John Loughlin

John Loughlin

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John Loughlin

Publications by authors named "John Loughlin"

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Functional testing of thousands of osteoarthritis-associated variants for regulatory activity.

Nat Commun 2019 06 4;10(1):2434. Epub 2019 Jun 4.

Department of Genome Sciences, University of Washington, Seattle, WA, 98195, USA.

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http://dx.doi.org/10.1038/s41467-019-10439-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547687PMC
June 2019

Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP.

Arthritis Res Ther 2019 Jun 18;21(1):149. Epub 2019 Jun 18.

Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, International Centre for Life, Newcastle upon Tyne, NE1 3BZ, UK.

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http://dx.doi.org/10.1186/s13075-019-1934-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582465PMC
June 2019

Functional Characterization of the Osteoarthritis Susceptibility Mapping to CHST11-A Bioinformatics and Molecular Study.

PLoS One 2016 8;11(7):e0159024. Epub 2016 Jul 8.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159024PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938163PMC
July 2017

The first international workshop on the epigenetics of osteoarthritis.

Connect Tissue Res 2017 01 30;58(1):37-48. Epub 2016 Mar 30.

f Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University , Newcastle-upon-Tyne , UK.

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http://dx.doi.org/10.3109/03008207.2016.1168409DOI Listing
January 2017

A proteomic analysis of chondrogenic, osteogenic and tenogenic constructs from ageing mesenchymal stem cells.

Stem Cell Res Ther 2016 09 14;7(1):133. Epub 2016 Sep 14.

Institute of Ageing and Chronic Disease, University of Liverpool, Leahurst, Chester High Road, Neston, CH64 7TE, UK.

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http://dx.doi.org/10.1186/s13287-016-0384-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022190PMC
September 2016

Translation of clinical problems in osteoarthritis into pathophysiological research goals.

RMD Open 2016 26;2(1):e000224. Epub 2016 May 26.

Laboratory of Tissue Homeostasis and Disease, Department of Development and Regeneration, KU Leuven and Division of Rheumatology , Skeletal Biology and Engineering Research Center, University Hospitals Leuven , Leuven , Belgium.

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http://dx.doi.org/10.1136/rmdopen-2015-000224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885448PMC
June 2016

Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874.

BMC Med Genet 2015 Nov 19;16:108. Epub 2015 Nov 19.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, 4th Floor Catherine Cookson Building, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1186/s12881-015-0254-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653905PMC
November 2015

Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients.

Ann Rheum Dis 2015 Sep 8;74(9):1778-82. Epub 2015 Apr 8.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2014-206752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552898PMC
September 2015

Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591.

BMC Med Genet 2015 Sep 7;16:81. Epub 2015 Sep 7.

Musculoskeletal Research Group, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, Framlington Place, Newcastle University, Newcastle-upon-Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1186/s12881-015-0215-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562116PMC
September 2015

Genetic contribution to osteoarthritis development: current state of evidence.

Authors:
John Loughlin

Curr Opin Rheumatol 2015 May;27(3):284-8

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1097/BOR.0000000000000171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423655PMC
May 2015

Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA.

Nat Rev Rheumatol 2015 Jan 4;11(1):6-7. Epub 2014 Nov 4.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, 4th Floor Catherine Cookson Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrrheum.2014.189DOI Listing
January 2015

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.

Ann Rheum Dis 2014 Dec 29;73(12):2130-6. Epub 2013 Aug 29.

Department of Twin Research & Genetic Epidemiology, King's College London, London, UK Department of Academic Rheumatology, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1136/annrheumdis-2012-203114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251181PMC
December 2014

Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5.

PLoS One 2014 21;9(1):e86590. Epub 2014 Jan 21.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086590PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897745PMC
September 2014

CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383.

Hum Genet 2014 Aug 27;133(8):1059-73. Epub 2014 May 27.

Musculoskeletal Research Group, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK,

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http://dx.doi.org/10.1007/s00439-014-1447-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099533PMC
August 2014

Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1.

BMC Med Genet 2014 May 4;15:53. Epub 2014 May 4.

Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1186/1471-2350-15-53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101866PMC
May 2014

Insights from human genetic studies into the pathways involved in osteoarthritis.

Nat Rev Rheumatol 2013 Oct 20;9(10):573-83. Epub 2013 Aug 20.

Musculoskeletal Research Group, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrrheum.2013.121DOI Listing
October 2013

The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383.

PLoS Genet 2013 Jun 27;9(6):e1003557. Epub 2013 Jun 27.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.plos.org/10.1371/journal.pgen.1003557
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http://dx.doi.org/10.1371/journal.pgen.1003557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694828PMC
June 2013

Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues.

BMC Musculoskelet Disord 2013 Mar 8;14:85. Epub 2013 Mar 8.

Newcastle University, Musculoskeletal Research Group, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1186/1471-2474-14-85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599795PMC
March 2013

The genetics and functional analysis of primary osteoarthritis susceptibility.

Expert Rev Mol Med 2013 Feb 18;15:e2. Epub 2013 Feb 18.

Newcastle University, Institute of Cellular Medicine, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1017/erm.2013.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575889PMC
February 2013

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.

Lancet 2012 Sep 3;380(9844):815-23. Epub 2012 Jul 3.

Wellcome Trust Sanger Institute, Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(
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http://linkinghub.elsevier.com/retrieve/pii/S014067361260681
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http://dx.doi.org/10.1016/S0140-6736(12)60681-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443899PMC
September 2012

Genetics and epigenetics of osteoarthritis.

Maturitas 2012 Mar 29;71(3):200-4. Epub 2011 Dec 29.

Newcastle University, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.maturitas.2011.12.001DOI Listing
March 2012

Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3.

BMC Med Genet 2012 Mar 2;13:12. Epub 2012 Mar 2.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle, UK.

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http://dx.doi.org/10.1186/1471-2350-13-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366887PMC
March 2012

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation.

Hum Mol Genet 2011 Sep 3;20(17):3450-60. Epub 2011 Jun 3.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1093/hmg/ddr253DOI Listing
September 2011

Genetics of osteoarthritis.

Authors:
John Loughlin

Curr Opin Rheumatol 2011 Sep;23(5):479-83

Institute of Cellular Medicine, Newcastle University, Newcastle, UK.

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http://dx.doi.org/10.1097/BOR.0b013e3283493ff0DOI Listing
September 2011

Osteoarthritis: All types of trouble--defining OA in the genomic era.

Authors:
John Loughlin

Nat Rev Rheumatol 2011 Apr 8;7(4):200-1. Epub 2011 Mar 8.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrrheum.2011.26DOI Listing
April 2011

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.

Ann Rheum Dis 2011 Feb 10;70(2):349-55. Epub 2010 Nov 10.

Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.

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http://dx.doi.org/10.1136/ard.2010.132787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615180PMC
February 2011

BMP5 activates multiple signaling pathways and promotes chondrogenic differentiation in the ATDC5 growth plate model.

Growth Factors 2010 Aug;28(4):268-79

School of Biological Sciences, Biomedical Research Centre, University of East Anglia, Norwich, NR4 7TJ, UK.

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http://dx.doi.org/10.3109/08977191003752296DOI Listing
August 2010

Identification and characterization of novel parathyroid-specific transcription factor Glial Cells Missing Homolog B (GCMB) mutations in eight families with autosomal recessive hypoparathyroidism.

Hum Mol Genet 2010 May 27;19(10):2028-38. Epub 2010 Feb 27.

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford OX3 7LJ, UK.

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http://dx.doi.org/10.1093/hmg/ddq084DOI Listing
May 2010

Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis.

BMC Med Genet 2009 Dec 19;10:141. Epub 2009 Dec 19.

University of Oxford, Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, OX3 7LD, UK.

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http://dx.doi.org/10.1186/1471-2350-10-141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807860PMC
December 2009

Novel mutations in exon 2 of MATN3 affect residues within the alpha-helices of the A-domain and can result in the intracellular retention of mutant matrilin-3.

Hum Mutat 2008 Feb;29(2):330

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

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http://doi.wiley.com/10.1002/humu.9518
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http://dx.doi.org/10.1002/humu.9518DOI Listing
February 2008

Variation in the secreted frizzled-related protein-3 gene and risk of osteolysis and heterotopic ossification after total hip arthroplasty.

J Orthop Res 2007 Dec;25(12):1665-70

Academic Unit of Bone Metabolism, University of Sheffield, Metabolic Bone Centre, Northern General Hospital, Sheffield, S5 7AU, United Kingdom.

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http://dx.doi.org/10.1002/jor.20446DOI Listing
December 2007

Meta-analysis of association between the ASPN D-repeat and osteoarthritis.

Hum Mol Genet 2007 Jul 20;16(14):1676-81. Epub 2007 May 20.

Laboratory for Statistical Analysis, SNP Research Center, RIKEN, Tokyo 108-8639, Japan.

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http://academic.oup.com/hmg/article/16/14/1676/2355956/Metaa
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http://dx.doi.org/10.1093/hmg/ddm115DOI Listing
July 2007

Extreme context specificity in differential allelic expression.

Hum Mol Genet 2007 Mar 12;16(5):537-46. Epub 2007 Jan 12.

University of Oxford, Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford OX3 7LD, UK.

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http://dx.doi.org/10.1093/hmg/ddl488DOI Listing
March 2007

Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine.

Biochem Biophys Res Commun 2006 Dec 30;351(4):890-5. Epub 2006 Oct 30.

Department of Biochemistry, National University of Ireland, Galway, Ireland.

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http://dx.doi.org/10.1016/j.bbrc.2006.10.104DOI Listing
December 2006

Crystals in hand.

Authors:
John Loughlin

Arthritis Res Ther 2005 19;7(5):187-8. Epub 2005 Aug 19.

University of Oxford, Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford, UK.

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http://dx.doi.org/10.1186/ar1807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257447PMC
April 2006

Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis in a UK Caucasian population.

Arthritis Rheum 2005 Nov;52(11):3502-6

Botnar Research Centre, Institute of Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, Oxford OX3 7LD, UK.

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http://dx.doi.org/10.1002/art.21399DOI Listing
November 2005

Polymorphism in signal transduction is a major route through which osteoarthritis susceptibility is acting.

Authors:
John Loughlin

Curr Opin Rheumatol 2005 Sep;17(5):629-33

University Lecturer in Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, UK.

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http://dx.doi.org/10.1097/01.bor.0000176687.85198.49DOI Listing
September 2005

The genetic epidemiology of human primary osteoarthritis: current status.

Authors:
John Loughlin

Expert Rev Mol Med 2005 May 24;7(9):1-12. Epub 2005 May 24.

University of Oxford, Institute of Musculoskeletal Science, Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, OX3 7LD, UK.

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http://dx.doi.org/10.1017/S1462399405009257DOI Listing
May 2005

Recent advances in the genetic investigation of osteoarthritis.

Trends Mol Med 2005 Apr;11(4):186-91

Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Oxford, OX3 7LD, UK.

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http://dx.doi.org/10.1016/j.molmed.2005.02.005DOI Listing
April 2005

Genetic background increases the risk of hip osteoarthritis.

Clin Orthop Relat Res 2005 Feb(431):134-7

Nuffield Department of Orthopaedic Surgery, The Nuffield Orthopaedic Centre, Windmill Road, Oxford OX3 7LD, UK.

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http://dx.doi.org/10.1097/01.blo.0000149242.85548.00DOI Listing
February 2005

The common HFE variants C282Y and H63D are not associated with primary OA of the hip or knee.

J Rheumatol 2005 Feb;32(2):391-2; author reply 392

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February 2005

Familial inheritance of osteoarthritis: documented family subsets.

Authors:
John Loughlin

Clin Orthop Relat Res 2004 Oct(427 Suppl):S22-5

Institute of Musculoskeletal Sciences, University of Oxford, United Kingdom.

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http://dx.doi.org/10.1097/01.blo.0000143803.19014.e1DOI Listing
October 2004

Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

Proc Natl Acad Sci U S A 2004 Jun 21;101(26):9757-62. Epub 2004 Jun 21.

Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford OX1 7LD, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0403456101
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http://dx.doi.org/10.1073/pnas.0403456101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC470747PMC
June 2004

Common variants within the interleukin 4 receptor alpha gene (IL4R) are associated with susceptibility to osteoarthritis.

Hum Genet 2004 Mar 24;114(4):391-5. Epub 2004 Jan 24.

Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, UK.

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http://dx.doi.org/10.1007/s00439-004-1083-0DOI Listing
March 2004

Genetics of osteoarthritis and potential for drug development.

Authors:
John Loughlin

Curr Opin Pharmacol 2003 Jun;3(3):295-9

University of Oxford, Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.

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June 2003

Finer linkage mapping of a primary hip osteoarthritis susceptibility locus on chromosome 6.

Eur J Hum Genet 2002 Sep;10(9):562-8

University of Oxford, Nuffield Department of Clinical Laboratory Sciences and Institute of Molecular Medicine, Oxford, UK.

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http://dx.doi.org/10.1038/sj.ejhg.5200848DOI Listing
September 2002

Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis.

Arthritis Rheum 2002 Jun;46(6):1519-27

Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1002/art.10260DOI Listing
June 2002

Genome studies and linkage in primary osteoarthritis.

Authors:
John Loughlin

Rheum Dis Clin North Am 2002 Feb;28(1):95-109

Nuffield Department of Clinical Laboratory Sciences, Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

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February 2002