Publications by authors named "John L Cleveland"

112Publications

Novel Transcriptomic Interactions Between Immune Content and Genomic Classifier Predict Lethal Outcomes in High-grade Prostate Cancer.

Authors:
Kosj Yamoah Shivanshu Awasthi Brandon A Mahal Shuang G Zhao G Daniel Grass Anders Berglund Julieta Abraham-Miranda Travis Gerke Robert J Rounbehler Elai Davicioni Yang Liu Jong Park John L Cleveland Julio M Pow-Sang Daniel Fernandez Javier Torres-Roca R Jeffrey Karnes Edward Schaeffer Stephen J Freedland Daniel E Spratt Robert B Den Timothy R Rebbeck Felix Feng

Eur Urol 2020 Dec 7. Epub 2020 Dec 7.

University of California, San Francisco, CA, USA.

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December 2020

Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia.

Authors:
Kamyar Zahedi Marybeth Brooks Sharon Barone Negah Rahmati Tracy Murray Stewart Matthew Dunworth Christina Destefano-Shields Nupur Dasgupta Steve Davidson Diana M Lindquist Christine E Fuller Roger D Smith John L Cleveland Robert A Casero Manoocher Soleimani

J Neuroinflammation 2020 Oct 14;17(1):301. Epub 2020 Oct 14.

Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.

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October 2020

Comparative Genomics Reveals Distinct Immune-oncologic Pathways in African American Men with Prostate Cancer.

Authors:
Shivanshu Awasthi Anders Berglund Julieta Abraham-Miranda Robert J Rounbehler Kevin Kensler Amparo Serna Adriana Vidal Sungyong You Michael R Freeman Elai Davicioni Yang Liu R Jeffrey Karnes Eric A Klein Robert B Den Bruce J Trock Joshua D Campbell David J Einstein Raavi Gupta Steven Balk Priti Lal Jong Y Park John L Cleveland Timothy R Rebbeck Stephen J Freedland Kosj Yamoah

Clin Cancer Res 2021 Jan 9;27(1):320-329. Epub 2020 Oct 9.

Department of Cancer Epidemiology, H Lee Moffitt Cancer Center & Research Institutes, Tampa, Florida.

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January 2021

TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype.

Authors:
David A Sallman Amy F McLemore Amy L Aldrich Rami S Komrokji Kathy L McGraw Abhishek Dhawan Susan Geyer Hsin-An Hou Erika Adriana Eksioglu Amy Sullivan Sarah Warren Kyle J MacBeth Manja Meggendorfer Torsten Haferlach Steffen Boettcher Benjamin L Ebert Najla Al-Ali Jeffrey E Lancet John L Cleveland Eric Padron Alan F List

Blood 2020 Jul 30. Epub 2020 Jul 30.

non-affiliated, Tampa, Florida, United States.

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July 2020

The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cells.

Authors:
Kamira Maharaj John J Powers Alex Achille Melanie Mediavilla-Varela Wael Gamal Karen L Burger Renee Fonseca Kun Jiang Hari P Miskin Dave Maryanski Andrii Monastyrskyi Derek R Duckett William R Roush John L Cleveland Eva Sahakian Javier Pinilla-Ibarz

Blood Adv 2020 Jul;4(13):3072-3084

Department of Malignant Hematology.

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July 2020

Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes.

Authors:
Rebecca S Hesterberg Matthew S Beatty Ying Han Mario R Fernandez Afua A Akuffo William E Goodheart Chunying Yang Shiun Chang Christelle M Colin Aileen Y Alontaga Jessica M McDaniel Adam W Mailloux Julia M R Billington Lanzhu Yue Shonagh Russell Robert J Gillies Sang Y Yun Muhammad Ayaz Nicholas J Lawrence Harshani R Lawrence Xue-Zhong Yu Jianing Fu Lancia N Darville John M Koomen Xiubao Ren Jane Messina Kun Jiang Timothy J Garrett Anjali M Rajadhyaksha John L Cleveland Pearlie K Epling-Burnette

Blood 2020 Aug;136(7):857-870

Department of Immunology, Moffitt Cancer Center and Research Institute, Tampa, FL.

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August 2020

Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling.

Authors:
Johanna C Sierra M Blanca Piazuelo Paula B Luis Daniel P Barry Margaret M Allaman Mohammad Asim Thomas A Sebrell Jordan L Finley Kristie L Rose Salisha Hill Steven L Holshouser Robert A Casero John L Cleveland Patrick M Woster Kevin L Schey Diane Bimczok Claus Schneider Alain P Gobert Keith T Wilson

Oncogene 2020 05 29;39(22):4465-4474. Epub 2020 Apr 29.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.

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May 2020

Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity.

Authors:
Kelly Walton Mario R Fernandez Elizabeth M Sagatys Jordan Reff Jongphil Kim Marie Catherine Lee John V Kiluk Jane Yuet Ching Hui David McKenna Meghan Hupp Colleen Forster Michael A Linden Nicholas J Lawrence Harshani R Lawrence Joseph Pidala Steven Z Pavletic Bruce R Blazar Said M Sebti John L Cleveland Claudio Anasetti Brian C Betts

JCI Insight 2020 05 7;5(9). Epub 2020 May 7.

Division of Hematology, Oncology, and Transplantation, Department of Medicine, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.

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May 2020

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.

Authors:
Arif Yurdagul Manikandan Subramanian Xiaobo Wang Scott B Crown Olga R Ilkayeva Lancia Darville Gopi K Kolluru Christina C Rymond Brennan D Gerlach Ze Zheng George Kuriakose Christopher G Kevil John M Koomen John L Cleveland Deborah M Muoio Ira Tabas

Cell Metab 2020 03 30;31(3):518-533.e10. Epub 2020 Jan 30.

Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Tumor Biology, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Department of Physiology, Columbia University, New York, NY 10032, USA. Electronic address:

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March 2020

Engineered BRET-Based Biologic Light Sources Enable Spatiotemporal Control over Diverse Optogenetic Systems.

Authors:
Kshitij Parag-Sharma Colin P O'Banion Erin C Henry Adele M Musicant John L Cleveland David S Lawrence Antonio L Amelio

ACS Synth Biol 2020 01 17;9(1):1-9. Epub 2019 Dec 17.

Division of Chemical Biology and Medicinal Chemistry , UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.

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January 2020

Commercial Gene Expression Tests for Prostate Cancer Prognosis Provide Paradoxical Estimates of Race-Specific Risk.

Authors:
Jordan H Creed Anders E Berglund Robert J Rounbehler Shivanshu Awasthi John L Cleveland Jong Y Park Kosj Yamoah Travis A Gerke

Cancer Epidemiol Biomarkers Prev 2020 01 22;29(1):246-253. Epub 2019 Nov 22.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

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January 2020

An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma.

Authors:
Miranda B Carper Scott Troutman Bethany L Wagner Kevin M Byrd Sara R Selitsky Kshitij Parag-Sharma Erin C Henry Weimin Li Joel S Parker Stephanie A Montgomery John L Cleveland Scott E Williams Joseph L Kissil David N Hayes Antonio L Amelio

Cell Rep 2019 11;29(6):1660-1674.e7

Lineberger Comprehensive Cancer Center, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Oral and Craniofacial Health Sciences, UNC Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Cell Biology and Physiology, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Biomedical Research Imaging Center, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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November 2019

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy.

Authors:
Kathrin Renner Christina Bruss Annette Schnell Gudrun Koehl Holger M Becker Matthias Fante Ayse-Nur Menevse Nathalie Kauer Raquel Blazquez Lisa Hacker Sonja-Maria Decking Toszka Bohn Stephanie Faerber Katja Evert Lisa Aigle Sabine Amslinger Maria Landa Oscar Krijgsman Elisa A Rozeman Christina Brummer Peter J Siska Katrin Singer Stefanie Pektor Matthias Miederer Katrin Peter Eva Gottfried Wolfgang Herr Ibtisam Marchiq Jacques Pouyssegur William R Roush SuFey Ong Sarah Warren Tobias Pukrop Philipp Beckhove Sven A Lang Tobias Bopp Christian U Blank John L Cleveland Peter J Oefner Katja Dettmer Mark Selby Marina Kreutz

Cell Rep 2019 10;29(1):135-150.e9

Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Regensburg Center for Interventional Immunology, Regensburg, Germany.

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October 2019

Betaglycan drives the mesenchymal stromal cell osteogenic program and prostate cancer-induced osteogenesis.

Authors:
Leah M Cook Jeremy S Frieling Niveditha Nerlakanti Jeremy J McGuire Paul A Stewart Karen L Burger John L Cleveland Conor C Lynch

Oncogene 2019 10 13;38(44):6959-6969. Epub 2019 Aug 13.

Tumor Biology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

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October 2019

Prognostic significance of MYC oncoprotein expression on survival outcome in patients with acute myeloid leukemia with myelodysplasia related changes (AML-MRC).

Authors:
Seongseok Yun Rohit Sharma Onyee Chan Nicole D Vincelette David A Sallman Kendra Sweet Eric Padron Rami Komrokji Jeffrey E Lancet Ivo Abraham Lynn C Moscinski John L Cleveland Alan F List Ling Zhang

Leuk Res 2019 09 18;84:106194. Epub 2019 Jul 18.

Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States. Electronic address:

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September 2019

African American Specific Gene Panel Predictive of Poor Prostate Cancer Outcome.

Authors:
Michelle I Echevarria Shivanshu Awasthi Chia-Ho Cheng Anders E Berglund Robert J Rounbehler Travis A Gerke Mandeep Takhar Elai Davicioni Eric A Klein Stephen J Freedland Ashley E Ross Edward M Schaeffer Robert B Den John L Cleveland Jong Y Park Walter Rayford Kosj Yamoah

J Urol 2019 08 8;202(2):247-255. Epub 2019 Jul 8.

H. Lee Moffitt Cancer Center and Research Institute , Tampa , Florida.

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August 2019

BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models.

Authors:
Xiaohong Zhao Yuan Ren Matthew Lawlor Bijal D Shah Paul M C Park Tint Lwin Xuefeng Wang Kenian Liu Michelle Wang Jing Gao Tao Li Mousheng Xu Ariosto S Silva Kaplan Lee Tinghu Zhang John M Koomen Huijuan Jiang Praneeth R Sudalagunta Mark B Meads Fengdong Cheng Chengfeng Bi Kai Fu Huitao Fan William S Dalton Lynn C Moscinski Kenneth H Shain Eduardo M Sotomayor Gang Greg Wang Nathanael S Gray John L Cleveland Jun Qi Jianguo Tao

Cancer Cell 2019 05;35(5):752-766.e9

Chemical Biology and Molecular Medicine Program, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Department of Laboratory Medicine and Hematopathology, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. Electronic address:

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May 2019

S100A9-induced overexpression of PD-1/PD-L1 contributes to ineffective hematopoiesis in myelodysplastic syndromes.

Authors:
Pinyang Cheng Erika A Eksioglu Xianghong Chen Wendy Kandell Thu Le Trinh Ling Cen Jin Qi David A Sallman Yu Zhang Nhan Tu William A Adams Chunze Zhang Jinhong Liu John L Cleveland Alan F List Sheng Wei

Leukemia 2019 08 8;33(8):2034-2046. Epub 2019 Feb 8.

Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

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August 2019

Distinct transcriptional repertoire of the androgen receptor in ETS fusion-negative prostate cancer.

Authors:
Anders E Berglund Robert J Rounbehler Travis Gerke Shivanshu Awasthi Chia-Ho Cheng Mandeep Takhar Elai Davicioni Mohammed Alshalalfa Nicholas Erho Eric A Klein Stephen J Freedland Ashley E Ross Edward M Schaeffer Bruce J Trock Robert B Den John L Cleveland Jong Y Park Jasreman Dhillon Kosj Yamoah

Prostate Cancer Prostatic Dis 2019 05 26;22(2):292-302. Epub 2018 Oct 26.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

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May 2019

ATF4-amino acid circuits: a recipe for resistance in melanoma.

Authors:
Mario R Fernandez John L Cleveland

EMBO J 2018 10 28;37(20). Epub 2018 Sep 28.

Department of Tumor Biology, H Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

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October 2018