John P Gibbs

John P Gibbs

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John P Gibbs

John P Gibbs

Publications by authors named "John P Gibbs"

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37Publications

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Quantitative Assessment of Elagolix Enzyme-Transporter Interplay and Drug-Drug Interactions Using Physiologically Based Pharmacokinetic Modeling.

Clin Pharmacokinet 2019 Nov 12. Epub 2019 Nov 12.

Clinical Pharmacology and Pharmacometrics, AbbVie, Department R4PK, Building AP31-3, 1 North Waukegan Road, North Chicago, IL, 60064, USA.

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http://dx.doi.org/10.1007/s40262-019-00833-6DOI Listing
November 2019

Accelerating Drug Development in Pediatric Oncology With the Clinical Pharmacology Storehouse.

J Clin Pharmacol 2019 May 18;59(5):625-637. Epub 2018 Dec 18.

Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, IL, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcph.1359
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http://dx.doi.org/10.1002/jcph.1359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590144PMC
May 2019

Receiver Operating Characteristic Analysis and Clinical Trial Simulation to Inform Dose Titration Decisions.

CPT Pharmacometrics Syst Pharmacol 2018 11 15;7(11):771-779. Epub 2018 Oct 15.

Clinical Pharmacology, Vertex Pharmaceuticals, Boston, Massachusetts, USA.

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http://doi.wiley.com/10.1002/psp4.12354
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http://dx.doi.org/10.1002/psp4.12354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263661PMC
November 2018

Bedside to Bench: Integrating Quantitative Clinical Pharmacology and Reverse Translation to Optimize Drug Development.

Clin Pharmacol Ther 2018 02 6;103(2):196-198. Epub 2017 Nov 6.

AbbVie Inc, Clinical Pharmacology and Pharmacometrics, Redwood City, California, USA.

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http://dx.doi.org/10.1002/cpt.897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813105PMC
February 2018

Population Pharmacokinetic and Pharmacodynamic Modeling of Etelcalcetide in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism Receiving Hemodialysis.

Clin Pharmacokinet 2018 01;57(1):71-85

Department of Clinical Pharmacology, Modeling and Simulation, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA, 91320, USA.

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http://dx.doi.org/10.1007/s40262-017-0550-4DOI Listing
January 2018

Association Between Circulating Baseline Proprotein Convertase Subtilisin Kexin Type 9 Levels and Efficacy of Evolocumab.

JAMA Cardiol 2017 05;2(5):556-560

Thrombolysis in Myocardial Infarction Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamacardio.2016.5395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814982PMC
May 2017

SRM-based measurements of proprotein convertase subtilisin/kexin type 9 and lipoprotein(a) kinetics in nonhuman primate serum.

Bioanalysis 2016 Dec;8(24):2551-2563

Department of Pharmacokinetics & Drug Metabolism, Amgen, Inc., South San Francisco, CA, 94080, USA.

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http://dx.doi.org/10.4155/bio-2016-0146DOI Listing
December 2016

Target-mediated metabolism and target-mediated drug disposition of the DPPIV inhibitor AMG 222.

Xenobiotica 2011 Nov 25;41(11):945-57. Epub 2011 Aug 25.

Amgen Inc., PKDM, Amgen Ct. West, Seattle, Washington 98119, USA.

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http://dx.doi.org/10.3109/00498254.2011.597455DOI Listing
November 2011

Prediction of exposure-response relationships to support first-in-human study design.

Authors:
John P Gibbs

AAPS J 2010 Dec 22;12(4):750-8. Epub 2010 Oct 22.

Amgen Inc., Seattle, WA, USA.

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http://dx.doi.org/10.1208/s12248-010-9236-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976982PMC
December 2010

Application of in vivo animal models to characterize the pharmacokinetic and pharmacodynamic properties of drug candidates in discovery settings.

Comb Chem High Throughput Screen 2010 Feb;13(2):207-18

Amgen, Inc., Department of Pharmacokinetics and Drug Metabolism, 2101 Amgen Court West, Seattle, WA 98119, USA.

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http://dx.doi.org/10.2174/138620710790596808DOI Listing
February 2010

Comment on "Intake of iodine and perchlorate and excretion in human milk".

Authors:
John P Gibbs

Environ Sci Technol 2009 Apr;43(7):2654-5; author reply 2656-8

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http://dx.doi.org/10.1021/es8031538DOI Listing
April 2009

Minimizing polymorphic metabolism in drug discovery: evaluation of the utility of in vitro methods for predicting pharmacokinetic consequences associated with CYP2D6 metabolism.

Drug Metab Dispos 2006 Sep 8;34(9):1516-22. Epub 2006 Jun 8.

Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc, Groton, CT 06340, USA.

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http://dx.doi.org/10.1124/dmd.105.008714DOI Listing
September 2006

The NAS perchlorate review: second-guessing the experts.

Environ Health Perspect 2005 Nov;113(11):A727-8; author reply A730-2

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310954PMC
http://dx.doi.org/10.1289/ehp.113-1310954DOI Listing
November 2005

Benchmark calculations for perchlorate from three human cohorts.

Environ Health Perspect 2005 Aug;113(8):1001-8

Environ Health Sciences Institute, Ruston, Louisiana 71270, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280340PMC
http://dx.doi.org/10.1289/ehp.7814DOI Listing
August 2005

Comment on "Perchlorate and iodide in dairy and breast milk".

Environ Sci Technol 2005 Aug;39(15):5900-01; author reply 5002-3

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http://dx.doi.org/10.1021/es0504690DOI Listing
August 2005

The effect of perchlorate, thiocyanate, and nitrate on thyroid function in workers exposed to perchlorate long-term.

J Clin Endocrinol Metab 2005 Feb 30;90(2):700-6. Epub 2004 Nov 30.

Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, Massachusetts 02118-2347, USA.

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http://dx.doi.org/10.1210/jc.2004-1821DOI Listing
February 2005

Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport.

Epilepsy Res 2004 Jan;58(1):53-66

Department of Pharmaceutics, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.eplepsyres.2003.12.008DOI Listing
January 2004

Reaction phenotyping in drug discovery: moving forward with confidence?

Curr Drug Metab 2003 Dec;4(6):527-34

Department of Pharmacokinetics, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA.

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http://dx.doi.org/10.2174/1389200033489235DOI Listing
December 2003