Rep 2017 Sep 7;20(12):2906-2920. Epub 2017 Sep 7.

Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia; The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia. Electronic address:

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September 2017

PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF.

Cell Death Differ 2017 10 30;24(10):1705-1716. Epub 2017 Jun 30.

Immune Defence Laboratory, Cancer Immunology Division, The Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.

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October 2017

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation.

J Invest Dermatol 2017 11 22;137(11):2371-2379. Epub 2017 Jun 22.

The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. Electronic address:

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November 2017

The small molecule that packs a punch: ubiquitin-mediated regulation of RIPK1/FADD/caspase-8 complexes.

Cell Death Differ 2017 07 2;24(7):1196-1204. Epub 2017 Jun 2.

Division of Inflammation, Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia.

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July 2017

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.

Mol Cell 2017 Jun 11;66(5):698-710.e5. Epub 2017 May 11.

Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK. Electronic address:

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June 2017

In vivo validation of a novel algorithm for automatic premature ventricular contractions recognition.

J Cardiovasc Electrophysiol 2017 Jul 29;28(7):828-833. Epub 2017 May 29.

Department of Electrophysiology, Heart Center Leipzig, Leipzig, Germany.

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July 2017

Engineered Exosomes as Vehicles for Biologically Active Proteins.

Mol Ther 2017 06 13;25(6):1269-1278. Epub 2017 Apr 13.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address:

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June 2017

Jekyll & Hyde: The Other Life of the Death Ligand TRAIL.

Mol Cell 2017 Feb;65(4):585-587

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia. Electronic address:

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February 2017

IAPs and Cell Death.

Curr Top Microbiol Immunol 2017;403:95-117

Department of Medical Biology, University of Melbourne, Melbourne, Australia.

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July 2017

'Did He Who Made the Lamb Make Thee?' New Developments in Treating the 'Fearful Symmetry' of Acute Myeloid Leukemia.

Trends Mol Med 2017 03 11;23(3):264-281. Epub 2017 Feb 11.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Australia. Electronic address:

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March 2017

Sinus node modification with an ultra high-density electroanatomical mapping system in inappropriate sinus tachycardia.

Europace 2017 10;19(10):1656

Department of Electrophysiology, HELIOS Klinikum, Heart Centre Leipzig, Germany, Strümpelstraße 39, 04289 Leipzig.

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October 2017

In the Midst of Life-Cell Death: What Is It, What Is It Good for, and How to Study It.

Cold Spring Harb Protoc 2016 12 1;2016(12). Epub 2016 Dec 1.

Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia.

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December 2016

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.

Immunity 2016 09 11;45(3):513-526. Epub 2016 Aug 11.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia. Electronic address:

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September 2016

Long-term adherence to dronedarone in patients with atrial arrhythmias.

Int J Cardiol 2016 Nov 3;222:676-677. Epub 2016 Aug 3.

Department of Electrophysiology, Heart Center Leipzig, Germany.

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November 2016

SPATA2 - Keeping the TNF signal short and sweet.

EMBO J 2016 09 28;35(17):1848-50. Epub 2016 Jul 28.

The Walter and Eliza Hall Institute, Melbourne, Vic., Australia.

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September 2016

Killing Lymphoma with Smac-Mimetics: As Easy as ABC?

Cancer Cell 2016 Apr;29(4):425-427

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.

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April 2016

The intersection of cell death and inflammasome activation.

Cell Mol Life Sci 2016 06 11;73(11-12):2349-67. Epub 2016 Apr 11.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.

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June 2016

The importance of being chaperoned: HSP90 and necroptosis.

Cell Chem Biol 2016 Feb;23(2):205-207

The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Australia. Electronic address:

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February 2016

Initial Experience With Ultra High-Density Mapping of Human Right Atria.

J Cardiovasc Electrophysiol 2016 Feb 23;27(2):154-60. Epub 2015 Nov 23.

Department of Electrophysiology, Heart Center, Leipzig, Leipzig, Germany.

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February 2016

Response to Heard et al.

EMBO J 2015 Oct;34(19):2396-7

The Walter and Eliza Hall Institute, Parkville, Vic., Australia Department of Medical Biology, The University of Melbourne, Parkville, Vic., Australia.

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October 2015

Effect of Immunosuppressive Agents on Hepatocyte Apoptosis Post-Liver Transplantation.

PLoS One 2015 21;10(9):e0138522. Epub 2015 Sep 21.

Department of Medicine, The University of Melbourne, Austin Hospital, Heidelberg, VIC, Australia; Department of Infectious Diseases, Austin Hospital, Heidelberg, VIC, Australia; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia.

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May 2016

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.

Biochem J 2015 Oct 17;471(2):255-65. Epub 2015 Aug 17.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia

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October 2015

The diverse role of RIP kinases in necroptosis and inflammation.

Nat Immunol 2015 Jul;16(7):689-97

Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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July 2015

Fight or flight: regulation of emergency hematopoiesis by pyroptosis and necroptosis.

Curr Opin Hematol 2015 Jul;22(4):293-301

aDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA bThe Walter and Eliza Hall Institute of Medical Research cDepartment of Medical Biology, University of Melbourne, Parkville, Victoria, Australia dDepartment of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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July 2015

Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis.

Proc Natl Acad Sci U S A 2015 May 20;112(18):5803-8. Epub 2015 Apr 20.

Division of Infection and Immunity and Cell Signaling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia;

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May 2015

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus.

Proc Natl Acad Sci U S A 2015 May 20;112(18):5797-802. Epub 2015 Apr 20.

Division of Infection and Immunity and Cell Signaling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia;

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May 2015

First Case of Automatic His Potential Detection With a Novel Ultra High-density Electroanatomical Mapping System for AV Nodal Ablation.

Indian Pacing Electrophysiol J 2015 Jan-Feb;15(1):79-81. Epub 2015 Apr 1.

Department of Electrophysiology, Heart Center, Leipzig, Leipzig, Germany.

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April 2015

An integrative approach to slow pathway modulation in AVNRT using a novel ultra high-density electroanatomical mapping system.

Clin Res Cardiol 2015 Aug 31;104(8):697-9. Epub 2015 Mar 31.

Department of Electrophysiology, Heart Center, Strümpellstr. 39, 04289, Leipzig, Germany,

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August 2015

Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity.

J Mol Cell Biol 2015 Apr 23;7(2):119-31. Epub 2015 Mar 23.

Brain Development and Regeneration Division, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia

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April 2015

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.

Nat Commun 2015 Feb 18;6:6282. Epub 2015 Feb 18.

1] Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia [2] Department of Medical Biology, the University of Melbourne, Parkville, Victoria 3050, Australia.

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February 2015

Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.

J Biol Chem 2015 Mar 28;290(11):7141-50. Epub 2015 Jan 28.

From the Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, 3010 Victoria, Australia,

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March 2015

A guide to the porcine anatomy for the interventional electrophysiologist. Fluoroscopy and high density electroanatomical mapping.

J Cardiovasc Transl Res 2015 Feb 29;8(1):67-75. Epub 2015 Jan 29.

Department of Electrophysiology, Heart Center Leipzig, Strümpellstr. 39, 04289, Leipzig, Germany,

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February 2015

IAP gene deletion and conditional knockout models.

Semin Cell Dev Biol 2015 Mar 26;39:97-105. Epub 2014 Dec 26.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia. Electronic address:

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March 2015

Ivabradine for rate control in atrial fibrillation.

Int J Cardiol 2015 Jan 22;179:27-8. Epub 2014 Oct 22.

Department of Electrophysiology, Heart Center Leipzig, Leipzig, Germany.

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January 2015

Insights from preclinical ultra high-density electroanatomical sinus node mapping.

Europace 2015 Mar 27;17(3):489-94. Epub 2014 Oct 27.

Department of Electrophysiology, Heart Center, Leipzig, Strümpellstr. 39, Leipzig 04289, Germany.

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March 2015

HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death.

Cell Rep 2014 Oct 2;9(1):153-165. Epub 2014 Oct 2.

Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK. Electronic address:

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October 2014

IAP family of cell death and signaling regulators.

Methods Enzymol 2014 ;545:35-65

Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, California, USA. Electronic address:

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March 2015

Hepatitis C virus-induced hepatocyte cell death and protection by inhibition of apoptosis.

J Gen Virol 2014 Oct 27;95(Pt 10):2204-2215. Epub 2014 Jun 27.

Department Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia.

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October 2014

The polycomb repressive complex 2 governs life and death of peripheral T cells.

Blood 2014 Jul 20;124(5):737-49. Epub 2014 Jun 20.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia; and.

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July 2014