Publications by authors named "John R Lukens"

46Publications

RIPK3-Dependent Recruitment of Low-Inflammatory Myeloid Cells Does Not Protect from Systemic Infection.

mBio 2020 10 6;11(5). Epub 2020 Oct 6.

Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

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http://dx.doi.org/10.1128/mBio.02588-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542371PMC
October 2020

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis.

Nat Commun 2020 09 10;11(1):4524. Epub 2020 Sep 10.

Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA.

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http://dx.doi.org/10.1038/s41467-020-18113-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483525PMC
September 2020

Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection.

Nat Commun 2020 07 23;11(1):3687. Epub 2020 Jul 23.

Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA.

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http://dx.doi.org/10.1038/s41467-020-17491-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378823PMC
July 2020

The role of innate immunity in Alzheimer's disease.

Immunol Rev 2020 Sep 26;297(1):225-246. Epub 2020 Jun 26.

Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1111/imr.12896DOI Listing
September 2020

Adapt(ed) to repair - T2 immune responses in the bladder promote recurrent infections.

Nat Immunol 2020 06;21(6):597-599

Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/s41590-020-0689-2DOI Listing
June 2020

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment.

Nature 2020 04 8;580(7805):647-652. Epub 2020 Apr 8.

Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1038/s41586-020-2174-3DOI Listing
April 2020

tRNA-derived fragments and microRNAs in the maternal-fetal interface of a mouse maternal-immune-activation autism model.

RNA Biol 2020 08 31;17(8):1183-1195. Epub 2020 Jan 31.

Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia , Charlottesville, VA, USA.

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http://dx.doi.org/10.1080/15476286.2020.1721047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549640PMC
August 2020

NLRP3 sets the table for a parasitic meal.

J Leukoc Biol 2019 09 7;106(3):505-507. Epub 2019 May 7.

Graduate Program in Neuroscience, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1002/JLB.4CE0319-088RDOI Listing
September 2019

Crosstalk Between the Microbiome and Gestational Immunity in Autism-Related Disorders.

DNA Cell Biol 2019 May 28;38(5):405-409. Epub 2019 Feb 28.

1 Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, Virginia.

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http://dx.doi.org/10.1089/dna.2019.4653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531905PMC
May 2019

Modeling Autism-Related Disorders in Mice with Maternal Immune Activation (MIA).

Methods Mol Biol 2019 ;1960:227-236

Department of Neuroscience, Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1007/978-1-4939-9167-9_20DOI Listing
July 2019

Th17 Cells in Parkinson's Disease: The Bane of the Midbrain.

Cell Stem Cell 2018 07;23(1):5-6

Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Graduate Program in Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.06.016DOI Listing
July 2018

Cutting Edge: Critical Roles for Microbiota-Mediated Regulation of the Immune System in a Prenatal Immune Activation Model of Autism.

J Immunol 2018 08 2;201(3):845-850. Epub 2018 Jul 2.

Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908;

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http://dx.doi.org/10.4049/jimmunol.1701755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057827PMC
August 2018

NLR-Dependent Regulation of Inflammation in Multiple Sclerosis.

Front Immunol 2017 18;8:2012. Epub 2018 Jan 18.

Program of Immunology, Faculty of Medicine and Health Sciences, Department of Pediatrics, CR-CHUS, University of Sherbrooke, Sherbrooke, QC, Canada.

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http://dx.doi.org/10.3389/fimmu.2017.02012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778124PMC
January 2018

Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.

Immunity 2017 04 11;46(4):635-648. Epub 2017 Apr 11.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501252PMC
April 2017

Emerging Roles for the Immune System in Traumatic Brain Injury.

Front Immunol 2016 5;7:556. Epub 2016 Dec 5.

Department of Neuroscience, Center for Brain Immunology and Glia, School of Medicine, University of Virginia , Charlottesville, VA , USA.

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http://dx.doi.org/10.3389/fimmu.2016.00556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137185PMC
December 2016

The brain's reward circuitry regulates immunity.

Nat Med 2016 08;22(8):835-7

Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1038/nm.4157DOI Listing
August 2016

Dealing with Danger in the CNS: The Response of the Immune System to Injury.

Neuron 2015 Jul;87(1):47-62

Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Graduate Program in Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491143PMC
July 2015

Drak2 is not required for tumor surveillance and suppression.

Int Immunol 2015 Mar 7;27(3):161-6. Epub 2015 Jan 7.

Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 351, Memphis, TN 38105, USA

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http://dx.doi.org/10.1093/intimm/dxu146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817074PMC
March 2015

Mitochondria: diversity in the regulation of the NLRP3 inflammasome.

Trends Mol Med 2015 Mar 27;21(3):193-201. Epub 2014 Nov 27.

Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2014.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352396PMC
March 2015

Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease.

Semin Immunopathol 2014 Sep 17;36(5):595-609. Epub 2014 May 17.

Department of Immunology, St. Jude Children's Research Hospital, MS #351, 262 Danny Thomas Place, Suite E7004, Memphis, TN, 38105-2794, USA.

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http://dx.doi.org/10.1007/s00281-014-0434-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189983PMC
September 2014

Critical role for inflammasome-independent IL-1β production in osteomyelitis.

Proc Natl Acad Sci U S A 2014 Jan 6;111(3):1066-71. Epub 2014 Jan 6.

Department of Immunology, Small Animal Imaging Core, and Animal Resources Center and the Veterinary Pathology Core, St. Jude Children's Research Hospital, Memphis, TN 38105.

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http://dx.doi.org/10.1073/pnas.1318688111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903206PMC
January 2014

Apolipoprotein A-I protection against atherosclerosis is dependent on genetic background.

Arterioscler Thromb Vasc Biol 2014 Feb 12;34(2):262-9. Epub 2013 Dec 12.

From the Department of Pathology, University of Chicago, IL.

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http://dx.doi.org/10.1161/ATVBAHA.113.302831DOI Listing
February 2014

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

Nature 2013 Jun 26;498(7453):224-7. Epub 2013 May 26.

Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/nature12174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683390PMC
June 2013

IL-1 family cytokines trigger sterile inflammatory disease.

Front Immunol 2012 9;3:315. Epub 2012 Oct 9.

Department of Immunology, St. Jude Children's Research Hospital Memphis, TN, USA.

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http://dx.doi.org/10.3389/fimmu.2012.00315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466588PMC
October 2012

Fat chance: not much against NKT cells.

Immunity 2012 Sep;37(3):447-9

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.immuni.2012.09.006DOI Listing
September 2012

Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4(+) T cells and γδ T cells.

J Immunol 2012 Apr 17;188(7):3107-15. Epub 2012 Feb 17.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.4049/jimmunol.1103308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758236PMC
April 2012

Inflammasome activation in obesity-related inflammatory diseases and autoimmunity.

Discov Med 2011 Jul;12(62):65-74

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266394PMC
July 2011

Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis.

J Immunol 2010 May 5;184(9):4610-4. Epub 2010 Apr 5.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38104, USA.

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http://dx.doi.org/10.4049/jimmunol.1000217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001131PMC
May 2010

Intrahepatic IL-10 maintains NKG2A+Ly49- liver NK cells in a functionally hyporesponsive state.

J Immunol 2010 Mar 1;184(5):2693-701. Epub 2010 Feb 1.

Beirne B. Carter Center for Immunology Research, Department ofMicrobiology, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.4049/jimmunol.0901362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885840PMC
March 2010

Liver is able to activate naïve CD8+ T cells with dysfunctional anti-viral activity in the murine system.

PLoS One 2009 Oct 30;4(10):e7619. Epub 2009 Oct 30.

Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007619PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764869PMC
October 2009

Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model.

J Immunol 2008 Apr;180(7):4875-84

Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904552PMC
http://dx.doi.org/10.4049/jimmunol.180.7.4875DOI Listing
April 2008

Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control.

J Immunol 2007 Nov;179(9):5829-38

Department of Pathology, Human Immune Therapy Center, University of Virginia Health System, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.4049/jimmunol.179.9.5829DOI Listing
November 2007

Fas ligand is responsible for CXCR3 chemokine induction in CD4+ T cell-dependent liver damage.

J Immunol 2006 May;176(10):6235-44

Beirne Carter Center for Immunology Research, and Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.4049/jimmunol.176.10.6235DOI Listing
May 2006