John S Floras

John S Floras

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John S Floras

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Simultaneous assessment of central and peripheral chemoreflex regulation of muscle sympathetic nerve activity and ventilation in healthy young men.

J Physiol 2019 Jul 28;597(13):3281-3296. Epub 2019 May 28.

University Health Network and Mount Sinai Hospital Division of Cardiology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1113/JP277691DOI Listing
July 2019

Training Heart Failure Patients with Reduced Ejection Fraction Attenuates Muscle Sympathetic Nerve Activation During Mild Dynamic Exercise.

Am J Physiol Regul Integr Comp Physiol 2019 Jul 31. Epub 2019 Jul 31.

Cardiology/Medicine, University Health Network and Mount Sinai Hospital, Canada.

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http://dx.doi.org/10.1152/ajpregu.00104.2019DOI Listing
July 2019

Effect of Trendelenburg position and lower-body positive pressure on neck fluid distribution.

J Appl Physiol (1985) 2019 May 28;126(5):1259-1264. Epub 2019 Feb 28.

Toronto Rehabilitation Institute, University Health Network , Toronto, Ontario , Canada.

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http://dx.doi.org/10.1152/japplphysiol.00926.2018DOI Listing
May 2019

Heart Failure-Specific Relationship Between Muscle Sympathetic Nerve Activity and Aortic Wave Reflection.

J Card Fail 2019 May 9;25(5):404-408. Epub 2019 Mar 9.

University Health Network and Mount Sinai Hospital Division of Cardiology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cardfail.2019.03.005DOI Listing
May 2019

Microneurographic characterization of sympathetic responses during 1-leg exercise in young and middle-aged humans.

Appl Physiol Nutr Metab 2019 Feb 31;44(2):194-199. Epub 2018 Jul 31.

a University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Toronto General Hospital, University Health Network, 200 Elizabeth St., Toronto, ON M5G 2C4, Canada.

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http://dx.doi.org/10.1139/apnm-2018-0101DOI Listing
February 2019

Predictors of 1-year compliance with adaptive servoventilation in patients with heart failure and sleep disordered breathing: preliminary data from the ADVENT-HF trial.

Eur Respir J 2019 Feb 21;53(2). Epub 2019 Feb 21.

Sleep Research Laboratory of the University Health Network Toronto Rehabilitation Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1183/13993003.01626-2018DOI Listing
February 2019

Exercise Blood Pressure Guidelines: Time to Re-evaluate What is Normal and Exaggerated?

Sports Med 2018 08;48(8):1763-1771

Faculty of Kinesiology and Physical Education, University of Toronto, 55 Harbord Street, Toronto, ON, M5S 2W6, Canada.

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http://link.springer.com/10.1007/s40279-018-0900-x
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http://dx.doi.org/10.1007/s40279-018-0900-xDOI Listing
August 2018

Sleep Apnea and Cardiovascular Disease: An Enigmatic Risk Factor.

Authors:
John S Floras

Circ Res 2018 06;122(12):1741-1764

From the University Health Network and Sinai Health System Division of Cardiology, Department of Medicine, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.310783DOI Listing
June 2018

Should Maternal Hemodynamics Guide Antihypertensive Therapy in Preeclampsia?

Hypertension 2018 04 5;71(4):550-556. Epub 2018 Feb 5.

From the Division of Cardiology, Department of Medicine (K.M., J.S.F., J.D.P.) and Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology (R.R.S., J.C.K.), Sinai Health System, University of Toronto, ON, Canada; and Centre for Women's and Infant's Health, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada (K.M., J.C.K.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10606DOI Listing
April 2018

Cortical Autonomic Network Grey Matter and Sympathetic Nerve Activity in Obstructive Sleep Apnea.

Sleep 2017 Dec 23. Epub 2017 Dec 23.

University Health Network and Mount Sinai Hospital Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/sleep/zsx208DOI Listing
December 2017

Acute effects of angiotensin-converting enzyme inhibition versus angiotensin II receptor blockade on cardiac sympathetic activity in patients with heart failure.

Am J Physiol Regul Integr Comp Physiol 2017 Oct 5;313(4):R410-R417. Epub 2017 Jul 5.

Division of Cardiology, Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, University of Toronto, Toronto, Ontario, Canada; and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1152/ajpregu.00095.2017DOI Listing
October 2017

Ambulatory Apnea Monitoring in Heart Failure: Proceed With Caution.

Authors:
John S Floras

J Am Coll Cardiol 2017 09;70(11):1365-1367

University Health Network and Sinai Health System Division of Cardiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.07.761DOI Listing
September 2017

Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Authors:
Ilja M Nolte M Loretto Munoz Vinicius Tragante Azmeraw T Amare Rick Jansen Ahmad Vaez Benedikt von der Heyde Christy L Avery Joshua C Bis Bram Dierckx Jenny van Dongen Stephanie M Gogarten Philippe Goyette Jussi Hernesniemi Ville Huikari Shih-Jen Hwang Deepali Jaju Kathleen F Kerr Alexander Kluttig Bouwe P Krijthe Jitender Kumar Sander W van der Laan Leo-Pekka Lyytikäinen Adam X Maihofer Arpi Minassian Peter J van der Most Martina Müller-Nurasyid Michel Nivard Erika Salvi James D Stewart Julian F Thayer Niek Verweij Andrew Wong Delilah Zabaneh Mohammad H Zafarmand Abdel Abdellaoui Sulayma Albarwani Christine Albert Alvaro Alonso Foram Ashar Juha Auvinen Tomas Axelsson Dewleen G Baker Paul I W de Bakker Matteo Barcella Riad Bayoumi Rob J Bieringa Dorret Boomsma Gabrielle Boucher Annie R Britton Ingrid Christophersen Andrea Dietrich George B Ehret Patrick T Ellinor Markku Eskola Janine F Felix John S Floras Oscar H Franco Peter Friberg Maaike G J Gademan Mark A Geyer Vilmantas Giedraitis Catharina A Hartman Daiane Hemerich Albert Hofman Jouke-Jan Hottenga Heikki Huikuri Nina Hutri-Kähönen Xavier Jouven Juhani Junttila Markus Juonala Antti M Kiviniemi Jan A Kors Meena Kumari Tatiana Kuznetsova Cathy C Laurie Joop D Lefrandt Yong Li Yun Li Duanping Liao Marian C Limacher Henry J Lin Cecilia M Lindgren Steven A Lubitz Anubha Mahajan Barbara McKnight Henriette Meyer Zu Schwabedissen Yuri Milaneschi Nina Mononen Andrew P Morris Mike A Nalls Gerjan Navis Melanie Neijts Kjell Nikus Kari E North Daniel T O'Connor Johan Ormel Siegfried Perz Annette Peters Bruce M Psaty Olli T Raitakari Victoria B Risbrough Moritz F Sinner David Siscovick Johannes H Smit Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Jan A Staessen Phyllis K Stein Adrienne M Stilp Katarzyna Stolarz-Skrzypek Konstantin Strauch Johan Sundström Cees A Swenne Ann-Christine Syvänen Jean-Claude Tardif Kent D Taylor Alexander Teumer Timothy A Thornton Lesley E Tinker André G Uitterlinden Jessica van Setten Andreas Voss Melanie Waldenberger Kirk C Wilhelmsen Gonneke Willemsen Quenna Wong Zhu-Ming Zhang Alan B Zonderman Daniele Cusi Michele K Evans Halina K Greiser Pim van der Harst Mohammad Hassan Erik Ingelsson Marjo-Riitta Järvelin Stefan Kääb Mika Kähönen Mika Kivimaki Charles Kooperberg Diana Kuh Terho Lehtimäki Lars Lind Caroline M Nievergelt Chris J O'Donnell Albertine J Oldehinkel Brenda Penninx Alexander P Reiner Harriëtte Riese Arie M van Roon John D Rioux Jerome I Rotter Tamar Sofer Bruno H Stricker Henning Tiemeier Tanja G M Vrijkotte Folkert W Asselbergs Bianca J J M Brundel Susan R Heckbert Eric A Whitsel Marcel den Hoed Harold Snieder Eco J C de Geus

Nat Commun 2017 08 2;8:16140. Epub 2017 Aug 2.

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http://dx.doi.org/10.1038/ncomms16140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543301PMC
August 2017

Sleep-Disordered Breathing in Heart Failure - A Therapeutic Dilemma.

Circ J 2017 Jun 23;81(7):903-912. Epub 2017 May 23.

The University Health Network and Sinai Health System Division of Cardiology, Department of Medicine, University of Toronto.

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http://dx.doi.org/10.1253/circj.CJ-17-0440DOI Listing
June 2017

Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Authors:
Ilja M Nolte M Loretto Munoz Vinicius Tragante Azmeraw T Amare Rick Jansen Ahmad Vaez Benedikt von der Heyde Christy L Avery Joshua C Bis Bram Dierckx Jenny van Dongen Stephanie M Gogarten Philippe Goyette Jussi Hernesniemi Ville Huikari Shih-Jen Hwang Deepali Jaju Kathleen F Kerr Alexander Kluttig Bouwe P Krijthe Jitender Kumar Sander W van der Laan Leo-Pekka Lyytikäinen Adam X Maihofer Arpi Minassian Peter J van der Most Martina Müller-Nurasyid Michel Nivard Erika Salvi James D Stewart Julian F Thayer Niek Verweij Andrew Wong Delilah Zabaneh Mohammad H Zafarmand Abdel Abdellaoui Sulayma Albarwani Christine Albert Alvaro Alonso Foram Ashar Juha Auvinen Tomas Axelsson Dewleen G Baker Paul I W de Bakker Matteo Barcella Riad Bayoumi Rob J Bieringa Dorret Boomsma Gabrielle Boucher Annie R Britton Ingrid Christophersen Andrea Dietrich George B Ehret Patrick T Ellinor Markku Eskola Janine F Felix John S Floras Oscar H Franco Peter Friberg Maaike G J Gademan Mark A Geyer Vilmantas Giedraitis Catharina A Hartman Daiane Hemerich Albert Hofman Jouke-Jan Hottenga Heikki Huikuri Nina Hutri-Kähönen Xavier Jouven Juhani Junttila Markus Juonala Antti M Kiviniemi Jan A Kors Meena Kumari Tatiana Kuznetsova Cathy C Laurie Joop D Lefrandt Yong Li Yun Li Duanping Liao Marian C Limacher Henry J Lin Cecilia M Lindgren Steven A Lubitz Anubha Mahajan Barbara McKnight Henriette Meyer Zu Schwabedissen Yuri Milaneschi Nina Mononen Andrew P Morris Mike A Nalls Gerjan Navis Melanie Neijts Kjell Nikus Kari E North Daniel T O'Connor Johan Ormel Siegfried Perz Annette Peters Bruce M Psaty Olli T Raitakari Victoria B Risbrough Moritz F Sinner David Siscovick Johannes H Smit Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Jan A Staessen Phyllis K Stein Adrienne M Stilp Katarzyna Stolarz-Skrzypek Konstantin Strauch Johan Sundström Cees A Swenne Ann-Christine Syvänen Jean-Claude Tardif Kent D Taylor Alexander Teumer Timothy A Thornton Lesley E Tinker André G Uitterlinden Jessica van Setten Andreas Voss Melanie Waldenberger Kirk C Wilhelmsen Gonneke Willemsen Quenna Wong Zhu-Ming Zhang Alan B Zonderman Daniele Cusi Michele K Evans Halina K Greiser Pim van der Harst Mohammad Hassan Erik Ingelsson Marjo-Riitta Järvelin Stefan Kääb Mika Kähönen Mika Kivimaki Charles Kooperberg Diana Kuh Terho Lehtimäki Lars Lind Caroline M Nievergelt Chris J O'Donnell Albertine J Oldehinkel Brenda Penninx Alexander P Reiner Harriëtte Riese Arie M van Roon John D Rioux Jerome I Rotter Tamar Sofer Bruno H Stricker Henning Tiemeier Tanja G M Vrijkotte Folkert W Asselbergs Bianca J J M Brundel Susan R Heckbert Eric A Whitsel Marcel den Hoed Harold Snieder Eco J C de Geus

Nat Commun 2017 06 14;8:15805. Epub 2017 Jun 14.

Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.

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http://dx.doi.org/10.1038/ncomms15805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474732PMC
June 2017

Complexity of Sympathetic Nerve Traffic in Human Heart Failure: Seeking Inspiration.

J Card Fail 2017 02 28;23(2):104-106. Epub 2016 Nov 28.

University Health Network and Mount Sinai Hospital Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cardfail.2016.11.007DOI Listing
February 2017

Sympathetic Nervous System in Patients with Sleep Related Breathing Disorders.

Authors:
John S Floras

Curr Hypertens Rev 2016 ;12(1):18-26

Suite 1614, 600 University Avenue, Toronto ON Canada M5G 1X5.

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December 2016

Sleep Apnea and Left Atrial Phasic Function in Heart Failure With Reduced Ejection Fraction.

Can J Cardiol 2016 12 13;32(12):1402-1410. Epub 2016 Feb 13.

University Health Network and Mount Sinai Hospital Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2016.02.047DOI Listing
December 2016

Arousal From Sleep and Sympathetic Excitation During Wakefulness.

Hypertension 2016 12 3;68(6):1467-1474. Epub 2016 Oct 3.

From the University Health Network and Mount Sinai Hospital Department of Medicine, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08212DOI Listing
December 2016

The SERVE-HF Trial.

Can Respir J 2015 Nov-Dec;22(6):313. Epub 2015 Oct 16.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676391PMC
http://dx.doi.org/10.1155/2015/751615DOI Listing
September 2016

After-exercise heart rate variability is attenuated in postmenopausal women and unaffected by estrogen therapy.

Menopause 2016 Apr;23(4):390-5

1Division of Cardiology, Women's College Hospital 2Division of Cardiology, University Health Network 3Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/GME.0000000000000568DOI Listing
April 2016

Adaptive Servo Ventilation for Central Sleep Apnea: More Data, Please.

Can J Cardiol 2016 Mar 22;32(3):396.e3. Epub 2015 Oct 22.

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http://dx.doi.org/10.1016/j.cjca.2015.10.004DOI Listing
March 2016

Adaptive Servo-ventilation and the Treatment of Central Sleep Apnea in Heart Failure. Let's Not Throw the Baby Out with the Bathwater.

Am J Respir Crit Care Med 2016 Feb;193(4):357-9

3 Department of Medicine University of Toronto Toronto, Ontario, Canada.

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http://dx.doi.org/10.1164/rccm.201511-2198EDDOI Listing
February 2016

Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure.

N Engl J Med 2016 02;374(7):689

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http://dx.doi.org/10.1056/NEJMc1515007DOI Listing
February 2016

Hemodynamic and neurochemical determinates of renal function in chronic heart failure.

Am J Physiol Regul Integr Comp Physiol 2016 Jan 11;310(2):R167-75. Epub 2015 Nov 11.

Division of Cardiology and Nephrology, Mount Sinai Hospital and University Health Network Hospital, Toronto, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada; and.

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http://dx.doi.org/10.1152/ajpregu.00190.2015DOI Listing
January 2016

To Pulse or Not to Pulse, Is That the Question?

Circulation 2015 Dec 28;132(24):2293-6. Epub 2015 Oct 28.

From University Health Network Divisions of Cardiology and Cardiovascular Surgery and Peter Munk Cardiac Centre, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.019461DOI Listing
December 2015

Augmented vagal heart rate modulation in active hypoestrogenic pre-menopausal women with functional hypothalamic amenorrhoea.

Clin Sci (Lond) 2015 Nov 28;129(10):885-93. Epub 2015 Jul 28.

Department of Medicine, Division of Cardiology, Women's College Hospital, University of Toronto, Ontario M5S 1B3, Canada

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http://dx.doi.org/10.1042/CS20150209DOI Listing
November 2015

Muscle sympathetic activity in resting and exercising humans with and without heart failure.

Appl Physiol Nutr Metab 2015 Nov 14;40(11):1107-15. Epub 2015 Aug 14.

a University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Toronto, ON M5G 2C4, Canada.

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http://dx.doi.org/10.1139/apnm-2015-0289DOI Listing
November 2015

Obstructive sleep apnea syndrome, continuous positive airway pressure and treatment of hypertension.

Authors:
John S Floras

Eur J Pharmacol 2015 Sep 18;763(Pt A):28-37. Epub 2015 Jun 18.

University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.06.024DOI Listing
September 2015

The sympathetic/parasympathetic imbalance in heart failure with reduced ejection fraction.

Eur Heart J 2015 Aug 13;36(30):1974-82b. Epub 2015 May 13.

Department for Heart Disease, Medical University, Clinical Military Hospital, Wroclaw, Poland.

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http://dx.doi.org/10.1093/eurheartj/ehv087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528097PMC
August 2015

Overnight Effects of Obstructive Sleep Apnea and Its Treatment on Stroke Volume in Patients With Heart Failure.

Can J Cardiol 2015 Jul 10;31(7):832-8. Epub 2015 Jan 10.

Sleep Research Laboratory of the University Health Network Toronto Rehabilitation Institute, Toronto, Ontario, Canada; Centre for Sleep Medicine and Circadian Biology, University of Toronto, Toronto, Ontario, Canada; Departments of Medicine of the University Health Network Toronto General Hospital, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2015.01.001DOI Listing
July 2015

Hypertension and Sleep Apnea.

Authors:
John S Floras

Can J Cardiol 2015 Jul 16;31(7):889-97. Epub 2015 May 16.

University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2015.05.003DOI Listing
July 2015

Sleep apnoea in acute heart failure: fluid in flux.

Eur Heart J 2015 Jun 22;36(23):1428-30. Epub 2015 Mar 22.

University Health Network and Mount Sinai Hospital Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/eurheartj/ehv084DOI Listing
June 2015

Discordant orthostatic reflex renin-angiotensin and sympathoneural responses in premenopausal exercising-hypoestrogenic women.

Hypertension 2015 May 16;65(5):1089-95. Epub 2015 Mar 16.

From the Cardiovascular Research Laboratory, Department of Exercise Sciences, University of Toronto, Toronto, Ontario, Canada (E.O'D., J.M.G.); and Department of Medicine, Division of Cardiology, University Health Network at Mount Sinai Hospital (J.M.G., S.M., H.M., B.L.M, J.S.F.), and Department of Medicine, Division of Cardiology at the Women's College Hospital (P.J.H.), University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04976DOI Listing
May 2015

Acute renal failure after renal denervation.

J Vasc Interv Radiol 2015 Mar;26(3):450-1

Department of Medical Imaging, University Health Network and Mount Sinai Hospital, University of Toronto, 585 University Avenue, NCSB 1C-553, Toronto, Ontario, Canada, M5G 2N2.; Peter Munk Cardiac Centre, University Health Network, University of Toronto, 585 University Avenue, NCSB 1C-553, Toronto, Ontario, Canada, M5G 2N2.

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http://dx.doi.org/10.1016/j.jvir.2014.11.017DOI Listing
March 2015

Divergent muscle sympathetic responses to dynamic leg exercise in heart failure and age-matched healthy subjects.

J Physiol 2015 Feb 15;593(3):715-22. Epub 2014 Dec 15.

University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1113/jphysiol.2014.281873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324715PMC
February 2015

Paradoxical muscle sympathetic reflex activation in human heart failure.

Circulation 2015 Feb 2;131(5):459-68. Epub 2014 Dec 2.

From the University Health Network and Mount Sinai Hospital Division of Cardiology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.010765DOI Listing
February 2015

Apnea-induced cortical BOLD-fMRI and peripheral sympathoneural firing response patterns of awake healthy humans.

PLoS One 2013 16;8(12):e82525. Epub 2013 Dec 16.

Clinical Cardiovascular Physiology Laboratory, University Health Network and Mount Sinai Hospital Division of Cardiology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082525PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865029PMC
September 2014

Estrogen status and the renin angiotensin aldosterone system.

Am J Physiol Regul Integr Comp Physiol 2014 Sep 18;307(5):R498-500. Epub 2014 Jun 18.

Division of Cardiology, Women's College Hospital, Department of Medicine, University of Toronto, Canada.

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http://dx.doi.org/10.1152/ajpregu.00182.2014DOI Listing
September 2014

Effects of short-term continuous positive airway pressure on myocardial sympathetic nerve function and energetics in patients with heart failure and obstructive sleep apnea: a randomized study.

Circulation 2014 Sep 3;130(11):892-901. Epub 2014 Jul 3.

From the National Cardiac PET Center, Division of Cardiology, Department of Medicine (A.B.H., M.C.Z., S.C., I.G.B., J.R., R.A.d., H.H., L.M.M., K.Y., A.G., O.W., L.G., J.N.D., R.S.B.B.), and Cardiac Research Methods Center (L.C.), University of Ottawa Heart Institute, Ottawa, Canada; Diagnostico Medico Oronia, Non Invasive Cardiovascular Imaging Department, Rosario, Santa Fe, Argentina (M.C.Z.); Division of Respirology, Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Canada (J.A.L.); Department of Molecular Imaging, Hokkaido University Graduate School of Medicince, Sapporo, Japan (K.Y.); and Division of Cardiology, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Canada (J.S.F.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.005893DOI Listing
September 2014

Coagulation factor XIIa-kinin-mediated contribution to hypertension of chronic kidney disease.

J Hypertens 2014 Jul;32(7):1523-33; discussion 1533

aHeart and Stroke/Richard Lewar Centre of Excellence bDepartment of Medicine, University Health Network and Mount Sinai Hospital cDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/HJH.0000000000000192DOI Listing
July 2014

Renal denervation for drug-resistant hypertension: suffering its original sin, seeking redemption.

Authors:
John S Floras

Can J Cardiol 2014 May 19;30(5):476-8. Epub 2014 Feb 19.

Peter Munk Cardiac Centre and University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2014.02.008DOI Listing
May 2014

Statins and the autonomic nervous system.

Clin Sci (Lond) 2014 Mar;126(6):401-15

*University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1042/CS20130332DOI Listing
March 2014

Relationship of heart rate variability to sleepiness in patients with obstructive sleep apnea with and without heart failure.

J Clin Sleep Med 2014 Mar 15;10(3):271-6. Epub 2014 Mar 15.

Sleep Research Laboratory of the Toronto Rehabilitation Institute ; Centre for Sleep Medicine and Circadian Biology of the University of Toronto ; the Departments of Medicine of the University Health Network Toronto General Hospital.

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http://dx.doi.org/10.5664/jcsm.3526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927432PMC
March 2014

Reply to letter from Zis and Zis--concerning blood pressure variability.

Authors:
John S Floras

Can J Cardiol 2014 Feb 11;30(2):248.e9. Epub 2013 Jul 11.

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http://dx.doi.org/10.1016/j.cjca.2013.05.008DOI Listing
February 2014

Inverse relationship between muscle sympathetic activity during exercise and peak oxygen uptake in subjects with and without heart failure.

J Am Coll Cardiol 2014 Feb 28;63(6):605-6. Epub 2013 Aug 28.

University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2013.08.693DOI Listing
February 2014

Sleep apnea and cardiovascular risk.

Authors:
John S Floras

J Cardiol 2014 Jan 29;63(1):3-8. Epub 2013 Sep 29.

University Health Network and Mount Sinai Hospital Division of Cardiology, Canada; Faculty of Medicine, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jjcc.2013.08.009DOI Listing
January 2014

Preventing cardiovascular events after percutaneous coronary intervention: have we been asleep at the switch?

Can J Cardiol 2014 Jan 13;30(1):8-11. Epub 2013 Nov 13.

University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2013.09.005DOI Listing
January 2014

Anterior crackles: a neglected sign?

Can J Cardiol 2013 Sep 8;29(9):1138.e1-2. Epub 2013 Feb 8.

University Health Network and Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2012.11.014DOI Listing
September 2013

Microneurographic evidence in healthy middle-aged humans for a sympathoexcitatory reflex activated by atrial pressure.

Am J Physiol Heart Circ Physiol 2013 Sep 12;305(6):H931-8. Epub 2013 Jul 12.

University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpheart.00375.2013DOI Listing
September 2013

Cardiometabolic consequences of gestational dysglycemia.

J Am Coll Cardiol 2013 Aug 21;62(8):677-84. Epub 2013 Mar 21.

Mount Sinai Hospital Department of Medicine, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2013.01.080DOI Listing
August 2013

Do high doses of AT(1)-receptor blockers attenuate central sympathetic outflow in humans with chronic heart failure?

Clin Sci (Lond) 2013 May;124(9):589-95

Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1042/CS20120437DOI Listing
May 2013

Blood pressure variability: a novel and important risk factor.

Authors:
John S Floras

Can J Cardiol 2013 May;29(5):557-63

University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2013.02.012DOI Listing
May 2013

Contrasting effects of lower body positive pressure on upper airways resistance and partial pressure of carbon dioxide in men with heart failure and obstructive or central sleep apnea.

J Am Coll Cardiol 2013 Mar 30;61(11):1157-66. Epub 2013 Jan 30.

Sleep Research Laboratory of the Toronto Rehabilitation Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2012.10.055DOI Listing
March 2013

Differing effects of obstructive and central sleep apneas on stroke volume in patients with heart failure.

Am J Respir Crit Care Med 2013 Feb 13;187(4):433-8. Epub 2012 Dec 13.

Sleep Research Laboratory, Centre for Sleep Health and Research, and Department of Medicine, University Health Network Toronto Rehabilitation Institute and Toronto General Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1164/rccm.201205-0894OCDOI Listing
February 2013

Simvastatin reduces sympathetic outflow and augments endothelium-independent dilation in non-hyperlipidaemic primary hypertension.

Heart 2013 Feb 20;99(4):240-6. Epub 2012 Dec 20.

University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, 600 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/heartjnl-2012-302980DOI Listing
February 2013

Inverse relationship of subjective daytime sleepiness to sympathetic activity in patients with heart failure and obstructive sleep apnea.

Chest 2012 Nov;142(5):1222-1228

Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, ON, Canada; Department of Medicine of the University Health Network and Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1378/chest.11-2963DOI Listing
November 2012

Sleep apnea and cardiovascular disease: a bidirectional relationship.

Circulation 2012 Sep;126(12):1495-510

Sleep Research Laboratory, Centre for Sleep Health and Research, and Department of Medicine of the University Health Network Toronto Rehabilitation Institute, Ontario, Canada.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.111.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.111.070813DOI Listing
September 2012

Activated plasma coagulation β-Factor XII-induced vasoconstriction in rats.

Clin Sci (Lond) 2012 Jun;122(12):581-90

Heart and Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1042/CS20110517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294432PMC
June 2012

Caffeine Enhances Heart Rate Variability in Middle-Aged Healthy, But Not Heart Failure Subjects.

J Caffeine Res 2012 Jun;2(2):77-82

Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto , Toronto, ON, Canada .

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http://dx.doi.org/10.1089/jcr.2012.0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621323PMC
June 2012

B-type natriuretic peptide-guided hypertension management?

Authors:
John S Floras

J Hypertens 2012 May;30(5):890-2

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http://dx.doi.org/10.1097/HJH.0b013e328352f562DOI Listing
May 2012

Effect of fitness on reflex sympathetic neurovascular transduction in middle-age men.

Med Sci Sports Exerc 2012 Feb;44(2):232-7

Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1249/MSS.0b013e31822a68a5DOI Listing
February 2012

A new enzyme-linked immunosorbent assay recognizing both rat and human activated coagulation Factor XII (FXIIa).

J Immunol Methods 2012 Feb 10;376(1-2):132-8. Epub 2012 Jan 10.

Heart and Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.jim.2012.01.002DOI Listing
February 2012

Activity with ambulation attenuates diuretic responsiveness in chronic heart failure.

J Card Fail 2011 Oct;17(10):797-803

University Health Network and Mount Sinai Hospital Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S107191641100975
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http://dx.doi.org/10.1016/j.cardfail.2011.06.652DOI Listing
October 2011

β-blockade restores muscle sympathetic rhythmicity in human heart failure.

Circ J 2011 26;75(6):1400-8. Epub 2011 Apr 26.

Division of Cardiology, Matsuyama Red Cross Hospital, Matsuyama, Japan.

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http://dx.doi.org/10.1253/circj.cj-10-0751DOI Listing
September 2011

Effect of angiotensin AT1 receptor blockade on sympathetic responses to handgrip in healthy men.

Am J Hypertens 2011 May 17;24(5):537-43. Epub 2011 Feb 17.

University Health Network, Mount Sinai Hospital, Division of Cardiology, Department of Medicine, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ajh.2011.14DOI Listing
May 2011

Reflex systemic sympatho-neural response to brachial adenosine infusion in treated heart failure.

Eur J Heart Fail 2011 May 23;13(5):475-81. Epub 2011 Feb 23.

Mount Sinai Hospital and University Health Network Division of Cardiology, Faculty of Medicine, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/eurjhf/hfr005DOI Listing
May 2011

Evaluation of 2 methods for sodium intake assessment in cardiac patients with and without heart failure: the confounding effect of loop diuretics.

Am J Clin Nutr 2011 Mar 29;93(3):535-41. Epub 2010 Dec 29.

Department of Nutritional Sciences, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.3945/ajcn.110.004457DOI Listing
March 2011

Relation of periodic leg movements during sleep and mortality in patients with systolic heart failure.

Am J Cardiol 2011 Feb;107(3):447-51

Toronto Rehabilitation Institute, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.amjcard.2010.09.037DOI Listing
February 2011

Dose-related effects of red wine and alcohol on heart rate variability.

Am J Physiol Heart Circ Physiol 2010 Jun 23;298(6):H2226-31. Epub 2010 Apr 23.

University Health Network and Mount Sinai Hospital Division of Cardiology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpheart.00700.2009DOI Listing
June 2010

Behavioral neurocardiac training in hypertension: a randomized, controlled trial.

Hypertension 2010 Apr 1;55(4):1033-9. Epub 2010 Mar 1.

Division of Cardiology, Faculty of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.146233DOI Listing
April 2010

Dissociation between reflex sympathetic and forearm vascular responses to lower body negative pressure in heart failure patients with coronary artery disease.

Am J Physiol Heart Circ Physiol 2009 Nov 4;297(5):H1760-6. Epub 2009 Sep 4.

Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpheart.00012.2009DOI Listing
November 2009

Association of blood pressure at hospital discharge with mortality in patients diagnosed with heart failure.

Circ Heart Fail 2009 Nov 24;2(6):616-23. Epub 2009 Sep 24.

Institute for Clinical Evaluative Sciences, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.109.869743DOI Listing
November 2009

Sympathetic nervous system activation in human heart failure: clinical implications of an updated model.

Authors:
John S Floras

J Am Coll Cardiol 2009 Jul;54(5):375-85

Mount Sinai Hospital and University Health Network Division of Cardiology, and the University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2009.03.061DOI Listing
July 2009

Prevalence and physiological predictors of sleep apnea in patients with heart failure and systolic dysfunction.

J Card Fail 2009 May 21;15(4):279-85. Epub 2009 Jan 21.

Sleep Research Laboratory, Toronto Rehabilitation Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cardfail.2008.11.015DOI Listing
May 2009

Hypertension, sleep apnea, and atherosclerosis.

Authors:
John S Floras

Hypertension 2009 Jan 17;53(1):1-3. Epub 2008 Nov 17.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.123711DOI Listing
January 2009

Obstructive sleep apnoea and its cardiovascular consequences.

Lancet 2009 Jan 26;373(9657):82-93. Epub 2008 Dec 26.

Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, Canada.

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http://dx.doi.org/10.1016/S0140-6736(08)61622-0DOI Listing
January 2009

Effects of drug, biobehavioral and exercise therapies on heart rate variability in coronary artery disease: a systematic review.

Eur J Cardiovasc Prev Rehabil 2008 Aug;15(4):386-96

Division of Cardiology, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/HJR.0b013e3283030a97DOI Listing
August 2008

Muscle sympathetic nerve activity and ventilation during exercise in subjects with and without chronic heart failure.

Can J Cardiol 2008 Apr;24(4):275-8

University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Ontario.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644031PMC
http://dx.doi.org/10.1016/s0828-282x(08)70176-4DOI Listing
April 2008

Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter.

Am J Physiol Heart Circ Physiol 2008 Feb 30;294(2):H605-12. Epub 2007 Nov 30.

University Health Network, Mount Sinai Hospital, Division of Cardiology, Department of Medicine, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpheart.01162.2007DOI Listing
February 2008

Adrenomedullary catecholamine, pressor and chronotropic responses to human coagulation beta-FXIIa mediated by endogenous kinins.

J Hypertens 2008 Jan;26(1):61-9

University Health Network and Mount Sinai Hospital Division of Cardiology, Department of Medicine, Canada.

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http://dx.doi.org/10.1097/HJH.0b013e3282f190cfDOI Listing
January 2008