Publications by authors named "John K Heath"

49Publications

Quantifying receptor trafficking and colocalization with confocal microscopy.

Methods 2017 02 26;115:42-54. Epub 2017 Jan 26.

School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK.

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February 2017

LAR protein tyrosine phosphatase regulates focal adhesions through CDK1.

J Cell Sci 2016 08 27;129(15):2962-71. Epub 2016 Jun 27.

School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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August 2016

Regulation of Platelet Derived Growth Factor Signaling by Leukocyte Common Antigen-related (LAR) Protein Tyrosine Phosphatase: A Quantitative Phosphoproteomics Study.

Mol Cell Proteomics 2016 06 13;15(6):1823-36. Epub 2016 Apr 13.

‡From the School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom

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June 2016

FAIMS and Phosphoproteomics of Fibroblast Growth Factor Signaling: Enhanced Identification of Multiply Phosphorylated Peptides.

J Proteome Res 2015 Dec 5;14(12):5077-87. Epub 2015 Nov 5.

School of Biosciences, University of Birmingham , Edgbaston, Birmingham B15 2TT, United Kingdom.

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December 2015

Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells.

J Cell Sci 2014 Dec 29;127(Pt 24):5303-16. Epub 2014 Oct 29.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, EH4 2XR Edinburgh, UK

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December 2014

RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly.

J Cell Sci 2014 Jul 13;127(Pt 14):3039-51. Epub 2014 Jun 13.

School of Immunity and Infection, Institute for Biomedical Research, The Medical School, University of Birmingham, Birmingham B15 2TT, UK

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July 2014

DiME: a scalable disease module identification algorithm with application to glioma progression.

PLoS One 2014 11;9(2):e86693. Epub 2014 Feb 11.

School of Computer Science, University of Birmingham, Birmingham, United Kingdom ; Centre for Systems Biology, School of Biological Sciences, University of Birmingham, Birmingham, United Kingdom.

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October 2014

The non-receptor tyrosine kinase Ack1 regulates the fate of activated EGFR by inducing trafficking to the p62/NBR1 pre-autophagosome.

J Cell Sci 2014 Mar 10;127(Pt 5):994-1006. Epub 2014 Jan 10.

School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

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March 2014

Novel binding partners and differentially regulated phosphorylation sites clarify Eps8 as a multi-functional adaptor.

PLoS One 2013 23;8(4):e61513. Epub 2013 Apr 23.

Cancer Research UK Growth Factor Signalling Group, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom.

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November 2013

Probing the complementarity of FAIMS and strong cation exchange chromatography in shotgun proteomics.

J Am Soc Mass Spectrom 2013 Mar 12;24(3):431-43. Epub 2013 Feb 12.

School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.

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March 2013

Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8.

J Cell Sci 2013 Jan 30;126(Pt 2):613-24. Epub 2012 Nov 30.

CRUK Growth Factor Group, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

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January 2013

Plakoglobin-dependent regulation of keratinocyte apoptosis by Rnd3.

J Cell Sci 2012 Jul 27;125(Pt 13):3202-9. Epub 2012 Mar 27.

School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, UK.

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July 2012

Computational modeling of biological pathways by executable biology.

Methods Enzymol 2011 ;487:217-51

Centre for Systems Biology at Edinburgh, University of Edinburgh, Edinburgh, United Kingdom.

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April 2011

Nbr1 is a novel inhibitor of ligand-mediated receptor tyrosine kinase degradation.

Mol Cell Biol 2010 Dec 11;30(24):5672-85. Epub 2010 Oct 11.

School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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December 2010

Critical role of FLRT1 phosphorylation in the interdependent regulation of FLRT1 function and FGF receptor signalling.

PLoS One 2010 Apr 22;5(4):e10264. Epub 2010 Apr 22.

Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom.

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April 2010

Signal transducers and activators of transcription-3 binding to the fibroblast growth factor receptor is activated by receptor amplification.

Cancer Res 2010 Apr 13;70(8):3391-401. Epub 2010 Apr 13.

CRUK Growth Factor Group, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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April 2010

Differential phosphoproteomics of fibroblast growth factor signaling: identification of Src family kinase-mediated phosphorylation events.

J Proteome Res 2010 May;9(5):2317-28

School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.

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May 2010

Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling.

J Cell Biol 2009 Oct 12;187(2):265-77. Epub 2009 Oct 12.

Cancer Research UK Growth Factor Group, University of Birmingham, Birmingham B15 2TT, England, UK.

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October 2009

Database search strategies for proteomic data sets generated by electron capture dissociation mass spectrometry.

J Proteome Res 2009 Dec;8(12):5475-84

School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

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December 2009

Biological pathways as communicating computer systems.

J Cell Sci 2009 Aug;122(Pt 16):2793-800

Oxford University Computing Laboratory, Oxford, UK.

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August 2009

Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway.

BMC Syst Biol 2009 Apr 15;3:40. Epub 2009 Apr 15.

Laboratory for Foundations of Computer Science, School of Informatics, University of Edinburgh, Informatics Forum, 10 Crichton Street, EH8 9AB, Edinburgh, UK.

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April 2009

SLoMo: automated site localization of modifications from ETD/ECD mass spectra.

J Proteome Res 2009 Apr;8(4):1965-71

School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

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April 2009

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

Mol Cell Proteomics 2009 May 8;8(5):904-12. Epub 2009 Jan 8.

Cancer Research UK Growth Factor Group, College of Life and Environmental Sciences, Universityof Birmingham, Edgbaston, Birmingham B152TT, United Kingdom.

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May 2009

The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src.

PLoS One 2008 Mar 26;3(3):e1873. Epub 2008 Mar 26.

CR-UK Growth Factor Group, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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March 2008

Alveolar epithelial type II cells induce T cell tolerance to specific antigen.

J Immunol 2008 Jan;180(2):881-8

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

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January 2008

Protein partners in the life history of activated fibroblast growth factor receptors.

Proteomics 2007 Dec;7(24):4565-78

CR-UK Growth Factor Group, School of Biosciences, University of Birmingham, Birmingham, UK.

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December 2007

Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors.

EMBO Rep 2007 Dec 2;8(12):1162-9. Epub 2007 Nov 2.

Cancer Research UK Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

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December 2007

The dynamics of signal triggering in a gp130-receptor complex.

Structure 2007 Apr;15(4):441-8

Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom.

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April 2007

Oncostatin M (OSM) cytostasis of breast tumor cells: characterization of an OSM receptor beta-specific kernel.

Cancer Res 2006 Nov;66(22):10891-901

Cancer Research UK Growth Factor Group, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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November 2006

Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development.

Dev Biol 2006 Sep 21;297(1):14-25. Epub 2006 Apr 21.

Section of Gene Function and Regulation, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

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September 2006

Residue-specific immobilization of protein molecules by size-selected clusters.

J R Soc Interface 2005 Jun;2(3):169-75

Nanoscale Physics Research Laboratory, School of Physics and Astronomy, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

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June 2005

Data-dependent electron capture dissociation FT-ICR mass spectrometry for proteomic analyses.

J Proteome Res 2005 Sep-Oct;4(5):1538-44

School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

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January 2006

The production of interleukin-11 and decidualization are compromised in endometrial stromal cells derived from patients with infertility.

J Clin Endocrinol Metab 2005 Mar 21;90(3):1607-12. Epub 2004 Dec 21.

Nuffield Department of Obstetrics and Gynecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

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March 2005

FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity.

J Cell Sci 2004 Dec;117(Pt 25):6007-17

CR-UK Growth Factor Group, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

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December 2004

Skeletal development is regulated by fibroblast growth factor receptor 1 signalling dynamics.

Development 2004 Jan 10;131(2):325-35. Epub 2003 Dec 10.

School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

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January 2004

Functional characterization of W147A: a high-affinity interleukin-11 antagonist.

Endocrinology 2003 Aug;144(8):3406-14

Cancer Research UK Growth Factor Group, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

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August 2003

Expression and function of interleukin-11 and its receptor alpha in the human endometrium.

Mol Hum Reprod 2003 Feb;9(2):75-80

Department of Obstretrics and Gynaecology, University of Oxford, Women's Centre, Level 3, John Radcliffe Hospital, UK.

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February 2003

Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst.

Mech Dev 2002 Dec;119(2):137-44

Nuffield Department of Obstetrics and Gynaecology, The Women's Centre, Level 3, John Radcliffe Hospital, University of Oxford, Headington, Oxford, OX3 9DU, UK.

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December 2002

An unexpected biochemical and functional interaction between gp130 and the EGF receptor family in breast cancer cells.

Oncogene 2002 Jan;21(3):460-74

The Rotary Bone Marrow Research Laboratories, PO Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia.

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January 2002