John M Scott

John M Scott

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Impact of voluntary fortification and supplement use on dietary intakes and biomarker status of folate and vitamin B-12 in Irish adults.

Am J Clin Nutr 2015 Jun 15;101(6):1163-72. Epub 2015 Apr 15.

From the Institute of Food and Health, University College Dublin, Belfield Dublin, Republic of Ireland (SMH, MJG, APN, and BAM); the Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland (HM, JJS, and MW); the School of Clinical Medicine, Trinity College, Dublin, Republic of Ireland (AMM and JMS); and the School of Food and Nutritional Sciences, University College Cork, Cork, Republic of Ireland (AF and JW).

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http://dx.doi.org/10.3945/ajcn.115.107151DOI Listing
June 2015

Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects.

BMC Med Genet 2014 Oct 8;15:102. Epub 2014 Oct 8.

Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Room 5306, 50 South Drive, Bethesda, MD, 20892-8004, USA.

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http://dx.doi.org/10.1186/s12881-014-0102-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411759PMC
October 2014

Is low iron status a risk factor for neural tube defects?

Birth Defects Res A Clin Mol Teratol 2014 Feb 18;100(2):100-6. Epub 2014 Feb 18.

The Institute of Molecular Medicine, School of Medicine, Trinity College Dublin, Ireland.

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http://dx.doi.org/10.1002/bdra.23223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018583PMC
February 2014

Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of Folic Acid Supplementation in the Second and Third Trimesters.

Am J Clin Nutr 2013 Jul 29;98(1):92-8. Epub 2013 May 29.

Northern Ireland Centre for Food & Health, School of Biomedical Sciences, University of Ulster, Coleraine, United Kingdom.

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http://dx.doi.org/10.3945/ajcn.112.057489DOI Listing
July 2013

The discovery of vitamin B(12).

Ann Nutr Metab 2012 26;61(3):239-45. Epub 2012 Nov 26.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland. jscott @ tcd.ie

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http://dx.doi.org/10.1159/000343114DOI Listing
April 2013

Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women.

Br J Nutr 2012 Oct 15;108(7):1264-71. Epub 2011 Dec 15.

Northern Ireland Centre for Food and Health (NICHE), University of Ulster, Coleraine, County Londonderry, UK.

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http://dx.doi.org/10.1017/S000711451100674XDOI Listing
October 2012

Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up.

Am J Clin Nutr 2012 Mar 25;95(3):766-72. Epub 2012 Jan 25.

Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.3945/ajcn.111.026245DOI Listing
March 2012

Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status?

Am J Clin Nutr 2011 Aug 8;94(2):495-500. Epub 2011 Jun 8.

Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3945/ajcn.111.014621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142724PMC
August 2011

B-vitamins, methylenetetrahydrofolate reductase (MTHFR) and hypertension.

Int J Vitam Nutr Res 2011 Jul;81(4):240-4

Nothern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK.

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http://dx.doi.org/10.1024/0300-9831/a000069DOI Listing
July 2011

Women's compliance with current folic acid recommendations and achievement of optimal vitamin status for preventing neural tube defects.

Hum Reprod 2011 Jun 25;26(6):1530-6. Epub 2011 Mar 25.

Northern Ireland Centre for Food & Health, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK.

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http://dx.doi.org/10.1093/humrep/der078DOI Listing
June 2011

A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy.

Am J Clin Nutr 2011 Jan 27;93(1):11-8. Epub 2010 Oct 27.

Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland and Biochemistry & Immunology, Trinity College, Dublin, Ireland.

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https://academic.oup.com/ajcn/article/93/1/11/4597600
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http://dx.doi.org/10.3945/ajcn.2010.29427DOI Listing
January 2011

Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population.

Am J Med Genet A 2011 Jan 10;155A(1):14-21. Epub 2010 Dec 10.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-7510, USA.

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http://dx.doi.org/10.1002/ajmg.a.33755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503244PMC
January 2011

Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR.

J Hypertens 2010 Mar;28(3):478-86

Northern Ireland Centre for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Coleraine, Ireland.

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http://dx.doi.org/10.1097/HJH.0b013e328334c126DOI Listing
March 2010

The genetic background of the curly tail strain confers susceptibility to folate-deficiency-induced exencephaly.

Birth Defects Res A Clin Mol Teratol 2010 Feb;88(2):76-83

Neural Development Unit, UCL Institute of Child Health, London, UK.

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http://dx.doi.org/10.1002/bdra.20632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071937PMC
February 2010

Testing reported associations of genetic risk factors for oral clefts in a large Irish study population.

Birth Defects Res A Clin Mol Teratol 2010 Feb;88(2):84-93

Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/bdra.20639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503531PMC
February 2010

Fracture localisation for cast wedging.

Ann R Coll Surg Engl 2009 Nov;91(8):714

Department of Anaesthetics, North Devon District Hospital, Raleigh Park, Barnstaple, EX31 4JB,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966263PMC
http://dx.doi.org/10.1308/rcsann.2009.91.8.714bDOI Listing
November 2009

Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.

Clin Immunol 2009 Oct 21;133(1):132-7. Epub 2009 Jul 21.

Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1016/j.clim.2009.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402225PMC
October 2009

The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women.

Ann Hum Genet 2009 Sep 28;73(Pt 5):484-91. Epub 2009 Jul 28.

Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1469-1809.2009.00529.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812009PMC
September 2009

Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?

BMC Public Health 2009 Aug 18;9:295. Epub 2009 Aug 18.

UCD School of Public Health and Population Science, University College Dublin, and Coombe Women's and Infant's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1186/1471-2458-9-295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734856PMC
August 2009

Cobalamin, folic acid, and homocysteine.

Nutr Rev 2009 May;67 Suppl 1:S69-72

Departamento de Nutrición, Bromatología y Tecnología de los Alimentos, Universidad San Pablo CEU, Facultad de Farmacia, Madrid, Spain.

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http://dx.doi.org/10.1111/j.1753-4887.2009.00163.xDOI Listing
May 2009

The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects.

Birth Defects Res A Clin Mol Teratol 2009 Apr;85(4):285-94

School of Biochemistry and Immunology, Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1002/bdra.20566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129971PMC
April 2009

Uncoupling protein 2 polymorphisms as risk factors for NTDs.

Birth Defects Res A Clin Mol Teratol 2009 Feb;85(2):156-60

Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, 50 South Drive, Bethesda, MD 20892-8004, USA.

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http://dx.doi.org/10.1002/bdra.20520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724655PMC
February 2009

Effect of selenium status and supplementation with high-selenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly.

Mol Nutr Food Res 2008 Nov;52(11):1324-33

Division of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.

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http://dx.doi.org/10.1002/mnfr.200700353DOI Listing
November 2008

Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate.

Birth Defects Res A Clin Mol Teratol 2008 Sep;82(9):636-43

Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://doi.wiley.com/10.1002/bdra.20491
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http://dx.doi.org/10.1002/bdra.20491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670560PMC
September 2008

Intake and status of folate and related B-vitamins: considerations and challenges in achieving optimal status.

Br J Nutr 2008 Jun;99 Suppl 3:S48-54

The Northern Ireland Centre for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland.

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http://www.journals.cambridge.org/abstract_S0007114508006855
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http://dx.doi.org/10.1017/S0007114508006855DOI Listing
June 2008

Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development.

Food Nutr Bull 2008 Jun;29(2 Suppl):S101-11; discussion S112-5

School of Medicine, Trinity College Dublin, Ireland.

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http://fnb.sagepub.com/content/29/2_suppl1/S101.full.pdf
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http://dx.doi.org/10.1177/15648265080292S114DOI Listing
June 2008

Evidence for sex differences in the determinants of homocysteine concentrations.

Mol Genet Metab 2008 Apr 3;93(4):355-62. Epub 2008 Jan 3.

Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1016/j.ymgme.2007.11.004DOI Listing
April 2008

An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women.

Hum Genet 2008 Apr 5;123(3):289-95. Epub 2008 Feb 5.

Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA, 19104-6084, USA.

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http://dx.doi.org/10.1007/s00439-008-0475-yDOI Listing
April 2008

Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults.

Am J Clin Nutr 2007 Nov;86(5):1405-13

Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom.

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http://dx.doi.org/10.1093/ajcn/86.5.1405DOI Listing
November 2007

Reduced folate status is common and increases disease risk. It can be corrected by daily ingestion of supplements or fortification.

Authors:
John M Scott

Novartis Found Symp 2007 ;282:105-17; discussion 117-22, 212-8

School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.

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October 2007

Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring.

J Nutr 2007 Aug;137(8):1863-7

Unitat de Medicina Preventiva i Salut Pública, IRCIS, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, 43201 Spain.

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http://dx.doi.org/10.1093/jn/137.8.1863DOI Listing
August 2007

Association between the NAT1 1095C > A polymorphism and homocysteine concentration.

Am J Med Genet A 2006 Nov;140(21):2374-7

Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6084, USA.

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http://dx.doi.org/10.1002/ajmg.a.31475DOI Listing
November 2006

The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels.

Mol Genet Metab 2006 Jul 18;88(3):290-4. Epub 2006 Apr 18.

School of Biochemistry and Immunology, Trinity College Dublin, Ireland.

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http://dx.doi.org/10.1016/j.ymgme.2006.02.011DOI Listing
July 2006

The effect of docosahexaenoic acid and folic acid supplementation on placental apoptosis and proliferation.

Br J Nutr 2006 Jul;96(1):182-90

Dr von Hauner Children's Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany.

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http://dx.doi.org/10.1079/bjn20061812DOI Listing
July 2006

Reduced folate carrier polymorphisms and neural tube defect risk.

Mol Genet Metab 2006 Apr 15;87(4):364-9. Epub 2005 Dec 15.

Department of Biochemistry, Trinity College Dublin, Ireland.

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http://dx.doi.org/10.1016/j.ymgme.2005.09.024DOI Listing
April 2006

Dietary and other lifestyle correlates of serum folate concentrations in a healthy adult population in Crete, Greece: a cross-sectional study.

Nutr J 2006 Feb 10;5. Epub 2006 Feb 10.

Preventive Medicine and Nutrition Clinic, Department of Social Medicine, Faculty of Medicine, University of Crete, P,O, Box 1352, 71110, Heraklion, Greece.

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http://link.springer.com/content/pdf/10.1186/1475-2891-5-5.p
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http://www.nutritionj.com/content/5/1/5
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http://dx.doi.org/10.1186/1475-2891-5-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1431550PMC
February 2006

Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism.

Circulation 2006 Jan 27;113(1):74-80. Epub 2005 Dec 27.

Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.105.580332DOI Listing
January 2006

Postprandial serum folic acid response to multiple doses of folic acid in fortified bread.

Br J Nutr 2006 Jan;95(1):145-51

Department of Clinical Medicine, University of Dublin, Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1079/bjn20051618DOI Listing
January 2006

Evidence of unmetabolised folic acid in cord blood of newborn and serum of 4-day-old infants.

Br J Nutr 2005 Nov;94(5):727-30

Department of Clinical Medicine, University of Dublin, Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1079/bjn20051572DOI Listing
November 2005

Screening for new MTHFR polymorphisms and NTD risk.

Am J Med Genet A 2005 Oct;138A(2):99-106

Department of Biochemistry, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1002/ajmg.a.30846DOI Listing
October 2005

Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery.

Am J Clin Nutr 2005 Oct;82(4):836-42

Department of Clinical Medicine and the National Human Genome Research Institute, the National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/ajcn/82.4.836DOI Listing
October 2005

Nutrition and metabolism.

Curr Opin Lipidol 2005 Aug;16(4):494-6

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August 2005

A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations.

Hum Genet 2005 Apr 29;116(5):347-53. Epub 2005 Jan 29.

Department of Pharmacology, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1007/s00439-004-1243-2DOI Listing
April 2005

Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population.

Birth Defects Res A Clin Mol Teratol 2005 Apr;73(4):239-44

Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/bdra.20122DOI Listing
April 2005

Homocysteine is lower in the third trimester of pregnancy in women with enhanced folate status from continued folic acid supplementation.

Clin Chem 2005 Mar 22;51(3):629-34. Epub 2004 Dec 22.

Northern Ireland Centre for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Coleraine, UK.

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http://www.clinchem.org/cgi/doi/10.1373/clinchem.2004.032698
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http://dx.doi.org/10.1373/clinchem.2004.032698DOI Listing
March 2005

Determining bioavailability of food folates in a controlled intervention study.

Am J Clin Nutr 2004 Oct;80(4):911-8

Northern Ireland Centre for Food and Health and the School of Hotel, Leisure, and Tourism, University of Ulster, Coleraine, United Kingdom.

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http://dx.doi.org/10.1093/ajcn/80.4.911DOI Listing
October 2004

Maternal homocysteine before conception and throughout pregnancy predicts fetal homocysteine and birth weight.

Clin Chem 2004 Aug 27;50(8):1406-12. Epub 2004 May 27.

Unit of Preventive Medicine and Public Health, Rovira i Virgili University, Reus, Spain.

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http://dx.doi.org/10.1373/clinchem.2004.032904DOI Listing
August 2004

Victor Herbert (1927-2002).

Authors:
John M Scott

J Nutr 2004 Jul;134(7):1678-80

Biochemistry Department, Trinity College, Dublin 2, Ireland.

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http://dx.doi.org/10.1093/jn/134.7.1678DOI Listing
July 2004

The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine.

Atherosclerosis 2004 Jun;174(2):315-22

Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2004.01.023DOI Listing
June 2004

The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men.

J Nutr 2004 Mar;134(3):580-5

Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland BT52 1SA.

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http://dx.doi.org/10.1093/jn/134.3.580DOI Listing
March 2004

Elevated plasma homocysteine in early pregnancy: a risk factor for the development of nonsevere preeclampsia.

Am J Obstet Gynecol 2003 Aug;189(2):391-4; discussion 394-6

Department of Biochemistry, Trinity College Dublin and Coombe Women's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1067/s0002-9378(03)00669-0DOI Listing
August 2003

Protocol for the production of concentrated extracts of food folate for use in human bioavailability studies.

J Agric Food Chem 2003 Jul;51(15):4382-8

Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland BT52 1SA.

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http://dx.doi.org/10.1021/jf0262312DOI Listing
July 2003

Screening for vitamin B-12 and folate deficiency in older persons.

Am J Clin Nutr 2003 May;77(5):1241-7

Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1093/ajcn/77.5.1241DOI Listing
May 2003

Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults.

Blood 2003 Apr;101(7):2483-8

Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood.V101.7.2483DOI Listing
April 2003

The effect of different cooking methods on folate retention in various foods that are amongst the major contributors to folate intake in the UK diet.

Br J Nutr 2002 Dec;88(6):681-8

Northern Ireland Centre for Food and Health (NICHE), University of Ulster, Coleraine, BT52 1SA, Northern Ireland, UK.

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http://dx.doi.org/10.1079/BJN2002733DOI Listing
December 2002

Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation.

Clin Chem 2002 Sep;48(9):1571-7

LOCUS for Homocysteine and Related Vitamins, University of Bergen, Armauer Hansens Hus, N-5021 Bergen, Norway.

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September 2002

Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements.

Am J Clin Nutr 2002 Aug;76(2):436-41

Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, United Kingdom.

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http://dx.doi.org/10.1093/ajcn/76.2.436DOI Listing
August 2002

MTRR and MTHFR polymorphism: link to Down syndrome?

Am J Med Genet 2002 Jan;107(2):151-5

Department of Biochemistry, Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1002/ajmg.10121DOI Listing
January 2002