John M Asara

John M Asara

UNVERIFIED PROFILE

Are you John M Asara?   Register this Author

Register author
John M Asara

John M Asara

Publications by authors named "John M Asara"

Are you John M Asara?   Register this Author

100Publications

4136Reads

40Profile Views

Metabolomics and the pig model reveal aberrant cardiac energy metabolism in metabolic syndrome.

Sci Rep 2020 Feb 26;10(1):3483. Epub 2020 Feb 26.

Division of Cardiothoracic Surgery, Department of Surgery, The Warren Alpert Medical School, Brown University, Providence, RI, 02903, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-60387-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044421PMC
February 2020

Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.

Cell Syst 2020 Jan 4;10(1):66-81.e11. Epub 2019 Dec 4.

Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA; Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cels.2019.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000271PMC
January 2020

PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.

Cancer Discov 2019 Sep 19;9(9):1306-1323. Epub 2019 Jun 19.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-18-0083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726527PMC
September 2019

LLGL2 rescues nutrient stress by promoting leucine uptake in ER breast cancer.

Nature 2019 05 17;569(7755):275-279. Epub 2019 Apr 17.

Department of Medicine, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41586-019-1126-2
Publisher Site
http://dx.doi.org/10.1038/s41586-019-1126-2DOI Listing
May 2019

Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer.

Elife 2019 05 20;8. Epub 2019 May 20.

Department of Cancer Physiology, H Lee Moffitt Cancer Center and Research Institute, Tampa, United States.

View Article

Download full-text PDF

Source
https://elifesciences.org/articles/45572
Publisher Site
http://dx.doi.org/10.7554/eLife.45572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584702PMC
May 2019

miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma.

Nat Metab 2019 Apr 8;1(4):460-474. Epub 2019 Apr 8.

HMS Initiative for RNA Medicine, Department of Pathology, Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s42255-019-0052-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750230PMC
April 2019

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3.

Immunity 2019 03 12;50(3):576-590.e6. Epub 2019 Feb 12.

Department of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747613193003
Publisher Site
http://dx.doi.org/10.1016/j.immuni.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426684PMC
March 2019

Direct stimulation of NADP synthesis through Akt-mediated phosphorylation of NAD kinase.

Science 2019 03;363(6431):1088-1092

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aau3903DOI Listing
March 2019

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.

Nat Cell Biol 2019 02 28;21(2):226-237. Epub 2019 Jan 28.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41556-018-0261-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377565PMC
February 2019

O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity.

Cell Host Microbe 2018 12;24(6):791-803.e6

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA; Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296827PMC
December 2018

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis.

Nat Commun 2018 11 23;9(1):4945. Epub 2018 Nov 23.

Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-07472-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251888PMC
November 2018

Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma.

Proc Natl Acad Sci U S A 2018 07 11;115(27):E6274-E6282. Epub 2018 Jun 11.

Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1710849115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142242PMC
July 2018

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.

Mol Cell 2018 06 31;70(5):949-960.e4. Epub 2018 May 31.

Meyer Cancer Center and Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; World Class Institute, Anticancer Agents Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang 363-883, Cheongwon, Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2018.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591025PMC
June 2018

The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming.

Cell Metab 2018 May 29;27(5):1040-1054.e8. Epub 2018 Mar 29.

Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2018.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100782PMC
May 2018

The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.

Nat Commun 2018 04 23;9(1):1603. Epub 2018 Apr 23.

Division of Translational Therapeutics, Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41467-018-03886-6
Publisher Site
http://dx.doi.org/10.1038/s41467-018-03886-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913134PMC
April 2018

Activation of Vibrio cholerae quorum sensing promotes survival of an arthropod host.

Nat Microbiol 2018 02 27;3(2):243-252. Epub 2017 Nov 27.

Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41564-017-0065-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260827PMC
February 2018

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.

J Lipid Res 2017 12 6;58(12):2275-2288. Epub 2017 Oct 6.

Lipidomics Core Facility and Department of Pathology, Wayne State University, Detroit, MI.

View Article

Download full-text PDF

Source
http://www.jlr.org/lookup/doi/10.1194/jlr.M079012
Publisher Site
http://dx.doi.org/10.1194/jlr.M079012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711491PMC
December 2017

Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling.

Cell Rep 2017 Dec;21(10):2965-2977

Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2017.07.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752146PMC
December 2017

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT.

Sci Signal 2017 Dec 19;10(510). Epub 2017 Dec 19.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.aao6604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808948PMC
December 2017

Serial-omics of P53-/-, Brca1-/- Mouse Breast Tumor and Normal Mammary Gland.

Sci Rep 2017 11 6;7(1):14503. Epub 2017 Nov 6.

Beth Israel Deaconess Medical Center, Division of Signal Transduction, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-15132-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674068PMC
November 2017

mRNA is linked to cholesterol metabolism in adipose tissue.

FASEB J 2017 10 23;31(10):4482-4491. Epub 2017 Jun 23.

Department of Diabetes, Endocrinology, and Nutrition, Institut d'Investigació Biomèdica de Girona (IdIBGi), Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Girona, Spain;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201700161RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602896PMC
October 2017

Serial-omics characterization of equine urine.

PLoS One 2017 13;12(10):e0186258. Epub 2017 Oct 13.

Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186258PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640239PMC
October 2017

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.

Cell Rep 2017 Oct;21(5):1331-1346

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2017.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689476PMC
October 2017

Multi-omic network-based interrogation of rat liver metabolism following gastric bypass surgery featuring SWATH proteomics.

Technology (Singap World Sci) 2017 Sep 26;5(3):139-184. Epub 2017 Sep 26.

Center for Engineering in Medicine, Harvard Medical School - Massachusetts General Hospital, 51 Blossom Street, Boston, MA 02114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S233954781750008XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956888PMC
September 2017

Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide.

PLoS Pathog 2017 Jun 6;13(6):e1006428. Epub 2017 Jun 6.

Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston MA, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1006428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473594PMC
June 2017

PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition.

Cancer Discov 2017 04 2;7(4):380-390. Epub 2017 Mar 2.

Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-16-0612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562025PMC
April 2017

Adaptive Reprogramming of Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer.

Cancer Discov 2017 04 2;7(4):391-399. Epub 2017 Mar 2.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
Publisher Site
http://dx.doi.org/10.1158/2159-8290.CD-16-0611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380483PMC
April 2017

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.

Mol Cell 2017 Mar;65(6):999-1013.e7

Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2017.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426642PMC
March 2017

A relative quantitative positive/negative ion switching method for untargeted lipidomics via high resolution LC-MS/MS from any biological source.

Metabolomics 2017 Mar 7;13(3). Epub 2017 Feb 7.

Division of Signal Transduction/Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11306-016-1157-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421409PMC
March 2017

Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2.

Mol Biol Cell 2017 01 9;28(1):192-200. Epub 2016 Nov 9.

Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois, Chicago, IL 60607

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E16-08-0573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221623PMC
January 2017

Sterol Regulatory Element Binding Protein Regulates the Expression and Metabolic Functions of Wild-Type and Oncogenic IDH1.

Mol Cell Biol 2016 09 26;36(18):2384-95. Epub 2016 Aug 26.

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00163-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007792PMC
September 2016

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.

Proc Natl Acad Sci U S A 2016 09 1;113(38):E5562-71. Epub 2016 Sep 1.

Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; Broad Institute of MIT and Harvard, Cambridge, MA 02142; Harvard Stem Cell Institute, Cambridge, MA 02138; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035897PMC
http://dx.doi.org/10.1073/pnas.1600204113DOI Listing
September 2016

An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling.

Cell Rep 2016 09;16(11):3062-3074

Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033061PMC
September 2016

Peripheral fibroblast metabolic pathway alterations in juvenile rhesus monkeys undergoing long-term fluoxetine administration.

Eur Neuropsychopharmacol 2016 07 12;26(7):1110-8. Epub 2016 Apr 12.

Department of Environmental Toxicology, University of California, Davis, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euroneuro.2016.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590669PMC
July 2016

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.

Cell Stem Cell 2016 07 16;19(1):66-80. Epub 2016 Jun 16.

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2016.05.009DOI Listing
July 2016

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.

Proc Natl Acad Sci U S A 2016 07 8;113(30):E4338-47. Epub 2016 Jul 8.

Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1522223113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968752PMC
July 2016

Selective Mitochondrial Targeting Exerts Anxiolytic Effects In Vivo.

Neuropsychopharmacology 2016 06 16;41(7):1751-8. Epub 2015 Nov 16.

Max Planck Institute of Psychiatry, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/npp.2015.341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869042PMC
June 2016

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila.

Genes Dev 2016 06 16;30(12):1409-22. Epub 2016 Jun 16.

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.282277.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926864PMC
June 2016

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

Nat Cell Biol 2016 05 18;18(5):572-8. Epub 2016 Apr 18.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb3341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848114PMC
May 2016

Endocrine and Metabolic Pathways Linked to Keratoconus: Implications for the Role of Hormones in the Stromal Microenvironment.

Sci Rep 2016 05 9;6:25534. Epub 2016 May 9.

Department of Cell Biology/ University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep25534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860577PMC
May 2016

Fluoxetine Treatment Rescues Energy Metabolism Pathway Alterations in a Posttraumatic Stress Disorder Mouse Model.

Mol Neuropsychiatry 2016 May 30;2(1):46-59. Epub 2016 Apr 30.

Departments of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany; Graduate School of Systemic Neurosciences, Ludwig Maximilians University Munich, Planegg-Martinsried, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000445377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996011PMC
May 2016

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.

Mol Cell 2016 Apr;62(1):34-46

Howard Hughes Medical Institute, Stem Cell Program and Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2016.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836061PMC
April 2016

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

Science 2016 Feb;351(6274):728-733

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aad0489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786372PMC
February 2016

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

Mol Cell 2016 Jan 7;61(2):187-98. Epub 2016 Jan 7.

Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Department of Cancer Biology and Department of Neurosurgery, University of Cincinnati College of Medicine, Brain Tumor Center at University of Cincinnati Neuroscience Institute, Cincinnati, OH 45267, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2015.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747657PMC
January 2016

EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.

Nat Struct Mol Biol 2015 Dec 9;22(12):983-90. Epub 2015 Nov 9.

Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.3117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824005PMC
December 2015