John R Edwards

John R Edwards

UNVERIFIED PROFILE

Are you John R Edwards?   Register this Author

Register author
John R Edwards

John R Edwards

Publications by authors named "John R Edwards"

Are you John R Edwards?   Register this Author

47Publications

1071Reads

31Profile Views

ME-Class2 reveals context dependent regulatory roles for 5-hydroxymethylcytosine.

Nucleic Acids Res 2019 03;47(5):e28

Center for Pharmacogenomics, Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkz001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412249PMC
March 2019

Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome.

Elife 2018 11 28;7. Epub 2018 Nov 28.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.39658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261255PMC
November 2018

DNA methylation and DNA methyltransferases.

Epigenetics Chromatin 2017 8;10:23. Epub 2017 May 8.

Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13072-017-0130-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422929PMC
July 2017

Modeling complex patterns of differential DNA methylation that associate with gene expression changes.

Nucleic Acids Res 2017 May;45(9):5100-5111

Center for Pharmacogenomics, Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/nar/article/45/9/5100/2972665
Publisher Site
http://dx.doi.org/10.1093/nar/gkx078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435975PMC
May 2017

Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation.

Biol Open 2016 Jun 15;5(6):866-74. Epub 2016 Jun 15.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA Developmental, Regenerative and Stem Cell Biology Program, Division of Biology and Biomedical Sciences, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/bio.019067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920199PMC
June 2016

Abnormal X chromosome inactivation and sex-specific gene dysregulation after ablation of FBXL10.

Epigenetics Chromatin 2016 31;9:22. Epub 2016 May 31.

Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W. 168th St., New York, NY 10032 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13072-016-0069-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888662PMC
June 2016

Cellular therapy in combination with cytokines improves survival in a xenograft mouse model of ovarian cancer.

Mol Cell Biochem 2015 Sep 6;407(1-2):281-7. Epub 2015 Jun 6.

Florida Hospital Gynecologic Oncology, Florida Hospital Cancer Institute, 2501 N. Orange Ave., Suite 786, Orlando, FL, 32804, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11010-015-2475-2DOI Listing
September 2015

Notes on the role of dynamic DNA methylation in mammalian development.

Proc Natl Acad Sci U S A 2015 Jun 3;112(22):6796-9. Epub 2014 Nov 3.

Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032; and.

View Article

Download full-text PDF

Source
http://www.pnas.org/lookup/doi/10.1073/pnas.1415301111
Publisher Site
http://dx.doi.org/10.1073/pnas.1415301111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460495PMC
June 2015

FBXL10 protects Polycomb-bound genes from hypermethylation.

Nat Genet 2015 May 6;47(5):479-85. Epub 2015 Apr 6.

Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3272DOI Listing
May 2015

Reply to Wilkinson: Minor role of programmed methylation and demethylation in mammalian development.

Proc Natl Acad Sci U S A 2015 Apr 6;112(17):E2117. Epub 2015 Apr 6.

Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032; and.

View Article

Download full-text PDF

Source
http://www.pnas.org/lookup/doi/10.1073/pnas.1504199112
Publisher Site
http://dx.doi.org/10.1073/pnas.1504199112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418894PMC
April 2015

Cellular therapy in combination with cytokines improves survival in a xenograft mouse model of ovarian cancer.

Mol Cell Biochem 2015 Sep 6;407(1-2):281-7. Epub 2015 Jun 6.

Florida Hospital Gynecologic Oncology, Florida Hospital Cancer Institute, 2501 N. Orange Ave., Suite 786, Orlando, FL, 32804, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11010-015-2475-2DOI Listing
September 2015

Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs.

Proc Natl Acad Sci U S A 2014 Aug 28;111(33):12264-9. Epub 2014 Jul 28.

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1410622111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143054PMC
August 2014

Temporal and optic pathway pilomyxoid astrocytoma mimicking dural-based lesion: case report and review of the literature.

Pediatr Neurosurg 2012 19;48(4):253-7. Epub 2013 Mar 19.

Division of Pediatric Neurosurgery, Department of Neurosurgery, Indiana University School of Medicine, Indianapolis, IN 46202-5200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000345634DOI Listing
February 2014

Senescent cells harbour features of the cancer epigenome.

Nat Cell Biol 2013 Dec 24;15(12):1495-506. Epub 2013 Nov 24.

1] Institute of Cancer Sciences, University of Glasgow and Beatson Institute for Cancer Research, Glasgow, G61 1BD, UK [2] [3].

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ncb2879
Publisher Site
http://dx.doi.org/10.1038/ncb2879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106249PMC
December 2013

Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes.

Nucleic Acids Res 2013 Aug 7;41(14):6816-27. Epub 2013 Jun 7.

Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Ave, Campus Box 8220, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737560PMC
August 2013

Cellular therapy for ovarian cancer: experimental and clinical perspectives.

Curr Med Chem 2012 ;19(22):3787-93

Florida Hospital Gynecologic Oncology, Florida Hospital Cancer Institute, 2501 N. Orange Ave., Suite 800, Orlando, FL 32804, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/092986712801661158DOI Listing
December 2012

Persistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions.

Nucleic Acids Res 2012 Nov 27;40(21):10765-79. Epub 2012 Sep 27.

Department of Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gks888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510497PMC
November 2012

Epitranscriptional orchestration of genetic reprogramming is an emergent property of stress-regulated cardiac microRNAs.

Proc Natl Acad Sci U S A 2012 Nov 12;109(48):19864-9. Epub 2012 Nov 12.

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1214996109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511760PMC
November 2012

Spontaneous intraventricular hemorrhage from low-grade optic glioma: case report and review of the literature.

Childs Nerv Syst 2012 Feb 2;28(2):327-30. Epub 2011 Dec 2.

Division of Pediatric Neurosurgery, Department of Neurosurgery, Indiana University School of Medicine, Goodman Campbell Brain and Spine, Indianapolis, IN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00381-011-1643-2DOI Listing
February 2012

Progression of cerebrospinal fluid cell count and differential over a treatment course of shunt infection.

J Neurosurg Pediatr 2011 Dec;8(6):613-9

Department of Neurosurgery, Division of Pediatric Neurosurgery, Indiana University School of Medicine, Goodman Campbell Brain and Spine, Indianapolis, Indiana 46202-5200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2011.8.PEDS11236DOI Listing
December 2011

Targeting the IL-6 pathway in multiple myeloma and its implications in cancer-associated gene hypermethylation.

Med Chem 2011 Sep;7(5):473-9

Principal Scientist, Florida Hospital Cancer Institute, Clinical Assistant Professor, Florida State University, 2501 N. Orange Ave., Suite 800, Orlando, FL 32804, USA.

View Article

Download full-text PDF

Source
September 2011

Functional characterization of a fluorescent highly tumorigenic ovarian cancer line to test cellular therapy in experimental models.

Int J Gynecol Cancer 2011 Apr;21(3):457-65

Florida Hospital Gynecologic Oncology, Florida Hospital Cancer Institute, Orlando, FL 32804, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IGC.0b013e31820f4ef0DOI Listing
April 2011

A retrospective study on the epidemiology of foot-and-mouth disease in Bhutan.

Trop Anim Health Prod 2011 Feb 10;43(2):495-502. Epub 2010 Nov 10.

National Centre for Animal Health, Department of Livestock, Ministry of Agriculture and Forests, PO Box 155, Thimphu, Bhutan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11250-010-9722-zDOI Listing
February 2011

Use of epidemiologic risk modeling to evaluate control of foot-and-mouth disease in southern Thailand.

Am J Vet Res 2008 Feb;69(2):240-51

Animal Population Health Institute, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2460/ajvr.69.2.240DOI Listing
February 2008

Assessment of the likelihood of the introduction of foot-and-mouth disease through importation of live animals into the Malaysia-Thailand-Myanmar peninsula.

Am J Vet Res 2008 Feb;69(2):252-60

Animal Population Health Institute, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

View Article

Download full-text PDF

Source
http://avmajournals.avma.org/doi/abs/10.2460/ajvr.69.2.252
Publisher Site
http://dx.doi.org/10.2460/ajvr.69.2.252DOI Listing
February 2008

Investigation of miRNA biology by bioinformatic tools and impact of miRNAs in colorectal cancer--regulatory relationship of c-Myc and p53 with miRNAs.

Cancer Inform 2007 May 31;3:245-53. Epub 2007 May 31.

Cancer Genomics Laboratory, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36688, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133370PMC
May 2007

Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators.

Proc Natl Acad Sci U S A 2006 Dec 14;103(52):19635-40. Epub 2006 Dec 14.

Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0609513103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702316PMC
December 2006

Computational prediction of methylation status in human genomic sequences.

Proc Natl Acad Sci U S A 2006 Jul 3;103(28):10713-6. Epub 2006 Jul 3.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0602949103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502297PMC
July 2006

Large-scale structure of genomic methylation patterns.

Genome Res 2006 Feb 19;16(2):157-63. Epub 2005 Dec 19.

Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, Columbia University, New York, NY 10032, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.4362006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361710PMC
February 2006

Mass-spectrometry DNA sequencing.

Mutat Res 2005 Jun;573(1-2):3-12

Columbia Genome Center, Columbia University College of Physicians and Surgeons, Room 405A, Russ Berrie Medical Science Pavilion, New York, NY 10032, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mrfmmm.2004.07.021DOI Listing
June 2005

Functional outcomes following displaced talar neck fractures.

J Orthop Trauma 2004 May-Jun;18(5):265-70

Division of Orthopaedic Surgery, University of Western Ontario, London, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/00005131-200405000-00001DOI Listing
September 2004

Multiplex genotyping of the human beta2-adrenergic receptor gene using solid-phase capturable dideoxynucleotides and mass spectrometry.

Anal Biochem 2003 May;316(2):251-8

Laboratory of DNA Sequencing and Chemical Biology, Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0003-2697(03)00080-0DOI Listing
May 2003

Solid phase capturable dideoxynucleotides for multiplex genotyping using mass spectrometry.

Nucleic Acids Res 2002 Aug;30(16):e85

Laboratory of DNA Sequencing and Chemical Biology, Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134258PMC
http://dx.doi.org/10.1093/nar/gnf084DOI Listing
August 2002