John S Welch

John S Welch

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John S Welch

John S Welch

Publications by authors named "John S Welch"

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TP53 immunohistochemistry correlates with mutation status and clearance in decitabine-treated patients with myeloid malignancies.

Haematologica 2019 Aug 21;104(8):e345-e348. Epub 2019 Feb 21.

Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA

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http://dx.doi.org/10.3324/haematol.2018.205302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669137PMC
August 2019

Serendipity: decitabine monotherapy induced complete molecular response in a 77-year-old patient with acute promyelocytic leukemia.

Haematologica 2019 Apr 7;104(4):e170-e173. Epub 2019 Feb 7.

BMT and Leukemia Program, Department of Medicine, Washington University School of Medicine, Saint Louis, MO

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http://dx.doi.org/10.3324/haematol.2018.209478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442953PMC
April 2019

Smc3 is required for mouse embryonic and adult hematopoiesis.

Exp Hematol 2019 02 13;70:70-84.e6. Epub 2018 Dec 13.

Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639053PMC
February 2019

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.

N Engl J Med 2018 12 31;379(24):2330-2341. Epub 2018 Oct 31.

From the Division of Oncology, Department of Internal Medicine (M.J.C., A.A.P., M.P.R., C.A.M., E.C., N.M.H., L.D.W., J.S.W., S.E.H., D.C.L., M.J.W., P.W., T.J.L., J.F.D.), the McDonnell Genome Institute (A.A.P., C.A.M., M.O., C.C.F., R.S.F., L.D.W., T.J.L.), the Department of Pathology and Immunology (E.J.D., J.E.P.), and the Division of Biostatistics (J.D.B.), Washington University in St. Louis, St. Louis; the Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN (J.M.K.); the Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH (R.K.W.); and the Center for Cancer Research, Massachusetts General Hospital, Boston (T.A.G.).

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http://www.nejm.org/doi/10.1056/NEJMoa1808777
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http://dx.doi.org/10.1056/NEJMoa1808777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322675PMC
December 2018

Patterns of mutations in TP53 mutated AML.

Authors:
John S Welch

Best Pract Res Clin Haematol 2018 12 20;31(4):379-383. Epub 2018 Sep 20.

Department of Internal Medicine, Washington University, 660 Euclid Ave, Box 8007, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482955PMC
December 2018

Mutation Clearance after Transplantation for Myelodysplastic Syndrome.

N Engl J Med 2018 Sep;379(11):1028-1041

From the Department of Pathology and Immunology (E.J.D.), the Department of Medicine, Division of Oncology (M.A.J., C.A.M., N.E., J.S., K.E., J.R., S.E.H., K.B., L.D.W., M.J.C., I.P., J.S.W., G.L.U., D.C.L., J.F.D., P.W., T.J.L., M.J.W.), the McDonnell Genome Institute (G.S.C., C.A.M., H.A., R.S.F., C.C.F., M.O.), the Department of Medicine, Division of Hospital Medicine (R.S.), and Siteman Biostatistics Shared Resource, Siteman Cancer Center (K.T.), Washington University School of Medicine in St. Louis, St. Louis; and Massachusetts General Hospital Cancer Center, Boston (T.A.G.).

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http://www.nejm.org/doi/10.1056/NEJMoa1804714
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http://dx.doi.org/10.1056/NEJMoa1804714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309244PMC
September 2018

Acute Myeloid Leukemia: The Good, the Bad, and the Ugly.

Am Soc Clin Oncol Educ Book 2018 May;38:555-573

From the Moffitt Cancer Center, Tampa, FL; CHU Lille, INSERM, Laboratory of Hematology, University of Lille, Lille, France; Hematology Department, Saint-Louis Hospital, Paris Diderot University, Paris, France; Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1200/EDBK_199519DOI Listing
May 2018

Endogenous retinoid X receptor ligands in mouse hematopoietic cells.

Sci Signal 2017 Oct 31;10(503). Epub 2017 Oct 31.

Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/scisignal.aan1011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777239PMC
October 2017

CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.

Cell 2017 02 16;168(5):801-816.e13. Epub 2017 Feb 16.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; The McDonnell Genome Institute, Washington University, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328582PMC
February 2017

Decitabine in TP53-Mutated AML.

N Engl J Med 2017 02;376(8):797-8

Washington University School of Medicine, St. Louis, MO

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http://dx.doi.org/10.1056/NEJMc1616062DOI Listing
February 2017

TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

N Engl J Med 2016 11;375(21):2023-2036

the Department of Internal Medicine, Division of Oncology (J.S.W., L.D.W., G.L.U., A.G., M.H.T., I.P., R.R., T.A.F., K.E.S.-G., R.V., S.T.O., C.N.A., A.F.C., M.A.S., M.A.J., S.E.H., K.L., M.R.J., M.J.W., P.W., D.C.L., J.F.D., T.J.L.), and the Division of Biostatistics (J.D.B.), and the Department of Pathology and Immunology (E.J.D., B.T., Y.-S.L.), Washington University School of Medicine, and McDonnell Genome Institute, Washington University in St. Louis (A.A.P., C.A.M., C.C.F., M.O., R.S.F., R.K.W., L.D.W., T.J.L.) - both in St. Louis; the Departments of Internal Medicine (A.H., N.K., M.J.S., W.S.) and Pharmacy (R.W.K.), University of Chicago, Chicago; and the Department of Internal Medicine (T.A.G.), Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1056/NEJMoa1605949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217532PMC
November 2016

Pathways of retinoid synthesis in mouse macrophages and bone marrow cells.

J Leukoc Biol 2016 06 14;99(6):797-810. Epub 2016 Jan 14.

Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA and

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http://doi.wiley.com/10.1189/jlb.2HI0415-146RR
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http://dx.doi.org/10.1189/jlb.2HI0415-146RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4952016PMC
June 2016

Hand-foot syndrome following decitabine.

Ann Hematol 2016 Feb 6;95(3):535-6. Epub 2015 Nov 6.

Division of Oncology, Stem Cell Biology Section, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8007, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s00277-015-2546-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175272PMC
February 2016

Age-related mutations associated with clonal hematopoietic expansion and malignancies.

Nat Med 2014 Dec 19;20(12):1472-8. Epub 2014 Oct 19.

1] The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, USA. [2] Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA. [3] Department of Genetics, Washington University in St. Louis, St. Louis, Missouri, USA. [4] Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1038/nm.3733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313872PMC
December 2014

Mutation position within evolutionary subclonal architecture in AML.

Authors:
John S Welch

Semin Hematol 2014 Oct 7;51(4):273-81. Epub 2014 Aug 7.

Washington University School of Medicine, Division of Oncology, Stem Cell Biology Section, St. Louis, MO. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2014.08.004DOI Listing
October 2014

SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution.

PLoS Comput Biol 2014 Aug 7;10(8):e1003665. Epub 2014 Aug 7.

The Genome Institute, Washington University, St. Louis, Missouri, United States of America; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Genetics, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1003665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125065PMC
August 2014

Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.

PLoS One 2012 8;7(10):e46529. Epub 2012 Oct 8.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046529PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466302PMC
June 2013

Solid, low-attenuation splenic lesions on computed tomography in patients with indolent lymphoma often signal transformation: a series of ten patients.

Clin Lymphoma Myeloma Leuk 2012 Dec 14;12(6):452-4. Epub 2012 Sep 14.

Division of Oncology, Washington University School of Medicine, St Louis, MO, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S215226501200146
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http://dx.doi.org/10.1016/j.clml.2012.08.001DOI Listing
December 2012

Genomics of AML: clinical applications of next-generation sequencing.

Hematology Am Soc Hematol Educ Program 2011 ;2011:30-5

Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1182/asheducation-2011.1.30DOI Listing
April 2012

Combination decitabine, arsenic trioxide, and ascorbic acid for the treatment of myelodysplastic syndrome and acute myeloid leukemia: a phase I study.

Am J Hematol 2011 Sep 3;86(9):796-800. Epub 2011 Aug 3.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1002/ajh.22092DOI Listing
September 2011

PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.

J Clin Invest 2011 Apr;121(4):1636-45

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63119, USA.

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http://dx.doi.org/10.1172/JCI42953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068978PMC
April 2011

Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.

Blood 2011 Feb 29;117(8):2460-8. Epub 2010 Dec 29.

Section of Stem Cell Biology, Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1182/blood-2010-08-300087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317790PMC
February 2011

A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia.

Blood 2010 Nov 20;116(18):3604-10. Epub 2010 Jul 20.

Section of Stem Cell Biology, Division of Oncology, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1182/blood-2008-11-189282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981479PMC
November 2010

Therapy related acute myeloid leukemia in breast cancer survivors, a population-based study.

Breast Cancer Res Treat 2009 Dec 26;118(3):593-8. Epub 2009 Mar 26.

Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8007, Saint Louis, MO 63110, USA.

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http://link.springer.com/10.1007/s10549-009-0376-3
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http://dx.doi.org/10.1007/s10549-009-0376-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400139PMC
December 2009

Cladribine in the treatment of acute myeloid leukemia: a single-institution experience.

Clin Lymphoma Myeloma 2009 Aug;9(4):298-301

Section of Leukemia and Bone Marrow Transplantation, Division of Oncology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.3816/CLM.2009.n.058DOI Listing
August 2009

PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages.

Proc Natl Acad Sci U S A 2003 May 9;100(11):6712-7. Epub 2003 May 9.

Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla 92093-0651, USA.

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http://dx.doi.org/10.1073/pnas.1031789100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164512PMC
May 2003

TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism.

J Biol Chem 2002 Nov 4;277(45):42821-9. Epub 2002 Sep 4.

Department of Cellular and Molecular Medicine, La Jolla, California 92093-0651, USA.

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http://dx.doi.org/10.1074/jbc.M205873200DOI Listing
November 2002