John P Atkinson

John P Atkinson

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Arthritis Rheumatol 2019 09 19;71(9):1590-1592. Epub 2019 Jul 19.

Washington University School of Medicine, Saint Louis, MO.

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http://dx.doi.org/10.1002/art.40923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716999PMC
September 2019

A Multimodality Approach to Assessing Factor I Genetic Variants in Atypical Hemolytic Uremic Syndrome.

Kidney Int Rep 2019 Jul 9;4(7):1007-1017. Epub 2019 Apr 9.

Department of Medicine, Division of Rheumatology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1016/j.ekir.2019.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609824PMC
July 2019

Fat-Produced Adipsin Regulates Inflammatory Arthritis.

Cell Rep 2019 06;27(10):2809-2816.e3

Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Shriners Hospitals for Children, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643993PMC
June 2019

Development and Optimization of an ELISA to Quantitate C3(H O) as a Marker of Human Disease.

Front Immunol 2019 4;10:703. Epub 2019 Apr 4.

Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458276PMC
April 2019

Thiol isomerase ERp57 targets and modulates the lectin pathway of complement activation.

J Biol Chem 2019 03 22;294(13):4878-4888. Epub 2019 Jan 22.

From the Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115,

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http://dx.doi.org/10.1074/jbc.RA118.006792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442054PMC
March 2019

Intracellular C3 Protects Human Airway Epithelial Cells from Stress-associated Cell Death.

Am J Respir Cell Mol Biol 2019 02;60(2):144-157

2 Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1165/rcmb.2017-0405OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376412PMC
February 2019

TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia.

Brain Pathol 2018 11 10;28(6):806-821. Epub 2018 Oct 10.

Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1111/bpa.12626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404532PMC
November 2018

Timing and mechanism of conceptus demise in a complement regulatory membrane protein deficient mouse.

Am J Reprod Immunol 2018 10 20;80(4):e12997. Epub 2018 Jun 20.

Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1111/aji.12997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160323PMC
October 2018

Preface to the Special issue for the 27th International complement workshop.

Mol Immunol 2018 10 27;102:1-2. Epub 2018 Jul 27.

University of Colorado School of Medicine, Auroro, CO, USA.

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http://dx.doi.org/10.1016/j.molimm.2018.07.010DOI Listing
October 2018

The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target?

J Allergy Clin Immunol 2018 05 12;141(5):1582-1586.e1. Epub 2018 Jan 12.

Division of Rheumatology, Department of Medicine, Washington University in St Louis, St Louis, Mo. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.11.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955701PMC
May 2018

Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy.

J Immunol 2018 04 12;200(8):2786-2797. Epub 2018 Mar 12.

Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110;

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http://dx.doi.org/10.4049/jimmunol.1701668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893424PMC
April 2018

Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population.

Hypertension 2017 08 26;70(2):365-371. Epub 2017 Jun 26.

From the Immunobiology, Research Programs Unit (A.I.L., S.M.), Molecular Neurology, Research Programs Unit (J.K.), and Institute for Molecular Medicine Finland/HiLIFE Unit (P.H., K.A., M.P., H.L.), University of Helsinki, Finland; Medical and Clinical Genetics (A.I.L., H.L.), Bacteriology and Immunology (A.I.L., S.M.), Obstetrics and Gynaecology (K.A., S.H., H.L.), and Children's Hospital (E.K), University of Helsinki and Helsinki University Hospital, Finland; Folkhälsan Institute of Genetics (J.K.), University of Helsinki, Finland; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA (E.D., M.I.K., M.D.); Department of Medicine, Division of Rheumatology (M.T., E.D.O.R., J.P.A.) and Department of Genetics (E.D.O.R.), Washington University School of Medicine, St. Louis, MO; Neurosurgery of Neuro Center, Kuopio University Hospital, Finland (M.I.K.); Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston (M.I.K.); Unit of Genetics and Biomarkers (K.A.), Department of Health (M.P., E.K.), Chronic Disease Prevention Unit, Department of Health (E.K.), and Department of Government Services (A.P.), National Institute for Health and Welfare, Helsinki, Finland; The Estonian Genome Center, University of Tartu, Estonia (M.P.); PEDEGO Research Unit, MRC Oulu, University of Oulu and Oulu University Hospital, Finland (E.K., A.P.); Department of Biosciences and Nutrition, Karolinska Institutet, Solna, Sweden (J.K.); Department of Medical and Molecular Genetics, King's College, London, United Kingdom (J.K.); Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (K.K.); Department of Medicine, Hospital for Special Surgery-Weill Cornell Medicine, New York, NY (J.E.S.); and Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston (M.D.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535812PMC
August 2017

Complement Dysregulation and Disease: Insights from Contemporary Genetics.

Annu Rev Pathol 2017 01 5;12:25-52. Epub 2016 Dec 5.

Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110; email:

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http://dx.doi.org/10.1146/annurev-pathol-012615-044145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020056PMC
January 2017

Evolution of the complement system: from defense of the single cell to guardian of the intravascular space.

Immunol Rev 2016 11;274(1):9-15

Department of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, Saint Louis, MO, USA.

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http://dx.doi.org/10.1111/imr.12474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108576PMC
November 2016

Secreted NS1 Protects Dengue Virus from Mannose-Binding Lectin-Mediated Neutralization.

J Immunol 2016 11 19;197(10):4053-4065. Epub 2016 Oct 19.

Division of Dengue Hemorrhagic Fever Research, Department of Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand;

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http://dx.doi.org/10.4049/jimmunol.1600323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123808PMC
November 2016

The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration-Like Phenotype.

Am J Pathol 2016 08 11;186(8):2088-2104. Epub 2016 Jun 11.

Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973660PMC
August 2016

Von Willebrand factor regulates complement on endothelial cells.

Kidney Int 2016 07 25;90(1):123-34. Epub 2016 May 25.

Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591736PMC
July 2016

A Familial C3GN Secondary to Defective C3 Regulation by Complement Receptor 1 and Complement Factor H.

J Am Soc Nephrol 2016 Jun 15;27(6):1665-77. Epub 2015 Oct 15.

Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S1138, Complément et Maladies, Centre de Recherche des Cordeliers, Paris, France; Assistance Publique-Hôpitaux de Paris, Service d'Immunologie Biologique, Hôpital européen Georges Pompidou, Paris, France;

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http://dx.doi.org/10.1681/ASN.2015040348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884110PMC
June 2016

Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.

EMBO J 2016 05 24;35(10):1133-49. Epub 2016 Mar 24.

Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science Utrecht University, Utrecht, The Netherlands

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http://dx.doi.org/10.15252/embj.201593673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868954PMC
May 2016

Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases.

Front Immunol 2016 15;7:36. Epub 2016 Feb 15.

Center for Molecular and Human Genetics, Division of Pediatric Rheumatology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University , Columbus, OH , USA.

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http://dx.doi.org/10.3389/fimmu.2016.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753731PMC
February 2016

Role of complement receptor 1 (CR1; CD35) on epithelial cells: A model for understanding complement-mediated damage in the kidney.

Mol Immunol 2015 Oct 7;67(2 Pt B):584-95. Epub 2015 Aug 7.

Department of Internal Medicine, Division of Rheumatology, 660 South Euclid Avenue, St. Louis, MO 63110 USA. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2015.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565762PMC
October 2015

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.

Immunity 2015 Sep 25;43(3):463-74. Epub 2015 Aug 25.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613150031
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http://dx.doi.org/10.1016/j.immuni.2015.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575271PMC
September 2015

Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels.

Hum Mol Genet 2015 Jul 18;24(13):3861-70. Epub 2015 Mar 18.

Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, MA, USA, Department of Ophthalmology, Tufts University School of Medicine, Boston, MA, USA and Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA

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http://dx.doi.org/10.1093/hmg/ddv091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459386PMC
July 2015

Complement regulator CD46: genetic variants and disease associations.

Hum Genomics 2015 Jun 10;9. Epub 2015 Jun 10.

Division of Rheumatology, Department of Medicine, Washington University School of Medicine, 660 South Euclid, Saint Louis, MO, 63110, USA.

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http://dx.doi.org/10.1186/s40246-015-0029-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469999PMC
June 2015

Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome.

Blood 2015 Apr 21;125(15):2359-69. Epub 2015 Jan 21.

INSERM UMRS 1138, Cordeliers Research Center, Paris, France; Université Paris Descartes Sorbonne Paris-Cité, Paris, France; Université Pierre et Marie Curie, Paris, France; Assistance Publique-Hôpitaux de Paris, Service d'Immunologie Biologique, Hôpital Européen Georges Pompidou, Paris, France.

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http://dx.doi.org/10.1182/blood-2014-10-609073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392009PMC
April 2015

Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration.

Hum Mol Genet 2014 Oct 20;23(19):5283-93. Epub 2014 May 20.

Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, MA, USA Department of Ophthalmology, Tufts University School of Medicine, Boston, MA, USA Sackler School of Graduate Medical Sciences, Tufts University, Boston, MA, USA

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http://dx.doi.org/10.1093/hmg/ddu226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159152PMC
October 2014

Genetic variants in the complement system predisposing to age-related macular degeneration: a review.

Mol Immunol 2014 Oct 15;61(2):118-125. Epub 2014 Jul 15.

Division of Rheumatology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.

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http://dx.doi.org/10.1016/j.molimm.2014.06.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149817PMC
October 2014

Complement regulatory protein CD46 protects against choroidal neovascularization in mice.

Am J Pathol 2014 Sep 11;184(9):2537-48. Epub 2014 Jul 11.

Department of Ophthalmology, Pat and Willard Walker Eye Research Center, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188132PMC
September 2014

Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis.

PLoS Pathog 2014 Apr 17;10(4):e1004086. Epub 2014 Apr 17.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America; Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990718PMC
April 2014

Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis.

J Immunol 2013 Dec 23;191(11):5625-35. Epub 2013 Oct 23.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.4049/jimmunol.1301903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906719PMC
December 2013

Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.

Nat Genet 2013 Nov 15;45(11):1366-70. Epub 2013 Sep 15.

1] Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, Massachusetts, USA. [2] Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts, USA. [3] Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.2741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902040PMC
November 2013

Immunology of age-related macular degeneration.

Nat Rev Immunol 2013 Jun;13(6):438-51

Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky 40506, USA.

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http://dx.doi.org/10.1038/nri3459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941009PMC
June 2013

The role of the immune response in age-related macular degeneration.

Int J Inflam 2013 23;2013:348092. Epub 2013 May 23.

Allergan, Inc., 2525 Dupont Drive, Irvine, CA 92612, USA.

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http://dx.doi.org/10.1155/2013/348092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676958PMC
June 2013

Congenital short bowel syndrome as the presenting symptom in male patients with FLNA mutations.

Genet Med 2013 Apr 4;15(4):310-3. Epub 2012 Oct 4.

Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1038/gim.2012.123DOI Listing
April 2013

Autoimmunity: homeostasis of innate immunity gone awry.

J Clin Immunol 2012 Dec 11;32(6):1148-52. Epub 2012 Oct 11.

Division of Rheumatology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8045, St. Louis, MO 63110, USA.

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http://link.springer.com/10.1007/s10875-012-9815-8
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http://dx.doi.org/10.1007/s10875-012-9815-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529793PMC
December 2012

Autoantibody stabilization of the classical pathway C3 convertase leading to C3 deficiency and Neisserial sepsis: C4 nephritic factor revisited.

Clin Immunol 2012 Dec 28;145(3):241-50. Epub 2012 Sep 28.

Division of Rheumatology, Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.clim.2012.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501611PMC
December 2012

The complement system in pediatric systemic lupus erythematosus, atypical hemolytic uremic syndrome, and complocentric membranoglomerulopathies.

Curr Opin Rheumatol 2012 Sep;24(5):522-9

Division of Infectious Diseases and Rheumatology, Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA.

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http://dx.doi.org/10.1097/BOR.0b013e328356896bDOI Listing
September 2012

Overcoming C2 deficiency.

Clin Immunol 2012 Sep 20;144(3):269-71. Epub 2012 Jul 20.

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http://dx.doi.org/10.1016/j.clim.2012.07.005DOI Listing
September 2012

Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis.

Blood 2012 May 4;119(20):4779-85. Epub 2012 Apr 4.

Program in Targeted Therapeutics, Institute for Translational Medicine and Therapeutics, and Department of Pharmacology, University of Pennsylvania School of Medicine, 3400 Civic Center Blvd., Philadelphia, PA 19104-5158, USA.

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http://dx.doi.org/10.1182/blood-2011-12-398149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367878PMC
May 2012

Too much of a good thing at the site of tissue injury: the instructive example of the complement system predisposing to thrombotic microangiopathy.

Hematology Am Soc Hematol Educ Program 2011 ;2011:9-14

Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1182/asheducation-2011.1.9DOI Listing
April 2012

Complement-mediated neutralization of dengue virus requires mannose-binding lectin.

mBio 2011 13;2(6). Epub 2011 Dec 13.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1128/mBio.00276-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236064PMC
March 2012

Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation.

Mol Genet Metab 2011 Dec 24;104(4):608-19. Epub 2011 Aug 24.

Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ymgme.2011.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283036PMC
December 2011

Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation.

J Immunol 2011 Jul 3;187(1):424-33. Epub 2011 Jun 3.

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.1100750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119735PMC
July 2011

Human immunodeficiency virus infection presenting as an unusual arthropathy.

Arthritis Care Res (Hoboken) 2011 Mar 27;63(3):450-3. Epub 2010 Oct 27.

Washington University School of Medicine in St. Louis, Missouri, USA.

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http://dx.doi.org/10.1002/acr.20383DOI Listing
March 2011

Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort.

PLoS Med 2011 Mar 22;8(3):e1001013. Epub 2011 Mar 22.

Autoimmunity and Inflammation Program, Hospital for Special Surgery, Cornell Weill Medical College, New York, New York, USA.

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http://dx.doi.org/10.1371/journal.pmed.1001013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062534PMC
March 2011

CD46 engagement on human CD4+ T cells produces T regulatory type 1-like regulation of antimycobacterial T cell responses.

Infect Immun 2010 Dec 4;78(12):5295-306. Epub 2010 Oct 4.

Department of Internal Medicine, Division of Immunobiology, Saint Louis University, St. Louis, MO 63104, USA.

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http://dx.doi.org/10.1128/IAI.00513-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981321PMC
December 2010

Properdin homeostasis requires turnover of the alternative complement pathway.

Proc Natl Acad Sci U S A 2010 Nov 25;107(45):19444-8. Epub 2010 Oct 25.

Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.1006608107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984156PMC
November 2010

Ectromelia virus inhibitor of complement enzymes protects intracellular mature virus and infected cells from mouse complement.

J Virol 2010 Sep 7;84(18):9128-39. Epub 2010 Jul 7.

Department of Medicine/Division of Rheumatology, Washington University School of Medicine, Campus Box 8045, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1128/JVI.02677-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937632PMC
September 2010

Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells.

Nat Immunol 2010 Sep 8;11(9):862-71. Epub 2010 Aug 8.

Division of Immunology, Infection and Inflammatory Diseases, King's College London, Medical Research Council Centre for Transplantation, Guy's Hospital, London, UK.

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http://www.tara.tcd.ie/bitstream/handle/2262/50383/PEER_stag
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http://www.nature.com/doifinder/10.1038/ni.1917
Publisher Site
http://dx.doi.org/10.1038/ni.1917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011020PMC
September 2010

Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation.

Blood 2010 Jun 21;115(25):5241-8. Epub 2010 Apr 21.

Program in Targeted Therapeutics, Institute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104-6068, USA.

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http://dx.doi.org/10.1182/blood-2010-01-261610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892950PMC
June 2010

Oversulfated heparin by-products induce thrombin generation in human plasmas through contact system activation.

Clin Appl Thromb Hemost 2010 Jun;16(3):244-50

Department of Pathology and Immunology, and Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1177/1076029610362071DOI Listing
June 2010

Properdin: emerging roles of a pattern-recognition molecule.

Annu Rev Immunol 2010 ;28:131-55

MRC Centre for Transplantation, King's College London, United Kingdom.

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http://dx.doi.org/10.1146/annurev-immunol-030409-101250DOI Listing
May 2010

Antagonism of the complement component C4 by flavivirus nonstructural protein NS1.

J Exp Med 2010 Apr 22;207(4):793-806. Epub 2010 Mar 22.

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1084/jem.20092545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856034PMC
April 2010

Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis.

J Pharmacol Exp Ther 2010 Mar 1;332(3):1022-31. Epub 2009 Dec 1.

IFEM, University of Pennsylvania School of Medicine, One John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104-6068, USA.

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http://dx.doi.org/10.1124/jpet.109.159194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835436PMC
March 2010

Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes.

Invest Ophthalmol Vis Sci 2009 Dec 6;50(12):5818-27. Epub 2009 Aug 6.

Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA.

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http://dx.doi.org/10.1167/iovs.09-3928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826794PMC
December 2009

CD46-induced human Treg enhance B-cell responses.

Eur J Immunol 2009 Nov;39(11):3097-109

Department of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1002/eji.200939392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856319PMC
November 2009

Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity.

J Immunol 2009 Sep 10;183(5):3150-9. Epub 2009 Aug 10.

Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.0901366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899487PMC
September 2009

Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm.

Circulation 2009 Apr 23;119(13):1805-13. Epub 2009 Mar 23.

Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, Mo., USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.108.832972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758616PMC
April 2009

Hepatic IL-17 responses in human and murine primary biliary cirrhosis.

J Autoimmun 2009 Feb 19;32(1):43-51. Epub 2008 Dec 19.

Division of Rheumatology, Allergy and Clinical Immunology, Genome and Biomedical Sciences Facility, University of California at Davis, 451 East Health Sciences Drive, Suite 6510, Davis, CA 95616, USA.

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http://dx.doi.org/10.1016/j.jaut.2008.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225053PMC
February 2009

Surviving mousepox infection requires the complement system.

PLoS Pathog 2008 Dec 26;4(12):e1000249. Epub 2008 Dec 26.

Rheumatology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.

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http://dx.doi.org/10.1371/journal.ppat.1000249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597719PMC
December 2008

Inhibiting complement activation on cells at the step of C3 cleavage.

Vaccine 2008 Dec;26 Suppl 8:I22-7

Washington University School of Medicine, Department of Internal Medicine, Division of Rheumatology, 660 S. Euclid, Box 8045, St. Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768381PMC
http://dx.doi.org/10.1016/j.vaccine.2008.11.001DOI Listing
December 2008

Advances in understanding of pathogenesis of aHUS and HELLP.

Br J Haematol 2008 Nov 4;143(3):336-48. Epub 2008 Aug 4.

Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07324.xDOI Listing
November 2008

Smallpox inhibitor of complement enzymes (SPICE): regulation of complement activation on cells and mechanism of its cellular attachment.

J Immunol 2008 Sep;181(6):4199-207

Department of Medicine/Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774262PMC
http://dx.doi.org/10.4049/jimmunol.181.6.4199DOI Listing
September 2008

Images in clinical medicine. New-onset clubbing associated with lung cancer.

N Engl J Med 2008 Sep;359(13):e15

Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1056/NEJMicm066228DOI Listing
September 2008

Membrane protein Crry maintains homeostasis of the complement system.

J Immunol 2008 Aug;181(4):2732-40

Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2580744PMC
http://dx.doi.org/10.4049/jimmunol.181.4.2732DOI Listing
August 2008

New roles for the major human 3'-5' exonuclease TREX1 in human disease.

Cell Cycle 2008 Jun 16;7(12):1718-25. Epub 2008 Jun 16.

Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825026PMC
http://dx.doi.org/10.4161/cc.7.12.6162DOI Listing
June 2008

Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly.

J Immunol 2007 Aug;179(4):2600-8

Division of Rheumatology, Department of Medicine, School of Medicine, Washington University, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.179.4.2600DOI Listing
August 2007

Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome.

Clin J Am Soc Nephrol 2007 May 14;2(3):591-6. Epub 2007 Feb 14.

Division of Rheumatology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.2215/CJN.03270906DOI Listing
May 2007