Publications by authors named "John M Denu"

100Publications

Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6.

Nat Commun 2020 10 16;11(1):5244. Epub 2020 Oct 16.

Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.

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http://dx.doi.org/10.1038/s41467-020-19018-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568541PMC
October 2020

Catalysis by protein acetyltransferase Gcn5.

Biochim Biophys Acta Gene Regul Mech 2020 Aug 22:194627. Epub 2020 Aug 22.

Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53715, USA.

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http://dx.doi.org/10.1016/j.bbagrm.2020.194627DOI Listing
August 2020

Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators.

J Biol Chem 2020 Aug 9;295(32):11021-11041. Epub 2020 Jun 9.

Wisconsin Institute for Discovery, University of Wisconsin, Madison, Wisconsin, USA

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http://dx.doi.org/10.1074/jbc.REV120.011438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415977PMC
August 2020

Metabolism and the Epigenome: A Dynamic Relationship.

Trends Biochem Sci 2020 Sep 6;45(9):731-747. Epub 2020 May 6.

Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53706, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2020.04.002DOI Listing
September 2020

Revealing Dynamic Protein Acetylation across Subcellular Compartments.

J Proteome Res 2020 06 27;19(6):2404-2418. Epub 2020 Apr 27.

Biomolecular Chemistry Department, School of Medicine and Public Health, University of Wisconsin-Madison, 53706 Madison, Wisconsin, United States.

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http://dx.doi.org/10.1021/acs.jproteome.0c00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427125PMC
June 2020

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence.

Mol Cell 2020 04 23;78(2):210-223.e8. Epub 2020 Mar 23.

Department of Biomolecular Chemistry, SMPH, University of Wisconsin-Madison, Madison, WI 53706, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191556PMC
April 2020

Mechanism of activation for the sirtuin 6 protein deacylase.

J Biol Chem 2020 01 10;295(5):1385-1399. Epub 2019 Dec 10.

Wisconsin Institute for Discovery, University of Wisconsin-Madison, Wisconsin 53715

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http://dx.doi.org/10.1074/jbc.RA119.011285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996886PMC
January 2020

A practical guide for analysis of histone post-translational modifications by mass spectrometry: Best practices and pitfalls.

Methods 2019 Dec 7. Epub 2019 Dec 7.

Wisconsin Institute for Discovery, 330 N. Orchard Street, Madison, WI, USA; Department of Biomolecular Chemistry, University of Wisconsin, Madison, 420 Henry Mall, Madison, WI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2019.12.001DOI Listing
December 2019

Histone Acetyltransferase 1 Links Metabolism and Transcription to Cell-Cycle Progression.

Authors:
John M Denu

Mol Cell 2019 08;75(4):664-665

Department of Biomolecular Chemistry, School of Medicine and Public Health, Wisconsin Institute for Discovery, Morgridge Institute for Research, University of Wisconsin, Madison, WI, 53706, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.08.004DOI Listing
August 2019

Site-Specific Lysine Acetylation Stoichiometry Across Subcellular Compartments.

Methods Mol Biol 2019 ;1983:79-106

Wisconsin Institute of Discovery, University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.1007/978-1-4939-9434-2_6DOI Listing
January 2020

Bacterial Analogs of Plant Tetrahydropyridine Alkaloids Mediate Microbial Interactions in a Rhizosphere Model System.

Appl Environ Microbiol 2019 05 2;85(10). Epub 2019 May 2.

Wisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA

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http://dx.doi.org/10.1128/AEM.03058-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498172PMC
May 2019

Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions.

Mol Cell 2018 09;71(5):718-732.e9

Wisconsin Institute for Discovery and Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health-Madison, Madison, WI 53715, USA; Morgridge Institute for Research, Madison, WI 53715, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.07.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188669PMC
September 2018

Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL.

Nat Commun 2018 06 21;9(1):2425. Epub 2018 Jun 21.

National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.

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http://dx.doi.org/10.1038/s41467-018-04836-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013494PMC
June 2018

General method for rapid purification of native chromatin fragments.

J Biol Chem 2018 08 24;293(31):12271-12282. Epub 2018 May 24.

From the Department of Biomolecular Chemistry,

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http://dx.doi.org/10.1074/jbc.RA118.002984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078465PMC
August 2018

Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys.

Cell Metab 2018 03;27(3):677-688.e5

Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; Geriatric Research, Education, and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844481PMC
March 2018

Identifying Dysregulated Epigenetic Enzyme Activity in Castrate-Resistant Prostate Cancer Development.

ACS Chem Biol 2017 11 11;12(11):2804-2814. Epub 2017 Oct 11.

Department of Biomolecular Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States.

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http://dx.doi.org/10.1021/acschembio.6b01035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594041PMC
November 2017

Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin.

Transl Res 2017 11 1;189:30-50. Epub 2017 Sep 1.

Department of Comparative Biosciences, University of Wisconsin - Madison, Madison, Wis.

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http://dx.doi.org/10.1016/j.trsl.2017.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659875PMC
November 2017

Chemical signaling between gut microbiota and host chromatin: What is your gut really saying?

J Biol Chem 2017 05 7;292(21):8582-8593. Epub 2017 Apr 7.

From the Wisconsin Institute for Discovery, Morgridge Institute for Research, and the Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53715 and

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http://dx.doi.org/10.1074/jbc.R116.761577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448088PMC
May 2017

Histone Lysine-to-Methionine Mutations Reduce Histone Methylation and Cause Developmental Pleiotropy.

Plant Physiol 2017 04 15;173(4):2243-2252. Epub 2017 Feb 15.

Laboratory of Genetics (D.S., S.Q., R.F., L.L., X.Z.) and Department of Biomolecular Chemistry (J.M.D.), University of Wisconsin-Madison, Madison, Wisconsin 53706; and

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http://dx.doi.org/10.1104/pp.16.01499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373047PMC
April 2017

Using comparative biology to understand how aging affects mitochondrial metabolism.

Mol Cell Endocrinol 2017 Nov 23;455:54-61. Epub 2016 Dec 23.

Department of Biomolecular Chemistry, University of Wisconsin- Madison, Madison, WI 53715, USA.

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http://dx.doi.org/10.1016/j.mce.2016.12.020DOI Listing
November 2017

Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues.

Mol Cell 2016 12 23;64(5):982-992. Epub 2016 Nov 23.

Wisconsin Institute for Discovery, Madison, WI 53715, USA; Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health - Madison, Madison, WI 53706, USA; Morgridge Institute for Research, Madison, WI 53715, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227652PMC
December 2016

Reader domain specificity and lysine demethylase-4 family function.

Nat Commun 2016 11 14;7:13387. Epub 2016 Nov 14.

Wisconsin Institute for Discovery, Morgridge Institute for Research, University of Wisconsin-Madison, Madison, Wisconsin 53715, USA.

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http://dx.doi.org/10.1038/ncomms13387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114558PMC
November 2016

Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells.

EBioMedicine 2016 11 8;13:146-156. Epub 2016 Oct 8.

Department of Cell and Regenerative Biology, School of Medicine and Public Health, United States; Paul C. Carbone Cancer Center, University of Wisconsin-Madison, United States.

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http://dx.doi.org/10.1016/j.ebiom.2016.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264313PMC
November 2016

Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis.

J Biol Chem 2016 Sep 5;291(40):20827-20837. Epub 2016 Aug 5.

From the Morgridge Institute for Research, Madison, Wisconsin 53715, the Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706

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http://dx.doi.org/10.1074/jbc.M116.727701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076495PMC
September 2016

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.

Diabetes 2016 09 9;65(9):2700-10. Epub 2016 Jun 9.

Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, WI Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI William S. Middleton Memorial Veterans Hospital, Madison, WI

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http://dx.doi.org/10.2337/db16-0432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001174PMC
September 2016

Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation.

J Exp Med 2016 06 30;213(7):1267-84. Epub 2016 May 30.

Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705 Department of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705 Geriatric Research Education Clinical Center, Veterans Affairs Medical Center, Madison, WI 53705

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http://dx.doi.org/10.1084/jem.20151776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925020PMC
June 2016

A Novel Quantitative Mass Spectrometry Platform for Determining Protein O-GlcNAcylation Dynamics.

Mol Cell Proteomics 2016 07 25;15(7):2462-75. Epub 2016 Apr 25.

From the ‡Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104;

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http://dx.doi.org/10.1074/mcp.O115.049627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937517PMC
July 2016

Mechanisms and Dynamics of Protein Acetylation in Mitochondria.

Trends Biochem Sci 2016 Mar 25;41(3):231-244. Epub 2016 Jan 25.

Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53715, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2015.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783225PMC
March 2016

Reading the Combinatorial Histone Language.

ACS Chem Biol 2016 Mar 21;11(3):564-74. Epub 2015 Dec 21.

Department of Biomolecular Chemistry and the Wisconsin Institute for Discovery, University of Wisconsin-Madison , Madison, Wisconsin 53715, United States.

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http://dx.doi.org/10.1021/acschembio.5b00864DOI Listing
March 2016

Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies.

J Biol Chem 2016 Feb 2;291(7):3268-79. Epub 2015 Dec 2.

From the Wisconsin Institute for Discovery and the Department of Biomolecular Chemistry, the University of Wisconsin Carbone Cancer Center, Madison, Wisconsin 53792

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http://dx.doi.org/10.1074/jbc.M115.702076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751373PMC
February 2016

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.

Cell Rep 2015 Oct 8;13(3):479-488. Epub 2015 Oct 8.

The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; The Center for Regenerative Medicine, The Massachusetts General Hospital, Boston, MA 02114, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618237PMC
October 2015

MARCC (Matrix-Assisted Reader Chromatin Capture): An Antibody-Free Method to Enrich and Analyze Combinatorial Nucleosome Modifications.

Curr Protoc Mol Biol 2015 Jul 1;111:21.32.1-21.32.21. Epub 2015 Jul 1.

Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin.

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http://dx.doi.org/10.1002/0471142727.mb2132s111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848750PMC
July 2015

Quantification of SAHA-Dependent Changes in Histone Modifications Using Data-Independent Acquisition Mass Spectrometry.

J Proteome Res 2015 Aug 13;14(8):3252-62. Epub 2015 Jul 13.

§BiognoSYS AG, Wagistrasse 25, CH-8952 Schlieren, Switzerland.

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http://dx.doi.org/10.1021/acs.jproteome.5b00245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564294PMC
August 2015

Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.

Biochemistry 2015 May 4;54(19):3037-3050. Epub 2015 May 4.

Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53715.

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http://dx.doi.org/10.1021/acs.biochem.5b00150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470489PMC
May 2015

Metabolic regulation of histone post-translational modifications.

ACS Chem Biol 2015 Jan;10(1):95-108

Department of Biomolecular Chemistry and the Wisconsin Institute for Discovery, University of Wisconsin-Madison , Madison, Wisconsin 53715, United States.

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http://dx.doi.org/10.1021/cb500846uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407823PMC
January 2015

Site-specific reactivity of nonenzymatic lysine acetylation.

ACS Chem Biol 2015 Jan;10(1):122-8

Department of Biomolecular Chemistry and ‡Wisconsin Institute for Discovery, University of Wisconsin , Madison, Wisconsin 53715, United States.

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http://dx.doi.org/10.1021/cb500848pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301072PMC
January 2015

Stoichiometry of site-specific lysine acetylation in an entire proteome.

J Biol Chem 2014 Aug 10;289(31):21326-38. Epub 2014 Jun 10.

From the Department of Biomolecular Chemistry, the Wisconsin Institute for Discovery, and

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http://dx.doi.org/10.1074/jbc.M114.581843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118097PMC
August 2014

ChIP-less analysis of chromatin states.

Epigenetics Chromatin 2014 24;7. Epub 2014 Apr 24.

Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA ; Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI 53715, USA.

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http://dx.doi.org/10.1186/1756-8935-7-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022240PMC
May 2014

NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function.

Cancer Discov 2014 May 17;4(5):564-77. Epub 2014 Feb 17.

1Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda; 2Department of Pathology, Johns Hopkins University, Baltimore, Maryland; 3Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin; and 4Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018760PMC
May 2014

NAD+ deficiency in age-related mitochondrial dysfunction.

Cell Metab 2014 Feb;19(2):178-80

Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15504131140001
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http://dx.doi.org/10.1016/j.cmet.2014.01.005DOI Listing
February 2014

Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins.

J Biol Chem 2013 Oct 18;288(43):31350-6. Epub 2013 Sep 18.

From the Department of Biomolecular Chemistry and.

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http://dx.doi.org/10.1074/jbc.C113.511261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829447PMC
October 2013

Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.

J Clin Invest 2013 Jul 17;123(7):3084-98. Epub 2013 Jun 17.

Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.

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http://dx.doi.org/10.1172/JCI64401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101988PMC
July 2013

Sirtuin catalysis and regulation.

J Biol Chem 2012 Dec 18;287(51):42419-27. Epub 2012 Oct 18.

Department of Biomolecular Chemistry and the Wisconsin Institute for Discovery, University of Wisconsin, Madison, Wisconsin 53715, USA.

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http://dx.doi.org/10.1074/jbc.R112.378877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522242PMC
December 2012

Minireview series on sirtuins: from biochemistry to health and disease.

J Biol Chem 2012 Dec 18;287(51):42417-8. Epub 2012 Oct 18.

Wisconsin Institute for Discovery, Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53715, USA.

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http://dx.doi.org/10.1074/jbc.R112.428862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522241PMC
December 2012

Identification and characterization of small molecule inhibitors of a plant homeodomain finger.

Biochemistry 2012 Oct 2;51(41):8293-306. Epub 2012 Oct 2.

Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA.

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http://dx.doi.org/10.1021/bi3009278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567257PMC
October 2012

High-throughput strategy to identify inhibitors of histone-binding domains.

Methods Enzymol 2012 ;512:161-85

Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1016/B978-0-12-391940-3.00008-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467374PMC
December 2012

Multivalent recognition of histone tails by the PHD fingers of CHD5.

Biochemistry 2012 Aug 8;51(33):6534-44. Epub 2012 Aug 8.

Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dx.doi.org/10.1021/bi3006972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518043PMC
August 2012

Fortifying the link between SIRT1, resveratrol, and mitochondrial function.

Authors:
John M Denu

Cell Metab 2012 May;15(5):566-7

Wisconsin Institute for Discovery and Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15504131120015
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http://dx.doi.org/10.1016/j.cmet.2012.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491563PMC
May 2012

SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status.

J Biol Chem 2012 Apr 13;287(17):14078-86. Epub 2012 Mar 13.

Department of Biomolecular Chemistry and the Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin 53715, USA.

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http://dx.doi.org/10.1074/jbc.M112.355206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340192PMC
April 2012

Structural and kinetic isotope effect studies of nicotinamidase (Pnc1) from Saccharomyces cerevisiae.

Biochemistry 2012 Jan 29;51(1):243-56. Epub 2011 Dec 29.

Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States.

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http://dx.doi.org/10.1021/bi2015508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257521PMC
January 2012

Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation.

J Biol Chem 2012 Feb 7;287(6):3850-8. Epub 2011 Dec 7.

Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin 53715, USA.

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http://www.jbc.org/content/287/6/3850.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M111.317404
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http://dx.doi.org/10.1074/jbc.M111.317404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281715PMC
February 2012

Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties.

J Biol Chem 2011 Oct 17;286(41):35955-65. Epub 2011 Aug 17.

Department of Biochemistry and Center for Eukaryotic Structural Genomics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

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http://dx.doi.org/10.1074/jbc.M111.276238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195580PMC
October 2011

Disrupting the reader of histone language.

Angew Chem Int Ed Engl 2011 Jun 25;50(26):5801-3. Epub 2011 May 25.

University of Wisconsin, Department of Biomolecular Chemistry and the Wisconsin Institute for Discovery, 330 North Orchard Street, Madison, WI 53715, USA.

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http://dx.doi.org/10.1002/anie.201101414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327163PMC
June 2011

Autoacetylation of the histone acetyltransferase Rtt109.

J Biol Chem 2011 Jul 23;286(28):24694-701. Epub 2011 May 23.

Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53715, USA.

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http://dx.doi.org/10.1074/jbc.M111.251579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137045PMC
July 2011

Hydrolysis of O-acetyl-ADP-ribose isomers by ADP-ribosylhydrolase 3.

J Biol Chem 2011 Jun 17;286(24):21110-7. Epub 2011 Apr 17.

Cardiovascular and Pulmonary Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.237636
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http://dx.doi.org/10.1074/jbc.M111.237636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122172PMC
June 2011

Structure and biochemical functions of SIRT6.

J Biol Chem 2011 Apr 1;286(16):14575-87. Epub 2011 Mar 1.

Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1074/jbc.M111.218990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077655PMC
April 2011

Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.

J Biol Chem 2011 Apr 21;286(15):13261-71. Epub 2011 Jan 21.

Department of Biomolecular Chemistry and Wisconsin Institute for Discovery, University of Wisconsin, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1074/jbc.M110.206771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075673PMC
April 2011

Dynamic interplay between histone H3 modifications and protein interpreters: emerging evidence for a "histone language".

Chembiochem 2011 Jan 29;12(2):299-307. Epub 2010 Oct 29.

Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dx.doi.org/10.1002/cbic.201000474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073147PMC
January 2011

KAT(ching) metabolism by the tail: insight into the links between lysine acetyltransferases and metabolism.

Chembiochem 2011 Jan 24;12(2):290-8. Epub 2010 Nov 24.

Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.

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http://dx.doi.org/10.1002/cbic.201000438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327878PMC
January 2011

Catalysis and mechanistic insights into sirtuin activation.

Chembiochem 2011 Jan 9;12(2):281-9. Epub 2010 Nov 9.

Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dx.doi.org/10.1002/cbic.201000434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327882PMC
January 2011

Processing mechanism and substrate selectivity of the core NuA4 histone acetyltransferase complex.

Biochemistry 2011 Feb 12;50(5):727-37. Epub 2011 Jan 12.

Department of Biomolecular Chemistry, University of Wisconsin, 1300 University Avenue, Madison, Wisconsin 53706, United States.

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http://dx.doi.org/10.1021/bi101355aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038686PMC
February 2011

Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone.

Proc Natl Acad Sci U S A 2010 Nov 5;107(47):20275-80. Epub 2010 Nov 5.

Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA.

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http://dx.doi.org/10.1073/pnas.1009860107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996700PMC
November 2010

SIRT3 substrate specificity determined by peptide arrays and machine learning.

ACS Chem Biol 2011 Feb 1;6(2):146-57. Epub 2010 Nov 1.

Department of Biomolecular Chemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.

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http://dx.doi.org/10.1021/cb100218dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042044PMC
February 2011

Kinetic mechanism of the Rtt109-Vps75 histone acetyltransferase-chaperone complex.

Biochemistry 2010 Aug;49(30):6375-85

Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA.

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http://dx.doi.org/10.1021/bi100381yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917178PMC
August 2010

Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain.

J Comp Neurol 2010 Aug;518(15):2952-77

Department of Anatomy, Molecular and Cell Biology Program and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA.

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http://dx.doi.org/10.1002/cne.22373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047483PMC
August 2010

Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease.

J Inherit Metab Dis 2010 Jun 13;33(3):195-210. Epub 2010 May 13.

Department of Anatomy, Physiology and Genetics, Neuroscience Program and Molecular and Cell Biology Program, Uniformed Services University of the Health Sciences, Building C, Bethesda, MD 20814, USA.

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http://dx.doi.org/10.1007/s10545-010-9100-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877317PMC
June 2010

Combinatorial profiling of chromatin binding modules reveals multisite discrimination.

Nat Chem Biol 2010 Apr 28;6(4):283-90. Epub 2010 Feb 28.

[1] Department of Chemistry, University of Wisconsin, Madison, Wisconsin, USA. [2] These authors contributed equally to this work.

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http://dx.doi.org/10.1038/nchembio.319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922993PMC
April 2010

Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose.

Biochim Biophys Acta 2010 Aug 20;1804(8):1617-25. Epub 2010 Feb 20.

Department of Biomolecular Chemistry, University of Wisconsin, School of Medicine and Public Health, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.bbapap.2010.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310390PMC
August 2010

Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications.

Biochem J 2009 Sep 25;423(2):179-87. Epub 2009 Sep 25.

Department of Pharmacology, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1042/BJ20090870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885444PMC
September 2009

A continuous microplate assay for sirtuins and nicotinamide-producing enzymes.

Anal Biochem 2009 Nov 16;394(1):101-9. Epub 2009 Jul 16.

Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.ab.2009.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752052PMC
November 2009

Ure(k)a! Sirtuins Regulate Mitochondria.

Cell 2009 May;137(3):404-6

Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, 53706, USA.

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http://dx.doi.org/10.1016/j.cell.2009.04.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310393PMC
May 2009

Hydrolase regulates NAD+ metabolites and modulates cellular redox.

J Biol Chem 2009 Apr 27;284(17):11256-66. Epub 2009 Feb 27.

Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1074/jbc.M809790200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670130PMC
April 2009

Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75.

Nat Struct Mol Biol 2008 Sep;15(9):948-56

Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, Madison, Wisconsin 53706, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678805PMC
http://dx.doi.org/10.1038/nsmb.1459DOI Listing
September 2008

Catalysis and substrate selection by histone/protein lysine acetyltransferases.

Curr Opin Struct Biol 2008 Dec;18(6):682-9

Department of Biomolecular Chemistry, University of Wisconsin-Madison School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.sbi.2008.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723715PMC
December 2008

Mechanisms and molecular probes of sirtuins.

Chem Biol 2008 Oct;15(10):1002-13

Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.chembiol.2008.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626554PMC
October 2008

Quantification of endogenous sirtuin metabolite O-acetyl-ADP-ribose.

Anal Biochem 2008 Dec 7;383(2):174-9. Epub 2008 Sep 7.

Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.ab.2008.08.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586145PMC
December 2008

A combinatorial H4 tail library for exploring the histone code.

Biochemistry 2008 Aug 11;47(31):8094-102. Epub 2008 Jul 11.

Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706-1532, USA.

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http://dx.doi.org/10.1021/bi800766kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614903PMC
August 2008

Chemical mechanisms of histone lysine and arginine modifications.

Biochim Biophys Acta 2009 Jan 14;1789(1):45-57. Epub 2008 Jun 14.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1016/j.bbagrm.2008.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642981PMC
January 2009

Where in the cell is SIRT3?--functional localization of an NAD+-dependent protein deacetylase.

Biochem J 2008 Apr;411(2):e11-3

Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.

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http://dx.doi.org/10.1042/BJ20080336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313448PMC
April 2008

The Sirtuin family: therapeutic targets to treat diseases of aging.

Curr Opin Chem Biol 2008 Feb 7;12(1):11-7. Epub 2008 Mar 7.

Sirtris Pharmaceuticals, Inc., 790 Memorial Drive, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cbpa.2008.01.019DOI Listing
February 2008