John S Millar

John S Millar

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John S Millar

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Differential Effects of Roux-en-Y Gastric Bypass Surgery and Laparoscopic Sleeve Gastrectomy on Fatty Acid Levels.

Obes Surg 2019 Jul 9. Epub 2019 Jul 9.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s11695-019-04062-5DOI Listing
July 2019

Cholesterol metabolism in humans: a review of methods and comparison of results.

Curr Opin Lipidol 2018 02;29(1):1-9

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MOL.0000000000000475DOI Listing
February 2018

CETP (Cholesteryl Ester Transfer Protein) Inhibition With Anacetrapib Decreases Production of Lipoprotein(a) in Mildly Hypercholesterolemic Subjects.

Arterioscler Thromb Vasc Biol 2017 09 20;37(9):1770-1775. Epub 2017 Jul 20.

From the Columbia University, New York (T.T., W.K., R.R., S.H., H.N.G., G.R.-S.); Merck & Co, Inc, Kenilworth, NJ (H.Z., Y.L., P.J., J.A.W., B.H., S.F.P., T.R., A.O.J.-L., D.E.G.); University of Washington, Seattle (S.M.M.); and University of Pennsylvania, Philadelphia (D.J.R., J.S.M.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567403PMC
September 2017

Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress.

Cell Rep 2017 05;19(7):1456-1466

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555078PMC
May 2017

Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly.

Biochim Biophys Acta 2016 12 24;1861(12 Pt A):1968-1979. Epub 2016 Sep 24.

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.09.017DOI Listing
December 2016

Targeting ApoC-III to Reduce Coronary Disease Risk.

Curr Atheroscler Rep 2016 09;18(9):54

Perelman School of Medicine, University of Pennsylvania, 11-125 SCTR, 3400 Civic Center Blvd, Philadelphia, PA, 19104, USA.

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http://link.springer.com/content/pdf/10.1007/s11883-016-0609
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http://link.springer.com/10.1007/s11883-016-0609-y
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http://dx.doi.org/10.1007/s11883-016-0609-yDOI Listing
September 2016

Lnc-ing Common Polymorphisms to Statin Responsiveness at the MYLIP Locus.

Circ Cardiovasc Genet 2016 06;9(3):206-9

Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001458DOI Listing
June 2016

Cholesteryl Ester Transfer Protein Inhibition With Anacetrapib Decreases Fractional Clearance Rates of High-Density Lipoprotein Apolipoprotein A-I and Plasma Cholesteryl Ester Transfer Protein.

Arterioscler Thromb Vasc Biol 2016 05 10;36(5):994-1002. Epub 2016 Mar 10.

From the Columbia University, New York, NY (G.R.-S., C.N., E.C., D.S.D., W.K., R.R., S.H., T.T., H.N.G.); University of Pennsylvania, Philadelphia (J.S.M., R.L.D., E.M.d., A.L.B., D.J.R.); Merck & Co., Inc., Kenilworth, NJ (P.J., A.O.J.-L., J.A.W., Y.L., M.E.L., D.E.G.); Tufts University School of Medicine, Boston, MA (B.A.); and Drexel Neurological Associates, Philadelphia, PA (H.R.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911016PMC
May 2016

Potent peroxisome proliferator-activated receptor-α agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome.

Eur Heart J 2015 Nov 25;36(43):3020-2. Epub 2015 Jun 25.

Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, Philadelphia, PA, USA

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http://dx.doi.org/10.1093/eurheartj/ehv291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644252PMC
November 2015

ApoA-I-Directed Therapies for the Management of Atherosclerosis.

Curr Atheroscler Rep 2015 Oct;17(10):60

Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Room 11-132, Philadelphia, PA, 19104, USA,

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http://dx.doi.org/10.1007/s11883-015-0539-0DOI Listing
October 2015

Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease.

Circ Res 2015 Jun 22;117(1):17-28. Epub 2015 Apr 22.

From the Cardiovascular Institute (H.Z., C.X., R.S., K.B., C.C.H., W.L., A.R., J.T.-M., E.E.P., E.E.M., D.J.R., M.P.R.), and Department of Biostatistics and Epidemiology (M.L.), Perelman School of Medicine, Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity, and Metabolism (A.R., M.C., E.E.P., D.J.R.), Department of Medicine, Metabolic Tracer Resource, Institute for Diabetes, Obesity, and Metabolism (J.S.M.), Institute for Regenerative Medicine (Y.L., R.Y., W.Y., E.E.M.), Department of Biology, Perelman School of Medicine and School of Arts and Science (S.J.G., B.D.G.), PENN Genome Frontiers Institute (S.J.G., B.D.G.), Department of Pediatrics, Perelman School of Medicine (S.T.C.), Department of Cell and Developmental Biology, Perelman School of Medicine (E.E.M.), and Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Division of Hematology, The Children's Hospital of Philadelphia, PA (D.V., S.T.C.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.305860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565503PMC
June 2015

Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein.

J Lipid Res 2015 May 4;56(5):972-85. Epub 2015 Feb 4.

Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208 Simpson Querrey Institute for BioNanotechnology and Medicine, Northwestern University, Chicago, IL 60611.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M054635
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http://dx.doi.org/10.1194/jlr.M054635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409287PMC
May 2015

RYR1-related malignant hyperthermia with marked cerebellar involvement - a paradigm of heat-induced CNS injury?

Neuromuscul Disord 2015 Feb 31;25(2):138-40. Epub 2014 Oct 31.

Department of Paediatric Neurology, Neuromuscular Service, Evelina's Children Hospital, Guy's & St. Thomas' Hospital NHS Foundation Trust, London, UK; Randall Division of Cell and Molecular Biophysics, Muscle Signalling Section, King's College, London, UK; Department of Clinical and Basic Neuroscience, IoPPN, King's College, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nmd.2014.10.008DOI Listing
February 2015

A novel ApoA-I truncation (ApoA-IMytilene) associated with decreased ApoA-I production.

Atherosclerosis 2014 Aug 2;235(2):470-6. Epub 2014 Jun 2.

Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA; Boston Heart Diagnostics, Framingham, MA 01702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2014.05.935DOI Listing
August 2014

A coding variant in SR-BI (I179N) significantly increases atherosclerosis in mice.

Mamm Genome 2013 Aug 31;24(7-8):257-65. Epub 2013 May 31.

Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, 654 BRBII/III Labs, 421 Curie Boulevard, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1007/s00335-013-9459-xDOI Listing
August 2013

Indirect and mitigated effects of pulsed resources on the population dynamics of a northern rodent.

J Anim Ecol 2013 Jul 5;82(4):814-25. Epub 2013 Mar 5.

Department of Biology, University of Western Ontario, 1151 Richmond Street, London, ON, N6A 5B7, Canada.

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http://dx.doi.org/10.1111/1365-2656.12062DOI Listing
July 2013

Novel benefits of peroxisome proliferator-activated receptors on cardiovascular risk.

Authors:
John S Millar

Curr Opin Lipidol 2013 Jun;24(3):233-8

Division of Translational Medicine and Human Genetics, Institute of Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MOL.0b013e3283613a7dDOI Listing
June 2013

The corporate determinants of health: how big business affects our health, and the need for government action!

Authors:
John S Millar

Can J Public Health 2013 May 14;104(4):e327-9. Epub 2013 May 14.

UBC, PHABC.

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May 2013

Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.

J Clin Invest 2012 Aug 2;122(8):2807-16. Epub 2012 Jul 2.

Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://www.jci.org/articles/view/63563
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http://dx.doi.org/10.1172/JCI63563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408750PMC
August 2012

Selective peroxisome proliferator-activated receptor-γ modulation to reduce cardiovascular risk in patients with insulin resistance.

Recent Pat Cardiovasc Drug Discov 2012 Apr;7(1):33-41

Division of Endocrinology, Department of Medicine, National University Health System, Singapore, 1E Kent Ridge Road, Level 10, Singapore.

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April 2012

PPARγ activation redirects macrophage cholesterol from fecal excretion to adipose tissue uptake in mice via SR-BI.

Biochem Pharmacol 2011 Apr 1;81(7):934-41. Epub 2011 Feb 1.

Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 421 Curie Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.bcp.2011.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315103PMC
April 2011

Effect of rosiglitazone on HDL metabolism in subjects with metabolic syndrome and low HDL.

J Lipid Res 2011 Jan 22;52(1):136-42. Epub 2010 Oct 22.

Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.P008136
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http://dx.doi.org/10.1194/jlr.P008136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999935PMC
January 2011

Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes.

Biochem Pharmacol 2010 Nov 22;80(9):1450-7. Epub 2010 Jul 22.

Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00062952100053
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http://dx.doi.org/10.1016/j.bcp.2010.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328801PMC
November 2010

Endovascular treatment of cranial dural arteriovenous fistulae: a single-centre, 14-year experience and the impact of Onyx on local practise.

Neuroradiology 2010 May 4;52(5):387-95. Epub 2009 Nov 4.

Wessex Neurological Centre, Southampton General Hospital, Southampton, SO16 6YD, UK.

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http://link.springer.com/10.1007/s00234-009-0620-x
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http://dx.doi.org/10.1007/s00234-009-0620-xDOI Listing
May 2010

The effect of PPAR-alpha agonism on apolipoprotein metabolism in humans.

Atherosclerosis 2010 May 14;210(1):35-40. Epub 2009 Dec 14.

University of Pennsylvania, Depts. of Medicine and Pharmacology, 652 BRB II/III, 421 Curie Blvd., Philadelphia, PA 19104, United States.

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http://dx.doi.org/10.1016/j.atherosclerosis.2009.11.010DOI Listing
May 2010

Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages.

Arterioscler Thromb Vasc Biol 2010 Mar 17;30(3):526-32. Epub 2009 Dec 17.

Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Maloney Building, Room 8039, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1161/ATVBAHA.109.196105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842952PMC
March 2010

Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein.

PLoS One 2009 Aug 5;4(8):e6521. Epub 2009 Aug 5.

School of Medicine, Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006521PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715880PMC
August 2009

Effects of nevirapine and efavirenz on HDL cholesterol levels and reverse cholesterol transport in mice.

Atherosclerosis 2009 Jun 27;204(2):418-23. Epub 2008 Sep 27.

Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2008.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755296PMC
June 2009

Canada's global position in life expectancy: a longitudinal comparison with the healthiest countries in the world.

Can J Public Health 2009 Jan-Feb;100(1):9-13

Population & Public Health, British Columbia Provincial Health Services Authority, 700-1380 Burrard Street, Vancouver, BC V6Z 2H3.

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April 2009

Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo.

Arterioscler Thromb Vasc Biol 2009 Jan 13;29(1):40-6. Epub 2008 Nov 13.

Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.108.177105
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http://dx.doi.org/10.1161/ATVBAHA.108.177105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766561PMC
January 2009

Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice.

Biochim Biophys Acta 2008 Mar 17;1781(3):97-104. Epub 2008 Jan 17.

Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1016/j.bbalip.2008.01.001DOI Listing
March 2008

Hepatic proprotein convertases modulate HDL metabolism.

Cell Metab 2007 Aug;6(2):129-36

Department of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.cmet.2007.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565575PMC
August 2007

Endothelial lipase is less effective at influencing HDL metabolism in vivo in mice expressing apoA-II.

J Lipid Res 2006 Oct 30;47(10):2191-7. Epub 2006 Jul 30.

Department of Medicine and Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M600036-JLR200
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http://dx.doi.org/10.1194/jlr.M600036-JLR200DOI Listing
October 2006

Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a].

J Lipid Res 2005 Dec 8;46(12):2681-91. Epub 2005 Sep 8.

Department of Biological Sciences, University of Delaware, Newark, DE, USA.

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http://dx.doi.org/10.1194/jlr.M500249-JLR200DOI Listing
December 2005

Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation.

Circ Res 2005 Oct 8;97(8):763-71. Epub 2005 Sep 8.

Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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https://www.ahajournals.org/doi/10.1161/01.RES.0000185320.82
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http://dx.doi.org/10.1161/01.RES.0000185320.82962.F7DOI Listing
October 2005

Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339.

J Lipid Res 2005 Sep 1;46(9):2023-8. Epub 2005 Jul 1.

Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1194/jlr.D500019-JLR200DOI Listing
September 2005

Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production.

Arterioscler Thromb Vasc Biol 2005 Mar 6;25(3):560-5. Epub 2005 Jan 6.

Department of Medicine, University of Pennsylvania, 644 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1161/01.ATV.0000155323.18856.a2DOI Listing
March 2005

The metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein (a) in human beings.

Metabolism 2005 Mar;54(3):361-9

Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

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http://dx.doi.org/10.1016/j.metabol.2004.10.001DOI Listing
March 2005

Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins.

Circ Res 2004 Jun 29;94(12):1554-61. Epub 2004 Apr 29.

University of Pennsylvania, Philadelphia, Pa, USA.

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http://dx.doi.org/10.1161/01.RES.0000130657.00222.39DOI Listing
June 2004

Apolipoprotein A-I deficiency results in markedly increased atherosclerosis in mice lacking the LDL receptor.

Arterioscler Thromb Vasc Biol 2003 Oct 21;23(10):1914-20. Epub 2003 Aug 21.

University of Pennsylvania School of Medicine, 654 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.

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https://www.ahajournals.org/doi/10.1161/01.ATV.0000092328.66
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http://dx.doi.org/10.1161/01.ATV.0000092328.66882.F5DOI Listing
October 2003

Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway.

J Biol Chem 2003 Sep 16;278(36):34331-8. Epub 2003 Jun 16.

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M302181200
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http://dx.doi.org/10.1074/jbc.M302181200DOI Listing
September 2003

Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo.

J Clin Invest 2003 Feb;111(3):357-62

Department of Medicine and Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://www.jci.org/articles/view/16146
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http://dx.doi.org/10.1172/JCI16146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151853PMC
February 2003

Female-biased sexual size dimorphism in the yellow-pine chipmunk (Tamias amoenus): sex-specific patterns of annual reproductive success and survival.

Evolution 2002 Dec;56(12):2519-29

Ecology and Evolution Group, Department of Zoology, University of Western Ontario, London, Ontario K7L 3N6, Canada.

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http://dx.doi.org/10.1111/j.0014-3820.2002.tb00176.xDOI Listing
December 2002

Normal production rate of apolipoprotein B in LDL receptor-deficient mice.

Arterioscler Thromb Vasc Biol 2002 Jun;22(6):989-94

Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA.

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http://dx.doi.org/10.1161/01.atv.0000018304.30943.06DOI Listing
June 2002

PRE-PARTUM REPRODUCTIVE CHARACTERISTICS OF EUTHERIAN MAMMALS.

Authors:
John S Millar

Evolution 1981 Nov;35(6):1149-1163

Department of Zoology, University of Western Ontario, London, Ontario, Canada, N6A 5B7.

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http://dx.doi.org/10.1111/j.1558-5646.1981.tb04986.xDOI Listing
November 1981

ADAPTIVE FEATURES OF MAMMALIAN REPRODUCTION.

Authors:
John S Millar

Evolution 1977 Jun;31(2):370-386

Department of Zoology, University of Western Ontario, London, Ontario, Canada, N6A 5B7.

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http://dx.doi.org/10.1111/j.1558-5646.1977.tb01019.xDOI Listing
June 1977

EVOLUTION OF LITTER-SIZE IN THE PIKA, OCHOTONA PRINCEPS (RICHARDSON).

Authors:
John S Millar

Evolution 1973 Mar;27(1):134-143

Department of Zoology, University of Alberta, Edmonton, Alberta.

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http://dx.doi.org/10.1111/j.1558-5646.1973.tb05925.xDOI Listing
March 1973