John L Cleveland

John L Cleveland

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John L Cleveland

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Commercial Gene Expression Tests for Prostate Cancer Prognosis Provide Paradoxical Estimates of Race-Specific Risk.

Cancer Epidemiol Biomarkers Prev 2020 Jan 22;29(1):246-253. Epub 2019 Nov 22.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

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http://dx.doi.org/10.1158/1055-9965.EPI-19-0407DOI Listing
January 2020

Engineered BRET-Based Biologic Light Sources Enable Spatiotemporal Control over Diverse Optogenetic Systems.

ACS Synth Biol 2020 Jan 17;9(1):1-9. Epub 2019 Dec 17.

Division of Chemical Biology and Medicinal Chemistry , UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.

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http://dx.doi.org/10.1021/acssynbio.9b00277DOI Listing
January 2020

An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma.

Cell Rep 2019 Nov;29(6):1660-1674.e7

Lineberger Comprehensive Cancer Center, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Oral and Craniofacial Health Sciences, UNC Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Cell Biology and Physiology, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Biomedical Research Imaging Center, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6870917PMC
November 2019

Betaglycan drives the mesenchymal stromal cell osteogenic program and prostate cancer-induced osteogenesis.

Oncogene 2019 Oct 13;38(44):6959-6969. Epub 2019 Aug 13.

Tumor Biology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

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http://dx.doi.org/10.1038/s41388-019-0913-4DOI Listing
October 2019

ATF4-amino acid circuits: a recipe for resistance in melanoma.

EMBO J 2018 10 28;37(20). Epub 2018 Sep 28.

Department of Tumor Biology, H Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

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http://dx.doi.org/10.15252/embj.2018100600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187218PMC
October 2018

Systems analysis of intracellular pH vulnerabilities for cancer therapy.

Nat Commun 2018 07 31;9(1):2997. Epub 2018 Jul 31.

Cancer Data Science Lab, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20894, USA.

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http://dx.doi.org/10.1038/s41467-018-05261-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068141PMC
July 2018

MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis.

Proc Natl Acad Sci U S A 2018 04 26;115(15):E3368-E3377. Epub 2018 Mar 26.

Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612;

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http://dx.doi.org/10.1073/pnas.1719090115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899450PMC
April 2018

Role of Polyamines in Immune Cell Functions.

Med Sci (Basel) 2018 Mar 8;6(1). Epub 2018 Mar 8.

Department Immunology, PharmD, Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, 23033 SRB, Tampa, FL 33612, USA.

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http://www.mdpi.com/2076-3271/6/1/22
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http://dx.doi.org/10.3390/medsci6010022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872179PMC
March 2018

Metabolic Reprogramming via Targeting CD38 NADase Augments Adoptive T Cell Therapy.

Cell Metab 2018 01;27(1):3-5

Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.12.014DOI Listing
January 2018

Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots.

Mol Cell Biol 2017 02 19;37(3). Epub 2017 Jan 19.

Department of Cancer Biology, The Scripps Research Institute, Jupiter, Florida, USA.

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http://dx.doi.org/10.1128/MCB.00942-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247613PMC
February 2017

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications.

Proc Natl Acad Sci U S A 2017 01 17;114(5):E751-E760. Epub 2017 Jan 17.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;

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http://dx.doi.org/10.1073/pnas.1614958114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293075PMC
January 2017

CK1δ: an exploitable vulnerability in breast cancer.

Ann Transl Med 2016 Dec;4(23):474

Department of Molecular Therapeutics, Scripps Florida, The Scripps Research Institute, Jupiter, FL, USA.

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http://dx.doi.org/10.21037/atm.2016.12.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220019PMC
December 2016

Lactate Wreaks Havoc on Tumor-Infiltrating T and NK Cells.

Cell Metab 2016 11;24(5):649-650

Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.10.015DOI Listing
November 2016

Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer.

Amino Acids 2016 10 29;48(10):2353-62. Epub 2016 Jun 29.

Department of Tumor Biology, The Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.

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http://dx.doi.org/10.1007/s00726-016-2275-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573165PMC
October 2016

Synthesis and Cytoxicity of Sempervirine and Analogues.

J Org Chem 2016 Mar 10;81(5):2194-200. Epub 2016 Feb 10.

Department of Chemistry, The Scripps Research Institute , Jupiter, Florida 33458, United States.

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http://dx.doi.org/10.1021/acs.joc.6b00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573167PMC
March 2016

Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis.

Cancer Res 2015 Dec 30;75(23):5023-33. Epub 2015 Sep 30.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://cancerres.aacrjournals.org/content/early/2015/09/30/0
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http://cancerres.aacrjournals.org/content/early/2015/11/17/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-3538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668208PMC
December 2015

CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin.

PLoS One 2014 26;9(12):e115517. Epub 2014 Dec 26.

Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115517PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277357PMC
August 2015

Development of an HTS-Compatible Assay for the Discovery of Ulk1 Inhibitors.

J Biomol Screen 2015 Aug 7;20(7):913-20. Epub 2015 Apr 7.

Department of Molecular Therapeutics, Scripps Florida, Jupiter, FL, USA

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http://journals.sagepub.com/doi/10.1177/1087057115579391
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http://dx.doi.org/10.1177/1087057115579391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744088PMC
August 2015

Tipping the MYC-MIZ1 balance: targeting the HUWE1 ubiquitin ligase selectively blocks MYC-activated genes.

EMBO Mol Med 2014 Dec;6(12):1509-11

Department of Tumor Biology, The Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

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http://dx.doi.org/10.15252/emmm.201404735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287968PMC
December 2014

Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors.

J Med Chem 2014 Sep 22;57(17):7317-24. Epub 2014 Aug 22.

Department of Chemistry, The Scripps Research Institute , 130 Scripps Way, Jupiter, Florida 33458, United States.

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http://dx.doi.org/10.1021/jm500640xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161152PMC
September 2014

Synthesis and SAR of Lehualide B: a marine-derived natural product with potent anti-multiple myeloma activity.

ACS Chem Biol 2013 2;8(6):1241-52. Epub 2013 Apr 2.

Departments of Chemistry, ‡Cancer Biology, and #Molecular Therapeutics, The Scripps Research Institute , Scripps Florida, Jupiter, Florida 33458, United States.

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http://dx.doi.org/10.1021/cb300582sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758376PMC
August 2014

Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.

Cancer Res 2014 Feb 27;74(3):908-20. Epub 2013 Nov 27.

Authors' Affiliations: Departments of Cancer Biology, Chemistry, and Metabolism and Aging; The Translational Research Institute, The Scripps Research Institute, Scripps Florida, Jupiter, Florida; Institute of Biochemistry II, Goethe University Medical School, Frankfurt am Main, Germany; Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland; The Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania; and Pfizer Oncology, Pearl River, New Jersey.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946415PMC
February 2014

Targeting lactate metabolism for cancer therapeutics.

J Clin Invest 2013 Sep 3;123(9):3685-92. Epub 2013 Sep 3.

Department of Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, USA.

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http://dx.doi.org/10.1172/JCI69741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754272PMC
September 2013

Mitochondrial dysfunction in ataxia-telangiectasia.

Blood 2012 Feb 5;119(6):1490-500. Epub 2011 Dec 5.

Department of Oncology, St Jude Children’s Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1182/blood-2011-08-373639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286212PMC
February 2012

Chlamydia species-dependent differences in the growth requirement for lysosomes.

PLoS One 2011 Mar 8;6(3):e16783. Epub 2011 Mar 8.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016783PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050816PMC
March 2011

Myc suppression of Nfkb2 accelerates lymphomagenesis.

BMC Cancer 2010 Jul 2;10:348. Epub 2010 Jul 2.

III. Medical Department, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1186/1471-2407-10-348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902445PMC
July 2010

Targeting the autophagy pathway for cancer chemoprevention.

Curr Opin Cell Biol 2010 Apr 22;22(2):218-25. Epub 2010 Jan 22.

Department of Cancer Biology, The Scripps Research Institute-Florida, 130 Scripps Way, Jupiter, FL 33458, United States.

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http://dx.doi.org/10.1016/j.ceb.2009.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854265PMC
April 2010

Mapping the phosphorylation sites of Ulk1.

J Proteome Res 2009 Nov;8(11):5253-63

Department of Cancer Biology, The Scripps Research Institute, Jupiter, Florida 33458, USA.

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http://dx.doi.org/10.1021/pr900583mDOI Listing
November 2009

Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation.

Blood 2009 Jul 5;114(1):157-64. Epub 2009 May 5.

Department of Biochemistry, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.1182/blood-2008-04-151639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710944PMC
July 2009

Monitoring the autophagy pathway in cancer.

Methods Enzymol 2009 ;453:251-71

Department of Cancer Biology, The Scripps Research Institute, Scripps-Florida, Jupiter, Florida, USA.

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http://dx.doi.org/10.1016/S0076-6879(08)04012-3DOI Listing
April 2009

Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma.

Cancer Res 2009 Jan;69(2):547-53

Department of Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749594PMC
January 2009

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.

Blood 2008 Oct 18;112(7):2917-26. Epub 2008 Jul 18.

The Institute for Drug Development, Cancer Therapy and Research Center at The University of Texas Health Science Center at San Antonio, USA.

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http://dx.doi.org/10.1182/blood-2007-12-130823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556625PMC
October 2008

Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis.

Mol Cell Biol 2008 Sep 23;28(17):5391-402. Epub 2008 Jun 23.

Department of Biochemistry, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00907-07
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http://dx.doi.org/10.1128/MCB.00907-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519737PMC
September 2008

A Myc-Slug (Snail2)/Twist regulatory circuit directs vascular development.

Development 2008 Jun;135(11):1903-11

Department of Biochemistry, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1242/dev.011296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741485PMC
June 2008

Targeting autophagy: a novel anticancer strategy with therapeutic implications for imatinib resistance.

Biologics 2008 Jun;2(2):201-4

The CTRC Institute for Drug Development, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721364PMC
http://dx.doi.org/10.2147/btt.s1840DOI Listing
June 2008

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Authors:
Daniel J Klionsky Hagai Abeliovich Patrizia Agostinis Devendra K Agrawal Gjumrakch Aliev David S Askew Misuzu Baba Eric H Baehrecke Ben A Bahr Andrea Ballabio Bruce A Bamber Diane C Bassham Ettore Bergamini Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Dale E Bredesen Jeffrey L Brodsky John H Brumell Ulf T Brunk Wilfried Bursch Nadine Camougrand Eduardo Cebollero Francesco Cecconi Yingyu Chen Lih-Shen Chin Augustine Choi Charleen T Chu Jongkyeong Chung Peter G H Clarke Robert S B Clark Steven G Clarke Corinne Clavé John L Cleveland Patrice Codogno María I Colombo Ana Coto-Montes James M Cregg Ana Maria Cuervo Jayanta Debnath Francesca Demarchi Patrick B Dennis Phillip A Dennis Vojo Deretic Rodney J Devenish Federica Di Sano J Fred Dice Marian Difiglia Savithramma Dinesh-Kumar Clark W Distelhorst Mojgan Djavaheri-Mergny Frank C Dorsey Wulf Dröge Michel Dron William A Dunn Michael Duszenko N Tony Eissa Zvulun Elazar Audrey Esclatine Eeva-Liisa Eskelinen László Fésüs Kim D Finley José M Fuentes Juan Fueyo Kozo Fujisaki Brigitte Galliot Fen-Biao Gao David A Gewirtz Spencer B Gibson Antje Gohla Alfred L Goldberg Ramon Gonzalez Cristina González-Estévez Sharon Gorski Roberta A Gottlieb Dieter Häussinger You-Wen He Kim Heidenreich Joseph A Hill Maria Høyer-Hansen Xun Hu Wei-Pang Huang Akiko Iwasaki Marja Jäättelä William T Jackson Xuejun Jiang Shengkan Jin Terje Johansen Jae U Jung Motoni Kadowaki Chanhee Kang Ameeta Kelekar David H Kessel Jan A K W Kiel Hong Pyo Kim Adi Kimchi Timothy J Kinsella Kirill Kiselyov Katsuhiko Kitamoto Erwin Knecht Masaaki Komatsu Eiki Kominami Seiji Kondo Attila L Kovács Guido Kroemer Chia-Yi Kuan Rakesh Kumar Mondira Kundu Jacques Landry Marianne Laporte Weidong Le Huan-Yao Lei Michael J Lenardo Beth Levine Andrew Lieberman Kah-Leong Lim Fu-Cheng Lin Willisa Liou Leroy F Liu Gabriel Lopez-Berestein Carlos López-Otín Bo Lu Kay F Macleod Walter Malorni Wim Martinet Ken Matsuoka Josef Mautner Alfred J Meijer Alicia Meléndez Paul Michels Giovanni Miotto Wilhelm P Mistiaen Noboru Mizushima Baharia Mograbi Iryna Monastyrska Michael N Moore Paula I Moreira Yuji Moriyasu Tomasz Motyl Christian Münz Leon O Murphy Naweed I Naqvi Thomas P Neufeld Ichizo Nishino Ralph A Nixon Takeshi Noda Bernd Nürnberg Michinaga Ogawa Nancy L Oleinick Laura J Olsen Bulent Ozpolat Shoshana Paglin Glen E Palmer Issidora Papassideri Miles Parkes David H Perlmutter George Perry Mauro Piacentini Ronit Pinkas-Kramarski Mark Prescott Tassula Proikas-Cezanne Nina Raben Abdelhaq Rami Fulvio Reggiori Bärbel Rohrer David C Rubinsztein Kevin M Ryan Junichi Sadoshima Hiroshi Sakagami Yasuyoshi Sakai Marco Sandri Chihiro Sasakawa Miklós Sass Claudio Schneider Per O Seglen Oleksandr Seleverstov Jeffrey Settleman John J Shacka Irving M Shapiro Andrei Sibirny Elaine C M Silva-Zacarin Hans-Uwe Simon Cristiano Simone Anne Simonsen Mark A Smith Katharina Spanel-Borowski Vickram Srinivas Meredith Steeves Harald Stenmark Per E Stromhaug Carlos S Subauste Seiichiro Sugimoto David Sulzer Toshihiko Suzuki Michele S Swanson Ira Tabas Fumihiko Takeshita Nicholas J Talbot Zsolt Tallóczy Keiji Tanaka Kozo Tanaka Isei Tanida Graham S Taylor J Paul Taylor Alexei Terman Gianluca Tettamanti Craig B Thompson Michael Thumm Aviva M Tolkovsky Sharon A Tooze Ray Truant Lesya V Tumanovska Yasuo Uchiyama Takashi Ueno Néstor L Uzcátegui Ida van der Klei Eva C Vaquero Tibor Vellai Michael W Vogel Hong-Gang Wang Paul Webster John W Wiley Zhijun Xi Gutian Xiao Joachim Yahalom Jin-Ming Yang George Yap Xiao-Ming Yin Tamotsu Yoshimori Li Yu Zhenyu Yue Michisuke Yuzaki Olga Zabirnyk Xiaoxiang Zheng Xiongwei Zhu Russell L Deter

Autophagy 2008 Feb 21;4(2):151-75. Epub 2007 Nov 21.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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http://www.dwalab.ca/common/pdf/cdd200944a.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654259PMC
http://dx.doi.org/10.4161/auto.5338DOI Listing
February 2008

Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.

J Clin Invest 2008 Jan;118(1):79-88

Division of Molecular Therapeutics, Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1172/JCI33700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148253PMC
January 2008

NIX is required for programmed mitochondrial clearance during reticulocyte maturation.

Proc Natl Acad Sci U S A 2007 Dec 29;104(49):19500-5. Epub 2007 Nov 29.

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1073/pnas.0708818104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148318PMC
December 2007

Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis.

Nature 2007 Dec;450(7173):1253-7

Department of Immunology, St Jude Children's Research Institute, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/nature06421DOI Listing
December 2007

Modulating autophagy for therapeutic benefit.

Autophagy 2007 Sep-Oct;3(5):464-7. Epub 2007 Apr 19.

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.4161/auto.4311DOI Listing
November 2007

Clearing the TRAIL for Cancer Therapy.

Cancer Cell 2007 Jul;12(1):4-6

Department of Cancer Biology, The Scripps Research Institute-Florida, Jupiter, FL 334548, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.06.011DOI Listing
July 2007

Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis.

Mol Cancer Res 2007 Jul;5(7):705-11

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-0058DOI Listing
July 2007

Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels.

Cancer Res 2007 Jul;67(14):6987-94

Division of Molecular Therapeutics, Departments of Oncology and Biochemistry, St. Jude Children's Research Hospital, 322 North Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0812DOI Listing
July 2007

FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma.

J Cell Biol 2007 May;177(3):563

Department of Biochemistry, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1083/jcb.20050104020070420rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064814PMC
May 2007

The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia.

J Biol Chem 2005 Dec 30;280(48):40097-103. Epub 2005 Sep 30.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M506855200
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http://dx.doi.org/10.1074/jbc.M506855200DOI Listing
December 2005

Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.

EMBO J 2005 Nov 20;24(22):3846-58. Epub 2005 Oct 20.

Department of Biochemistry, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1038/sj.emboj.7600846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283945PMC
November 2005

Nfkb 1 is dispensable for Myc-induced lymphomagenesis.

Oncogene 2005 Sep;24(41):6231-40

Department of Biochemistry, St Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1038/sj.onc.1208779DOI Listing
September 2005

FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma.

J Cell Biol 2005 Sep;170(6):903-12

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1083/jcb.200501040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171446PMC
September 2005

Mechanisms of group B streptococcal-induced apoptosis of murine macrophages.

J Immunol 2005 Aug;175(4):2555-62

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.4049/jimmunol.175.4.2555DOI Listing
August 2005

Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation.

Cancer Cell 2005 May;7(5):433-44

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.03.036DOI Listing
May 2005

The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis.

Mol Cell Biol 2005 Mar;25(6):2395-405

Department of Genetics, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1128/MCB.25.6.2395-2405.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1061619PMC
March 2005

Haploinsufficiency for odc modifies mouse skin tumor susceptibility.

Cancer Res 2005 Feb;65(4):1146-9

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3244DOI Listing
February 2005

Antagonism of Myc functions by Arf.

Cancer Cell 2004 Oct;6(4):309-11

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.ccr.2004.09.020DOI Listing
October 2004

Id2 is dispensable for myc-induced lymphomagenesis.

Cancer Res 2004 Oct;64(20):7296-301

Department of Biochemistry and the Animal Resource Center, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2133DOI Listing
October 2004

Mnt: master regulator of the Max network.

Cell Cycle 2004 May 12;3(5):588-90. Epub 2004 May 12.

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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May 2004

Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation.

Mol Cell Biol 2004 Feb;24(4):1560-9

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC344188PMC
http://dx.doi.org/10.1128/mcb.24.4.1560-1569.2004DOI Listing
February 2004

Arf tumor suppressor promoter monitors latent oncogenic signals in vivo.

Proc Natl Acad Sci U S A 2003 Dec 9;100(26):15930-5. Epub 2003 Dec 9.

Departments of Genetics and Tumor Cell Biology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1073/pnas.2536808100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC307670PMC
December 2003

Arf tumor suppressor promoter monitors latent oncogenic signals in vivo.

Proc Natl Acad Sci U S A 2003 Dec 9;100(26):15930-5. Epub 2003 Dec 9.

Departments of Genetics and Tumor Cell Biology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1073/pnas.2536808100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC307670PMC
December 2003

c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL.

Mol Cell Biol 2003 Oct;23(20):7256-70

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230315PMC
http://dx.doi.org/10.1128/mcb.23.20.7256-7270.2003DOI Listing
October 2003

A new piece of the ALS puzzle.

Authors:
John L Cleveland

Nat Genet 2003 Aug;34(4):357-8

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http://dx.doi.org/10.1038/ng0803-357DOI Listing
August 2003

Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis.

EMBO J 2003 Mar;22(6):1442-50

Eppley Institute for Cancer Research, Department of Pathology and Microbiology, 987696 University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1093/emboj/cdg133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151074PMC
March 2003

Novel extranuclear-targeted anthracyclines override the antiapoptotic functions of Bcl-2 and target protein kinase C pathways to induce apoptosis.

Mol Cancer Ther 2002 May;1(7):469-81

Department of Pharmacology, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

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May 2002

A novel Eyes Absent 2 protein is expressed in the human eye.

Gene 2002 Feb;285(1-2):221-8

Department of Biology, Manhattan College, Riverdale, NY 10471, USA.

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http://dx.doi.org/10.1016/s0378-1119(02)00404-3DOI Listing
February 2002