John R Gordon

John R Gordon

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John R Gordon

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CXCR1/CXCR2 antagonist G31P inhibits nephritis in a mouse model of uric acid nephropathy.

Biomed Pharmacother 2018 Nov 28;107:1142-1150. Epub 2018 Aug 28.

Department of Immunology, Dalian Medical University, Dalian, Liaoning, China. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2018.07.077DOI Listing
November 2018

Cytotoxic effect of interleukin-8 in retinal ganglion cells and its possible mechanisms.

Int J Ophthalmol 2018 18;11(8):1277-1283. Epub 2018 Aug 18.

Department of Immunology, Dalian Medical University, Dalian 116044, Liaoning Province, China.

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2018.08.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090122PMC
August 2018

IL-8 antagonist, CXCL8(3-72)K11R/G31P coupled with probiotic exhibit variably enhanced therapeutic potential in ameliorating ulcerative colitis.

Biomed Pharmacother 2018 Jul 24;103:253-261. Epub 2018 Apr 24.

Department of Immunology, Dalian Medical University, Dalian, Liaoning, China. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2018.04.008DOI Listing
July 2018

Contributions of direct versus indirect mechanisms for regulatory dendritic cell suppression of asthmatic allergen-specific IgG1 antibody responses.

PLoS One 2018 2;13(1):e0190414. Epub 2018 Jan 2.

Division of Respirology, Critical Care and Sleep Medicine, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190414PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749789PMC
February 2018

Effects of K11R and G31P Mutations on the Structure and Biological Activities of CXCL8: Solution Structure of Human CXCL8K11R/G31P.

Molecules 2017 Jul 21;22(7). Epub 2017 Jul 21.

Institute of Biotechnology and Department of Medical Science, National Tsing Hua University, Hsinchu 300, Taiwan.

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http://dx.doi.org/10.3390/molecules22071229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152285PMC
July 2017

CXCL8 Antagonist Improves Diabetic Nephropathy in Male Mice With Diabetes and Attenuates High Glucose-Induced Mesangial Injury.

Endocrinology 2017 06;158(6):1671-1684

Department of Immunology, Dalian Medical University, Dalian 116011, Liaoning, China.

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http://dx.doi.org/10.1210/en.2016-1781DOI Listing
June 2017

Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3CD49bFoxp3 regulatory T cells.

J Allergy Clin Immunol 2017 May 26;139(5):1608-1620.e3. Epub 2016 Oct 26.

Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749163096
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http://dx.doi.org/10.1016/j.jaci.2016.07.042DOI Listing
May 2017

ELR-CXC chemokine antagonism is neuroprotective in a rat model of ischemic stroke.

Neurosci Lett 2015 Oct 28;606:117-22. Epub 2015 Aug 28.

Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, P.E.I. C1A 4P3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2015.08.041DOI Listing
October 2015

Identification of Escherichia coli F4ac-binding proteins in porcine milk fat globule membrane.

Can J Vet Res 2015 Apr;79(2):120-8

Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan (Novakovic, Huang, Lockerbie, Middleton, Kidney, Simko); California Animal Health and Food Safety Laboratory System, University of California, Davis, 105 West Central Avenue, San Bernardino, California, USA (Shahriar); Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario (Kelly); Department of Medicine, College of Medicine, University of Saskatchewan (Gordon); Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan (Loewen).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365703PMC
April 2015

Behavioral alterations in rat offspring following maternal immune activation and ELR-CXC chemokine receptor antagonism during pregnancy: implications for neurodevelopmental psychiatric disorders.

Prog Neuropsychopharmacol Biol Psychiatry 2015 Mar 12;57:155-65. Epub 2014 Nov 12.

Dept. of Physiology, University of Saskatchewan, GB33, Health Sciences Building, 107 Wiggins Rd, Saskatoon, SK S7N5E5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2014.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464825PMC
March 2015

Regulatory dendritic cells for immunotherapy in immunologic diseases.

Front Immunol 2014 31;5. Epub 2014 Jan 31.

Department of Medicine, University of Saskatchewan , Saskatoon, SK , Canada.

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http://dx.doi.org/10.3389/fimmu.2014.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907717PMC
June 2014

ELR-CXC chemokine antagonism and cisplatin co-treatment additively reduce H22 hepatoma tumor progression and ameliorate cisplatin-induced nephrotoxicity.

Oncol Rep 2014 Apr 24;31(4):1599-604. Epub 2014 Jan 24.

Department of Immunology, Dalian Medical University, Dalian 116044, P.R. China.

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http://dx.doi.org/10.3892/or.2014.2996DOI Listing
April 2014

CXCR1/CXCR2 antagonism is effective in pulmonary defense against Klebsiella pneumoniae infection.

Biomed Res Int 2013 18;2013:720975. Epub 2013 Mar 18.

Department of Immunology, Dalian Medical University, Dalian 116044, China.

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http://dx.doi.org/10.1155/2013/720975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613076PMC
November 2013

Comparison of induced versus natural regulatory T cells of the same TCR specificity for induction of tolerance to an environmental antigen.

J Immunol 2013 Aug 1;191(3):1136-43. Epub 2013 Jul 1.

Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada.

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http://dx.doi.org/10.4049/jimmunol.1201899DOI Listing
August 2013

Recombinant human CXCL8(3-72)K11R/G31P regulates smooth muscle cell proliferation and migration through blockage of interleukin-8 receptor.

IUBMB Life 2013 Jan;65(1):67-75

Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, China.

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http://dx.doi.org/10.1002/iub.1107DOI Listing
January 2013

G31P, an antagonist against CXC chemokine receptors 1 and 2, inhibits growth of human prostate cancer cells in nude mice.

Tohoku J Exp Med 2012 10;228(2):147-56

Department of Microbiology, Dalian Medical University, Dailan, PR China.

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October 2012

Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling.

J Leukoc Biol 2012 Aug 27;92(2):289-300. Epub 2012 Apr 27.

Research Unit, Saskatchewan Cancer Agency, Department of Oncology, University of Saskatchewan, Saskatoon, Saskatchewan Canada.

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http://dx.doi.org/10.1189/jlb.1211631DOI Listing
August 2012

Induction of prolonged asthma tolerance by IL-10-differentiated dendritic cells: differential impact on airway hyperresponsiveness and the Th2 immunoinflammatory response.

J Immunol 2012 Jul 25;189(1):72-9. Epub 2012 May 25.

Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada.

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http://dx.doi.org/10.4049/jimmunol.1103286DOI Listing
July 2012

Plasma protein profiles of neonatal pigs before and after suckling.

Can J Vet Res 2012 Jan;76(1):1-7

Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, Saskatchewan, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244282PMC
January 2012

Compound CVT-E002 attenuates allergen-induced airway inflammation and airway hyperresponsiveness, in vivo.

Mol Nutr Food Res 2011 Dec 31;55(12):1905-8. Epub 2011 Oct 31.

Pulmonary Research Group, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.

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http://doi.wiley.com/10.1002/mnfr.201100216
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http://dx.doi.org/10.1002/mnfr.201100216DOI Listing
December 2011

Medicolegal aspects of the third wave of asbestos-related disease in Australia.

Med J Aust 2011 Sep;195(5):247-8

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September 2011

Combined CXCR1/CXCR2 antagonism decreases radiation-induced alveolitis in the mouse.

Radiat Res 2011 May 22;175(5):657-64. Epub 2011 Feb 22.

Department of Medicine and the Meakins-Christie Laboratories, McGill University, 3626 St. Urbain Montreal, Quebec, Canada, H2X 2P2.

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http://dx.doi.org/10.1667/RR2449.1DOI Listing
May 2011

Tolerogenic dendritic cells induce CD4+CD25hiFoxp3+ regulatory T cell differentiation from CD4+CD25-/loFoxp3- effector T cells.

J Immunol 2010 Nov 24;185(9):5003-10. Epub 2010 Sep 24.

Department of Veterinary Microbiology, of Saskatchewan, Saskatoon, Saskatchewan, Canada.

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http://dx.doi.org/10.4049/jimmunol.0903446DOI Listing
November 2010

A novel ELR-CXC chemokine antagonist reduces intestinal ischemia reperfusion-induced mortality, and local and remote organ injury.

J Surg Res 2010 Aug 6;162(2):264-73. Epub 2009 Jun 6.

Immunology Research Group (Department of Veterinary Microbiology), University of Saskatchewan, Saskatoon, Canada.

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http://dx.doi.org/10.1016/j.jss.2009.04.047DOI Listing
August 2010

Fractionation of swine barn dust and assessment of its impact on the respiratory tract following repeated airway exposure.

J Toxicol Environ Health A 2010 ;73(16):1090-101

Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan.

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http://dx.doi.org/10.1080/15287394.2010.482916DOI Listing
July 2010

The effect of early-life stress on airway inflammation in adult mice.

Neuroimmunomodulation 2010 5;17(4):229-39. Epub 2010 Mar 5.

Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alta., Canada.

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http://dx.doi.org/10.1159/000290039DOI Listing
June 2010

Induction of type 2 T helper cell allergen tolerance by IL-10-differentiated regulatory dendritic cells.

Am J Respir Cell Mol Biol 2010 Feb 16;42(2):190-9. Epub 2009 Apr 16.

Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada.

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http://dx.doi.org/10.1165/rcmb.2009-0023OCDOI Listing
February 2010

Blockade of neutrophil responses in aspiration pneumonia via ELR-CXC chemokine antagonism does not predispose to airway bacterial outgrowth.

Pulm Pharmacol Ther 2010 Feb 12;23(1):22-8. Epub 2009 Sep 12.

Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada.

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http://dx.doi.org/10.1016/j.pupt.2009.09.001DOI Listing
February 2010

The functional significance behind expressing two IL-8 receptor types on PMN.

J Leukoc Biol 2009 Sep 29;86(3):529-43. Epub 2009 Jun 29.

Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1189/jlb.0208125DOI Listing
September 2009

Amelioration of pathology by ELR-CXC chemokine antagonism in a swine model of airway endotoxin exposure.

J Agromedicine 2009 ;14(2):235-41

Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada.

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http://dx.doi.org/10.1080/10599240902845047DOI Listing
August 2009

ELR-CXC chemokine receptor antagonism targets inflammatory responses at multiple levels.

J Immunol 2009 Mar;182(5):3213-22

Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada.

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http://dx.doi.org/10.4049/jimmunol.0800551DOI Listing
March 2009

A new protocol for high-yield purification of recombinant human CXCL8((3-72))K11R/G31P expressed in Escherichia coli.

Protein Expr Purif 2008 Sep 1;61(1):65-72. Epub 2008 May 1.

Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu 300, Taiwan.

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http://dx.doi.org/10.1016/j.pep.2008.04.007DOI Listing
September 2008

Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation.

Toxicol Lett 2008 Mar 19;177(2):130-7. Epub 2008 Jan 19.

UMR-INSERM U620, Team Toxicity of Polycyclic Aromatic Hydrocarbons (labellisée Ligue contre le Cancer), IFR140, Université de Rennes 1, France.

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http://linkinghub.elsevier.com/retrieve/pii/S037842740800008
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http://dx.doi.org/10.1016/j.toxlet.2008.01.006DOI Listing
March 2008

Humanized forms of the CXCR1/CXCR2 antagonist, bovine CXCL8((3-74))K11R/G31P, effectively block ELR-CXC chemokine activity and airway endotoxemia pathology.

Int Immunopharmacol 2007 Dec 29;7(13):1723-31. Epub 2007 Sep 29.

Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada.

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http://dx.doi.org/10.1016/j.intimp.2007.09.008DOI Listing
December 2007

Proinflammatory and proapoptotic effects of methylglyoxal on neutrophils from patients with type 2 diabetes mellitus.

Clin Biochem 2007 Nov 11;40(16-17):1232-9. Epub 2007 Aug 11.

Department of Pharmacology, University of Saskatchewan, Saskatoon, 107 Wiggins Road, Canada S7N 5E5.

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http://dx.doi.org/10.1016/j.clinbiochem.2007.07.016DOI Listing
November 2007

Proteinase-activated receptor-2 promotes allergic sensitization to an inhaled antigen through a TNF-mediated pathway.

J Immunol 2007 Sep;179(5):2910-7

Pulmonary Research Group, Department of Medicine, 550 Heritage Medical Research Center, University of Alberta, Edmonton, Alberta, Canada.

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September 2007

Identification of lipopolysaccharide-binding proteins in porcine milk.

Can J Vet Res 2006 Oct;70(4):243-50

Department of Veterinary Pathology, University of Saskatchewan, Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1562535PMC
October 2006

Identification by mass spectroscopy of F4ac-fimbrial-binding proteins in porcine milk and characterization of lactadherin as an inhibitor of F4ac-positive Escherichia coli attachment to intestinal villi in vitro.

Dev Comp Immunol 2006 8;30(8):723-34. Epub 2005 Nov 8.

Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Dr, Saskatoon, Sask., Canada SK S7N 5B4.

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http://dx.doi.org/10.1016/j.dci.2005.10.003DOI Listing
July 2006

Temporomandibular joint cytokine profiles in the horse.

J Vet Dent 2006 Jun;23(2):83-8

Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.

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http://dx.doi.org/10.1177/089875640602300204DOI Listing
June 2006

The combined CXCR1/CXCR2 antagonist CXCL8(3-74)K11R/G31P blocks neutrophil infiltration, pyrexia, and pulmonary vascular pathology in endotoxemic animals.

J Leukoc Biol 2005 Dec 4;78(6):1265-72. Epub 2005 Oct 4.

Immunology Research Group, Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada S7N 5B4.

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http://dx.doi.org/10.1189/jlb.0805458DOI Listing
December 2005

CD8 alpha+, but not CD8 alpha-, dendritic cells tolerize Th2 responses via contact-dependent and -independent mechanisms, and reverse airway hyperresponsiveness, Th2, and eosinophil responses in a mouse model of asthma.

J Immunol 2005 Aug;175(3):1516-22

Immunology Research Group, Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

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August 2005

Proteinase-activated receptor 2 activation in the airways enhances antigen-mediated airway inflammation and airway hyperresponsiveness through different pathways.

J Allergy Clin Immunol 2005 Mar;115(3):623-30

Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1016/j.jaci.2004.11.042DOI Listing
March 2005

Opposing effects of short- and long-term stress on airway inflammation.

Am J Respir Crit Care Med 2004 Jan 6;169(2):220-6. Epub 2003 Nov 6.

Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1164/rccm.200307-979OCDOI Listing
January 2004

Genetic engineering of a recombinant fusion protein possessing an antitumor antibody fragment and a TNF-alpha moiety.

Methods Mol Biol 2003 ;215:201-12

Saskatoon Cancer Center, Departments of Microbiology and Oncology, University of Saskatchewan, Saskatoon, Canada.

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June 2003

Advances in dendritic cell-based vaccine of cancer.

Cancer Biother Radiopharm 2002 Dec;17(6):601-19

Research Unit, Health Research Division, Saskatchewan Cancer Agency, Department of Oncology, Saskatoon, Saskatchewan, Canada.

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http://www.liebertpub.com/doi/10.1089/108497802320970217
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http://dx.doi.org/10.1089/108497802320970217DOI Listing
December 2002

DNA microarray analysis of the gene expression profiles of naïve versus activated tumor-specific T cells.

Life Sci 2002 Nov;71(25):3005-17

Department of Oncology, Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon Cancer Center, 20 Campus Drive CM200, Saskatoon, Saskatchewan, Canada S7N 0W0.

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November 2002

CXCL8((3-73))K11R/G31P antagonizes the neutrophil chemoattractants present in pasteurellosis and mastitis lesions and abrogates neutrophil influx into intradermal endotoxin challenge sites in vivo.

Vet Immunol Immunopathol 2002 Nov;90(1-2):65-77

Department of Veterinary Microbiology, University of Saskatchewan, SK, S7N 5B4, Saskatoon, Canada.

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November 2002

Preliminary observations on expression of transforming growth factors beta1 and beta3 in equine full-thickness skin wounds healing normally or with exuberant granulation tissue.

Vet Surg 2002 May-Jun;31(3):266-73

Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

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August 2002

Temporal localization of immunoreactive transforming growth factor beta1 in normal equine skin and in full-thickness dermal wounds.

Vet Surg 2002 May-Jun;31(3):274-80

Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

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August 2002

CXCL8((3-73))K11R/G31P antagonizes ligand binding to the neutrophil CXCR1 and CXCR2 receptors and cellular responses to CXCL8/IL-8.

Biochem Biophys Res Commun 2002 May;293(3):939-44

Department of Veterinary Microbiology, 52 Campus Dr., University of Saskatchewan, Saskatoon, SK, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0200318
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http://dx.doi.org/10.1016/S0006-291X(02)00318-2DOI Listing
May 2002

Synergistic enhancement of antitumor immunity with adoptively transferred tumor-specific CD4+ and CD8+ T cells and intratumoral lymphotactin transgene expression.

Cancer Res 2002 Apr;62(7):2043-51

Research Unit, Saskatchewan Cancer Agency, Departments of Oncology, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 4H4 Canada.

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April 2002

Analysis of the gene expression profiles of immature versus mature bone marrow-derived dendritic cells using DNA arrays.

Biochem Biophys Res Commun 2002 Jan;290(1):66-72

Research Unit, Saskatchewan Cancer Agency, 20 Campus Drive, Saskatoon, Saskatchewan, S7N 4H4, Canada.

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http://dx.doi.org/10.1006/bbrc.2001.6147DOI Listing
January 2002