Publications by authors named "John P Lynch"

60Publications

Increasing the Complexity of Organoid Cultures: Current Status and Future Challenges.

Authors:
John P Lynch

Cell Mol Gastroenterol Hepatol 2019 15;8(1):155-156. Epub 2019 May 15.

Director, Immunology Clinical Development, Janssen Research & Development, Spring House, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599095PMC
December 2019

Organoids and Engineered Organ Systems.

Cell Mol Gastroenterol Hepatol 2019 2;7(3):679-681. Epub 2019 Mar 2.

Janssen Research and Development, Spring House, Pennsylvania.

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http://dx.doi.org/10.1016/j.jcmgh.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477475PMC
June 2019

GUCY2C maintains intestinal LGR5 stem cells by opposing ER stress.

Oncotarget 2017 Nov 26;8(61):102923-102933. Epub 2017 Oct 26.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, United States of America, PA, USA.

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http://dx.doi.org/10.18632/oncotarget.22084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732700PMC
November 2017

Modeling Esophagitis Using Human Three-Dimensional Organotypic Culture System.

Am J Pathol 2017 Aug 13;187(8):1787-1799. Epub 2017 Jun 13.

Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974532PMC
August 2017

Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche.

Nat Commun 2017 03 17;8:14766. Epub 2017 Mar 17.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ncomms14766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357864PMC
March 2017

Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins.

Infect Immun 2016 10 19;84(10):3083-91. Epub 2016 Sep 19.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/IAI.00639-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038068PMC
October 2016

Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia.

JAMA Oncol 2016 Oct;2(10):1333-1339

Division of Gastroenterology and Liver Disease, Department of Medicine, Case Medical Center, Cleveland, Ohio6Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063702PMC
http://dx.doi.org/10.1001/jamaoncol.2016.2054DOI Listing
October 2016

Culturing adult stem cells from mouse small intestinal crypts.

Cold Spring Harb Protoc 2015 Apr 1;2015(4):354-8. Epub 2015 Apr 1.

Gastroenterology Division, Departments of Medicine and Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania and Abramson Cancer Center, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1101/pdb.prot078303DOI Listing
April 2015

Mechanisms of Barrett's oesophagus: intestinal differentiation, stem cells, and tissue models.

Best Pract Res Clin Gastroenterol 2015 Feb 12;29(1):3-16. Epub 2014 Nov 12.

Division of Gastroenterology, 421 Curie Boulevard, 956 Biomedical Research Building, Philadelphia, PA, 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bpg.2014.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352719PMC
February 2015

Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems.

Exp Biol Med (Maywood) 2014 Sep 29;239(9):1108-23. Epub 2014 Apr 29.

Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

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http://dx.doi.org/10.1177/1535370214529388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156523PMC
September 2014

You're the flight surgeon: aortic aneurysm.

Authors:
John P Lynch

Aviat Space Environ Med 2012 Oct;83(10):1015-8

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http://dx.doi.org/10.3357/asem.3303.2012DOI Listing
October 2012

H. pylori infection is associated with DNA damage of Lgr5-positive epithelial stem cells in the stomach of patients with gastric cancer.

Dig Dis Sci 2013 Jan 4;58(1):140-9. Epub 2012 Sep 4.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Founders 6, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s10620-012-2360-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816997PMC
January 2013

How changes in Washington University's Medicare coordinated care demonstration pilot ultimately achieved savings.

Health Aff (Millwood) 2012 Jun;31(6):1216-26

Mathematica Policy Research, in Princeton, New Jersey, USA.

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http://dx.doi.org/10.1377/hlthaff.2011.0593DOI Listing
June 2012

Math1/Atoh1 contributes to intestinalization of esophageal keratinocytes by inducing the expression of Muc2 and Keratin-20.

Dig Dis Sci 2012 Apr 7;57(4):845-57. Epub 2011 Dec 7.

Department of Medicine, Division of Gastroenterology, University of Pennsylvania, 650 CRB 415 Curie Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s10620-011-1998-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407817PMC
April 2012

Molecular mechanisms of Barrett's esophagus and adenocarcinoma.

Ann N Y Acad Sci 2011 Sep;1232:381-91

Department of Cell Biology and Anatomy, College of Medicine, Tucson, Arizona, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2011.06062.xDOI Listing
September 2011

Ectopic Cdx2 expression in murine esophagus models an intermediate stage in the emergence of Barrett's esophagus.

PLoS One 2011 Apr 6;6(4):e18280. Epub 2011 Apr 6.

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018280PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071814PMC
April 2011

Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development.

Gastroenterology 2011 Feb 13;140(2):517-528.e8. Epub 2010 Nov 13.

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.11.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031739PMC
February 2011

Cdx genes, inflammation, and the pathogenesis of intestinal metaplasia.

Prog Mol Biol Transl Sci 2010 ;96:231-70

Department of Medicine, Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/B978-0-12-381280-3.00010-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005371PMC
July 2011

Intestine-specific transcription factor Cdx2 induces E-cadherin function by enhancing the trafficking of E-cadherin to the cell membrane.

Am J Physiol Gastrointest Liver Physiol 2010 Nov 29;299(5):G1054-67. Epub 2010 Jul 29.

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1152/ajpgi.00297.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993167PMC
November 2010

Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus.

Gastroenterology 2010 Jul 17;139(1):194-203.e1. Epub 2010 Mar 17.

Department of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.03.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902607PMC
July 2010

Modelling Barrett's oesophagus.

Biochem Soc Trans 2010 Apr;38(2):321-6

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1042/BST0380321DOI Listing
April 2010

The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex.

Carcinogenesis 2010 Feb 4;31(2):159-66. Epub 2009 Sep 4.

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgp213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812568PMC
February 2010

The modulation of IGF-1 signalling by the intestine-specific factor CDX2.

Gut 2009 Sep;58(9):1179-80

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1136/gut.2009.179291DOI Listing
September 2009

At the crossroads in the management of gastroesophageal junction carcinomas-where do we go from here?

Gastrointest Cancer Res 2008 Sep;2(5):253-5

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632553PMC
September 2008

Systemic and targeted therapy for advanced colon cancer.

Expert Rev Gastroenterol Hepatol 2008 Feb;2(1):135-49

University of Pennsylvania School of Medicine, Division of Gastroenterology, 650 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1586/17474124.2.1.135DOI Listing
February 2008

Induction of intestinalization in human esophageal keratinocytes is a multistep process.

Carcinogenesis 2009 Jan 8;30(1):122-30. Epub 2008 Oct 8.

Department of Medicine, Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1093/carcin/bgn227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722140PMC
January 2009

Repression of the desmocollin 2 gene expression in human colon cancer cells is relieved by the homeodomain transcription factors Cdx1 and Cdx2.

Mol Cancer Res 2008 Sep;6(9):1478-90

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-2161DOI Listing
September 2008

The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine.

Neoplasia 2008 Jan;10(1):8-19

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, 600 Clinical Research Building, 415 Curie Blvd., Philadelphia, PA 19104 USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213897PMC
http://dx.doi.org/10.1593/neo.07703DOI Listing
January 2008

A randomized controlled trial of tacrolimus versus cyclosporine after lung transplantation.

J Heart Lung Transplant 2007 Oct;26(10):1012-8

Division of Pulmonary & Critical Care, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1016/j.healun.2007.07.027DOI Listing
October 2007

The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation.

Am J Physiol Gastrointest Liver Physiol 2007 Jul 26;293(1):G54-65. Epub 2007 Apr 26.

Division of Gastroenterology/650 CRB, Department of Medicine, University of Pennsylvania, 415 Curie Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1152/ajpgi.00533.2006DOI Listing
July 2007

A comparison of basiliximab and anti-thymocyte globulin as induction agents after lung transplantation.

J Heart Lung Transplant 2005 Sep;24(9):1320-6

Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1016/j.healun.2004.09.002DOI Listing
September 2005

Intestinal metaplasia with a high salt diet induces epithelial proliferation and alters cell composition in the gastric mucosa of mice.

Cancer Biol Ther 2005 Jun 11;4(6):669-75. Epub 2005 Jun 11.

Gastroenterology Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.4161/cbt.4.6.1734DOI Listing
June 2005

Reliability for grading acute rejection and airway inflammation after lung transplantation.

J Heart Lung Transplant 2005 Jun;24(6):652-7

Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1016/j.healun.2004.04.002DOI Listing
June 2005

Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity.

J Biol Chem 2004 Aug 23;279(35):36865-75. Epub 2004 Jun 23.

Division of Gastroenterology, the Department of Medicine, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1074/jbc.M405213200DOI Listing
August 2004

The role of Cdx proteins in intestinal development and cancer.

Cancer Biol Ther 2004 Jul 9;3(7):593-601. Epub 2004 Jul 9.

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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https://fly-bay.com/journals/cbt/guo3-7.pdf
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http://dx.doi.org/10.4161/cbt.3.7.913DOI Listing
July 2004

Health-related behaviors in young military smokers.

Mil Med 2004 Mar;169(3):230-5

Residency Program of Preventive Medicine, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-1854, USA.

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http://dx.doi.org/10.7205/milmed.169.3.230DOI Listing
March 2004

Cdx1 or Cdx2 expression activates E-cadherin-mediated cell-cell adhesion and compaction in human COLO 205 cells.

Am J Physiol Gastrointest Liver Physiol 2004 Jul 19;287(1):G104-14. Epub 2004 Feb 19.

Division of Gastroenterology/660 CRB, University of Pennsylvania, 415 Curie Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1152/ajpgi.00484.2003DOI Listing
July 2004

Abdominal-pelvic lymphoproliferative disease after lung transplantation: presentation and outcome.

Transplantation 2004 Feb;77(3):431-7

Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.

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http://dx.doi.org/10.1097/01.TP.0000112938.88948.F5DOI Listing
February 2004

The predictive value of bronchiolitis obliterans syndrome stage 0-p.

Am J Respir Crit Care Med 2004 Feb 11;169(4):468-72. Epub 2003 Dec 11.

Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1164/rccm.200307-1018OCDOI Listing
February 2004

Impact of prophylaxis with cytogam alone on the incidence of CMV viremia in CMV-seropositive lung transplant recipients.

J Heart Lung Transplant 2003 Jul;22(7):754-63

Department of Medicine, Washington University School of Medicine, Barnes-Jewish Hospital, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1016/s1053-2498(02)00648-4DOI Listing
July 2003

Thirteen-year experience in lung transplantation for emphysema.

Ann Thorac Surg 2002 Nov;74(5):1663-9; discussion 1669-70

Division of Cardiothoracic Surgery, Washington University Medical Center, St. Louis, Missouri 63110-1013, USA.

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http://dx.doi.org/10.1016/s0003-4975(02)04064-xDOI Listing
November 2002

The genetic pathogenesis of colorectal cancer.

Hematol Oncol Clin North Am 2002 Aug;16(4):775-810

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, 415 Curie, Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/s0889-8588(02)00029-1DOI Listing
August 2002

To differentiate or proliferate? The interaction between PI3K/PTEN and Cdx2.

Gastroenterology 2002 Oct;123(4):1395-7

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http://dx.doi.org/10.1053/gast.2002.36374DOI Listing
October 2002

Lung transplantation for pulmonary vascular disease.

Ann Thorac Surg 2002 Jan;73(1):209-17; discussion 217-9

Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1016/s0003-4975(01)03082-xDOI Listing
January 2002