John Semple

John Semple

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Transfusion-related Acute Lung Injury in the Perioperative Patient.

Anesthesiology 2019 Sep;131(3):693-715

From the Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Canada (M.J.M., J.W.S., W.M.K) Departments of Physiology and Anesthesia (M.J.M.) Pharmacology (J.W.S.) Laboratory Medicine-Pathobiology (C.C.-G.) Medicine-Division of Hematology (C.C.-G.) Anesthesia and Pain Management, University Health Network (K.K.) Physiology and Surgery (W.M.K.) University of Toronto, Toronto, Canada (C.C.-G.) Sickkids Department of Anesthesia and Pain Medicine (M.J.M.) Division of Hematology and Transfusion Medicine (R.K., J.W.S.), Lund University, Lund, Sweden Department of Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands (R.K.) Departments of Laboratory Hematology (Blood Transfusion Laboratory), Laboratory Medicine Program (C.C.-G.) Medical Oncology and Hematology (C.C.-G.) University Health Network, Toronto, Canada (K.K.) Department of Clinical Pathology, Blood and Tissue Bank, Sunnybrook Health Sciences Centre, Toronto, Canada (C.C.-G.) Institute of Physiology, Charité University Berlin, Berlin, Germany (W.M.K.).

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http://dx.doi.org/10.1097/ALN.0000000000002687DOI Listing
September 2019

Implementing Mobile Health Interventions to Capture Post-Operative Patient-Generated Health Data.

Surg Infect (Larchmt) 2019 Aug 20. Epub 2019 Aug 20.

4Department of Surgery, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1089/sur.2019.151DOI Listing
August 2019

Engaging Patients in Co-Design of Mobile Health Tools for Surgical Site Infection Surveillance: Implications for Research and Implementation.

Surg Infect (Larchmt) 2019 Aug 20. Epub 2019 Aug 20.

4Department of Surgery, Medical University of South Carolina, Charleston, South Carolina.

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http://dx.doi.org/10.1089/sur.2019.148DOI Listing
August 2019

Osteopontin mediates murine transfusion-related acute lung injury via stimulation of pulmonary neutrophil accumulation.

Blood 2019 Jul 10;134(1):74-84. Epub 2019 May 10.

Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine and.

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http://dx.doi.org/10.1182/blood.2019000972DOI Listing
July 2019

Transfusion-associated circulatory overload and transfusion-related acute lung injury.

Blood 2019 Apr 26;133(17):1840-1853. Epub 2019 Feb 26.

Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-10
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http://dx.doi.org/10.1182/blood-2018-10-860809DOI Listing
April 2019

The Ultimate Murine Model of Immune Thrombocytopaenia.

Thromb Haemost 2019 Mar 6;119(3):353-354. Epub 2019 Feb 6.

Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678697
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http://dx.doi.org/10.1055/s-0039-1678697DOI Listing
March 2019

A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP).

Br J Haematol 2018 11 19;183(3):501-503. Epub 2017 Oct 19.

Division of Haematology and Transfusion Medicine, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1111/bjh.14985DOI Listing
November 2018

The Pathogenic Involvement of Neutrophils in Acute Respiratory Distress Syndrome and Transfusion-Related Acute Lung Injury.

Transfus Med Hemother 2018 Oct 21;45(5):290-298. Epub 2018 Sep 21.

Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1159/000492950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257140PMC
October 2018

Moving target PF4 directs HIT responses.

Blood 2018 08;132(7):678-679

Lund University.

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http://dx.doi.org/10.1182/blood-2018-07-859975DOI Listing
August 2018

Targeting Transfusion-Related Acute Lung Injury: The Journey From Basic Science to Novel Therapies.

Crit Care Med 2018 05;46(5):e452-e458

Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden.

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http://Insights.ovid.com/crossref?an=00003246-201805000-0004
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http://dx.doi.org/10.1097/CCM.0000000000002989DOI Listing
May 2018

Intravenous immunoglobulin treatment of spleen cells from patients with immune thrombocytopenia significantly increases the percentage of myeloid-derived suppressor cells.

Br J Haematol 2018 04 6;181(2):262-264. Epub 2017 Feb 6.

Keenan Research Centre for Biomedical Science of St. Michaels Hospital, Rochester, NY, USA.

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http://dx.doi.org/10.1111/bjh.14542DOI Listing
April 2018

Mobile Web-Based Follow-up for Postoperative ACL Reconstruction: A Single-Center Experience.

Orthop J Sports Med 2017 Dec 22;5(12):2325967117745278. Epub 2017 Dec 22.

University of Toronto Orthopaedic Sports Medicine, Women's College Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/2325967117745278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753986PMC
December 2017

Breast Cancer Genetics for Plastic Surgeons.

Plast Reconstr Surg 2017 Sep;140(3):455-460

Toronto, Ontario, Canada From the Department of Surgery and the Division of Plastic and Reconstructive Surgery, University of Toronto and Women's College Hospital; and the Familial Breast Cancer Unit, Women's College Research Institute.

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http://dx.doi.org/10.1097/PRS.0000000000003577DOI Listing
September 2017

Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets.

Blood Adv 2017 Sep 8;1(20):1773-1785. Epub 2017 Sep 8.

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/bloodadvances.2017007021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728336PMC
September 2017

Low levels of interleukin-10 in patients with transfusion-related acute lung injury.

Ann Transl Med 2017 Aug;5(16):339

Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden.

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http://dx.doi.org/10.21037/atm.2017.04.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566739PMC
August 2017

Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia.

Platelets 2017 Jul 25;28(5):521-524. Epub 2016 Nov 25.

a The Toronto Platelet Immunobiology Group , Keenan Research Centre for Biomedical Science of St. Michael's Hospital , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/09537104.2016.1246718DOI Listing
July 2017

Effect of Home Monitoring via Mobile App on the Number of In-Person Visits Following Ambulatory Surgery: A Randomized Clinical Trial.

JAMA Surg 2017 07;152(7):622-627

Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada3Women's College Research Institute, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1001/jamasurg.2017.0111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547920PMC
July 2017

The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia () mutation.

Dis Model Mech 2017 05 12;10(5):581-595. Epub 2017 Jan 12.

Lunenfeld-Tanenbaum Research Institute, Room 876, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada

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http://dmm.biologists.org/lookup/doi/10.1242/dmm.027433
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http://dx.doi.org/10.1242/dmm.027433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451163PMC
May 2017

Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets.

Am J Physiol Lung Cell Mol Physiol 2017 05 10;312(5):L625-L637. Epub 2017 Mar 10.

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada;

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http://dx.doi.org/10.1152/ajplung.00317.2016DOI Listing
May 2017

Consensus Review of Optimal Perioperative Care in Breast Reconstruction: Enhanced Recovery after Surgery (ERAS) Society Recommendations.

Plast Reconstr Surg 2017 May;139(5):1056e-1071e

Calgary, Alberta, and Toronto, Ontario, Canada; Duarte, Calif.; Recife, Pernambuco, Brazil; Ghent, Belgium; New York, N.Y.; and Örebro, Sweden From the Departments of Surgery, Oncology, and Anesthesiology and Pain Medicine, University of Calgary; the Tom Baker Cancer Centre; the Cancer Strategic Clinical Network, Alberta Health Services; the City of Hope National Medical Center; the Department of Surgery, University of Toronto; the Department of Plastic and Reconstructive Surgery, University Hospital of Ghent; Memorial Sloan Kettering Cancer Center; Department of Surgery, Faculty of Medicine and Health, Örebro University; and private practice.

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http://dx.doi.org/10.1097/PRS.0000000000003242DOI Listing
May 2017

Why Some Mastectomy Patients Opt to Undergo Delayed Breast Reconstruction: Results of a Long-Term Prospective Study.

Plast Reconstr Surg 2017 Feb;139(2):267-275

Toronto, Ontario, and Calgary, Alberta, Canada From the Lawrence S. Bloomberg Faculty of Nursing, University of Toronto; Women's College Research Institute; Sunnybrook Regional Cancer Centre; University Health Network; and Foothills Medical Centre.

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http://dx.doi.org/10.1097/PRS.0000000000002943DOI Listing
February 2017

Pathogenesis and Therapeutic Mechanisms in  Immune Thrombocytopenia (ITP).

J Clin Med 2017 Feb 9;6(2). Epub 2017 Feb 9.

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.

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http://dx.doi.org/10.3390/jcm6020016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332920PMC
February 2017

The impact of nodal micrometastasis on mortality among women with early-stage breast cancer.

Breast Cancer Res Treat 2017 01 28;161(1):103-115. Epub 2016 Oct 28.

Women's College Research Institute/Women's College Hospital, 76 Grenville Street, Toronto, ON, M5S 1B2, Canada.

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http://dx.doi.org/10.1007/s10549-016-4015-5DOI Listing
January 2017

Mobile applications for postoperative monitoring after discharge.

CMAJ 2017 01 5;189(1):E22-E24. Epub 2016 Dec 5.

Division of Plastic Surgery (Semple, Armstrong), Women's College Hospital; Department of Surgery (Semple), University of Toronto, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.160195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224949PMC
January 2017

High Concentrations of Ozone Air Pollution on Mount Everest: Health Implications for Sherpa Communities and Mountaineers.

High Alt Med Biol 2016 Dec 20;17(4):365-369. Epub 2016 Oct 20.

4 Institute of Atmospheric Sciences and Climate , National Research Council of Italy, Bologna, Italy .

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http://dx.doi.org/10.1089/ham.2016.0042DOI Listing
December 2016

Alleviation of gram-negative bacterial lung inflammation by targeting HECTD2.

Ann Transl Med 2016 Dec;4(24):488

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Canadian Blood Services,; Department of Pharmacology, Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada;; Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden.

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http://dx.doi.org/10.21037/atm.2016.11.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233488PMC
December 2016

Elevation of C-reactive protein levels in patients with transfusion-related acute lung injury.

Oncotarget 2016 Nov;7(47):78048-78054

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.18632/oncotarget.12872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363642PMC
November 2016

Platelets as immune-sensing cells.

Blood Adv 2016 Nov 22;1(1):10-14. Epub 2016 Nov 22.

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Canadian Blood Services, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/bloodadvances.2016000067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744049PMC
November 2016

How Social Are We? A Cross-Sectional Study of the Website Presence and Social Media Activity of Canadian Plastic Surgeons.

Aesthet Surg J 2016 Oct 18;36(9):1079-84. Epub 2016 May 18.

Dr McEvenue is a Resident, Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Ms Copeland is a Medical Student, University of Toronto Medical School, Toronto, Ontario, Canada. Dr Devon is an Assistant Professor, Department of Surgery, Women's College Hospital, Toronto, Ontario, Canada; and an Assistant Professor, Joint Center for Bioethics, and the Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. Dr Semple is Surgeon-in-Chief and Division Head, Department of Surgery, Women's College Hospital, Toronto, Ontario, Canada; and a Professor, Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/asj/sjw069DOI Listing
October 2016

The spleen dictates platelet destruction, anti-platelet antibody production, and lymphocyte distribution patterns in a murine model of immune thrombocytopenia.

Exp Hematol 2016 10 12;44(10):924-930.e1. Epub 2016 Jul 12.

Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Departments of Medicine and Pharmacology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.07.004DOI Listing
October 2016

Determinants of increased acute postoperative pain after autologous breast reconstruction within an enhanced recovery after surgery protocol: A prospective cohort study.

J Plast Reconstr Aesthet Surg 2016 Aug 13;69(8):1157-60. Epub 2016 May 13.

Department of Ambulatory Surgery, Women's College Hospital, 76 Grenville Street, 6th Floor, Toronto, Ontario, M5S 1B2, Canada; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bjps.2016.04.019DOI Listing
August 2016

Microparticles as biomarkers of lung disease: enumeration in biological fluids using lipid bilayer microspheres.

Am J Physiol Lung Cell Mol Physiol 2016 05 4;310(9):L802-14. Epub 2016 Mar 4.

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada; Departments of Physiology, Surgery, University of Toronto, Toronto, Ontario, Canada; Institute of Physiology, Charité-Universitätsmedizin Berlin, Germany; and German Heart Institute, Berlin, Germany.

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http://dx.doi.org/10.1152/ajplung.00369.2015DOI Listing
May 2016

Splenic lymphocyte subtypes in immune thrombocytopenia: increased presence of a subtype of B-regulatory cells.

Br J Haematol 2016 Apr 24;173(1):159-60. Epub 2015 Jun 24.

Keenan Research Centre for Biomedical Science, St. Michaels Hospital, Toronto, ON, Canada.

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http://doi.wiley.com/10.1111/bjh.13567
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http://dx.doi.org/10.1111/bjh.13567DOI Listing
April 2016

The nonhemostatic immune functions of platelets.

Semin Hematol 2016 04 6;53 Suppl 1:S2-6. Epub 2016 Apr 6.

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael׳s Hospital, Canadian Blood Services, Toronto, Ontario, Canada; Departments of Pharmacology, Medicine, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2016.04.002DOI Listing
April 2016

The Effect of Mobile App Follow-up Care on the Number of In-person Visits Following Ambulatory Surgery: A Randomized Control Trial.

Stud Health Technol Inform 2015 ;216:894

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, CAN.

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March 2016

Move over Tregs, MDSCs are here.

Authors:
John W Semple

Blood 2016 Mar;127(12):1526-8

ST. MICHAEL'S HOSPITAL.

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http://dx.doi.org/10.1182/blood-2016-01-692160DOI Listing
March 2016

Acute Lung Injury Causes Asynchronous Alveolar Ventilation That Can Be Corrected by Individual Sighs.

Am J Respir Crit Care Med 2016 Feb;193(4):396-406

1 Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1164/rccm.201505-0901OCDOI Listing
February 2016

CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia.

Blood 2016 Feb 10;127(6):735-8. Epub 2015 Nov 10.

The Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; and Department of Medicine, Department of Laboratory Medicine and Pathobiology, and Department of Pharmacology, University of Toronto, Toronto, ON, Canada.

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http://www.bloodjournal.org/content/bloodjournal/127/6/735.f
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-06-65
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http://dx.doi.org/10.1182/blood-2015-06-655126DOI Listing
February 2016

C-reactive protein enhances murine antibody-mediated transfusion-related acute lung injury.

Blood 2015 Dec 9;126(25):2747-51. Epub 2015 Oct 9.

The Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; and Departments of Pharmacology, Medicine, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2015-09-672592DOI Listing
December 2015

Long-Term Psychosocial Functioning in Women with Bilateral Prophylactic Mastectomy: Does Preservation of the Nipple-Areolar Complex Make a Difference?

Ann Surg Oncol 2015 Oct 25;22(10):3324-30. Epub 2015 Jul 25.

Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada,

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http://dx.doi.org/10.1245/s10434-015-4761-3DOI Listing
October 2015

Shifting Autologous Breast Reconstruction into an Ambulatory Setting: Patient-Reported Quality of Recovery.

Plast Reconstr Surg 2015 Oct;136(4):657-65

Toronto, Ontario, Canada From The Hospital for Sick Children, the Division of Plastic and Reconstructive Surgery, Department of Surgery, the Institute of Health, Management, and Evaluation, and the Department of Anesthesia, University of Toronto; and the Departments of Ambulatory Surgery and Anesthesia, Women's College Hospital.

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http://dx.doi.org/10.1097/PRS.0000000000001575DOI Listing
October 2015

The effect of mobile app home monitoring on number of in-person visits following ambulatory surgery: protocol for a randomized controlled trial.

JMIR Res Protoc 2015 Jun 3;4(2):e65. Epub 2015 Jun 3.

Division of Plastic & Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

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http://www.researchprotocols.org/2015/2/e65/
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http://dx.doi.org/10.2196/resprot.4352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526905PMC
June 2015

Nouvelle cuisine: platelets served with inflammation.

J Immunol 2015 Jun;194(12):5579-87

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario M5B 1W8, Canada; Canadian Blood Services, Toronto, Ontario M5B 1W8, Canada; Department of Pharmacology, University of Toronto, Toronto, Ontario M5B 1W8, Canada; Department of Medicine, University of Toronto, Toronto, Ontario M5B 1W8, Canada; and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5B 1W8, Canada

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1500259
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http://dx.doi.org/10.4049/jimmunol.1500259DOI Listing
June 2015

Next-generation sampling: Pairing genomics with herbarium specimens provides species-level signal in Solidago (Asteraceae).

Appl Plant Sci 2015 Jun 8;3(6). Epub 2015 Jun 8.

Department of Biology, University of Waterloo, Waterloo, Ontario NL2 3G1 Canada.

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http://dx.doi.org/10.3732/apps.1500014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467758PMC
June 2015

Comparing the DN4 tool with the IASP grading system for chronic neuropathic pain screening after breast tumor resection with and without paravertebral blocks: a prospective 6-month validation study.

Pain 2015 Apr;156(4):740-9

aDepartment of Anesthesia, University of Toronto, Toronto, Ontario, Canada bDepartment of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada cKeenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada dDepartment of Anesthesia, Women's College Hospital, Toronto, Ontario, Canada eDepartment of Surgery, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada fDepartment of Anesthesia, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/j.pain.0000000000000108DOI Listing
April 2015

A prospective study of mastectomy patients with and without delayed breast reconstruction: long-term psychosocial functioning in the breast cancer survivorship period.

J Surg Oncol 2015 Mar 29;111(3):258-64. Epub 2014 Dec 29.

Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada; Women's College Research Institute, Toronto, Canada; Faculty of Medicine, Department of Surgery in the Division of Plastic and Reconstructive Surgery, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/jso.23829DOI Listing
March 2015

Does breast reconstruction after mastectomy for breast cancer affect overall survival? Long-term follow-up of a retrospective population-based cohort.

Plast Reconstr Surg 2015 Mar;135(3):468e-476e

Toronto, Ontario, Canada From the Division of Plastic and Reconstructive Surgery, the Department of Surgery and Li KaShing Knowledge Institute, St. Michael's Hospital, the Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, and Women's College Hospital and Research Institute, University of Toronto.

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http://dx.doi.org/10.1097/PRS.0000000000001054DOI Listing
March 2015

C-reactive protein boosts antibody-mediated platelet destruction.

Authors:
John W Semple

Blood 2015 Mar;125(11):1690-1

ST. MICHAEL'S HOSPITAL.

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http://dx.doi.org/10.1182/blood-2015-01-621219DOI Listing
March 2015

The first smartphone application for microsurgery monitoring: SilpaRamanitor.

Plast Reconstr Surg 2015 Feb;135(2):458e

Division of Plastic and Reconstructive Surgery, Department of Surgery Institute of Health Policy, Management and Evaluation Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/PRS.0000000000000896DOI Listing
February 2015

Using a mobile app for monitoring post-operative quality of recovery of patients at home: a feasibility study.

JMIR Mhealth Uhealth 2015 Feb 12;3(1):e18. Epub 2015 Feb 12.

Women\'s College Hospital, Department of Surgery, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.2196/mhealth.3929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342621PMC
February 2015

Replacing ambulatory surgical follow-up visits with mobile app home monitoring: modeling cost-effective scenarios.

J Med Internet Res 2014 Sep 22;16(9):e213. Epub 2014 Sep 22.

Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.2196/jmir.3528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211032PMC
September 2014

A comprehensive study of ovine haemostasis to assess suitability to model human coagulation.

Thromb Res 2014 Aug 27;134(2):468-73. Epub 2014 May 27.

Critical Care Research Group, The University of Queensland and The Prince Charles Hospital, Brisbane, QLD, Australia; School of Health and Sports Science, University of Sunshine Coast, Sippy Downs, QLD, Australia.

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http://dx.doi.org/10.1016/j.thromres.2014.05.026DOI Listing
August 2014

Lymphatic function is impaired following irradiation of a single lymph node.

Lymphat Res Biol 2014 Jun 16;12(2):76-88. Epub 2014 May 16.

1 Sunnybrook Research Institute, Department of Laboratory Medicine and Pathobiology, Women's College Hospital, University of Toronto , Toronto, Ontario, Canada .

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http://dx.doi.org/10.1089/lrb.2013.0036DOI Listing
June 2014

MRI volumetric analysis of breast fibroglandular tissue to assess risk of the spared nipple in BRCA1 and BRCA2 mutation carriers.

Ann Surg Oncol 2014 May 14;21(5):1583-8. Epub 2014 Feb 14.

Division of Plastic and Reconstructive Surgery, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1245/s10434-014-3532-xDOI Listing
May 2014

Peripheral blood monocyte-derived chemokine blockade prevents murine transfusion-related acute lung injury (TRALI).

Blood 2014 May 17;123(22):3496-503. Epub 2014 Mar 17.

Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Keenan Center for Biomedical Research, St. Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; and Departments of Medicine, Pharmacology, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-11-53
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http://dx.doi.org/10.1182/blood-2013-11-536755DOI Listing
May 2014

Platelet GPIb-IX has suppressive effects on septic inflammation.

Authors:
John W Semple

Arterioscler Thromb Vasc Biol 2014 May;34(5):962-3

From the Keenan Center for Biomedical Research, St. Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.114.303367DOI Listing
May 2014

Pathogenesis of immune thrombocytopenia.

Presse Med 2014 Apr 12;43(4 Pt 2):e49-59. Epub 2014 Mar 12.

The Keenan Research Centre for Biomedical Science in St. Michael's Hospital, Departments of Laboratory Medicine and Pathobiology, Toronto, ON M5B 1W8, Canada.

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http://dx.doi.org/10.1016/j.lpm.2014.01.010DOI Listing
April 2014

Genus-wide microsatellite primers for the goldenrods (Solidago; Asteraceae).

Appl Plant Sci 2014 Apr 4;2(4). Epub 2014 Apr 4.

Field Station, University of Wisconsin-Milwaukee, 3095 Blue Goose Road, Saukville, Wisconsin 53080 USA.

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http://dx.doi.org/10.3732/apps.1300093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103136PMC
April 2014

Ultrasound-guided multilevel paravertebral blocks and total intravenous anesthesia improve the quality of recovery after ambulatory breast tumor resection.

Anesthesiology 2014 Mar;120(3):703-13

Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada, and Department of Anesthesia, St. Michael's Hospital, and Keenan Research Centre, Li Ka Shing Knowledge Institute, and Department of Anesthesia, Women's College Hospital (F.W.A.); Department of Anesthesia, University of Toronto, and Department of Anesthesia, Women's College Hospital (P.J.M.); Department of Surgery, Women's College Hospital, University of Toronto (T.C., J.M.E., J.L.S.); Department of Anesthesia, University of Toronto, and Department of Anesthesia, Women's College Hospital, and Department of Anesthesia, Sunnybrook Hospital (A.M.); Women's College Research Institute, University of Toronto (W.W.); and Department of Anesthesia, University of Toronto; and Department of Anesthesia, Toronto Western Hospital, University Health Network (V.W.C.).

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http://dx.doi.org/10.1097/ALN.0000436117.52143.bcDOI Listing
March 2014

Assessing competence of orthopaedic residents: the reliability and validity of an objective structured clinical examination after a sports medicine rotation.

J Bone Joint Surg Am 2013 Nov;95(22):e177

Women's College Hospital, Toronto Western and Sunnybrook Hospital, University of Toronto Orthopaedics Sports Medicine, 76 Grenville Street, Toronto, ON M5S 1B1, Canada. E-mail address for T. Dwyer:

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http://dx.doi.org/10.2106/JBJS.M.00148DOI Listing
November 2013

Cellular immune dysfunction in immune thrombocytopenia (ITP).

Br J Haematol 2013 Oct 12;163(1):10-23. Epub 2013 Aug 12.

Toronto Platelet Immunobiology Group, University of Toronto, Toronto, ON, Canada; Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/bjh.12480DOI Listing
October 2013

Processes of care in autogenous breast reconstruction with pedicled TRAM flaps: expediting postoperative discharge in an ambulatory setting.

Plast Reconstr Surg 2013 Sep;132(3):339e-44e

Department of Ambulatory Surgery, Women's College Hospital, 76 Grenville Street, Toronto, Ontario M5S 1B2, Canada.

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http://dx.doi.org/10.1097/PRS.0b013e31829ace62DOI Listing
September 2013

Platelets deliver small packages of genetic function.

Authors:
John W Semple

Blood 2013 Jul;122(2):155-6

St. Michael's Hospital.

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http://dx.doi.org/10.1182/blood-2013-05-502609DOI Listing
July 2013

Surgical safety checklist: implementation in an ambulatory surgical facility.

Can J Anaesth 2013 Jun 16;60(6):528-38. Epub 2013 Mar 16.

Department of Anesthesia, Women's College Hospital, University of Toronto, 76 Grenville St, Toronto, ON M5S 1B2, Canada.

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http://dx.doi.org/10.1007/s12630-013-9916-8DOI Listing
June 2013

Experimental assessment of pro-lymphangiogenic growth factors in the treatment of post-surgical lymphedema following lymphadenectomy.

Breast Cancer Res 2010 8;12(5):R70. Epub 2010 Sep 8.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1186/bcr2638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096957PMC
February 2013

Innate and adaptive immunity in immune thrombocytopenia.

Semin Hematol 2013 Jan;50 Suppl 1:S68-70

The Canadian Blood Services, Ottawa, Canada.

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http://dx.doi.org/10.1053/j.seminhematol.2013.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691820PMC
January 2013

Bregging rights in ITP.

Authors:
John W Semple

Blood 2012 Oct;120(16):3169

St Michael's Hospital, Canada.

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http://dx.doi.org/10.1182/blood-2012-08-448522DOI Listing
October 2012

Environmental conditions at the South Col of Mount Everest and their impact on hypoxia and hypothermia experienced by mountaineers.

Extrem Physiol Med 2012 Sep 4;1(1). Epub 2012 Sep 4.

Department of Physics, University of Toronto, Toronto, Ontario M5S 1A7, Canada.

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http://dx.doi.org/10.1186/2046-7648-1-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707097PMC
September 2012

The immunopathogenesis of immune thrombocytopenia: T cells still take center-stage.

Curr Opin Hematol 2012 Sep;19(5):357-62

Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Department of Pharmacology, University of Toronto, Canadian Blood Services, Ontario, Canada.

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http://dx.doi.org/10.1097/MOH.0b013e3283567541DOI Listing
September 2012

Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia.

Blood 2012 Sep 3;120(10):2127-32. Epub 2012 Jul 3.

Toronto Platelet Immunobiology Group, Li Ka Shing Knowledge Institute of St Michael's Hospital, Toronto, ON.

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http://dx.doi.org/10.1182/blood-2012-02-413526DOI Listing
September 2012

A tale of two climbers: hypothermia, death, and survival on Mount Everest.

High Alt Med Biol 2012 Mar;13(1):51-6

Department of Physics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1089/ham.2011.1061DOI Listing
March 2012

Changes in psychosocial functioning 1 year after mastectomy alone, delayed breast reconstruction, or immediate breast reconstruction.

Ann Surg Oncol 2012 Jan 15;19(1):233-41. Epub 2011 Jun 15.

Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1245/s10434-011-1828-7DOI Listing
January 2012

Management of immune thrombocytopenic purpura in children: potential role of novel agents.

Paediatr Drugs 2011 Aug;13(4):213-23

Department of Pediatrics, Division of Hematology/Oncology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA.

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http://dx.doi.org/10.2165/11591640-000000000-00000DOI Listing
August 2011

Platelets and the immune continuum.

Nat Rev Immunol 2011 Apr;11(4):264-74

Toronto Platelet Immunobiology Group, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8.

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http://dx.doi.org/10.1038/nri2956DOI Listing
April 2011

Current problems and future directions of transfusion-induced alloimmunization: summary of an NHLBI working group.

Transfusion 2011 Feb 20;51(2):435-41. Epub 2011 Jan 20.

Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Children's Healthcare of Atlanta, Division of Pediatric Hematology/Oncology, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1111/j.1537-2995.2010.03024.xDOI Listing
February 2011

Recent progress in understanding the pathogenesis of immune thrombocytopenia.

Curr Opin Hematol 2010 Nov;17(6):590-5

Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Department of Pharmacology, University of Toronto, Canadian Blood Services, Toronto, Ontario, Canada.

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https://insights.ovid.com/crossref?an=00062752-201011000-000
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http://dx.doi.org/10.1097/MOH.0b013e32833eaef3DOI Listing
November 2010

Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury.

Blood 2010 Oct 8;116(16):3073-9. Epub 2010 Jul 8.

Prince Charles Hospital, University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1182/blood-2010-05-284570DOI Listing
October 2010

Future research in ITP: an ICIS consensus.

Ann Hematol 2010 Jul 23;89 Suppl 1:19-23. Epub 2010 Mar 23.

Department of Pathology, Stanford University School of Medicine, L235, Stanford, CA, 94305, USA,

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http://dx.doi.org/10.1007/s00277-010-0917-1DOI Listing
July 2010

Animal models of immune thrombocytopenia (ITP).

Authors:
John W Semple

Ann Hematol 2010 Jul 25;89 Suppl 1:37-44. Epub 2010 Mar 25.

Toronto Platelet Immunobiology Group, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Canadian Blood Services, Departments of Pharmacology, Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada,

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http://link.springer.com/10.1007/s00277-009-0882-8
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http://dx.doi.org/10.1007/s00277-009-0882-8DOI Listing
July 2010

The impact of global warming on Mount Everest.

High Alt Med Biol 2009 ;10(4):383-5

Department of Physics, University of Toronto, Ontario, Canada.

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http://www.liebertpub.com/doi/10.1089/ham.2009.1039
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http://dx.doi.org/10.1089/ham.2009.1039DOI Listing
March 2010

Platelets and innate immunity.

Cell Mol Life Sci 2010 Feb 18;67(4):499-511. Epub 2009 Dec 18.

Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada.

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http://dx.doi.org/10.1007/s00018-009-0205-1DOI Listing
February 2010

ITP has elevated BAFF expression.

Authors:
John W Semple

Blood 2009 Dec;114(26):5248-9

Saint Michael's Hospital.

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http://dx.doi.org/10.1182/blood-2009-10-247536DOI Listing
December 2009