John S Tsang

John S Tsang

UNVERIFIED PROFILE

Are you John S Tsang?   Register this Author

Register author
John S Tsang

John S Tsang

Publications by authors named "John S Tsang"

Are you John S Tsang?   Register this Author

30Publications

749Reads

9Profile Views

IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses.

Elife 2019 08 6;8. Epub 2019 Aug 6.

Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.46836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684266PMC
August 2019

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.

Cell 2019 Apr 4;177(3):541-555.e17. Epub 2019 Apr 4.

Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2019.02.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474841PMC
April 2019

eNetXplorer: an R package for the quantitative exploration of elastic net families for generalized linear models.

BMC Bioinformatics 2019 Apr 16;20(1):189. Epub 2019 Apr 16.

Trans-NIH Center for Human Immunology (CHI), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
https://bmcbioinformatics.biomedcentral.com/articles/10.1186
Publisher Site
http://dx.doi.org/10.1186/s12859-019-2778-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469092PMC
April 2019

Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses.

J Exp Med 2019 Feb 23;216(2):384-406. Epub 2019 Jan 23.

Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20180595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363437PMC
February 2019

Assessment of Variability in the SOMAscan Assay.

Sci Rep 2017 10 27;7(1):14248. Epub 2017 Oct 27.

Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, National Institutes of Health, Bethesda, MD, 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-14755-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660188PMC
October 2017

Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network.

Cell Syst 2017 04 29;4(4):379-392.e12. Epub 2017 Mar 29.

Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institutes of Health, Bethesda, MD 20892, USA; Trans-NIH Center for Human Immunology (CHI), National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cels.2017.03.002DOI Listing
April 2017

Solving Immunology?

Trends Immunol 2017 02 13;38(2):116-127. Epub 2016 Dec 13.

Center for Advanced Research on Diagnostic Assays, Immunology Institute, Friedman Brain Institute, and Departments of Neurology, Neuroscience, Pharmacology, and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.it.2016.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695553PMC
February 2017

Expanding the Immunology Toolbox: Embracing Public-Data Reuse and Crowdsourcing.

Immunity 2016 12;45(6):1191-1204

Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2016.12.008DOI Listing
December 2016

Meta-analysis of crowdsourced data compendia suggests pan-disease transcriptional signatures of autoimmunity.

F1000Res 2016 20;5:2884. Epub 2016 Dec 20.

Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/f1000research.10465.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399965PMC
December 2016

Systematic Analysis of Cell-to-Cell Expression Variation of T Lymphocytes in a Human Cohort Identifies Aging and Genetic Associations.

Immunity 2016 11;45(5):1162-1175

Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, MD 20892, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747613163043
Publisher Site
http://dx.doi.org/10.1016/j.immuni.2016.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532399PMC
November 2016

A crowdsourcing approach for reusing and meta-analyzing gene expression data.

Nat Biotechnol 2016 08 20;34(8):803-6. Epub 2016 Jun 20.

Systems Genomics and Bioinformatics Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nbt.3603DOI Listing
August 2016

Robust Inference of Cell-to-Cell Expression Variations from Single- and K-Cell Profiling.

PLoS Comput Biol 2016 07 20;12(7):e1005016. Epub 2016 Jul 20.

Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1005016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954693PMC
July 2016

Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses.

Cell Syst 2016 06 26;2(6):378-90. Epub 2016 May 26.

Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cels.2016.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919147PMC
June 2016

Humoral Fingerprinting of Immune Responses: 'Super-Resolution', High-Dimensional Serology.

Trends Immunol 2016 Mar 29;37(3):167-169. Epub 2016 Jan 29.

Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.it.2016.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955921PMC
March 2016

Effects of Systemically Administered Hydrocortisone on the Human Immunome.

Sci Rep 2016 Mar 14;6:23002. Epub 2016 Mar 14.

Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep23002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789739PMC
March 2016

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network.

EMBO Rep 2015 Oct 24;16(10):1378-93. Epub 2015 Aug 24.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embr.201540837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766451PMC
October 2015

Utilizing population variation, vaccination, and systems biology to study human immunology.

Authors:
John S Tsang

Trends Immunol 2015 Aug 14;36(8):479-93. Epub 2015 Jul 14.

Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD 20892, USA; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.it.2015.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979540PMC
August 2015

Random yet deterministic: convergent immunoglobulin responses to influenza.

Trends Microbiol 2014 Sep;22(9):488-9

Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; Trans-NIH Center for Human Immunology, National Institutes of Health, Bethesda, MD, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tim.2014.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961090PMC
September 2014

The National Institutes of Health Center for Human Immunology, Autoimmunity, and Inflammation: history and progress.

Ann N Y Acad Sci 2013 May;1285:133-47

Center for Human Immunology, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.12101DOI Listing
May 2013

From finger pricks to point-and-click.

Immunity 2013 Apr;38(4):622-4

Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2013.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701406PMC
April 2013

MicroRNAs can generate thresholds in target gene expression.

Nat Genet 2011 Aug 21;43(9):854-9. Epub 2011 Aug 21.

Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163764PMC
August 2011

Genome-wide dissection of microRNA functions and cotargeting networks using gene set signatures.

Mol Cell 2010 Apr;38(1):140-53

Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2010.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110938PMC
April 2010