Publications by authors named "John R Bradley"

49Publications

Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19.

Authors:
Nick K Jones Lucy Rivett Dominic Sparkes Sally Forrest Sushmita Sridhar Jamie Young Joana Pereira-Dias Claire Cormie Harmeet Gill Nicola Reynolds Michelle Wantoch Matthew Routledge Ben Warne Jack Levy William David Córdova Jiménez Fathima Nisha Begum Samad Chris McNicholas Mark Ferris Jane Gray Michael Gill Stephen Baker John Bradley Gordon Dougan Ian Goodfellow Ravi Gupta Paul J Lehner Paul A Lyons Nicholas J Matheson Kenneth Gc Smith M Estee Torok Mark Toshner Michael P Weekes Nicholas K Jones Lucy Rivett Matthew Routledge Dominic Sparkes Ben Warne Claire Cormie Sally Forrest Harmeet Gill Iain Kean Joana Pereira-Dias Nicola Reynolds Sushmita Sridhar Michelle Wantoch Jamie Young Sarah Caddy Laura Caller Theresa Feltwell Grant Hall William Hamilton Myra Hosmillo Charlotte Houldcroft Aminu Jahun Fahad Khokhar Luke Meredith Anna Yakovleva Helen Butcher Daniela Caputo Debra Clapham-Riley Helen Dolling Anita Furlong Barbara Graves Emma Le Gresley Nathalie Kingston Sofia Papadia Hannah Stark Kathleen E Stirrups Jennifer Webster Joanna Calder Julie Harris Sarah Hewitt Jane Kennet Anne Meadows Rebecca Rastall Criona O Brien Jo Price Cherry Publico Jane Rowlands Valentina Ruffolo Hugo Tordesillas Michael Gill Jane Gray Greg Hannon Karen Brookes Laura Canna Isabel Cruz Katie Dempsey Anne Elmer Naidine Escoffery Stewart Fuller Heather Jones Carla Ribeiro Caroline Saunders Angela Wright Rutendo Nyagumbo Anne Roberts Ashlea Bucke Simone Hargreaves Danielle Johnson Aileen Narcorda Debbie Read Christian Sparke Lucy Worboys Kirsty Lagadu Lenette Mactavous Tim Gould Tim Raine Ashley Shaw Claire Mather Nicola Ramenatte Anne-Laure Vallier Mary Kasanicki Penelope-Jane Eames Chris McNicholas Lisa Thake Neil Bartholomew Nick Brown Martin Curran Surendra Parmar Hongyi Zhang Ailsa Bowring Mark Ferris Geraldine Martell Natalie Quinnell Giles Wright Jo Wright Helen Murphy Benjamin J Dunmore Ekaterina Legchenko Stefan Gräf Christopher Huang Josh Hodgson Kelvin Hunter Jennifer Martin Federica Mescia Ciara ODonnell Linda Pointon Joy Shih Rachel Sutcliffe Tobias Tilly Zhen Tong Carmen Treacy Jennifer Wood Laura Bergamaschi Ariana Betancourt Georgie Bowyer Aloka De Sa Maddie Epping Andrew Hinch Oisin Huhn Isobel Jarvis Daniel Lewis Joe Marsden Simon McCallum Francescsa Nice Ommar Omarjee Marianne Perera Nika Romashova Mateusz Strezlecki Natalia Savoinykh Yarkoni Lori Turner Barrie Bailey Afzal Chaudhry Rachel Doughton Chris Workman Caroline Trotter William David Cordova Jiménez Jack Levy Fatima Nb Samad Martin D Curran Stewart Fuller Afzal Chaudhry Ashley Shaw John R Bradley Gregory J Hannon Ian G Goodfellow Gordon Dougan Kenneth Gc Smith Paul J Lehner Giles Wright Nicholas J Matheson Stephen Baker Michael P Weekes

Elife 2020 06 19;9. Epub 2020 Jun 19.

Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.59391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326489PMC
June 2020

Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission.

Authors:
Lucy Rivett Sushmita Sridhar Dominic Sparkes Matthew Routledge Nick K Jones Sally Forrest Jamie Young Joana Pereira-Dias William L Hamilton Mark Ferris M Estee Torok Luke Meredith Ravi Gupta Paul A Lyons Mark Toshner Ben Warne Josefin Bartholdson Scott Claire Cormie Harmeet Gill Iain Kean Mailis Maes Nicola Reynolds Michelle Wantoch Sarah Caddy Laura Caller Theresa Feltwell Grant Hall Myra Hosmillo Charlotte Houldcroft Aminu Jahun Fahad Khokhar Anna Yakovleva Helen Butcher Daniela Caputo Debra Clapham-Riley Helen Dolling Anita Furlong Barbara Graves Emma Le Gresley Nathalie Kingston Sofia Papadia Hannah Stark Kathleen E Stirrups Jennifer Webster Joanna Calder Julie Harris Sarah Hewitt Jane Kennet Anne Meadows Rebecca Rastall Criona O Brien Jo Price Cherry Publico Jane Rowlands Valentina Ruffolo Hugo Tordesillas Karen Brookes Laura Canna Isabel Cruz Katie Dempsey Anne Elmer Naidine Escoffery Heather Jones Carla Ribeiro Caroline Saunders Angela Wright Rutendo Nyagumbo Anne Roberts Ashlea Bucke Simone Hargreaves Danielle Johnson Aileen Narcorda Debbie Read Christian Sparke Lucy Warboys Kirsty Lagadu Lenette Mactavous Tim Gould Tim Raine Claire Mather Nicola Ramenatte Anne-Laure Vallier Mary Kasanicki Penelope-Jane Eames Chris McNicholas Lisa Thake Neil Bartholomew Nick Brown Surendra Parmar Hongyi Zhang Ailsa Bowring Geraldine Martell Natalie Quinnell Jo Wright Helen Murphy Benjamin J Dunmore Ekaterina Legchenko Stefan Gräf Christopher Huang Josh Hodgson Kelvin Hunter Jennifer Martin Federica Mescia Ciara O'Donnell Linda Pointon Joy Shih Rachel Sutcliffe Tobias Tilly Zhen Tong Carmen Treacy Jennifer Wood Laura Bergamaschi Ariana Betancourt Georgie Bowyer Aloka De Sa Maddie Epping Andrew Hinch Oisin Huhn Isobel Jarvis Daniel Lewis Joe Marsden Simon McCallum Francescsa Nice Martin D Curran Stewart Fuller Afzal Chaudhry Ashley Shaw Richard J Samworth John R Bradley Gordon Dougan Kenneth Gc Smith Paul J Lehner Nicholas J Matheson Giles Wright Ian G Goodfellow Stephen Baker Michael P Weekes

Elife 2020 05 11;9. Epub 2020 May 11.

Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.58728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314537PMC
May 2020

Signaling through tumor necrosis receptor 2 induces stem cell marker in CD133 regenerating tubular epithelial cells in acute cell-mediated rejection of human renal allografts.

Am J Transplant 2020 09 14;20(9):2380-2391. Epub 2020 Apr 14.

Department of Medicine, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/ajt.15846DOI Listing
September 2020

Tumor necrosis factor receptor-2 signaling pathways promote survival of cancer stem-like CD133 cells in clear cell renal carcinoma.

FASEB Bioadv 2020 Feb 3;2(2):126-144. Epub 2020 Jan 3.

Department of Medicine NIHR Cambridge Biomedical Research Centre University of Cambridge Cambridge UK.

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http://dx.doi.org/10.1096/fba.2019-00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003657PMC
February 2020

Human Organ Culture: Updating the Approach to Bridge the Gap from to in Inflammation, Cancer, and Stem Cell Biology.

Front Med (Lausanne) 2017 11;4:148. Epub 2017 Sep 11.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, United States.

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http://dx.doi.org/10.3389/fmed.2017.00148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601956PMC
September 2017

A 3D tri-culture system reveals that activin receptor-like kinase 5 and connective tissue growth factor drive human glomerulosclerosis.

J Pathol 2017 11 3;243(3):390-400. Epub 2017 Oct 3.

Department of Medicine, University of Cambridge, Addenbrooke's Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

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http://dx.doi.org/10.1002/path.4960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309868PMC
November 2017

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.

Nat Commun 2017 01 13;8:14079. Epub 2017 Jan 13.

Division of Respiratory Medicine, Department of Medicine, Box 157, Level 5, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospitals, Hills Road, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1038/ncomms14079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241886PMC
January 2017

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

Cell 2016 11;167(5):1415-1429.e19

Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; Department of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge CB1 8RN, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300907PMC
November 2016

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.

Sci Transl Med 2016 Mar 2;8(328):328ra30. Epub 2016 Mar 2.

Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. National Institute for Health Research (NIHR) BioResource-Rare Diseases, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1126/scitranslmed.aad7666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903547PMC
March 2016

TL1-A can engage death receptor-3 and activate NF-kappa B in endothelial cells.

BMC Nephrol 2014 Nov 16;15:178. Epub 2014 Nov 16.

Department of nephrology, First Hospital of China Medical University, Nanjing Street, 110001 Shenyang, P,R, China.

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http://bmcnephrol.biomedcentral.com/articles/10.1186/1471-23
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http://dx.doi.org/10.1186/1471-2369-15-178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239315PMC
November 2014

Tumour necrosis factor and cancer.

J Pathol 2013 Jul;230(3):241-8

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1002/path.4188DOI Listing
July 2013

Tumour necrosis factor in infectious disease.

J Pathol 2013 Jun;230(2):132-47

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://doi.wiley.com/10.1002/path.4187
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http://dx.doi.org/10.1002/path.4187DOI Listing
June 2013

DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor.

Am J Pathol 2012 Apr 11;180(4):1454-64. Epub 2012 Feb 11.

Department of Medicine, Biomedical Research Center, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/j.ajpath.2012.01.003DOI Listing
April 2012

New gene functions in megakaryopoiesis and platelet formation.

Authors:
Christian Gieger Aparna Radhakrishnan Ana Cvejic Weihong Tang Eleonora Porcu Giorgio Pistis Jovana Serbanovic-Canic Ulrich Elling Alison H Goodall Yann Labrune Lorna M Lopez Reedik Mägi Stuart Meacham Yukinori Okada Nicola Pirastu Rossella Sorice Alexander Teumer Katrin Voss Weihua Zhang Ramiro Ramirez-Solis Joshua C Bis David Ellinghaus Martin Gögele Jouke-Jan Hottenga Claudia Langenberg Peter Kovacs Paul F O'Reilly So-Youn Shin Tõnu Esko Jaana Hartiala Stavroula Kanoni Federico Murgia Afshin Parsa Jonathan Stephens Pim van der Harst C Ellen van der Schoot Hooman Allayee Antony Attwood Beverley Balkau François Bastardot Saonli Basu Sebastian E Baumeister Ginevra Biino Lorenzo Bomba Amélie Bonnefond François Cambien John C Chambers Francesco Cucca Pio D'Adamo Gail Davies Rudolf A de Boer Eco J C de Geus Angela Döring Paul Elliott Jeanette Erdmann David M Evans Mario Falchi Wei Feng Aaron R Folsom Ian H Frazer Quince D Gibson Nicole L Glazer Chris Hammond Anna-Liisa Hartikainen Susan R Heckbert Christian Hengstenberg Micha Hersch Thomas Illig Ruth J F Loos Jennifer Jolley Kay Tee Khaw Brigitte Kühnel Marie-Christine Kyrtsonis Vasiliki Lagou Heather Lloyd-Jones Thomas Lumley Massimo Mangino Andrea Maschio Irene Mateo Leach Barbara McKnight Yasin Memari Braxton D Mitchell Grant W Montgomery Yusuke Nakamura Matthias Nauck Gerjan Navis Ute Nöthlings Ilja M Nolte David J Porteous Anneli Pouta Peter P Pramstaller Janne Pullat Susan M Ring Jerome I Rotter Daniela Ruggiero Aimo Ruokonen Cinzia Sala Nilesh J Samani Jennifer Sambrook David Schlessinger Stefan Schreiber Heribert Schunkert James Scott Nicholas L Smith Harold Snieder John M Starr Michael Stumvoll Atsushi Takahashi W H Wilson Tang Kent Taylor Albert Tenesa Swee Lay Thein Anke Tönjes Manuela Uda Sheila Ulivi Dirk J van Veldhuisen Peter M Visscher Uwe Völker H-Erich Wichmann Kerri L Wiggins Gonneke Willemsen Tsun-Po Yang Jing Hua Zhao Paavo Zitting John R Bradley George V Dedoussis Paolo Gasparini Stanley L Hazen Andres Metspalu Mario Pirastu Alan R Shuldiner L Joost van Pelt Jaap-Jan Zwaginga Dorret I Boomsma Ian J Deary Andre Franke Philippe Froguel Santhi K Ganesh Marjo-Riitta Jarvelin Nicholas G Martin Christa Meisinger Bruce M Psaty Timothy D Spector Nicholas J Wareham Jan-Willem N Akkerman Marina Ciullo Panos Deloukas Andreas Greinacher Steve Jupe Naoyuki Kamatani Jyoti Khadake Jaspal S Kooner Josef Penninger Inga Prokopenko Derek Stemple Daniela Toniolo Lorenz Wernisch Serena Sanna Andrew A Hicks Augusto Rendon Manuel A Ferreira Willem H Ouwehand Nicole Soranzo

Nature 2011 Nov 30;480(7376):201-8. Epub 2011 Nov 30.

Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1038/nature10659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335296PMC
November 2011

The role of tumor necrosis factor-α converting enzyme in renal transplant rejection.

Am J Nephrol 2010 22;32(4):362-8. Epub 2010 Sep 22.

Department of Nephrology, First Hospital of China Medical University, Shenyang, PR China.

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http://dx.doi.org/10.1159/000320467DOI Listing
January 2011

Targeting of tumor necrosis factor receptor 1 to low density plasma membrane domains in human endothelial cells.

J Biol Chem 2010 Jul 28;285(31):23868-79. Epub 2010 May 28.

Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06520-8089, USA.

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http://dx.doi.org/10.1074/jbc.M110.122853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911292PMC
July 2010

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.

Nat Genet 2009 Nov 11;41(11):1182-90. Epub 2009 Oct 11.

Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108459PMC
November 2009

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.

Nat Genet 2009 Sep 23;41(9):1011-5. Epub 2009 Aug 23.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, UK.

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http://www.nature.com/articles/ng.434
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http://dx.doi.org/10.1038/ng.434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749506PMC
September 2009

Endothelial cells in allograft rejection.

Transplantation 2008 Nov;86(10):1340-8

Department of Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom.

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https://insights.ovid.com/crossref?an=00007890-200811270-000
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http://dx.doi.org/10.1097/TP.0b013e3181891d8bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658756PMC
November 2008

Mechanisms of endothelial dysfunction, injury, and death.

Annu Rev Pathol 2009 ;4:71-95

Departments of Immunobiology and Dermatology, Yale University School of Medicine, New Haven, CT 06520-8089, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.pathol.4.11
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http://dx.doi.org/10.1146/annurev.pathol.4.110807.092155DOI Listing
May 2009

TL1A both promotes and protects from renal inflammation and injury.

J Am Soc Nephrol 2008 May 20;19(5):953-60. Epub 2008 Feb 20.

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1681/ASN.2007060706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386725PMC
May 2008

Chronic kidney disease in primary care.

J R Soc Med 2007 Jan;100(1):40-5

St James Medical Practice, King's Lynn, Norfolk PE30 4ET, UK.

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http://dx.doi.org/10.1177/014107680710000115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761681PMC
January 2007

Aminopeptidase N (CD13) regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils.

J Biol Chem 2006 May 13;281(18):12458-67. Epub 2006 Mar 13.

Respiratory Medicine Division, Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M511277200DOI Listing
May 2006

Caveolae participate in tumor necrosis factor receptor 1 signaling and internalization in a human endothelial cell line.

Am J Pathol 2005 Apr;166(4):1273-82

Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Ave., New Haven, CT 06536-0812, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401062346
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602396PMC
http://dx.doi.org/10.1016/S0002-9440(10)62346-2DOI Listing
April 2005

Radionuclide method for evaluating the performance of hemodialysis in vivo.

Kidney Int 2005 Feb;67(2):721-31

Hemodialysis Unit and Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1111/j.1523-1755.2005.67133.xDOI Listing
February 2005

Histamine antagonizes tumor necrosis factor (TNF) signaling by stimulating TNF receptor shedding from the cell surface and Golgi storage pool.

J Biol Chem 2003 Jun 19;278(24):21751-60. Epub 2003 Mar 19.

Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Box 157, Hills Road, Cambridge CB2 2QQ, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M212662200
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http://dx.doi.org/10.1074/jbc.M212662200DOI Listing
June 2003

Structural equation modeling of drinking motives in male DUI offenders.

J Drug Educ 2002 ;32(1):69-79

South Dakota State University, USA.

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http://dx.doi.org/10.2190/5V04-F8RF-WDTJ-XNNNDOI Listing
July 2002