John P H Wilding

John P H Wilding

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John P H Wilding

Publications by authors named "John P H Wilding"

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Weight loss variability with SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes mellitus and obesity: Mechanistic possibilities.

Obes Rev 2019 Jun 10;20(6):816-828. Epub 2019 Apr 10.

Metabolism and Nutrition Research Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1111/obr.12841DOI Listing
June 2019

A review of the mechanism of action, metabolic profile and haemodynamic effects of sodium-glucose co-transporter-2 inhibitors.

Diabetes Obes Metab 2019 Apr;21 Suppl 2:9-18

Obesity and Endocrinology Research, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1111/dom.13650DOI Listing
April 2019

Incorporating patients' perspectives into the initial stages of core outcome set development: a rapid review of qualitative studies of type 2 diabetes.

BMJ Open Diabetes Res Care 2019 28;7(1):e000615. Epub 2019 Feb 28.

MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1136/bmjdrc-2018-000615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398822PMC
February 2019

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes.

N Engl J Med 2019 01 10;380(4):347-357. Epub 2018 Nov 10.

From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital (S.D.W., M.P.B., T.A.Z., J.F.K., S.A.M., D.L.B., C.T.R., M.S.S.), and the Cardiology Division, Massachusetts General Hospital (M.G.S.) - both in Boston; the Diabetes Unit, Hadassah Hebrew University Hospital, Jerusalem (I.R., O.M., A.C.); the Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (E.T.K.); Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Division of Cardiology, University of Texas Southwestern Medical Center, Dallas (D.K.M.); Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom (J.P.H.W.); and AstraZeneca Gothenburg, Mölndal, Sweden (I.A.M.G.-N., M.F., P.A.J., A.-M.L.).

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http://dx.doi.org/10.1056/NEJMoa1812389DOI Listing
January 2019

1α,25(OH)D attenuates IL-6 and IL-1β-mediated inflammatory responses in macrophage conditioned medium-stimulated human white preadipocytes by modulating p44/42 MAPK and NF-κB signaling pathways.

Diabetol Metab Syndr 2019 25;11. Epub 2019 Jan 25.

1Institute of Ageing and Chronic Disease, William Henry Duncan Building, University of Liverpool, 6 West Derby Street, Liverpool, L7 8TX UK.

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http://dx.doi.org/10.1186/s13098-019-0405-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346557PMC
January 2019

Patients' Perspectives of Oral and Injectable Type 2 Diabetes Medicines, Their Body Weight and Medicine-Taking Behavior in the UK: A Systematic Review and Meta-Ethnography.

Diabetes Ther 2018 Oct 17;9(5):1791-1810. Epub 2018 Aug 17.

Obesity and Endocrinology Research, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1007/s13300-018-0490-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167276PMC
October 2018

Vitamin D receptor ligands attenuate the inflammatory profile of IL-1β-stimulated human white preadipocytes via modulating the NF-κB and unfolded protein response pathways.

Biochem Biophys Res Commun 2018 09 23;503(2):1049-1056. Epub 2018 Jun 23.

Institute of Ageing and Chronic Disease, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool, L7 8TX, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.06.115DOI Listing
September 2018

Why I eat at night: A qualitative exploration of the development, maintenance and consequences of Night Eating Syndrome.

Appetite 2018 06 14;125:270-277. Epub 2018 Feb 14.

Department of Obesity and Endocrinology, University of Liverpool, Merseyside, L7 8TX, UK.

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http://dx.doi.org/10.1016/j.appet.2018.02.005DOI Listing
June 2018

DECLARE-TIMI 58: Participants' baseline characteristics.

Diabetes Obes Metab 2018 05 14;20(5):1102-1110. Epub 2018 Feb 14.

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/dom.13217DOI Listing
May 2018

Medication use for the treatment of diabetes in obese individuals.

Authors:
John P H Wilding

Diabetologia 2018 Feb 14;61(2):265-272. Epub 2017 May 14.

Obesity and Endocrinology Research, Institute of Ageing and Chronic Disease, Clinical Sciences Centre, University of Liverpool, Longmoor Lane, Liverpool, L9 7AL, UK.

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http://dx.doi.org/10.1007/s00125-017-4288-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448959PMC
February 2018

Neuropsychiatric safety with liraglutide 3.0 mg for weight management: Results from randomized controlled phase 2 and 3a trials.

Diabetes Obes Metab 2017 11 21;19(11):1529-1536. Epub 2017 Jul 21.

Department of Obesity and Endocrinology, Obesity and Endocrinology Clinical Research Group, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1111/dom.12963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655710PMC
November 2017

Effects of canagliflozin on cardiovascular risk factors in patients with type 2 diabetes mellitus.

Int J Clin Pract 2017 May;71(5)

Obesity and Endocrinology Clinical Research, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1111/ijcp.12948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488174PMC
May 2017

Glucose-dependent insulinotropic polypeptide promotes lipid deposition in subcutaneous adipocytes in obese type 2 diabetes patients: a maladaptive response.

Am J Physiol Endocrinol Metab 2017 03 10;312(3):E224-E233. Epub 2017 Jan 10.

Obesity and Endocrinology Research Group, University Hospital Aintree, Liverpool, United Kingdom.

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http://dx.doi.org/10.1152/ajpendo.00347.2016DOI Listing
March 2017

Positioning SGLT2 Inhibitors/Incretin-Based Therapies in the Treatment Algorithm.

Diabetes Care 2016 Aug;39 Suppl 2:S154-64

Diabetes Division, The University of Texas Health Science Center at San Antonio, San Antonio, TX.

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http://dx.doi.org/10.2337/dcS15-3005DOI Listing
August 2016

Weighing up dietary patterns - Authors' reply.

Lancet 2016 Aug;388(10046):759-60

Department of Medicine (Obesity), University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1016/S0140-6736(16)31359-9DOI Listing
August 2016

Management of obesity.

Lancet 2016 May 10;387(10031):1947-56. Epub 2016 Feb 10.

Department of Medicine (Obesity) University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1016/S0140-6736(16)00271-3DOI Listing
May 2016

Effect of CPAP on arterial stiffness in severely obese patients with obstructive sleep apnoea.

Sleep Breath 2015 Dec 6;19(4):1155-65. Epub 2015 Feb 6.

Department of Obesity and Endocrinology, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1007/s11325-015-1131-0DOI Listing
December 2015

Serum urate and obstructive sleep apnoea in severe obesity.

Chron Respir Dis 2015 Aug 19;12(3):238-46. Epub 2015 May 19.

Department of Academic Rheumatology, Institute of Chronic Disease and Ageing, University of Liverpool, University Hospital Aintree, Liverpool, UK

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http://dx.doi.org/10.1177/1479972315586197DOI Listing
August 2015

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management.

N Engl J Med 2015 Jul;373(1):11-22

From the Division of Endocrinology and Obesity Research Center, Columbia University, New York (X.P.-S.); Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg (A.A.), and Novo Nordisk, Søborg (C.B.J.) - both in Denmark; Department of Nutrition and Metabolic Research, Division of Endocrinology, Scripps Clinic, La Jolla, CA (K.F.); Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge (F.G.); Obesity and Metabolic Syndrome Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, University of São Paulo Medical School, São Paulo (A.H.); Clinique d'Endocrinologie et Nutrition, Centre Hospitalier Universitaire, Nantes, France (M.K.); Departments of Medicine and Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada (D.C.W.L.); Diabetes Complications Research Centre, Conway Institute, University College Dublin, Dublin (C.W.R.); Departamento Endocrinología, Instituto Mexicano del Seguro Social, Cuidad Madero, Mexico (R.V.O.); and Department of Obesity and Endocrinology, University of Liverpool, Liverpool, United Kingdom (J.P.H.W.).

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http://dx.doi.org/10.1056/NEJMoa1411892DOI Listing
July 2015

Efficacy and safety of canagliflozin by baseline HbA1c and known duration of type 2 diabetes mellitus.

J Diabetes Complications 2015 Apr 31;29(3):438-44. Epub 2014 Dec 31.

Janssen Research & Development, LLC, Raritan, NJ, USA.

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http://dx.doi.org/10.1016/j.jdiacomp.2014.12.016DOI Listing
April 2015

Obstructive sleep apnea is associated with increased arterial stiffness in severe obesity.

J Sleep Res 2014 Dec 15;23(6):700-708. Epub 2014 Apr 15.

Department of Obesity and Endocrinology, University of Liverpool, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK.

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http://dx.doi.org/10.1111/jsr.12156DOI Listing
December 2014

Urinary proteomics in obstructive sleep apnoea and obesity.

Eur J Clin Invest 2014 Nov;44(11):1104-15

Department of Obesity & Endocrinology, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1111/eci.12346DOI Listing
November 2014

Sleep-disordered breathing, type 2 diabetes and the metabolic syndrome.

Chron Respir Dis 2014 Nov 3;11(4):257-75. Epub 2014 Oct 3.

Department of Obesity and Endocrinology, University of Liverpool, Liverpool, UK

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http://search.proquest.com/openview/ff5a60466eeac118e1526293
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http://crd.sagepub.com/cgi/doi/10.1177/1479972314552806
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http://dx.doi.org/10.1177/1479972314552806DOI Listing
November 2014

A safety evaluation of canagliflozin : a first-in-class treatment for type 2 diabetes.

Expert Opin Drug Saf 2014 Nov;13(11):1535-44

University of Liverpool, University Hospital Aintree, Clinical Sciences Centre, Department of Obesity and Endocrinology , 3rd floor, CSC, Longmoor Lane, Liverpool, L9 7AL , UK +44 151 529 5885 ; +44 151 529 5888 ;

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http://dx.doi.org/10.1517/14740338.2014.959488DOI Listing
November 2014

The role of the kidneys in glucose homeostasis in type 2 diabetes: clinical implications and therapeutic significance through sodium glucose co-transporter 2 inhibitors.

Authors:
John P H Wilding

Metabolism 2014 Oct 2;63(10):1228-37. Epub 2014 Jul 2.

Department of Obesity and Endocrinology, University of Liverpool, United Kingdom. Electronic address:

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http://www.iqanda-cme.com/assets/pdf/defronzo.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S002604951400195
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http://dx.doi.org/10.1016/j.metabol.2014.06.018DOI Listing
October 2014

Liraglutide in the treatment of obesity.

Expert Opin Biol Ther 2014 Aug 6;14(8):1215-24. Epub 2014 Jun 6.

University of Liverpool, Aintree University Hospitals NHS Foundation Trust, Clinical Sciences Centre, Department of Diabetes and Endocrinology , Longmoor Lane, Liverpool L9 7AL , UK.

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http://dx.doi.org/10.1517/14712598.2014.925870DOI Listing
August 2014

1,25-dihydroxyvitamin D3 protects against macrophage-induced activation of NFκB and MAPK signalling and chemokine release in human adipocytes.

PLoS One 2013 24;8(4):e61707. Epub 2013 Apr 24.

Obesity Biology Research Unit, Department of Obesity and Endocrinology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061707PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634852PMC
December 2013

Correlations between night eating, sleep quality, and excessive daytime sleepiness in a severely obese UK population.

Sleep Med 2013 Nov 8;14(11):1151-6. Epub 2013 Aug 8.

Department of Obesity and Endocrinology, University of Liverpool, United Kingdom; University of Manchester, School of Nursing, Midwifery and Social Work, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2013.04.026DOI Listing
November 2013

Emerging sodium/glucose co-transporter 2 inhibitors for type 2 diabetes.

Expert Opin Emerg Drugs 2013 Sep;18(3):375-91

University of Liverpool, Aintree University Hospital NHS Foundation Trust, Clinical Sciences Centre, Department of Obesity & Endocrinology, Longmoor Lane, Liverpool L9 7AL, UK.

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http://dx.doi.org/10.1517/14728214.2013.831405DOI Listing
September 2013

How to approach endocrine assessment in severe obesity?

Clin Endocrinol (Oxf) 2013 Aug;79(2):163-7

Department of Obesity and Endocrinology, University of Liverpool, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK.

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http://dx.doi.org/10.1111/cen.12256DOI Listing
August 2013

Screening for obstructive sleep apnoea in obesity and diabetes--potential for future approaches.

Eur J Clin Invest 2013 Jun 16;43(6):640-55. Epub 2013 Apr 16.

Department of Obesity & Endocrinology, University of Liverpool, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK.

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http://dx.doi.org/10.1111/eci.12083DOI Listing
June 2013

The effect of continuous positive airway pressure usage on sleepiness in obstructive sleep apnoea: real effects or expectation of benefit?

Thorax 2012 Oct 26;67(10):920-4. Epub 2012 May 26.

NHMRC Centre for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1136/thoraxjnl-2012-201622DOI Listing
October 2012

Anti-obesity drugs: past, present and future.

Dis Model Mech 2012 Sep;5(5):621-6

Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.1242/dmm.009621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424459PMC
September 2012

Risk of misdiagnosis, health-related quality of life, and BMI in patients who are overweight with doctor-diagnosed asthma.

Chest 2012 Mar 25;141(3):616-624. Epub 2011 Aug 25.

Clinical Science Centre, University Hospital Aintree, Liverpool University, Liverpool, England.

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https://linkinghub.elsevier.com/retrieve/pii/S00123692126015
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http://dx.doi.org/10.1378/chest.11-0948DOI Listing
March 2012

Human RBP4 adipose tissue expression is gender specific and influenced by leptin.

Clin Endocrinol (Oxf) 2011 Feb;74(2):197-205

Department of Diabetes and Vascular Medicine, Peninsula Medical School, University of Exeter, Exeter, UK.

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http://dx.doi.org/10.1111/j.1365-2265.2010.03892.xDOI Listing
February 2011

Glucagon-like peptide-1 analogues for type 2 diabetes.

BMJ 2011 Feb 16;342:d410. Epub 2011 Feb 16.

University of Liverpool Diabetes and Endocrinology Clinical Research Unit, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK.

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http://dx.doi.org/10.1136/bmj.d410DOI Listing
February 2011

SPARC: a key player in the pathologies associated with obesity and diabetes.

Nat Rev Endocrinol 2010 Apr 2;6(4):225-35. Epub 2010 Mar 2.

Department of Diabetes and Vascular Medicine, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX2 5DW, UK.

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http://www.nature.com/articles/nrendo.2010.18
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http://dx.doi.org/10.1038/nrendo.2010.18DOI Listing
April 2010

Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus.

J Clin Endocrinol Metab 2010 Jan 5;95(1):34-42. Epub 2009 Nov 5.

Diabetes and Endocrinology Research Unit, Clinical Sciences Centre, University Hospital Aintree, Longmoore Lane, Liverpool L9 7AL, United Kingdom.

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http://dx.doi.org/10.1210/jc.2009-0473DOI Listing
January 2010

Modern management of obesity.

Clin Med (Lond) 2009 Dec;9(6):617-21; quiz 622-3

Diabetes and Endocrinology Clinical Research Unit, University of Liverpool, University Hospital Aintree, Liverpool.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4952310PMC
December 2009

Adipokines: emerging therapeutic targets.

Curr Opin Investig Drugs 2009 Oct;10(10):1061-8

University Hospital Aintree, Diabetes and Endocrinology Research Unit, Longmoor Lane, Liverpool L9 7AL, UK.

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October 2009

Tesaglitazar, as add-on therapy to sulphonylurea, dose-dependently improves glucose and lipid abnormalities in patients with type 2 diabetes.

Diab Vasc Dis Res 2007 Sep;4(3):194-203

Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK.

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http://dx.doi.org/10.3132/dvdr.2007.040DOI Listing
September 2007

Is there a role for ghrelin and peptide-YY in the pathogenesis of obesity in adults with acquired structural hypothalamic damage?

J Clin Endocrinol Metab 2005 Sep 21;90(9):5025-30. Epub 2005 Jun 21.

University Hospital Aintree, Diabetes and Endocrinology Research Group, Clinical Sciences Center, Longmoor Lane, Liverpool L9 7AL, United Kingdom.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2004-1874DOI Listing
September 2005

Effects of insulin-induced hypoglycaemia on energy intake and food choice at a subsequent test meal.

Diabetes Metab Res Rev 2004 Sep-Oct;20(5):405-10

Diabetes and Endocrinology Research Group, University Hospital Aintree, Liverpool, UK.

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http://dx.doi.org/10.1002/dmrr.471DOI Listing
February 2005

Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome.

Eur Heart J 2004 May;25(9):735-41

Department of Medicine, Clinical Sciences Centre, University of Liverpool, Lower Lane, Liverpool L9 7AL, UK.

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http://dx.doi.org/10.1016/j.ehj.2004.02.021DOI Listing
May 2004

The relationship of ghrelin to biochemical and anthropometric markers of adult growth hormone deficiency.

Clin Endocrinol (Oxf) 2004 Jan;60(1):137-41

Diabetes and Endocrinology Research group, University Hospital Aintree, Liverpool, UK.

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January 2004

Obesity and type-2 diabetes in the elderly.

Gerontology 2003 May-Jun;49(3):137-45

Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK.

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http://dx.doi.org/10.1159/000069176DOI Listing
August 2003

Plasma adiponectin increases postprandially in obese, but not in lean, subjects.

Obes Res 2003 Jul;11(7):839-44

The University of Liverpool Diabetes and Endocrinology Research Group, Clinical Sciences Centre, Liverpool, United Kingdom.

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http://dx.doi.org/10.1038/oby.2003.115DOI Listing
July 2003

Ghrelin: sweet regulation?

Clin Sci (Lond) 2002 Sep;103(3):329-30

Diabetes and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, U.K.

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http://dx.doi.org/10.1042/DOI Listing
September 2002