John M Hallenbeck

John M Hallenbeck

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John M Hallenbeck

Publications by authors named "John M Hallenbeck"

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The Role of SUMOylation and Ubiquitination in Brain Ischaemia: Critical Concepts and Clinical Implications.

Curr Issues Mol Biol 2020 18;35:127-144. Epub 2019 Aug 18.

Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA. 6Department of Neurosurgery, Goethe University Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.21775/cimb.035.127DOI Listing
August 2019

Development of a systems-based in situ multiplex biomarker screening approach for the assessment of immunopathology and neural tissue plasticity in male rats after traumatic brain injury.

J Neurosci Res 2018 04 2;96(4):487-500. Epub 2017 May 2.

Flow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH), Bethesda, Maryland.

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http://dx.doi.org/10.1002/jnr.24054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668208PMC
April 2018

Drugging SUMOylation for neuroprotection and oncotherapy.

Neural Regen Res 2018 Mar;13(3):415-416

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH), Bethesda, MD, USA.

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http://dx.doi.org/10.4103/1673-5374.228718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900498PMC
March 2018

SUMOylation in brain ischemia: Patterns, targets, and translational implications.

J Cereb Blood Flow Metab 2018 01 17;38(1):5-16. Epub 2017 Nov 17.

3 Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1177/0271678X17742260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757445PMC
January 2018

Cerebral Ischemia Increases Small Ubiquitin-Like Modifier Conjugation within Human Penumbral Tissue: Radiological-Pathological Correlation.

Front Neurol 2017 12;8:738. Epub 2018 Jan 12.

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.

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http://dx.doi.org/10.3389/fneur.2017.00738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770374PMC
January 2018

Akt Protein Kinase, miR-200/miR-182 Expression and Epithelial-Mesenchymal Transition Proteins in Hibernating Ground Squirrels.

Front Mol Neurosci 2018 30;11:22. Epub 2018 Jan 30.

Clinical Investigation Section, Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH), Bethesda, MD, United States.

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http://dx.doi.org/10.3389/fnmol.2018.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797618PMC
January 2018

Neural stem cell transplantation in ischemic stroke: A role for preconditioning and cellular engineering.

J Cereb Blood Flow Metab 2017 Jul 17;37(7):2314-2319. Epub 2017 Mar 17.

2 Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH), Bethesda, MD, USA.

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http://dx.doi.org/10.1177/0271678X17700432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531358PMC
July 2017

Global SUMOylation facilitates the multimodal neuroprotection afforded by quercetin against the deleterious effects of oxygen/glucose deprivation and the restoration of oxygen/glucose.

J Neurochem 2016 07 6;138(1):101-16. Epub 2016 Jun 6.

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH), Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/jnc.13643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916017PMC
July 2016

Hypophosphorylation of ribosomal protein S6 is a molecular mechanism underlying ischemic tolerance induced by either hibernation or preconditioning.

J Neurochem 2015 Dec 22;135(5):943-57. Epub 2015 Oct 22.

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/jnc.13368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715778PMC
December 2015

Global SUMOylation is a molecular mechanism underlying hypothermia-induced ischemic tolerance.

Front Cell Neurosci 2014 4;8:416. Epub 2014 Dec 4.

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health Bethesda, MD, USA.

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http://dx.doi.org/10.3389/fncel.2014.00416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255597PMC
December 2014

Anti-lymphoproliferative activity of alpha-2-macroglobulin in the plasma of hibernating 13-lined ground squirrels and woodchucks.

Vet Immunol Immunopathol 2014 Sep 20;161(1-2):1-11. Epub 2014 May 20.

Naval Medical Research Center, Silver Spring, MD 20910, United States; Department of Pathology, USUHS, Bethesda, MD 20814, United States. Electronic address:

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http://dx.doi.org/10.1016/j.vetimm.2014.05.006DOI Listing
September 2014

SUMO and ischemic tolerance.

Neuromolecular Med 2013 Dec 18;15(4):771-81. Epub 2013 Jun 18.

Stroke Branch, National Institute of Neurological Disease and Stroke, National Institutes of Health (NINDS/NIH), Bldg10/Rm5B06, MSC 1401, 10 Center Drive, Bethesda, MD, 20892, USA,

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http://dx.doi.org/10.1007/s12017-013-8239-9DOI Listing
December 2013

Global protein conjugation by ubiquitin-like-modifiers during ischemic stress is regulated by microRNAs and confers robust tolerance to ischemia.

PLoS One 2012 18;7(10):e47787. Epub 2012 Oct 18.

Stroke Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047787PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475703PMC
April 2013

A method for hypothermia-induction and maintenance allows precise body and brain temperature control in mice.

J Neurosci Methods 2013 Feb 19;213(1):1-5. Epub 2012 Nov 19.

Clinical Investigations Section, Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2012.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570728PMC
February 2013

Biological networks in ischemic tolerance - rethinking the approach to clinical conditioning.

Transl Stroke Res 2013 Feb;4(1):114-29

Brain and Mind Research Institute, Weill Cornell Medical College, 407 East 61 Street, RR303, New York, NY 10065.

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http://link.springer.com/10.1007/s12975-012-0244-z
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http://dx.doi.org/10.1007/s12975-012-0244-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821776PMC
February 2013

Elevated global SUMOylation in Ubc9 transgenic mice protects their brains against focal cerebral ischemic damage.

PLoS One 2011 7;6(10):e25852. Epub 2011 Oct 7.

Stroke Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025852PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189225PMC
February 2012

Tracks of a non-main path traveler: 2011 Thomas Willis Lecture.

Stroke 2012 Feb 12;43(2):585-90. Epub 2012 Jan 12.

Stroke Branch, NINDS, NIH, 10 Center Drive MSC 1401, Building 10/Room 5B02, Bethesda, MD 20892-1401, USA.

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http://dx.doi.org/10.1161/STROKEAHA.111.643668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458306PMC
February 2012

Intranasal delivery of E-selectin reduces atherosclerosis in ApoE-/- mice.

PLoS One 2011 20;6(6):e20620. Epub 2011 Jun 20.

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020620PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119064PMC
October 2011

Disruption of downstream MyD88 or TRIF Toll-like receptor signaling does not protect against cerebral ischemia.

Brain Res 2011 May 1;1388:148-56. Epub 2011 Mar 1.

Stroke Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Building 10, Rm 5B06, MSC 1401, Bethesda, MD 20892-1401, USA.

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http://dx.doi.org/10.1016/j.brainres.2011.02.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126100PMC
May 2011

Regulation of Akt during torpor in the hibernating ground squirrel, Ictidomys tridecemlineatus.

J Comp Physiol B 2010 Aug 30;180(6):927-34. Epub 2010 Mar 30.

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1401, Bethesda, MD 20892-1401, USA.

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http://dx.doi.org/10.1007/s00360-010-0468-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957659PMC
August 2010

Increased plasma and tissue MMP levels are associated with BCSFB and BBB disruption evident on post-contrast FLAIR after experimental stroke.

J Cereb Blood Flow Metab 2010 Jun 3;30(6):1188-99. Epub 2010 Mar 3.

Stroke Diagnostics and Therapeutics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://journals.sagepub.com/doi/10.1038/jcbfm.2010.1
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http://dx.doi.org/10.1038/jcbfm.2010.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879459PMC
June 2010

Introduction of a new journal.

Transl Stroke Res 2010 Mar;1(1)

NINDS, NIH, Bethesda, MD, USA,

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http://dx.doi.org/10.1007/s12975-010-0013-9DOI Listing
March 2010

Feridex preloading permits tracking of CNS-resident macrophages after transient middle cerebral artery occlusion.

J Cereb Blood Flow Metab 2009 Jul 6;29(7):1229-39. Epub 2009 May 6.

Section on Stroke Diagnostics and Therapeutics, Stroke Branch, National Institute of Neurological Disorders and Stroke, Building 10, Room B1D733, 10 Center

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http://dx.doi.org/10.1038/jcbfm.2009.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744340PMC
July 2009

SUMOylation participates in induction of ischemic tolerance.

J Neurochem 2009 Apr 5;109(1):257-67. Epub 2009 Feb 5.

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.05957.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692380PMC
April 2009

Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive rats.

J Cereb Blood Flow Metab 2009 Mar 24;29(3):606-20. Epub 2008 Dec 24.

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, Maryland 20892-4476, USA.

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http://dx.doi.org/10.1038/jcbfm.2008.153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692388PMC
March 2009

Reperfusion-associated hemorrhagic transformation in SHR rats: evidence of symptomatic parenchymal hematoma.

Stroke 2008 Dec 28;39(12):3405-10. Epub 2008 Aug 28.

Section on Stroke Diagnostics and Therapeutics, Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.108.520304
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http://dx.doi.org/10.1161/STROKEAHA.108.520304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138858PMC
December 2008

Mucosal tolerization to E-selectin protects against memory dysfunction and white matter damage in a vascular cognitive impairment model.

J Cereb Blood Flow Metab 2008 Feb 18;28(2):341-53. Epub 2007 Jul 18.

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4476, USA.

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http://search.proquest.com/openview/d93435f41d5233a29239d472
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http://jcb.sagepub.com/lookup/doi/10.1038/sj.jcbfm.960052
Publisher Site
http://dx.doi.org/10.1038/sj.jcbfm.9600528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2601631PMC
February 2008

Spatial and temporal activation of brain regions in hibernation: c-fos expression during the hibernation bout in thirteen-lined ground squirrel.

J Comp Neurol 2007 Dec;505(4):443-58

Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/cne.21507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774134PMC
December 2007

Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells.

J Cereb Blood Flow Metab 2007 May 6;27(5):950-62. Epub 2006 Sep 6.

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, Maryland 20892-4476, USA.

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http://journals.sagepub.com/doi/10.1038/sj.jcbfm.9600395
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http://dx.doi.org/10.1038/sj.jcbfm.9600395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396349PMC
May 2007

Neuroprotection by endogenous and exogenous PACAP following stroke.

Regul Pept 2006 Nov 4;137(1-2):4-19. Epub 2006 Oct 4.

Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.regpep.2006.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183206PMC
November 2006

Involvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cells.

J Cereb Blood Flow Metab 2006 Oct 1;26(10):1323-31. Epub 2006 Mar 1.

1Stroke Branch, Department of Health and Human Services, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4476, USA.

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http://dx.doi.org/10.1038/sj.jcbfm.9600286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855183PMC
October 2006

Immunology of ischemic vascular disease: plaque to attack.

Trends Immunol 2005 Oct;26(10):550-6

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg. 49/Room 2A10, 49 Convent Drive MSC 4476, Bethesda, MD 20892-4476, USA.

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http://dx.doi.org/10.1016/j.it.2005.08.007DOI Listing
October 2005

Antibiotics for vascular diseases: a meta-analysis of randomized controlled trials.

Atherosclerosis 2005 Apr 18;179(2):403-12. Epub 2004 Dec 18.

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002191500400571
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http://dx.doi.org/10.1016/j.atherosclerosis.2004.10.034DOI Listing
April 2005

Development of an ischemic tolerance model in a PC12 cell line.

J Cereb Blood Flow Metab 2005 Feb;25(2):154-162

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/sj.jcbfm.9600003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1378216PMC
February 2005

Determining the fetal inflammatory response in an experimental model of intrauterine inflammation in rats.

Pediatr Res 2004 Oct 4;56(4):541-6. Epub 2004 Aug 4.

Center for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington University School of Medicine, Washington, D.C., 20010. USA

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http://dx.doi.org/10.1203/01.PDR.0000139407.89883.6BDOI Listing
October 2004

Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning.

J Cereb Blood Flow Metab 2004 Jun;24(6):623-7

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1097/01.WCB.0000119990.06999.A9DOI Listing
June 2004

Mucosal tolerance to E-selectin provides cell-mediated protection against ischemic brain injury.

Proc Natl Acad Sci U S A 2003 Dec 26;100(25):15107-12. Epub 2003 Nov 26.

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.2436538100
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http://dx.doi.org/10.1073/pnas.2436538100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC299916PMC
December 2003

Overexpression of monocyte chemoattractant protein 1 in the brain exacerbates ischemic brain injury and is associated with recruitment of inflammatory cells.

J Cereb Blood Flow Metab 2003 Jun;23(6):748-55

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4128, USA.

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http://journals.sagepub.com/doi/10.1097/01.WCB.0000071885.63
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http://dx.doi.org/10.1097/01.WCB.0000071885.63724.20DOI Listing
June 2003

Ischemic tolerance and endogenous neuroprotection.

Trends Neurosci 2003 May;26(5):248-54

Experimental Neurology, Charite Hospital, Humboldt University, 10098 Berlin, Germany.

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http://dx.doi.org/10.1016/S0166-2236(03)00071-7DOI Listing
May 2003

Neuregulin expression after focal stroke in the rat.

Neurosci Lett 2002 Dec;334(3):169-72

Johns Hopkins School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/s0304-3940(02)01126-6DOI Listing
December 2002

The many faces of tumor necrosis factor in stroke.

Nat Med 2002 Dec;8(12):1363-8

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/nm1202-1363DOI Listing
December 2002

Effects of intrauterine inflammation on developing rat brain.

J Neurosci Res 2002 Nov;70(4):570-9

Stroke Branch, National Institute of Neurological Diseases and Stroke, National Institute of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/jnr.10423DOI Listing
November 2002

Elevated arylalkylamine-N-acetyltransferase (AA-NAT) gene expression in medial habenular and suprachiasmatic nuclei of hibernating ground squirrels.

Brain Res Mol Brain Res 2002 Jun;102(1-2):9-17

Resuscitative Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910-7500, USA.

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http://dx.doi.org/10.1016/s0169-328x(02)00138-9DOI Listing
June 2002

TNF-alpha-induced tolerance to ischemic injury involves differential control of NF-kappaB transactivation: the role of NF-kappaB association with p300 adaptor.

J Cereb Blood Flow Metab 2002 Feb;22(2):142-52

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4092, USA.

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http://dx.doi.org/10.1097/00004647-200202000-00002DOI Listing
February 2002