John P Neoptolemos

John P Neoptolemos

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John P Neoptolemos

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Patterns of Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Secondary Analysis of the ESPAC-4 Randomized Adjuvant Chemotherapy Trial.

Authors:
Robert P Jones Eftychia-Eirini Psarelli Richard Jackson Paula Ghaneh Christopher M Halloran Daniel H Palmer Fiona Campbell Juan W Valle Olusola Faluyi Derek A O'Reilly David Cunningham Jonathan Wadsley Suzanne Darby Tim Meyer Roopinder Gillmore Alan Anthoney Pehr Lind Bengt Glimelius Stephen Falk Jakob R Izbicki Gary William Middleton Sebastian Cummins Paul J Ross Harpreet Wasan Alec McDonald Tom Crosby Yuk Ting Kinnari Patel David Sherriff Rubin Soomal David Borg Sharmila Sothi Pascal Hammel Markus M Lerch Julia Mayerle Christine Tjaden Oliver Strobel Thilo Hackert Markus W Büchler John P Neoptolemos

JAMA Surg 2019 Sep 4. Epub 2019 Sep 4.

University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1001/jamasurg.2019.3337DOI Listing
September 2019

A systematic review and meta-analysis of metal versus plastic stents for drainage of pancreatic fluid collections: metal stents are advantageous.

Authors:
Rebecca Saunders Jayapal Ramesh Silvia Cicconi Jonathan Evans Vincent S Yip Michael Raraty Paula Ghaneh Robert Sutton John P Neoptolemos Christopher Halloran

Surg Endosc 2019 May 6;33(5):1412-1425. Epub 2018 Sep 6.

Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1007/s00464-018-6416-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484810PMC
May 2019

Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study.

Authors:
John N Primrose Richard P Fox Daniel H Palmer Hassan Z Malik Raj Prasad Darius Mirza Alan Anthony Pippa Corrie Stephen Falk Meg Finch-Jones Harpreet Wasan Paul Ross Lucy Wall Jonathan Wadsley Jeff T R Evans Deborah Stocken Raaj Praseedom Yuk Ting Ma Brian Davidson John P Neoptolemos Tim Iveson James Raftery Shihua Zhu David Cunningham O James Garden Clive Stubbs Juan W Valle John Bridgewater

Lancet Oncol 2019 May 25;20(5):663-673. Epub 2019 Mar 25.

UCL Cancer Institute, University College London, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183091
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http://dx.doi.org/10.1016/S1470-2045(18)30915-XDOI Listing
May 2019

Response to: Comment on "The Impact of Positive Resection Margins on Survival and Recurrence Following Resection and Adjuvant Chemotherapy for Pancreatic Ductal Adenocarcinoma." By Niccolo Petrucciani, MD, PhD, FACS, Laura Antolino, MD, Giovanni Moschetta, MD, Giovanni Ramacciato, MD, FACS.

Authors:
John P Neoptolemos Paula Ghaneh Jörg Kleeff Christopher M Halloran Markus W Büchler

Ann Surg 2019 May 9. Epub 2019 May 9.

The Department of Surgery, University of Heidelberg, Heidelberg, Germany The Department of Surgery, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK The Department of Surgery, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Germany The Department of Surgery, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK The Department of Surgery, University of Heidelberg, Heidelberg, Germany.

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http://Insights.ovid.com/crossref?an=00000658-900000000-9509
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http://dx.doi.org/10.1097/SLA.0000000000003371DOI Listing
May 2019

Adjuvant treatment for pancreatic cancer.

Authors:
Ulla Klaiber Thilo Hackert John P Neoptolemos

Transl Gastroenterol Hepatol 2019 29;4:27. Epub 2019 Apr 29.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.21037/tgh.2019.04.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509427PMC
April 2019

The Impact of Positive Resection Margins on Survival and Recurrence Following Resection and Adjuvant Chemotherapy for Pancreatic Ductal Adenocarcinoma.

Authors:
Paula Ghaneh Jorg Kleeff Christopher M Halloran Michael Raraty Richard Jackson James Melling Owain Jones Daniel H Palmer Trevor F Cox Chloe J Smith Derek A O'Reilly Jakob R Izbicki Andrew G Scarfe Juan W Valle Alexander C McDonald Ross Carter Niall C Tebbutt David Goldstein Robert Padbury Jennifer Shannon Christos Dervenis Bengt Glimelius Mark Deakin Alan Anthoney Markus M Lerch Julia Mayerle Attila Oláh Charlotte L Rawcliffe Fiona Campbell Oliver Strobel Markus W Büchler John P Neoptolemos

Ann Surg 2019 Mar;269(3):520-529

Liverpool Cancer Research U.K. Cancer Trials Unit, University of Liverpool, Liverpool, United Kingdom University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1097/SLA.0000000000002557DOI Listing
March 2019

Chemotherapy for pancreatic cancer.

Authors:
Christoph Springfeld Dirk Jäger Markus W Büchler Oliver Strobel Thilo Hackert Daniel H Palmer John P Neoptolemos

Presse Med 2019 Mar 15;48(3 Pt 2):e159-e174. Epub 2019 Mar 15.

Heidelberg University Hospital, Department of Surgery, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.lpm.2019.02.025DOI Listing
March 2019

Prognostic Factors of Survival After Neoadjuvant Treatment and Resection for Initially Unresectable Pancreatic Cancer.

Authors:
Ulla Klaiber Eva S Schnaidt Ulf Hinz Matthias M Gaida Ulrike Heger Thomas Hank Oliver Strobel John P Neoptolemos André L Mihaljevic Markus W Büchler Thilo Hackert

Ann Surg 2019 Mar 20. Epub 2019 Mar 20.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1097/SLA.0000000000003270DOI Listing
March 2019

Neoadjuvant and adjuvant chemotherapy in pancreatic cancer.

Authors:
Ulla Klaiber Carl-Stephan Leonhardt Oliver Strobel Christine Tjaden Thilo Hackert John P Neoptolemos

Langenbecks Arch Surg 2018 Dec 5;403(8):917-932. Epub 2018 Nov 5.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00423-018-1724-8
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http://dx.doi.org/10.1007/s00423-018-1724-8DOI Listing
December 2018

S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes.

Authors:
Taoufik Nedjadi Anthony Evans Adnan Sheikh Lawrence Barerra Suliman Al-Ghamdi Lucy Oldfield W Greenhalf John P Neoptolemos Eithne Costello

BMC Cancer 2018 Dec 17;18(1):1255. Epub 2018 Dec 17.

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1186/s12885-018-5161-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296088PMC
December 2018

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma.

Authors:
Ujjwal Mukund Mahajan Eno Langhoff Elisabetta Goni Eithne Costello William Greenhalf Christopher Halloran Steffen Ormanns Stephan Kruger Stefan Boeck Silvia Ribback Georg Beyer Frank Dombroswki Frank-Ulrich Weiss John P Neoptolemos Jens Werner Jan G D'Haese Alexandr Bazhin Julian Peterhansl Svenja Pichlmeier Markus W Büchler Jörg Kleeff Paula Ganeh Matthias Sendler Daniel H Palmer Thomas Kohlmann Roland Rad Ivonne Regel Markus M Lerch Julia Mayerle

Gastroenterology 2018 11 6;155(5):1625-1639.e2. Epub 2018 Aug 6.

Department of Medicine II, University Hospital, LMU Munich, Germany; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.08.009DOI Listing
November 2018

The diagnostic value of Rosemont and Japanese diagnostic criteria for 'indeterminate', 'suggestive', 'possible' and 'early' chronic pancreatitis.

Authors:
Andrea R G Sheel Ryan D Baron Ioannis Sarantitis Jayapal Ramesh Paula Ghaneh Michael G T Raraty Vincent Yip Robert Sutton Michael R Goulden Fiona Campbell Ammad Farooq Priya Healey Richard Jackson Christopher M Halloran John P Neoptolemos

Pancreatology 2018 Oct 7;18(7):774-784. Epub 2018 Aug 7.

Department of Surgery, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.pan.2018.08.002DOI Listing
October 2018

Guidelines for the Diagnostic Cross Sectional Imaging and Severity Scoring of Chronic Pancreatitis.

Authors:
Jens Brøndum Frøkjær Fatih Akisik Ammad Farooq Burcu Akpinar Anil Dasyam Asbjørn Mohr Drewes Ingfrid S Haldorsen Giovanni Morana John P Neoptolemos Søren Schou Olesen Maria Chiara Petrone Andrea Sheel Tooru Shimosoegawa David C Whitcomb

Pancreatology 2018 Oct 28;18(7):764-773. Epub 2018 Aug 28.

Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh and UPMC, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.pan.2018.08.012DOI Listing
October 2018

Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker.

Authors:
Neus Martinez-Bosch Luis E Barranco Carlos A Orozco Mireia Moreno Laura Visa Mar Iglesias Lucy Oldfield John P Neoptolemos William Greenhalf Julie Earl Alfredo Carrato Eithne Costello Pilar Navarro

Oncotarget 2018 Aug 31;9(68):32984-32996. Epub 2018 Aug 31.

Cancer Research Program, IMIM, Hospital del Mar Medical Research Institute, Unidad Asociade CSIC, Barcelona, Spain.

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http://dx.doi.org/10.18632/oncotarget.26034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152472PMC
August 2018

Common genetic variants associated with pancreatic adenocarcinoma may also modify risk of pancreatic neuroendocrine neoplasms.

Authors:
Ofure Obazee Gabriele Capurso Francesca Tavano Livia Archibugi Antonio De Bonis William Greenhalf Tim Key Claudio Pasquali Anna Caterina Milanetto Thilo Hackert Paola Fogar Valbona Lico Christos Dervenis Rita T Lawlor Luca Landoni Maria Gazouli Carlo Federico Zambon Niccola Funel Oliver Strobel Krzysztof Jamroziak Cinzia Cantu Ewa Malecka-Panas Stefano Landi John P Neoptolemos Daniela Basso Renata Talar-Wojnarowska Maria Rinzivillo Angelo Andriulli Federico Canzian Daniele Campa

Carcinogenesis 2018 07;39(7):969

Department of Biology, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1093/carcin/bgy067DOI Listing
July 2018

Guidelines for the understanding and management of pain in chronic pancreatitis.

Authors:
Asbjørn M Drewes Stefan A W Bouwense Claudia M Campbell Güralp O Ceyhan Myriam Delhaye Ihsan Ekin Demir Pramod K Garg Harry van Goor Christopher Halloran Shuiji Isaji John P Neoptolemos Søren S Olesen Tonya Palermo Pankaj Jay Pasricha Andrea Sheel Tooru Shimosegawa Eva Szigethy David C Whitcomb Dhiraj Yadav

Pancreatology 2017 Sep - Oct;17(5):720-731. Epub 2017 Jul 13.

Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh and UPMC, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.pan.2017.07.006DOI Listing
June 2018

Therapeutic developments in pancreatic cancer: current and future perspectives.

Authors:
John P Neoptolemos Jörg Kleeff Patrick Michl Eithne Costello William Greenhalf Daniel H Palmer

Nat Rev Gastroenterol Hepatol 2018 06;15(6):333-348

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1038/s41575-018-0005-xDOI Listing
June 2018

International consensus statements on early chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with The International Association of Pancreatology, American Pancreatic Association, Japan Pancreas Society, PancreasFest Working Group and European Pancreatic Club.

Authors:
David C Whitcomb Tooru Shimosegawa Suresh T Chari Christopher E Forsmark Luca Frulloni Pramod Garg Peter Hegyi Yoshiki Hirooka Atsushi Irisawa Takuya Ishikawa Shuiji Isaji Markus M Lerch Philippe Levy Atsushi Masamune Charles M Wilcox John Windsor Dhiraj Yadav Andrea Sheel John P Neoptolemos

Pancreatology 2018 May 21. Epub 2018 May 21.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.pan.2018.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748871PMC
May 2018

Minimally invasive and endoscopic versus open necrosectomy for necrotising pancreatitis: a pooled analysis of individual data for 1980 patients.

Authors:
Sandra van Brunschot Robbert A Hollemans Olaf J Bakker Marc G Besselink Todd H Baron Hans G Beger Marja A Boermeester Thomas L Bollen Marco J Bruno Ross Carter Jeremy J French Djalma Coelho Björn Dahl Marcel G Dijkgraaf Nilesh Doctor Peter J Fagenholz Gyula Farkas Carlos Fernandez Del Castillo Paul Fockens Martin L Freeman Timothy B Gardner Harry van Goor Hein G Gooszen Gerjon Hannink Rajiv Lochan Colin J McKay John P Neoptolemos Atilla Oláh Rowan W Parks Miroslav P Peev Michael Raraty Bettina Rau Thomas Rösch Maroeska Rovers Hans Seifert Ajith K Siriwardena Karen D Horvath Hjalmar C van Santvoort

Gut 2018 04 3;67(4):697-706. Epub 2017 Aug 3.

Department of Surgery, University Medical Center Utrecht, Utrecht.

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http://dx.doi.org/10.1136/gutjnl-2016-313341DOI Listing
April 2018

Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer.

Authors:
Andrea S Bauer Petr V Nazarov Nathalia A Giese Stefania Beghelli Anette Heller William Greenhalf Eithne Costello Arnaud Muller Melanie Bier Oliver Strobel Thilo Hackert Laurent Vallar Aldo Scarpa Markus W Büchler John P Neoptolemos Stephanie Kreis Jörg D Hoheisel

Int J Cancer 2018 03 17;142(5):1010-1021. Epub 2017 Oct 17.

Division of Functional Genome Analysis, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.31087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813190PMC
March 2018

Common genetic variants associated with pancreatic adenocarcinoma may also modify risk of pancreatic neuroendocrine neoplasms.

Authors:
Ofure Obazee Gabriele Capurso Francesca Tavano Livia Archibugi Antonio De Bonis William Greenhalf Tim Key Claudio Pasquali Anna Caterina Milanetto Thilo Hackert Paola Fogar Valbona Liço Christos Dervenis Rita T Lawlor Luca Landoni Maria Gazouli Carlo Federico Zambon Niccola Funel Oliver Strobel Krzysztof Jamroziak Cinzia Cantù Ewa Malecka-Panas Stefano Landi John P Neoptolemos Daniela Basso Renata Talar-Wojnarowska Maria Rinzivillo Angelo Andriulli Federico Canzian Daniele Campa

Carcinogenesis 2018 03;39(3):360-367

Department of Biology, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1093/carcin/bgx150DOI Listing
March 2018

Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable disease.

Authors:
Emil Ter Veer L Bengt van Rijssen Marc G Besselink Rosa M A Mali Jordan D Berlin Stefan Boeck Franck Bonnetain Ian Chau Thierry Conroy Eric Van Cutsem Gael Deplanque Helmut Friess Bengt Glimelius David Goldstein Richard Herrmann Roberto Labianca Jean-Luc Van Laethem Teresa Macarulla Jonathan H M van der Meer John P Neoptolemos Takuji Okusaka Eileen M O'Reilly Uwe Pelzer Philip A Philip Marcel J van der Poel Michele Reni Werner Scheithauer Jens T Siveke Chris Verslype Olivier R Busch Johanna W Wilmink Martijn G H van Oijen Hanneke W M van Laarhoven

Lancet Oncol 2018 03;19(3):e151-e160

Department of Medical Oncology, Cancer Center Amsterdam, Academic Medical Center, Amsterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(18)30098-6DOI Listing
March 2018

Cytoplasmic HuR Status Predicts Disease-free Survival in Resected Pancreatic Cancer: A Post-hoc Analysis From the International Phase III ESPAC-3 Clinical Trial.

Authors:
Talar Tatarian Wei Jiang Benjamin E Leiby Amanda Grigoli Masaya Jimbo Nooreen Dabbish John P Neoptolemos William Greenhalf Eithne Costello Paula Ghaneh Christopher Halloran Daniel Palmer Markus Buchler Charles J Yeo Jordan M Winter Jonathan R Brody

Ann Surg 2018 02;267(2):364-369

Jefferson Pancreas, Biliary, and Related Cancer Center, Department of Surgery, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.

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http://dx.doi.org/10.1097/SLA.0000000000002088DOI Listing
February 2018

Pancreatic Cancer and FOLFIRINOX: Should We Resect All Responders?

Authors:
John P Neoptolemos Christopher M Halloran Paula Ghaneh Jorg Kleeff

Ann Surg 2018 02;267(2):e35-e36

NIHR Pancreas Biomedical Research Unit, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK.

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http://dx.doi.org/10.1097/SLA.0000000000002026DOI Listing
February 2018

PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer.

Authors:
Paula Ghaneh Robert Hanson Andrew Titman Gill Lancaster Catrin Plumpton Huw Lloyd-Williams Seow Tien Yeo Rhiannon Tudor Edwards Colin Johnson Mohammed Abu Hilal Antony P Higginson Tom Armstrong Andrew Smith Andrew Scarsbrook Colin McKay Ross Carter Robert P Sutcliffe Simon Bramhall Hemant M Kocher David Cunningham Stephen P Pereira Brian Davidson David Chang Saboor Khan Ian Zealley Debashis Sarker Bilal Al Sarireh Richard Charnley Dileep Lobo Marianne Nicolson Christopher Halloran Michael Raraty Robert Sutton Sobhan Vinjamuri Jonathan Evans Fiona Campbell Jon Deeks Bal Sanghera Wai-Lup Wong John P Neoptolemos

Health Technol Assess 2018 02;22(7):1-114

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.3310/hta22070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817411PMC
February 2018

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

Authors:
Alison P Klein Brian M Wolpin Harvey A Risch Rachael Z Stolzenberg-Solomon Evelina Mocci Mingfeng Zhang Federico Canzian Erica J Childs Jason W Hoskins Ashley Jermusyk Jun Zhong Fei Chen Demetrius Albanes Gabriella Andreotti Alan A Arslan Ana Babic William R Bamlet Laura Beane-Freeman Sonja I Berndt Amanda Blackford Michael Borges Ayelet Borgida Paige M Bracci Lauren Brais Paul Brennan Hermann Brenner Bas Bueno-de-Mesquita Julie Buring Daniele Campa Gabriele Capurso Giulia Martina Cavestro Kari G Chaffee Charles C Chung Sean Cleary Michelle Cotterchio Frederike Dijk Eric J Duell Lenka Foretova Charles Fuchs Niccola Funel Steven Gallinger J Michael M Gaziano Maria Gazouli Graham G Giles Edward Giovannucci Michael Goggins Gary E Goodman Phyllis J Goodman Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Peter Hegyi Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Eric J Jacobs Krzysztof Jamroziak Vladimir Janout Rudolf Kaaks Kay-Tee Khaw Eric A Klein Manolis Kogevinas Charles Kooperberg Matthew H Kulke Juozas Kupcinskas Robert J Kurtz Daniel Laheru Stefano Landi Rita T Lawlor I-Min Lee Loic LeMarchand Lingeng Lu Núria Malats Andrea Mambrini Satu Mannisto Roger L Milne Beatrice Mohelníková-Duchoňová Rachel E Neale John P Neoptolemos Ann L Oberg Sara H Olson Irene Orlow Claudio Pasquali Alpa V Patel Ulrike Peters Raffaele Pezzilli Miquel Porta Francisco X Real Nathaniel Rothman Ghislaine Scelo Howard D Sesso Gianluca Severi Xiao-Ou Shu Debra Silverman Jill P Smith Pavel Soucek Malin Sund Renata Talar-Wojnarowska Francesca Tavano Mark D Thornquist Geoffrey S Tobias Stephen K Van Den Eeden Yogesh Vashist Kala Visvanathan Pavel Vodicka Jean Wactawski-Wende Zhaoming Wang Nicolas Wentzensen Emily White Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Wei Zheng Peter Kraft Donghui Li Stephen Chanock Ofure Obazee Gloria M Petersen Laufey T Amundadottir

Nat Commun 2018 02 8;9(1):556. Epub 2018 Feb 8.

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-02942-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805680PMC
February 2018

Chronic pancreatitis.

Authors:
Jorg Kleeff David C Whitcomb Tooru Shimosegawa Irene Esposito Markus M Lerch Thomas Gress Julia Mayerle Asbjørn Mohr Drewes Vinciane Rebours Fatih Akisik J Enrique Domínguez Muñoz John P Neoptolemos

Nat Rev Dis Primers 2017 Sep 7;3:17060. Epub 2017 Sep 7.

Department of General Surgery, University of Heidelberg, Heidelberg, Germany.

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http://www.nature.com/articles/nrdp201760
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http://dx.doi.org/10.1038/nrdp.2017.60DOI Listing
September 2017

High versus low energy administration in the early phase of acute pancreatitis (GOULASH trial): protocol of a multicentre randomised double-blind clinical trial.

Authors:
Katalin Márta Anikó N Szabó Dániel Pécsi Péter Varjú Judit Bajor Szilárd Gódi Patrícia Sarlós Alexandra Mikó Kata Szemes Mária Papp Tamás Tornai Áron Vincze Zsolt Márton Patrícia A Vincze Erzsébet Lankó Andrea Szentesi Tímea Molnár Roland Hágendorn Nándor Faluhelyi István Battyáni Dezső Kelemen Róbert Papp Attila Miseta Zsófia Verzár Markus M Lerch John P Neoptolemos Miklós Sahin-Tóth Ole H Petersen Péter Hegyi

BMJ Open 2017 Sep 14;7(9):e015874. Epub 2017 Sep 14.

Institute for Translational Medicine, University of Pécs, Pecs, Hungary.

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http://dx.doi.org/10.1136/bmjopen-2017-015874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722094PMC
September 2017

Lack of Association for Reported Endocrine Pancreatic Cancer Risk Loci in the PANDoRA Consortium.

Authors:
Daniele Campa Ofure Obazee Manuela Pastore Francesco Panzuto Valbona Liço William Greenhalf Verena Katzke Francesca Tavano Eithne Costello Vincenzo Corbo Renata Talar-Wojnarowska Oliver Strobel Carlo Federico Zambon John P Neoptolemos Giulia Zerboni Rudolf Kaaks Timothy J Key Carlo Lombardo Krzysztof Jamroziak Domenica Gioffreda Thilo Hackert Kay-Tee Khaw Stefano Landi Anna Caterina Milanetto Luca Landoni Rita T Lawlor Franco Bambi Felice Pirozzi Daniela Basso Claudio Pasquali Gabriele Capurso Federico Canzian

Cancer Epidemiol Biomarkers Prev 2017 08;26(8):1349-1351

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1158/1055-9965.EPI-17-0075DOI Listing
August 2017

Management and Outcome of 64 Patients with Pancreatic Serous Cystic Neoplasms.

Authors:
Ilias P Gomatos Christopher Halloran Paula Ghaneh Michael Raraty Fotis Polydoros Fiona Campbell Jonathan Evans Robert Sutton Jo Garry Philip Whelan John P Neoptolemos

Dig Surg 2016 27;33(3):203-12. Epub 2016 Feb 27.

National Institutes of Health Research Liverpool Pancreas Biomedical Research Unit and Clinical Directorate of General Surgery, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1159/000442094DOI Listing
June 2017

Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.

Authors:
Ashton A Connor Robert E Denroche Gun Ho Jang Lee Timms Sangeetha N Kalimuthu Iris Selander Treasa McPherson Gavin W Wilson Michelle A Chan-Seng-Yue Ivan Borozan Vincent Ferretti Robert C Grant Ilinca M Lungu Eithne Costello William Greenhalf Daniel Palmer Paula Ghaneh John P Neoptolemos Markus Buchler Gloria Petersen Sarah Thayer Michael A Hollingsworth Alana Sherker Daniel Durocher Neesha Dhani David Hedley Stefano Serra Aaron Pollett Michael H A Roehrl Prashant Bavi John M S Bartlett Sean Cleary Julie M Wilson Ludmil B Alexandrov Malcolm Moore Bradly G Wouters John D McPherson Faiyaz Notta Lincoln D Stein Steven Gallinger

JAMA Oncol 2017 Jun;3(6):774-783

PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada3Hepatobiliary/Pancreatic Surgical Oncology Program, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1001/jamaoncol.2016.3916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824324PMC
June 2017

Pancreatic anastomosis after pancreatoduodenectomy: A position statement by the International Study Group of Pancreatic Surgery (ISGPS).

Authors:
Shailesh V Shrikhande Masillamany Sivasanker Charles M Vollmer Helmut Friess Marc G Besselink Abe Fingerhut Charles J Yeo Carlos Fernandez-delCastillo Christos Dervenis Christoper Halloran Dirk J Gouma Dejan Radenkovic Horacio J Asbun John P Neoptolemos Jakob R Izbicki Keith D Lillemoe Kevin C Conlon Laureano Fernandez-Cruz Marco Montorsi Max Bockhorn Mustapha Adham Richard Charnley Ross Carter Thilo Hackert Werner Hartwig Yi Miao Michael Sarr Claudio Bassi Markus W Büchler

Surgery 2017 05 24;161(5):1221-1234. Epub 2016 Dec 24.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.surg.2016.11.021DOI Listing
May 2017

Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial.

Authors:
Gary Middleton Daniel H Palmer William Greenhalf Paula Ghaneh Richard Jackson Trevor Cox Anthony Evans Victoria E Shaw Jonathan Wadsley Juan W Valle David Propper Harpreet Wasan Stephen Falk David Cunningham Fareeda Coxon Paul Ross Srinivasan Madhusudan Nick Wadd Pippa Corrie Tamas Hickish Eithne Costello Fiona Campbell Charlotte Rawcliffe John P Neoptolemos

Lancet Oncol 2017 04 2;18(4):486-499. Epub 2017 Mar 2.

Liverpool Cancer Research UK Cancer Trials Unit and LCTU-GCPLabs, University of Liverpool, Liverpool, UK. Electronic address:

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April 2017

Beyond ESPAC-4: better surgery and systemic therapy.

Authors:
Eftychia E Psarelli Richard Jackson John P Neoptolemos Daniel H Palmer Paula Ghaneh Christopher M Halloran Markus W Büchler

Lancet 2017 04;389(10078):1517-1518

Department of General, Abdominal and Transplant Surgery, University of Heidelberg, Heidelberg, Germany.

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April 2017

The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After.

Authors:
Claudio Bassi Giovanni Marchegiani Christos Dervenis Micheal Sarr Mohammad Abu Hilal Mustapha Adham Peter Allen Roland Andersson Horacio J Asbun Marc G Besselink Kevin Conlon Marco Del Chiaro Massimo Falconi Laureano Fernandez-Cruz Carlos Fernandez-Del Castillo Abe Fingerhut Helmut Friess Dirk J Gouma Thilo Hackert Jakob Izbicki Keith D Lillemoe John P Neoptolemos Attila Olah Richard Schulick Shailesh V Shrikhande Tadahiro Takada Kyoichi Takaori William Traverso Charles R Vollmer Christopher L Wolfgang Charles J Yeo Roberto Salvia Marcus Buchler

Surgery 2017 03 28;161(3):584-591. Epub 2016 Dec 28.

Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.surg.2016.11.014DOI Listing
March 2017

Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial.

Authors:
John P Neoptolemos Daniel H Palmer Paula Ghaneh Eftychia E Psarelli Juan W Valle Christopher M Halloran Olusola Faluyi Derek A O'Reilly David Cunningham Jonathan Wadsley Suzanne Darby Tim Meyer Roopinder Gillmore Alan Anthoney Pehr Lind Bengt Glimelius Stephen Falk Jakob R Izbicki Gary William Middleton Sebastian Cummins Paul J Ross Harpreet Wasan Alec McDonald Tom Crosby Yuk Ting Ma Kinnari Patel David Sherriff Rubin Soomal David Borg Sharmila Sothi Pascal Hammel Thilo Hackert Richard Jackson Markus W Büchler

Lancet 2017 03 25;389(10073):1011-1024. Epub 2017 Jan 25.

University of Heidelberg, Germany.

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http://dx.doi.org/10.1016/S0140-6736(16)32409-6DOI Listing
March 2017

Definition and classification of chyle leak after pancreatic operation: A consensus statement by the International Study Group on Pancreatic Surgery.

Authors:
Marc G Besselink L Bengt van Rijssen Claudio Bassi Christos Dervenis Marco Montorsi Mustapha Adham Horacio J Asbun Maximillian Bockhorn Oliver Strobel Markus W Büchler Olivier R Busch Richard M Charnley Kevin C Conlon Laureano Fernández-Cruz Abe Fingerhut Helmut Friess Jakob R Izbicki Keith D Lillemoe John P Neoptolemos Michael G Sarr Shailesh V Shrikhande Robert Sitarz Charles M Vollmer Charles J Yeo Werner Hartwig Christopher L Wolfgang Dirk J Gouma

Surgery 2017 02 28;161(2):365-372. Epub 2016 Sep 28.

Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.surg.2016.06.058DOI Listing
February 2017

International Association of Pancreatology (IAP)/European Pancreatic Club (EPC) consensus review of guidelines for the treatment of pancreatic cancer.

Authors:
Kyoichi Takaori Claudio Bassi Andrew Biankin Thomas B Brunner Ivana Cataldo Fiona Campbell David Cunningham Massimo Falconi Adam E Frampton Junji Furuse Marc Giovannini Richard Jackson Akira Nakamura William Nealon John P Neoptolemos Francisco X Real Aldo Scarpa Francesco Sclafani John A Windsor Koji Yamaguchi Christopher Wolfgang Colin D Johnson

Pancreatology 2016 Jan-Feb;16(1):14-27. Epub 2015 Nov 12.

University Surgical Unit, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1016/j.pan.2015.10.013DOI Listing
December 2016

Evidence-based Guidelines for the Management of Exocrine Pancreatic Insufficiency After Pancreatic Surgery.

Authors:
Luis Sabater Fabio Ausania Olaf J Bakker Jaume Boadas J Enrique Domínguez-Muñoz Massimo Falconi Laureano Fernández-Cruz Luca Frulloni Víctor González-Sánchez José Lariño-Noia Björn Lindkvist Félix Lluís Francisco Morera-Ocón Elena Martín-Pérez Carlos Marra-López Ángel Moya-Herraiz John P Neoptolemos Isabel Pascual Ángeles Pérez-Aisa Raffaele Pezzilli José M Ramia Belinda Sánchez Xavier Molero Inmaculada Ruiz-Montesinos Eva C Vaquero Enrique de-Madaria

Ann Surg 2016 Dec;264(6):949-958

*Department of Surgery, Hospital Clinico, University of Valencia, Valencia, Spain †Department of Surgery, Complejo Hospitalario Universitario de Vigo, Vigo, Spain ‡Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands §Department of Gastroenterology, Consorci Sanitari de Terrassa, Terrassa, Spain ¶Department of Gastroenterology, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain ||Department of Surgery, Università Vita e Salute, Ospedale San Raffaele IRCCS, Milano, Italy **Department of Surgery, Institut de Malalties Digestives I Metabòliques, Hospital Clínic, IDIBAPS, Barcelona, Spain ††Department of Medicine, Pancreas Center, University of Verona, Verona, Italy ‡‡Department of Endocrinology and Nutrition, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain. §§Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden ¶¶Department of Surgery, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain. ||||Department of Surgery, Hospital Universitario de La Princesa, Madrid, Spain ***Department of Gastroenterology, Complejo Hospitalario de Navarra, Pamplona, Spain †††Unidad de Cirugía Hepato-bilio-pancreática y Trasplante, Hospital Universitari i Politecnic. La Fe, Valencia, Spain ‡‡‡NIHR Pancreas Biomedical Research Unit, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK §§§Department of Gastroenterology, Hospital Clinico, University of Valencia, Valencia, Spain ¶¶¶Unit of Digestive Disease, Agencia Sanitaria Costa del Sol, Marbella, Málaga ||||||Department Digestive System, Sant'Orsola-Malpighi Hospital, Bologna, Italy ****Department of Surgery, Hospital Universitario de Guadalajara, Guadalajara, Spain ††††Department of HPB Surgery and Liver Transplantation, Hospital Carlos Haya, Malaga, Spain ‡‡‡‡Exocrine Pancreas Research Unit, Hospital Universitari Vall d'Hebron, Institut de Recerca, Universitat Autònoma de Barcelona, CIBEREHD, Barcelona, Spain §§§§Department of Digestive Surgery- Division of HBP Surgery, Hospital Universitario Donostia, San Sebastián, Spain ¶¶¶¶Department of Gastroenterology, Institut de Malalties Digestives i Metabòliques, Hospital Clínic, IDIBAPS, CiberEHD, Barcelona, Spain ||||||||Department of Gastroenterology, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain.

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December 2016

Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice.

Authors:
Pouria Jandaghi Hamed S Najafabadi Andrea S Bauer Andreas I Papadakis Matteo Fassan Anita Hall Anie Monast Magnus von Knebel Doeberitz John P Neoptolemos Eithne Costello William Greenhalf Aldo Scarpa Bence Sipos Daniel Auld Mark Lathrop Morag Park Markus W Büchler Oliver Strobel Thilo Hackert Nathalia A Giese George Zogopoulos Veena Sangwan Sidong Huang Yasser Riazalhosseini Jörg D Hoheisel

Gastroenterology 2016 12 28;151(6):1218-1231. Epub 2016 Aug 28.

Functional Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

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http://dx.doi.org/10.1053/j.gastro.2016.08.040DOI Listing
December 2016

The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer.

Authors:
Jörg Kleeff Eithne Costello Richard Jackson Chris Halloran William Greenhalf Paula Ghaneh Richard F Lamb Markus M Lerch Julia Mayerle Daniel Palmer Trevor Cox Charlotte L Rawcliffe Oliver Strobel Markus W Büchler John P Neoptolemos

Br J Cancer 2016 09 1;115(7):887-94. Epub 2016 Sep 1.

Liverpool Cancer Research UK Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1038/bjc.2016.277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046218PMC
September 2016

Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk.

Authors:
Daniele Campa Manuela Pastore Manuel Gentiluomo Renata Talar-Wojnarowska Juozas Kupcinskas Ewa Malecka-Panas John P Neoptolemos Willem Niesen Pavel Vodicka Gianfranco Delle Fave H Bas Bueno-de-Mesquita Maria Gazouli Paola Pacetti Milena Di Leo Hidemi Ito Harald Klüter Pavel Soucek Vincenzo Corbo Kenji Yamao Satoyo Hosono Rudolf Kaaks Yogesh Vashist Domenica Gioffreda Oliver Strobel Yasuhiro Shimizu Frederike Dijk Angelo Andriulli Audrius Ivanauskas Peter Bugert Francesca Tavano Ludmila Vodickova Carlo Federico Zambon Martin Lovecek Stefano Landi Timothy J Key Ugo Boggi Raffaele Pezzilli Krzysztof Jamroziak Beatrice Mohelnikova-Duchonova Andrea Mambrini Franco Bambi Olivier Busch Valerio Pazienza Roberto Valente George E Theodoropoulos Thilo Hackert Gabriele Capurso Giulia Martina Cavestro Claudio Pasquali Daniela Basso Cosimo Sperti Keitaro Matsuo Markus Büchler Kay-Tee Khaw Jakob Izbicki Eithne Costello Verena Katzke Christoph Michalski Anna Stepien Cosmeri Rizzato Federico Canzian

Oncotarget 2016 08;7(35):57011-57020

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.18632/oncotarget.10935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302969PMC
August 2016

Early Epigenetic Downregulation of microRNA-192 Expression Promotes Pancreatic Cancer Progression.

Authors:
Sandeep K Botla Soniya Savant Pouria Jandaghi Andrea S Bauer Oliver Mücke Evgeny A Moskalev John P Neoptolemos Eithne Costello William Greenhalf Aldo Scarpa Matthias M Gaida Markus W Büchler Oliver Strobel Thilo Hackert Nathalia A Giese Hellmut G Augustin Jörg D Hoheisel

Cancer Res 2016 07 23;76(14):4149-59. Epub 2016 May 23.

Division of Functional Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0390DOI Listing
July 2016

Outcomes From Minimal Access Retroperitoneal and Open Pancreatic Necrosectomy in 394 Patients With Necrotizing Pancreatitis.

Authors:
Ilias P Gomatos Christopher M Halloran Paula Ghaneh Michael G T Raraty Fotis Polydoros Jonathan C Evans Howard L Smart R Yagati-Satchidanand Jo M Garry Philip A Whelan Faye E Hughes Robert Sutton John P Neoptolemos

Ann Surg 2016 May;263(5):992-1001

*Clinical Directorate of General Surgery, National Institutes of Health Research Liverpool Pancreas Biomedical Research Unit, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK †Liverpool Clinical Trials Unit, University of Liverpool, Liverpool, UK ‡Clinical Directorate of Radiology, National Institutes of Health Research Liverpool Pancreas Biomedical Research Unit, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK §Clinical Directorate of Gastroenterology, National Institutes of Health Research Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital NHS Trust, Liverpool, UK.

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http://dx.doi.org/10.1097/SLA.0000000000001407DOI Listing
May 2016

Stratification of pancreatic tissue samples for molecular studies: RNA-based cellular annotation procedure.

Authors:
Anette Heller Matthias M Gaida D Männle Thomas Giese Aldo Scarpa John P Neoptolemos Thilo Hackert Oliver Strobel Jörg D Hoheisel Nathalia A Giese Andrea S Bauer

Pancreatology 2015 Jul-Aug;15(4):423-31. Epub 2015 Jun 15.

Functional Genome Analysis, German Research Cancer Center, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.pan.2015.05.480DOI Listing
April 2016

Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus.

Authors:
Claire Jenkinson Victoria L Elliott Anthony Evans Lucy Oldfield Rosalind E Jenkins Darragh P O'Brien Sophia Apostolidou Aleksandra Gentry-Maharaj Evangelia-O Fourkala Ian J Jacobs Usha Menon Trevor Cox Fiona Campbell Stephen P Pereira David A Tuveson B Kevin Park William Greenhalf Robert Sutton John F Timms John P Neoptolemos Eithne Costello

Clin Cancer Res 2016 Apr 16;22(7):1734-1743. Epub 2015 Nov 16.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, UK.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820087PMC
April 2016

Pancreatic cancer.

Authors:
Jorg Kleeff Murray Korc Minoti Apte Carlo La Vecchia Colin D Johnson Andrew V Biankin Rachel E Neale Margaret Tempero David A Tuveson Ralph H Hruban John P Neoptolemos

Nat Rev Dis Primers 2016 04 21;2:16022. Epub 2016 Apr 21.

NIHR Pancreas Biomedical Research Unit, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Duncan Building, Daulby Street, Liverpool L69 3GA, UK.

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http://dx.doi.org/10.1038/nrdp.2016.22DOI Listing
April 2016

Xanthogranulomatous pancreatitis associated with a mucinous cystic neoplam.

Authors:
Thomas Hanna Zainab Abdul-Rahman William Greenhalf Ammad Farooq John P Neoptolemos

Pathol Int 2016 03 12;66(3):174-176. Epub 2015 Nov 12.

National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, Liverpool, UK.

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http://dx.doi.org/10.1111/pin.12356DOI Listing
March 2016

Immunobiological effects of gemcitabine and capecitabine combination chemotherapy in advanced pancreatic ductal adenocarcinoma.

Authors:
Gary Middleton William Greenhalf Eithne Costello Victoria Shaw Trevor Cox Paula Ghaneh Daniel H Palmer John P Neoptolemos

Br J Cancer 2016 Mar 4;114(5):510-8. Epub 2016 Feb 4.

National Institutes of Health Research Liverpool Pancreas Biomedical Research Unit and Clinical Directorate of General Surgery, Royal Liverpool and Broadgreen University Hospitals NHS Trust and the University of Liverpool, Liverpool L69 3GA, UK.

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http://dx.doi.org/10.1038/bjc.2015.468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782200PMC
March 2016

UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis.

Authors:
Wafa Abu-Alainin Thompson Gana Triantafillos Liloglou Adedamola Olayanju Lawrence N Barrera Robert Ferguson Fiona Campbell Timothy Andrews Christopher Goldring Neil Kitteringham Brian K Park Taoufik Nedjadi Michael C Schmid Joseph R Slupsky William Greenhalf John P Neoptolemos Eithne Costello

J Pathol 2016 Feb 30;238(3):423-33. Epub 2015 Nov 30.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, UK.

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http://dx.doi.org/10.1002/path.4665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738372PMC
February 2016

PANasta Trial; Cattell Warren versus Blumgart techniques of panreatico-jejunostomy following pancreato-duodenectomy: Study protocol for a randomized controlled trial.

Authors:
Christopher M Halloran Kellie Platt Abbie Gerard Fotis Polydoros Derek A O'Reilly Dhanwant Gomez Andrew Smith John P Neoptolemos Zahir Soonwalla Mark Taylor Jane M Blazeby Paula Ghaneh

Trials 2016 Jan 15;17:30. Epub 2016 Jan 15.

National Institutes of Health Research Liverpool Pancreas Biomedical Research Unit and Clinical Directorate of General Surgery, Royal Liverpool and Broadgreen University Hospitals NHS Trust and the University of Liverpool, Liverpool, L69 3GA, UK.

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http://dx.doi.org/10.1186/s13063-015-1144-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714471PMC
January 2016

What Is the Best Way to Identify Malignant Transformation Within Pancreatic IPMN: A Systematic Review and Meta-Analyses.

Authors:
Asma Sultana Richard Jackson Gilbert Tim Emma Bostock Eftychia E Psarelli Trevor F Cox Robert Sutton Paula Ghaneh Michael G T Raraty John P Neoptolemos Christopher M Halloran

Clin Transl Gastroenterol 2015 Dec 10;6:e130. Epub 2015 Dec 10.

NIHR Pancreas Biomedical Research Unit, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1038/ctg.2015.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816095PMC
December 2015

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.

Authors:
Erica J Childs Evelina Mocci Daniele Campa Paige M Bracci Steven Gallinger Michael Goggins Donghui Li Rachel E Neale Sara H Olson Ghislaine Scelo Laufey T Amundadottir William R Bamlet Maarten F Bijlsma Amanda Blackford Michael Borges Paul Brennan Hermann Brenner H Bas Bueno-de-Mesquita Federico Canzian Gabriele Capurso Giulia M Cavestro Kari G Chaffee Stephen J Chanock Sean P Cleary Michelle Cotterchio Lenka Foretova Charles Fuchs Niccola Funel Maria Gazouli Manal Hassan Joseph M Herman Ivana Holcatova Elizabeth A Holly Robert N Hoover Rayjean J Hung Vladimir Janout Timothy J Key Juozas Kupcinskas Robert C Kurtz Stefano Landi Lingeng Lu Ewa Malecka-Panas Andrea Mambrini Beatrice Mohelnikova-Duchonova John P Neoptolemos Ann L Oberg Irene Orlow Claudio Pasquali Raffaele Pezzilli Cosmeri Rizzato Amethyst Saldia Aldo Scarpa Rachael Z Stolzenberg-Solomon Oliver Strobel Francesca Tavano Yogesh K Vashist Pavel Vodicka Brian M Wolpin Herbert Yu Gloria M Petersen Harvey A Risch Alison P Klein

Nat Genet 2015 Aug 22;47(8):911-6. Epub 2015 Jun 22.

1] Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. [2] Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/ng.3341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520746PMC
August 2015

Incidence of post-ERCP pancreatitis from direct pancreatic juice collection in hereditary pancreatitis and familial pancreatic cancer before and after the introduction of prophylactic pancreatic stents and rectal diclofenac.

Authors:
James A Nicholson William Greenhalf Richard Jackson Trevor F Cox Jane V Butler Thomas Hanna Sara Harrison Christopher J Grocock Christopher M Halloran Nathan R Howes Michael G Raraty Paula Ghaneh Marianne Johnstone Sanchoy Sarkar Howard L Smart Jonathan C Evans Guruprasad P Aithal Robert Sutton John P Neoptolemos Martin G Lombard

Pancreas 2015 Mar;44(2):260-5

From the *National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital; †Liverpool Clinical Trials Unit; Departments of ‡Gastroenterology, and §Radiology, Royal Liverpool University Hospital, Liverpool; and ║Digestive Diseases Biomedical Research Unit, National Institute for Health Research Nottingham, Queen's Medical Centre, Nottingham, United Kingdom.

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http://dx.doi.org/10.1097/MPA.0000000000000246DOI Listing
March 2015

Pancreatic mass in a young CFTR carrier with a heterozygous p.R117H CFTR gene mutation and homozygous 7T.

Authors:
Thomas Hanna Zainab Abdul-Rahman William Greenhalf Eithne Costello John P Neoptolemos

Pancreas 2015 Mar;44(2):343-5

National Institute for Health Research Liverpool Pancreas Biomedical Research Unit Royal Liverpool University Hospital Liverpool, UK Department of Cellular Pathology Royal Liverpool University Hospital Liverpool, UK National Institute for Health Research Liverpool Pancreas Biomedical Research Unit Royal Liverpool University Hospital Liverpool, UK National Institute for Health Research Liverpool Pancreas Biomedical Research Unit Royal Liverpool University Hospital Liverpool, UK

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http://dx.doi.org/10.1097/MPA.0000000000000244DOI Listing
March 2015

Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: a consensus statement by the International Study Group on Pancreatic Surgery (ISGPS).

Authors:
Johanna A M G Tol Dirk J Gouma Claudio Bassi Christos Dervenis Marco Montorsi Mustapha Adham Ake Andrén-Sandberg Horacio J Asbun Maximilian Bockhorn Markus W Büchler Kevin C Conlon Laureano Fernández-Cruz Abe Fingerhut Helmut Friess Werner Hartwig Jakob R Izbicki Keith D Lillemoe Miroslav N Milicevic John P Neoptolemos Shailesh V Shrikhande Charles M Vollmer Charles J Yeo Richard M Charnley

Surgery 2014 Sep 22;156(3):591-600. Epub 2014 Jul 22.

Department of HPB & Transplant Surgery, Freeman Hospital, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/j.surg.2014.06.016DOI Listing
September 2014

Extended pancreatectomy in pancreatic ductal adenocarcinoma: definition and consensus of the International Study Group for Pancreatic Surgery (ISGPS).

Authors:
Werner Hartwig Charles M Vollmer Abe Fingerhut Charles J Yeo John P Neoptolemos Mustapha Adham Ake Andrén-Sandberg Horacio J Asbun Claudio Bassi Max Bockhorn Richard Charnley Kevin C Conlon Christos Dervenis Laureano Fernandez-Cruz Helmut Friess Dirk J Gouma Clem W Imrie Keith D Lillemoe Miroslav N Milićević Marco Montorsi Shailesh V Shrikhande Yogesh K Vashist Jakob R Izbicki Markus W Büchler

Surgery 2014 Jul 20;156(1):1-14. Epub 2014 Feb 20.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2014.02.009DOI Listing
July 2014

Borderline resectable pancreatic cancer: a consensus statement by the International Study Group of Pancreatic Surgery (ISGPS).

Authors:
Maximilian Bockhorn Faik G Uzunoglu Mustapha Adham Clem Imrie Miroslav Milicevic Aken A Sandberg Horacio J Asbun Claudio Bassi Markus Büchler Richard M Charnley Kevin Conlon Laureano Fernandez Cruz Christos Dervenis Abe Fingerhutt Helmut Friess Dirk J Gouma Werner Hartwig Keith D Lillemoe Marco Montorsi John P Neoptolemos Shailesh V Shrikhande Kyoichi Takaori William Traverso Yogesh K Vashist Charles Vollmer Charles J Yeo Jakob R Izbicki

Surgery 2014 Jun 7;155(6):977-88. Epub 2014 Feb 7.

Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2014.02.001DOI Listing
June 2014

When to perform a pancreatoduodenectomy in the absence of positive histology? A consensus statement by the International Study Group of Pancreatic Surgery.

Authors:
Horacio J Asbun Kevin Conlon Laureano Fernandez-Cruz Helmut Friess Shailesh V Shrikhande Mustapha Adham Claudio Bassi Maximilian Bockhorn Markus Büchler Richard M Charnley Christos Dervenis Abe Fingerhutt Dirk J Gouma Werner Hartwig Clem Imrie Jakob R Izbicki Keith D Lillemoe Miroslav Milicevic Marco Montorsi John P Neoptolemos Aken A Sandberg Michael Sarr Charles Vollmer Charles J Yeo L William Traverso

Surgery 2014 May 2;155(5):887-92. Epub 2014 Jan 2.

St. Luke's Clinic - Center For Pancreatic and Liver Diseases, Boise, ID.

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http://dx.doi.org/10.1016/j.surg.2013.12.032DOI Listing
May 2014

Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease.

Authors:
Victoria E Shaw Brian Lane Claire Jenkinson Trevor Cox William Greenhalf Christopher M Halloran Joseph Tang Robert Sutton John P Neoptolemos Eithne Costello

Mol Cancer 2014 May 20;13:114. Epub 2014 May 20.

NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool and Broadgreen University Hospital NHS Trust, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3GA, UK.

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http://dx.doi.org/10.1186/1476-4598-13-114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032456PMC
May 2014

Prognostic markers in acute pancreatitis.

Authors:
Ilias P Gomatos Xu Xiaodong Paula Ghaneh Christopher Halloran Michael Raraty Brian Lane Robert Sutton John P Neoptolemos

Expert Rev Mol Diagn 2014 Apr;14(3):333-46

NIHR Pancreas Biomedical Research Unit, the Royal Liverpool University and Broadgreen Hospitals NHS Trust and the University of Liverpool, Liverpool L69 3GA, UK.

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http://dx.doi.org/10.1586/14737159.2014.897608DOI Listing
April 2014

The effects of gemcitabine and capecitabine combination chemotherapy and of low-dose adjuvant GM-CSF on the levels of myeloid-derived suppressor cells in patients with advanced pancreatic cancer.

Authors:
Nicola E Annels Victoria E Shaw Rachel F Gabitass Lucinda Billingham Pippa Corrie Martin Eatock Juan Valle David Smith Jonathan Wadsley David Cunningham Hardev Pandha John P Neoptolemos Gary Middleton

Cancer Immunol Immunother 2014 Feb 29;63(2):175-83. Epub 2013 Nov 29.

University of Surrey, Guildford, UK,

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February 2014

Optimal duration and timing of adjuvant chemotherapy after definitive surgery for ductal adenocarcinoma of the pancreas: ongoing lessons from the ESPAC-3 study.

Authors:
Juan W Valle Daniel Palmer Richard Jackson Trevor Cox John P Neoptolemos Paula Ghaneh Charlotte L Rawcliffe Claudio Bassi Deborah D Stocken David Cunningham Derek O'Reilly David Goldstein Bridget A Robinson Christos Karapetis Andrew Scarfe Francois Lacaine Juhani Sand Jakob R Izbicki Julia Mayerle Christos Dervenis Attila Oláh Giovanni Butturini Pehr A Lind Mark R Middleton Alan Anthoney Kate Sumpter Ross Carter Markus W Büchler

J Clin Oncol 2014 Feb 13;32(6):504-12. Epub 2014 Jan 13.

Juan W. Valle, Derek O'Reilly, Manchester Academic Health Sciences Centre, Christie Hospital NHS Foundation Trust and University of Manchester, Manchester; Richard Jackson, Trevor Cox, John P. Neoptolemos, Paula Ghaneh, Charlotte L. Rawcliffe, Liverpool Cancer Research UK Centre and the National Institute for Health Research Pancreas Biomedical Research Unit, University of Liverpool, Liverpool; Daniel Palmer, the Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust; Deborah D. Stocken, the Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham; David Cunningham, Royal Marsden Hospital Foundation Trust, Sutton; Mark R. Middleton, Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford; Alan Anthoney, The Leeds Teaching Hospital Trust, Leeds; Kate Sumpter, Freeman Hospital, Newcastle upon Tyne; Ross Carter, Glasgow Royal Infirmary, Glasgow, United Kingdom; Claudio Bassi, Giovanni Butturini, University of Verona, Verona, Italy; David Goldstein, Bridget A. Robinson, Christos Karapetis, the Australasian Gastro-Intestinal Trials Group, Camperdown, Australia; Andrew Scarfe, University of Alberta, Edmonton, Canada; Francois Lacaine, Hôpital TENON, Assistance Publique Hôpitaux de Paris, Universite Pierre Et Marie Curie, Paris, France; Juhani Sand, Tampere University Hospital, Tampere, Finland; Jakob R. Izbicki, University of Hamburg, Hamburg; Julia Mayerle, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald; Markus W. Büchler, University of Heidelberg, Heidelberg, Germany; Christos Dervenis, the Agia Olga Hospital, Athens, Greece; Attila Oláh, the Petz Aladar Hospital, Gyor, Hungary; Pehr A. Lind, Karolinska-Stockholm Söder Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1200/JCO.2013.50.7657DOI Listing
February 2014

Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial.

Authors:
William Greenhalf Paula Ghaneh John P Neoptolemos Daniel H Palmer Trevor F Cox Richard F Lamb Elizabeth Garner Fiona Campbell John R Mackey Eithne Costello Malcolm J Moore Juan W Valle Alexander C McDonald Ross Carter Niall C Tebbutt David Goldstein Jennifer Shannon Christos Dervenis Bengt Glimelius Mark Deakin Richard M Charnley François Lacaine Andrew G Scarfe Mark R Middleton Alan Anthoney Christopher M Halloran Julia Mayerle Attila Oláh Richard Jackson Charlotte L Rawcliffe Aldo Scarpa Claudio Bassi Markus W Büchler

J Natl Cancer Inst 2014 Jan 3;106(1):djt347. Epub 2013 Dec 3.

Affiliations of authors: Liverpool Cancer Research UK Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool, Liverpool, UK (WG, JPN, EG, TFC, PG, EC, CMH, CLR, FC, RJ); the Princess Margaret Hospital, Toronto, Canada (MJM); Manchester Academic Health Sciences Centre, Christie NHS Foundation Trust, School of Cancer and Enabling Sciences, University of Manchester, UK (JWV); Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK (DHP); Beatson West of Scotland Cancer Centre, Glasgow, UK (ACM); Glasgow Royal Infirmary, Glasgow, UK (RC); Hôpital Tenon, Université, Pierre et Marie Curie, Paris, France (FL); Austin Health, Melbourne, Australia (NCT); Prince of Wales Hospital and Clinical School University of New South Wales, New South Wales, Australia (DG); Nepean Cancer Centre and University of Sydney, Sydney, Australia (JS); Agia Olga Hospital, Athens, Greece (CD); Medical Oncology, Clatterbridge Centre for Oncology, Bebington, Merseyside, UK (DS); Department of Oncology, Akademiska Sjukhuset, Uppsala University, Uppsala, Sweden (BG); University Hospital, North Staffordshire, UK (MD); Freeman Hospital, Newcastle upon Tyne, UK (RMC); Service de Chirurgie Digestive et Viscérale, Hôpital Tenon, Paris, France (FL); Cross Cancer Institute and University of Alberta, Alberta, Canada (JRM, AGS); Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford, UK (MRM); St James's University Hospital, Leeds, UK (AA); Department of Medicine A, University Medicine Greifswald, Greifswald, Germany (JM); Petz Aladar Hospital, Gyor, Hungary (AO); Departments of Surgery and Pathology and ARC-NET Research Center, University of Verona, Italy (AS, CB); Department of Surgery, University of Heidelberg, Heidelberg, Germany (MWB).

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http://dx.doi.org/10.1093/jnci/djt347DOI Listing
January 2014

Bayesian analysis unravels pancreas-cancer adjuvant therapy.

Authors:
John P Neoptolemos Trevor F Cox

Lancet Oncol 2013 Oct 12;14(11):1034-1035. Epub 2013 Sep 12.

Cancer Research UK Liverpool Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool, Liverpool, UK; NIHR Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, L69 3GA, UK.

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http://dx.doi.org/10.1016/S1470-2045(13)70403-0DOI Listing
October 2013

Somatic mutations in exocrine pancreatic tumors: association with patient survival.

Authors:
P Sivaramakrishna Rachakonda Andrea S Bauer Huaping Xie Daniele Campa Cosmeri Rizzato Federico Canzian Stefania Beghelli William Greenhalf Eithne Costello Michaela Schanne Anette Heller Aldo Scarpa John P Neoptolemos Jens Werner Markus Büchler Jörg D Hoheisel Kari Hemminki Nathalia Giese Rajiv Kumar

PLoS One 2013 2;8(4):e60870. Epub 2013 Apr 2.

Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614935PMC
September 2013

The value of source data verification in a cancer clinical trial.

Authors:
Catrin Tudur Smith Deborah D Stocken Janet Dunn Trevor Cox Paula Ghaneh David Cunningham John P Neoptolemos

PLoS One 2012 12;7(12):e51623. Epub 2012 Dec 12.

Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520949PMC
June 2013

Adjuvant therapy for pancreatic cancer.

Authors:
Asma Sultana Trevor Cox Paula Ghaneh John P Neoptolemos

Recent Results Cancer Res 2012 ;196:65-88

Department of Molecular and Clinical Cancer Medicine Centre, University of Liverpool, Liverpool, L69 3GA, UK.

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http://dx.doi.org/10.1007/978-3-642-31629-6_5DOI Listing
April 2013

ABO blood groups and pancreatic cancer risk and survival: results from the PANcreatic Disease ReseArch (PANDoRA) consortium.

Authors:
Cosmeri Rizzato Daniele Campa Raffaele Pezzilli Pavel Soucek William Greenhalf Gabriele Capurso Renata Talar-Wojnarowska Anette Heller Krzysztof Jamroziak Kay-Tee Khaw Tim J Key Franco Bambi Stefano Landi Beatrice Mohelnikova-Duchonova Ludmila Vodickova Markus W Büchler Peter Bugert Pavel Vodicka John P Neoptolemos Jens Werner Jörg D Hoheisel Andrea S Bauer Nathalia Giese Federico Canzian

Oncol Rep 2013 Apr 12;29(4):1637-44. Epub 2013 Feb 12.

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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April 2013

Genetic susceptibility to pancreatic cancer and its functional characterisation: the PANcreatic Disease ReseArch (PANDoRA) consortium.

Authors:
Daniele Campa Cosmeri Rizzato Gabriele Capurso Nathalia Giese Niccola Funel William Greenhalf Pavel Soucek Maria Gazouli Raffaele Pezzilli Claudio Pasquali Renata Talar-Wojnarowska Maurizio Cantore Angelo Andriulli Aldo Scarpa Krzysztof Jamroziak Gianfranco Delle Fave Eithne Costello Kay-Tee Khaw Anette Heller Tim J Key George Theodoropoulos Ewa Malecka-Panas Andrea Mambrini Franco Bambi Stefano Landi Sergio Pedrazzoli Claudio Bassi Paola Pacetti Ada Piepoli Francesca Tavano Pierluigi di Sebastiano Ludmila Vodickova Daniela Basso Mario Plebani Paola Fogar Markus W Büchler Peter Bugert Pavel Vodicka Ugo Boggi John P Neoptolemos Jens Werner Federico Canzian

Dig Liver Dis 2013 Feb 1;45(2):95-9. Epub 2012 Dec 1.

German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.dld.2012.09.014DOI Listing
February 2013

Lack of replication of seven pancreatic cancer susceptibility loci identified in two Asian populations.

Authors:
Daniele Campa Cosmeri Rizzato Andrea S Bauer Jens Werner Gabriele Capurso Eithne Costello Renata Talar-Wojnarowska Krzysztof Jamroziak Raffaele Pezzilli Maria Gazouli Kay-Tee Khaw Timothy J Key Franco Bambi Beatrice Mohelnikova-Duchonova Anette Heller Stefano Landi Ludmila Vodickova George Theodoropoulos Peter Bugert Pavel Vodicka Jörg D Hoheisel Gianfranco Delle Fave John P Neoptolemos Pavel Soucek Markus W Büchler Nathalia Giese Federico Canzian

Cancer Epidemiol Biomarkers Prev 2013 Feb 18;22(2):320-3. Epub 2012 Dec 18.

German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1158/1055-9965.EPI-12-1182DOI Listing
February 2013

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.

Authors:
David C Whitcomb Jessica LaRusch Alyssa M Krasinskas Lambertus Klei Jill P Smith Randall E Brand John P Neoptolemos Markus M Lerch Matt Tector Bimaljit S Sandhu Nalini M Guda Lidiya Orlichenko Samer Alkaade Stephen T Amann Michelle A Anderson John Baillie Peter A Banks Darwin Conwell Gregory A Coté Peter B Cotton James DiSario Lindsay A Farrer Chris E Forsmark Marianne Johnstone Timothy B Gardner Andres Gelrud William Greenhalf Jonathan L Haines Douglas J Hartman Robert A Hawes Christopher Lawrence Michele Lewis Julia Mayerle Richard Mayeux Nadine M Melhem Mary E Money Thiruvengadam Muniraj Georgios I Papachristou Margaret A Pericak-Vance Joseph Romagnuolo Gerard D Schellenberg Stuart Sherman Peter Simon Vijay P Singh Adam Slivka Donna Stolz Robert Sutton Frank Ulrich Weiss C Mel Wilcox Narcis Octavian Zarnescu Stephen R Wisniewski Michael R O'Connell Michelle L Kienholz Kathryn Roeder M Michael Barmada Dhiraj Yadav Bernie Devlin

Nat Genet 2012 Dec 11;44(12):1349-54. Epub 2012 Nov 11.

Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1038/ng.2466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510344PMC
December 2012

New biomarkers and targets in pancreatic cancer and their application to treatment.

Authors:
Eithne Costello William Greenhalf John P Neoptolemos

Nat Rev Gastroenterol Hepatol 2012 Aug 26;9(8):435-44. Epub 2012 Jun 26.

National Institute for Health Research Pancreas Biomedical Research Unit and Liverpool Cancer Research UK Centre, Department of Molecular, University of Liverpool, Liverpool, L69 3GA, UK.

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http://dx.doi.org/10.1038/nrgastro.2012.119DOI Listing
August 2012

Partial pancreatic resection for pancreatic malignancy is associated with sustained pancreatic exocrine failure and reduced quality of life: a prospective study.

Authors:
Christopher M Halloran Trevor F Cox Seema Chauhan Michael G T Raraty Robert Sutton John P Neoptolemos Paula Ghaneh

Pancreatology 2011 15;11(6):535-45. Epub 2011 Nov 15.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, and National Institute for Pancreas Biomedical Research Unit, Liverpool, UK.

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http://dx.doi.org/10.1159/000333308DOI Listing
July 2012

Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.

Authors:
John P Neoptolemos Malcolm J Moore Trevor F Cox Juan W Valle Daniel H Palmer Alexander C McDonald Ross Carter Niall C Tebbutt Christos Dervenis David Smith Bengt Glimelius Richard M Charnley François Lacaine Andrew G Scarfe Mark R Middleton Alan Anthoney Paula Ghaneh Christopher M Halloran Markus M Lerch Attila Oláh Charlotte L Rawcliffe Caroline S Verbeke Fiona Campbell Markus W Büchler

JAMA 2012 Jul;308(2):147-56

Institute of Translational Medicine, Liverpool Cancer Trials Unit, Liverpool Cancer Research United Kingdom Centre, University of Liverpool, Liverpool, England, United Kingdom.

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http://dx.doi.org/10.1001/jama.2012.7352DOI Listing
July 2012

Nanotechnology advances in upper gastrointestinal, liver and pancreatic cancer.

Authors:
Paul D Sykes John P Neoptolemos Eithne Costello Christopher M Halloran

Expert Rev Gastroenterol Hepatol 2012 Jun;6(3):343-56

Liverpool Cancer Research UK Centre, Department of Molecular and Clinical Cancer Studies, University of Liverpool, Daulby Street, Liverpool, L69 3GA, UK.

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http://dx.doi.org/10.1586/egh.12.13DOI Listing
June 2012

Pancreatic cancer susceptibility loci and their role in survival.

Authors:
Cosmeri Rizzato Daniele Campa Nathalia Giese Jens Werner P Sivaramakrishna Rachakonda Rajiv Kumar Michaela Schanné William Greenhalf Eithne Costello Kay-Tee Khaw Tim J Key Afshan Siddiq Justo Lorenzo-Bermejo Barbara Burwinkel John P Neoptolemos Markus W Büchler Jörg D Hoheisel Andrea Bauer Federico Canzian

PLoS One 2011 18;6(11):e27921. Epub 2011 Nov 18.

German Cancer Research Center-DKFZ, Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027921PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220706PMC
April 2012

Understanding metastasis in pancreatic cancer: a call for new clinical approaches.

Authors:
David A Tuveson John P Neoptolemos

Cell 2012 Jan;148(1-2):21-3

Li Ka Shing Centre, Cancer Research UK Cambridge Research Institute, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1016/j.cell.2011.12.021DOI Listing
January 2012

Circulating microRNAs as potential markers of human drug-induced liver injury.

Authors:
Philip J Starkey Lewis James Dear Vivien Platt Kenneth J Simpson Darren G N Craig Daniel J Antoine Neil S French Neeraj Dhaun David J Webb Eithne M Costello John P Neoptolemos Jonathan Moggs Chris E Goldring B Kevin Park

Hepatology 2011 Nov;54(5):1767-76

MRC Center for Drug Safety Science, Department of Clinical and Molecular Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1002/hep.24538DOI Listing
November 2011

Adjuvant treatment of pancreatic cancer.

Authors:
John P Neoptolemos

Eur J Cancer 2011 Sep;47 Suppl 3:S378-80

National Institute for Health Research Pancreas Biomédical Research Unit and the Department of Molecular and Clinical Cancer Medicine, Liverpool Cancer Research UK Centre, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1016/S0959-8049(11)70210-6DOI Listing
September 2011

Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells.

Authors:
David M Booth John A Murphy Rajarshi Mukherjee Muhammad Awais John P Neoptolemos Oleg V Gerasimenko Alexei V Tepikin Ole H Petersen Robert Sutton David N Criddle

Gastroenterology 2011 Jun 24;140(7):2116-25. Epub 2011 Feb 24.

Physiological Laboratory, University of Liverpool, National Institute for Health Research Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool.

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http://dx.doi.org/10.1053/j.gastro.2011.02.054DOI Listing
June 2011

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy.

Authors:
Adam Lister Taoufik Nedjadi Neil R Kitteringham Fiona Campbell Eithne Costello Bryony Lloyd Ian M Copple Samantha Williams Andrew Owen John P Neoptolemos Chris E Goldring B Kevin Park

Mol Cancer 2011 Apr 13;10:37. Epub 2011 Apr 13.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, UK.

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http://dx.doi.org/10.1186/1476-4598-10-37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098205PMC
April 2011

Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial.

Authors:
Markus K Diener Christoph M Seiler Inga Rossion Jörg Kleeff Matthias Glanemann Giovanni Butturini Ales Tomazic Christiane J Bruns Olivier R C Busch Stefan Farkas Orlin Belyaev John P Neoptolemos Christopher Halloran Tobias Keck Marco Niedergethmann Klaus Gellert Helmut Witzigmann Otto Kollmar Peter Langer Ulrich Steger Jens Neudecker Frederik Berrevoet Silke Ganzera Markus M Heiss Steffen P Luntz Thomas Bruckner Meinhard Kieser Markus W Büchler

Lancet 2011 Apr;377(9776):1514-22

Study Centre of the German Surgical Society and Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S014067361160237
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http://dx.doi.org/10.1016/S0140-6736(11)60237-7DOI Listing
April 2011

Adjuvant therapy in pancreatic cancer.

Authors:
Amy Thomas Khaled Dajani John P Neoptolemos Paula Ghaneh

Dig Dis 2010 18;28(4-5):684-92. Epub 2010 Nov 18.

Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1159/000320099DOI Listing
March 2011

Pancreatic cancer in 2010: new insights for early intervention and detection.

Authors:
Eithne Costello John P Neoptolemos

Nat Rev Gastroenterol Hepatol 2011 Feb;8(2):71-3

Liverpool CR-UK Centre, NIHR Pancreas Biomedical Research Unit, Department of Molecular and Clinical Cancer Medicine, Daulby Street, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1038/nrgastro.2010.214DOI Listing
February 2011

Analysis of serum proteins by LC-MS/MS.

Authors:
Sarah Tonack John P Neoptolemos Eithne Costello

Methods Mol Biol 2010 ;658:281-91

Division of Surgery and Oncology, Royal Liverpool University Hospital, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1007/978-1-60761-780-8_17DOI Listing
December 2010

Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer.

Authors:
Elizabeth M Tweedle Ilyas Khattak Chin Wee Ang Taoufik Nedjadi Rosalind Jenkins B Kevin Park Helen Kalirai Andy Dodson Bahram Azadeh Monica Terlizzo Heike Grabsch Wolfram Mueller Sun Myint Peter Clark Helen Wong William Greenhalf John P Neoptolemos Paul S Rooney Eithne Costello

Gut 2010 Nov;59(11):1501-10

Royal Liverpool University Hospital, University of Liverpool, Liverpool, CH48 4DQ, UK.

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http://dx.doi.org/10.1136/gut.2009.196626DOI Listing
November 2010

Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells.

Authors:
Chin Wee Ang Taoufik Nedjadi Adnan A Sheikh Elizabeth M Tweedle Sarah Tonack Sailish Honap Rosalind E Jenkins B Kevin Park Irmgard Schwarte-Waldhoff Ilyas Khattak Bahram Azadeh Andrew Dodson Helen Kalirai John P Neoptolemos Paul S Rooney Eithne Costello

Carcinogenesis 2010 Sep 9;31(9):1541-51. Epub 2010 Jul 9.

The Liverpool Cancer Research-UK Centre, Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool L69 3GA, UK.

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http://dx.doi.org/10.1093/carcin/bgq137DOI Listing
September 2010

Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial.

Authors:
John P Neoptolemos Deborah D Stocken Claudio Bassi Paula Ghaneh David Cunningham David Goldstein Robert Padbury Malcolm J Moore Steven Gallinger Christophe Mariette Moritz N Wente Jakob R Izbicki Helmut Friess Markus M Lerch Christos Dervenis Attila Oláh Giovanni Butturini Ryuichiro Doi Pehr A Lind David Smith Juan W Valle Daniel H Palmer John A Buckels Joyce Thompson Colin J McKay Charlotte L Rawcliffe Markus W Büchler

JAMA 2010 Sep;304(10):1073-81

Liverpool Cancer Research UK Cancer Trials Unit, Cancer Research UK Centre, University of Liverpool, Fifth Floor, UCD Bldg, Daulby Street, Liverpool, L69 3GA, United Kingdom.

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http://dx.doi.org/10.1001/jama.2010.1275DOI Listing
September 2010

Dual-color proteomic profiling of complex samples with a microarray of 810 cancer-related antibodies.

Authors:
Christoph Schröder Anette Jacob Sarah Tonack Tomasz P Radon Martin Sill Manuela Zucknick Sven Rüffer Eithne Costello John P Neoptolemos Tatjana Crnogorac-Jurcevic Andrea Bauer Kurt Fellenberg Jörg D Hoheisel

Mol Cell Proteomics 2010 Jun 16;9(6):1271-80. Epub 2010 Feb 16.

Division of Functional Genome Analysis, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1074/mcp.M900419-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877986PMC
June 2010

Minimal access retroperitoneal pancreatic necrosectomy: improvement in morbidity and mortality with a less invasive approach.

Authors:
Michael G T Raraty Christopher M Halloran Susanna Dodd Paula Ghaneh Saxon Connor Jonathan Evans Robert Sutton John P Neoptolemos

Ann Surg 2010 May;251(5):787-93

Pancreatic Biomedical Research Unit, Royal Liverpool and Broadgreen University Hospital NHS Trust and University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1097/SLA.0b013e3181d96c53DOI Listing
May 2010

Surgical oncology: PBD-better stents in specialized centers are needed.

Authors:
John P Neoptolemos Christopher M Halloran

Nat Rev Clin Oncol 2010 May;7(5):244-6

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http://dx.doi.org/10.1038/nrclinonc.2010.45DOI Listing
May 2010

The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families.

Authors:
Christopher J Grocock Vinciane Rebours Myriam N Delhaye Ake Andrén-Sandberg Frank Ulrich Weiss Roger Mountford Matthew J Harcus Edyta Niemczyck Louis J Vitone Susanna Dodd Maiken Thyregod Jørgensen Rudolf W Ammann Ove Schaffalitzky de Muckadell Jane V Butler Phillip Burgess Bronwyn Kerr Richard Charnley Robert Sutton Michael G Raraty Jacques Devière David C Whitcomb John P Neoptolemos Philippe Lévy Markus M Lerch William Greenhalf

Gut 2010 Mar 1;59(3):357-63. Epub 2009 Dec 1.

School of Cancer Studies, University of Liverpool, UCD Building, Daulby Street, Liverpool, UK.

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http://dx.doi.org/10.1136/gut.2009.186817DOI Listing
March 2010

Pancreatic cancer: proteomic approaches to a challenging disease.

Authors:
Sarah Tonack Mark Aspinall-O'Dea John P Neoptolemos Eithne Costello

Pancreatology 2009 4;9(5):567-76. Epub 2009 Aug 4.

Division of Surgery and Oncology, Royal Liverpool University Hospital, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1159/000212083DOI Listing
February 2010

A preoperative prognostic score for resected pancreatic and periampullary neuroendocrine tumours.

Authors:
Nicole Sakka Richard A Smith Philip Whelan Paula Ghaneh Robert Sutton Michael Raraty Fiona Campbell John P Neoptolemos

Pancreatology 2009 14;9(5):670-6. Epub 2009 Aug 14.

Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1159/000181179DOI Listing
February 2010

A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ.

Authors:
Sarah Tonack Mark Aspinall-O'Dea Rosalind E Jenkins Victoria Elliot Seonaid Murray Catherine S Lane Neil R Kitteringham John P Neoptolemos Eithne Costello

J Proteomics 2009 Dec 3;73(2):352-6. Epub 2009 Aug 3.

Royal Liverpool University Hospital, University of Liverpool, United Kingdom.

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http://dx.doi.org/10.1016/j.jprot.2009.07.009DOI Listing
December 2009

Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer.

Authors:
David Cunningham Ian Chau Deborah D Stocken Juan W Valle David Smith William Steward Peter G Harper Janet Dunn Catrin Tudur-Smith Julia West Stephen Falk Adrian Crellin Fawzi Adab Joyce Thompson Pauline Leonard Joe Ostrowski Martin Eatock Werner Scheithauer Richard Herrmann John P Neoptolemos

J Clin Oncol 2009 Nov 26;27(33):5513-8. Epub 2009 Oct 26.

Royal Marsden National HealthService (NHS) Foundation Trust, London and Surrey, United Kingdom.

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http://ascopubs.org/doi/10.1200/JCO.2009.24.2446
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http://dx.doi.org/10.1200/JCO.2009.24.2446DOI Listing
November 2009

Classification of R1 resections for pancreatic cancer: the prognostic relevance of tumour involvement within 1 mm of a resection margin.

Authors:
Fiona Campbell Richard A Smith Philip Whelan Robert Sutton Michael Raraty John P Neoptolemos Paula Ghaneh

Histopathology 2009 Sep;55(3):277-83

Department of Pathology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, , 5th Floor Duncan Building, Daulby Street, Liverpool L69 3GA, UK.

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http://dx.doi.org/10.1111/j.1365-2559.2009.03376.xDOI Listing
September 2009

Longitudinal quality of life data can provide insights on the impact of adjuvant treatment for pancreatic cancer-Subset analysis of the ESPAC-1 data.

Authors:
Ross Carter Deborah D Stocken Payla Ghaneh Simon R Bramhall Attila Olah Deszo Kelemen Claudio Bassi Helmut Friess Christo Dervenis Nigel Spry Markus W Büchler John P Neoptolemos

Int J Cancer 2009 Jun;124(12):2960-5

Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom.

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http://dx.doi.org/10.1002/ijc.24270DOI Listing
June 2009

Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I(131) KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma.

Authors:
Asma Sultana Susannah Shore Michael Gt Raraty Sobhan Vinjamuri Jonathan E Evans Catrin Tudur Smith Steven Lane Seema Chauhan Lorraine Bosonnet Conall Garvey Robert Sutton John P Neoptolemos Paula Ghaneh

BMC Cancer 2009 Feb 25;9:66. Epub 2009 Feb 25.

Division of Surgery and Oncology, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1186/1471-2407-9-66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656541PMC
February 2009