Publications by authors named "John K Brooks"

111 Publications

Paxlovid-associated dysgeusia.

Oral Dis 2022 Jul 13. Epub 2022 Jul 13.

Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1111/odi.14312DOI Listing
July 2022

Multiple miliary osteoma cutis, renal failure and secondary hyperparathyroidism in a geriatric patient.

Gerodontology 2022 Jun;39(2):213-217

Director of Oral and Maxillofacial Radiology, Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.

Introduction: Miliary osteoma cutis (MOC) is a cutaneous disorder that develops in response to an ill-defined process or following acne vulgaris. Most cases present incidentally as small radiographic aggregations of normal bone within the cheeks. Infrequently, MOC has been reported with systemic disease, including renal failure.

Case Presentation: An 82-year-old man presented with renal failure and secondary hyperparathyroidism. Intraoral radiographs displayed bilateral radiopacities. This is the first documented case of MOC synchronous with renal failure and secondary hyperparathyroidism in a geriatric patient.

Conclusions: Patients with MOC and manifestations associated with nephropathy should undergo a comprehensive medical work-up and laboratory studies. Timely recognition of incidental radiographic findings may improve clinical outcomes.
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http://dx.doi.org/10.1111/ger.12576DOI Listing
June 2022

Occult Mönckeberg medial calcinosis of the facial and infraorbital arteries in an elderly edentulous patient.

Spec Care Dentist 2022 Apr 1. Epub 2022 Apr 1.

Oral and Maxillofacial Radiology, Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, Maryland, USA.

Mönckeberg medial calcinosis (MMC) is a potentially serious vasculopathy involving calcification of the arterial tunica media of the extremities, heart, and other viscera. There are a limited number of cases reported in the dental literature, usually associated with the facial artery. Although MMC is often discerned as an occult radiologic finding in middle-aged adults, its presence may serve as a harbinger for end-stage renal disease, diabetes, other pathologic processes, and possible regional hypoperfusion. The objective of this report is to feature an elderly patient with MMC of the facial and infraorbital arteries. In addition, a brief review of published cases of MMC and its differential diagnosis have been provided. It is recommended that affected patients be referred for a comprehensive medical assessment. Timely discovery of calcified arteries may improve patient outcomes.
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http://dx.doi.org/10.1111/scd.12718DOI Listing
April 2022

Review of general and head and neck/oral and maxillofacial features of Charcot-Marie-Tooth disease and dental management considerations.

Oral Surg Oral Med Oral Pathol Oral Radiol 2022 06 25;133(6):e170-e177. Epub 2021 Dec 25.

Professor, Director of Clinical Genetics Service, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.

Charcot-Marie-Tooth disease (CMTD) is an uncommon progressive neuromuscular disorder of the peripheral nervous system and primarily leads to distal extremity weakness and sensory deficits. Frequently, affected patients manifest pes cavus, drop foot, and digit contractures that may pose significant challenges in ambulation and grasping objects. Although there are numerous articles of this syndrome in the medical literature, there is a limited number of dental publications. The objective of this article is to review the general and head and neck/oral and maxillofacial features of CMTD. General guidelines for dental management are also provided.
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http://dx.doi.org/10.1016/j.oooo.2021.12.125DOI Listing
June 2022

Face Mask Metal Nosepiece Artifact on Various Extraoral Radiologic Imaging Examinations Associated with the Covid-19 Pandemic.

Acad Radiol 2022 05 7;29(5):791-793. Epub 2022 Jan 7.

Department of Oncology and Diagnostic Sciences (J.K.B.), University of Maryland School of Dentistry, Room 7210, 650 West Baltimore Street, Baltimore, Maryland 21201; Staff Oral Surgeon (G.M.E.), Lifebridge Health, Bel Air, Maryland; Department of Oncology and Diagnostic Sciences (J.C.D.), University of Maryland School of Dentistry, Baltimore, Maryland; Director of Oral and Maxillofacial Radiology, Department of Oncology and Diagnostic Sciences (J.B.P.), University of Maryland School of Dentistry, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.acra.2021.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739012PMC
May 2022

Radiographic presentation of artifactual dyed hair on lateral cephalograms, chemical processing, and forensic application: Novel case report.

J Forensic Sci 2022 May 13;67(3):1274-1279. Epub 2022 Jan 13.

Director of Oral and Maxillofacial Radiology, Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.

Forensic assessment employs an array of methods to identify human remains. Radiologic examinations with panoramic radiographs, computed tomography scans, Waters view, and nuclear magnetic resonance imaging may offer evidentiary clues in challenging cases, such as mass disasters. In these cases, alternative forensic tools are used to narrow lists of target victims using their biological features. This study aims to I) report on the unusual radiographic aspect of chemicals used for hair dyeing, and II) discuss the potential forensic application of this finding for human identification. The case depicts an asymptomatic 14-years-old female who presented for orthodontic therapy. During radiographic examination on a lateral cephalogram, numerous thin radiopaque streaks were visible, extending to the posterior neck between the occipital region of the skull base and vertebra C6. Clinical investigations revealed that these were artifactual hair images (possibly documented for the first time in the scientific literature). Inductively coupled plasma mass spectrometry (ICP-MS) analysis of the patient's scalp hair was performed for 10 heavy metals, including zinc, copper, iron, chromium, nickel, cadmium, tin, lead, antimony, and bismuth. Eight of these metals were detected at normal levels, ranging from 160 parts per million (ppm) for zinc to less than 1 ppm for nickel, cadmium, tin, lead, and antimony. Conversely, slightly elevated levels of chromium at 0.41 ppm and bismuth at 0.025 ppm were found in the hair sample. The distinctive radiographic presentation of artifactual hair images combined with the chemical properties of hair exposed to dye products may provide useful traces for human identification, especially in mass disasters.
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http://dx.doi.org/10.1111/1556-4029.14971DOI Listing
May 2022

Prolonged facial mask wear is a concern for the development of dysbiotic microbiome.

Respir Med Res 2022 05 27;81:100877. Epub 2021 Nov 27.

Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1016/j.resmer.2021.100877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627006PMC
May 2022

Perioral and gingival hyperpigmentation secondary to cultural tattooing.

Int J Womens Dermatol 2021 Jun 27;7(3):365-366. Epub 2020 Nov 27.

Department of Medicine, European University of Madrid, Madrid, Spain.

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http://dx.doi.org/10.1016/j.ijwd.2020.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243163PMC
June 2021

What every dentist needs to know about electronic cigarettes.

Gen Dent 2021 May-Jun;69(3):31-35

Electronic cigarette (EC) use is on a steady rise, leading to increased concerns about its efficacy with regard to tobacco cessation goals and safety with regard to systemic and oral health. Recent studies have shown that EC flavoring agents can have adverse effects similar to those of combustible tobacco products. Evidence is mounting that EC use should not be considered a healthier alternative to tobacco smoking. The aerosols produced by ECs have been associated with respiratory, cardiac, and central nervous system disease as well as oral mucosal alterations. In addition, ECs can affect kidney and liver function. Their use has also resulted in EC explosions and burn injuries, some of which have been fatal. The aim of this article is to review the systemic and oral health concerns associated with EC use.
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April 2021

What every dentist needs to know about human papillomavirus.

Gen Dent 2021 Mar-Apr;69(2):23-27

Human papillomavirus (HPV) has a nearly ubiquitous prevalence within the adolescent and adult populations worldwide. The virus has been implicated for decades in cervical and uterine cancers, but recent data have shown an increase in cases of virally related oropharyngeal squamous cell carcinoma in both male and female cohorts. The objective of this article is to review the oral health implications of HPV infection, including oral and oropharyngeal prevalence, manifestations, neoplastic potential of HPV-associated head and neck lesions, treatment modalities, and vaccine use. The article will also discuss the continuing education needs of oral healthcare providers. Dental professionals should routinely screen patients for oral and oropharyngeal manifestations of HPV infection, seek timely referral for therapeutic intervention of potentially malignant lesions, and become strong proponents of HPV vaccinations for at-risk patients.
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March 2021

Concurrent giant sialoliths within the submandibular gland parenchyma and distal segment of Wharton's duct: Novel case report.

Gerodontology 2021 Dec 15;38(4):437-440. Epub 2021 Feb 15.

Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.

Objective: This article discusses the clinical significance of an unusual case of the simultaneous occurrence of 2 giant sialoliths within the ipsilateral submandibular gland and distal aspect of Wharton's duct in a 63-year-old patient.

Background: The majority of submandibular gland sialoliths are found in Wharton's duct, with fewer within the gland parenchyma. Giant sialoliths (exceeding 15 mm in size) are rare.

Materials And Methods: An asymptomatic, otherwise healthy older patient sought dental care and underwent a comprehensive oral and radiographic examination.

Results: A panoramic radiograph revealed 2 incidental radiopaque structures, representing giant sialoliths within the submandibular gland and along the distal segment of Wharton's duct. This synchronous finding apparently represents the first case reported in the geriatric literature.

Conclusions: The detection of 1 salivary stone should heighten the scrutiny for additional stones. Practitioners should carefully weigh the risk of sialolith removal versus deferment of treatment in older medically compromised patients.
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http://dx.doi.org/10.1111/ger.12544DOI Listing
December 2021

Odontoma associated with mandibular transmigrated canine in a geriatric patient: Second case report.

Gerodontology 2020 Dec;37(4):411-415

Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.

Objective: This report discusses the clinical relevance of a novel case of an odontoma and transmigrated canine in the setting of florid cemento-osseous dysplasia (COD), hypercementosis and moderate to severe periodontitis in a 66-year-old patient.

Background: An odontoma may infrequently impede tooth eruption and rarely has been implicated with canine transmigration. COD is a benign fibro-osseous lesion associated with decreased vascularity and poorer surgical intervention.

Materials And Methods: A partially edentulous woman, in no acute distress, underwent clinical and radiographic evaluation in pursuit of comprehensive dental care.

Results: Radiographic assessment demonstrated multiple occult pathologies of the mandible, including compound odontoma, canine transmigration, florid COD, hypercementosis and moderate to severe periodontitis, a concurrence thought to be previously unreported. Furthermore, the presence of the odontoma and transmigrated canine is apparently the second reported case in the geriatric population.

Conclusions: The attending clinician should carefully weigh removal of an impacted and transmigrated canine associated with an odontoma in the setting of COD and compromised bone, particularly in older individuals. When surgical intervention is deferred in these clinical situations, patients should continue to be monitored for clinical and radiographic development of pathologic processes.
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http://dx.doi.org/10.1111/ger.12495DOI Listing
December 2020

What every dentist should know about oral mucosal wound healing.

Gen Dent 2020 Nov-Dec;68(6):24-26

The oral mucosa has superior wound healing potential compared to other mucosal tissues. The objective of this article is to review the current state of evidence on the mechanisms that govern accelerated oral mucosal wound healing and explore clinical approaches that facilitate the natural course of these processes.
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December 2020

Giant sialolith and tonsillolith with ghost images: rare presentations.

Gen Dent 2020 Nov-Dec;68(6):18-22

Panoramic radiography is a useful screening tool for an array of dental and nonodontogenic disorders related to calcification as well as assessment of trauma and development of the oral and maxillofacial complex. Rotational movements of the radiographic source and detector plate may promote ghost image formation, particularly with larger radiopaque objects, and complicate the radiographic interpretation. This article describes cases of a giant submandibular gland sialolith and a giant tonsillolith, each of which appeared as a bilateral presentation due to contralateral ghost images, and discusses their clinical, demographic, and radiographic characteristics. Computed tomographic examinations were used to confirm the unilateral presentation of these objects and for determination of the extent of adjacent soft tissue impingement. Distinguishing an actual panoramic image from a ghost artifact may avoid unnecessary surgical intervention and improve clinical outcomes.
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December 2020

Central compact osteoma of the mandible: case report featuring unusual radiographic and computed tomographic presentations and brief literature review.

J Stomatol Oral Maxillofac Surg 2021 11 6;122(5):516-520. Epub 2020 Oct 6.

Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA. Electronic address:

Central osteomas of the jaws have been infrequently reported, mostly presenting as a well-defined opacity on conventional radiography projections and as a hyperdensity on computed tomography scans. To increase the knowledge of the phenotypic expression of gnathic central osteomas, an unusual case has been described, including the clinical, radiographic, cone beam computed tomography (CBCT) and histopathologic findings. The lesion was initially discovered 4 years prior as an asymptomatic ovoid radiolucency in the posterior mandible. A 25-year-old female presented with a hyperdense expansile mass with a hypodense rim on a CBCT scan. The enucleated mass was diagnosed as a compact central osteoma. A literature search has identified 4 other cases with similar hypodense borders on CT scans. We propose that a subset of central osteomas should be considered in the differential diagnosis of osteopathologies of the jaws with hyperdense internal architecture and hypodense borders, as seen on CT images.
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http://dx.doi.org/10.1016/j.jormas.2020.09.014DOI Listing
November 2021

Value of Performing Routine Vascular Mapping Synchronous with Radiographic Assessment of Endodontic Lesions: Case Series.

J Endod 2021 Jan 15;47(1):112-124. Epub 2020 Sep 15.

Department of Oncology and Diagnostic Sciences, University of Maryland, School of Dentistry, Baltimore, Maryland.

With the adoption of limited-volume cone beam computed tomographic (CBCT) imaging in dentistry, high resolution of the maxillomandibular complex has led to the recognition of numerous accessory neurovascular canals. The preoperative identification of these structures is essential to facilitate the safe performance of an assortment of invasive dental procedures; however, there is limited information in the endodontic literature regarding mapping of these neurovascular canals and their anatomic variants. To emphasize the utility of accessory neurovascular channel mapping in conjunction with endodontic therapy, we have presented the clinical findings of 4 diverse cases. Comprehensive evaluation of the CBCT scans showed relevant underlying etiopathologies, prompting clinical modifications that led to enhanced patient outcomes.
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http://dx.doi.org/10.1016/j.joen.2020.09.004DOI Listing
January 2021

What every dentist needs to know about obstructive sleep apnea.

Gen Dent 2020 Sep-Oct;68(5):30-34

Sleep apnea has 2 variants that are classified by their etiologic mechanism, namely, an obstructive or a central origin. Despite the clinical and scientific advancements in obstructive sleep apnea (OSA) over the past 20 years, a majority of affected patients remain undiagnosed. This article reviews aspects of unmanaged OSA, including the oral and maxillofacial signs and symptoms, systemic risk factors, diagnostic criteria, guidelines for patient referral to a sleep physician, and clinical management techniques. Additionally, the role of dentists in oral appliance therapy is explored.
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December 2020

What every dentist needs to know about clear aligners.

Gen Dent 2020 Jul-Aug;68(4):23-26

In recent years, the demand for esthetic orthodontic treatment options for adult patients has increased dramatically. Clear aligner therapy (CAT) has become a popular method of orthodontic therapy that now allows for comprehensive treatment with more complex dental movements. Moreover, the increasing role of technology in dental treatments has made CAT more appealing to providers and patients. The aim of this article is to highlight the clinical scope and limitations of CAT and to outline the differences among various clear aligner products.
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December 2020

Possible association of sialolithiasis with HIV infection and highly active antiretroviral therapy: A case report.

Spec Care Dentist 2020 May 11;40(3):298-302. Epub 2020 Mar 11.

Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, Maryland.

Although there appears to be an overall trend of diminishing oral manifestations of HIV infection, evidence is emerging on the increased incidence of concomitant parotid gland enlargement and xerostomia. Furthermore, several case narrations and a limited series have suggested a possible association of sialolithiasis with highly active antiretroviral therapy, mostly involving the parotid gland. The aim of this report is to present a patient with a giant sialolith of the submandibular gland following a 27-year intake of various antiretrovirals for HIV infection and review the relevant literature.
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http://dx.doi.org/10.1111/scd.12455DOI Listing
May 2020

Charcoal-based mouthwashes: a literature review.

Br Dent J 2020 02;228(4):290-294

Professor, Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, Maryland, USA.

The commercial marketplace has seen a rapid increase in the number of over-the-counter charcoal-containing mouthwashes. The purpose of this systemic review was to examine the clinical and laboratory evidence supporting therapeutic claims of efficacy and safety of use of charcoal-based mouthwashes. Secondly, the product labels and information of 36 commercially marketed charcoal mouthwashes were reviewed for active ingredients. Only 8% of charcoal mouthwashes contained an active ingredient, such as cetylpyridinium chloride or chlorhexidine. There is insufficient evidence to substantiate the therapeutic and cosmetic marketing claims of charcoal-based mouthwashes, including antimicrobial activity, anti-halitosis, tooth whitening, periodontal disease control, caries reduction and tooth remineralisation, among others. Moreover, there is no available information on charcoal particulate size or abrasivity of any of these products. Dental clinicians should advise their patients to exercise caution when using over-the-counter charcoal-containing mouthwashes because of the lack of evidence supporting therapeutic or cosmetic effectiveness as well as safety.
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http://dx.doi.org/10.1038/s41415-020-1265-8DOI Listing
February 2020

Face transplantation: general review and long-term management of the dental patient.

Quintessence Int 2020 ;51(4):334-342

Facial allotransplantation (FA) is an emerging alternative modality following severe loss of hard and soft tissues. Although there are vast numbers of publications on the surgical aspects of this technique, limited information is available in the literature with regard to the long-term dental care of affected patients following postoperative stabilization and return to their locally based clinical milieu. The objective of this report is to review patient demographics, etiologies, structural graft components, immunosuppressive strategies, donor tissue pathogenicity, neurologic recovery, potential complications, and present clinical guidelines for dental management. Additionally, a brief discussion of the preparation of the donor mask, and cutaneous and intraoral images of allograft rejection have been provided.
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http://dx.doi.org/10.3290/j.qi.a44143DOI Listing
March 2020

Autism Spectrum Disorder: Techniques for dental radiographic examinations.

J Dent Hyg 2019 Dec;93(6):35-41

Autism spectrum disorder (ASD) is associated with maldevelopment of the brain that leads to impaired communication and social interaction skills, possible cognitive decline, and an inability to cope with environmental stimuli. Affected individuals may also exhibit a myriad of stereotypic and maladaptive behaviors. With the increasing prevalence of ASD in the United States, oral healthcare professionals (OHCP) will encounter greater opportunities for patient interactions. There is limited information in the literature regarding ASD and dental radiography. The task of taking diagnostically acceptable radiographs on ASD-affected patients may be hindered by a lack of cooperative behavior, communication difficulties, and an incapacity to understand instructions. This report will review various ASD-related characteristics, comorbidities, and an assortment of general behavior guidance techniques (Picture Exchange Communication System, visual scheduling, social stories, first-then board, voice control, tell-show-do, electronic media devices, nonverbal communication, and desensitization). Guidelines for applying basic and advanced techniques for dental radiographic examinations will be discussed with the goal of improved patient interactions and positive outcomes.
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December 2019

Pathologic root migration secondary to vertical root fracture and full-coverage crowns: a report of 3 cases.

Gen Dent 2020 Jan-Feb;68(1):30-35

Occasionally, tooth fractures may demonstrate exaggerated pathologic root migration (PRM), often resulting in tooth loss. The early propagation of the root fracture may not be readily identifiable through clinical inspection and conventional radiographic imaging. Ultimately, increased root separation, isolated deep periodontal probing depth, and characteristic radiolucent changes may facilitate the diagnosis. This article describes 3 patients with unusual presentations of PRM in endodontically treated teeth restored with full-coverage crowns. One case illustrates the use of cone beam computed tomography for restorative assessment following root separation. Although it is efficacious to place crowns on most posterior endodontically treated teeth to maintain structural integrity, patients may remain at risk for catastrophic PRM and tooth loss. Timely extraction of teeth with hopeless PRM may minimize underlying bone resorption and the need for osseous regenerative procedures, ultimately improving the dental implant recipient site.
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January 2020

Subpontic Osseous Hyperplasia: Comprehensive Review of the Literature and Presentation of New Case History.

Int J Prosthodont 2019 Jul/Aug;32(4):339-344

Purpose: To increase awareness of subpontic osseous hyperplasia (SOH), an uncommon benign mass found underneath the pontics of fixed partial dentures (FPDs) and occasionally in implant-supported dental prostheses.

Materials And Methods: A PubMed search in the English-language literature was conducted for case reports and case series of SOH. Demographic information gleaned from these publications included patient age and gender, lesion sites, outcomes, comorbidities, symptomatology, and periodontal involvement. To exemplify the findings of SOH, a clinical investigation of a 73-year-old affected woman has been detailed.

Results/conclusion: With the inclusion of this featured case, 71 patients with 80 affected sites were identified with SOH and served as the basis for the provided database. To date, this aggregation of cases represents the largest collection to undergo clinicopathologic review. SOHs appeared as dome-shaped radiopacities and tended to exhibit increased osteosclerosis with increased duration. The average age at discovery was 57 years, and SOH was found somewhat more often in women. Lesions were more likely to occur in the left posterior mandible. Affected patients may experience increased difficulty maintaining adequate oral hygiene, potentially leading to periodontal disease or discomfort. Overgrowths should be surgically removed when satisfactory oral hygiene measures have been compromised, when there are atypical clinical or radiographic presentations, or with incident symptomatology.
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http://dx.doi.org/10.11607/ijp.6118DOI Listing
October 2019

Combination Nivolumab/Ipilimumab Immunotherapy For Melanoma With Subsequent Unexpected Cardiac Arrest: A Case Report and Review of Literature.

J Immunother 2019 10;42(8):313-317

Departments of Oncology and Diagnostic Sciences.

The success of immunotherapy in the treatment of patients with advanced melanoma has paved the way for unprecedented successes in the treatment of many other malignancies. We present a case of extensively metastatic oral mucosal melanoma that responded successfully to combined immune checkpoint blockade with ipilimumab and nivolumab but developed multiple immune-related adverse events, including myocarditis, a rare event associated with immunotherapy of elderly melanoma patients. Though the acute myocarditis was managed successfully, the patient succumbed to sudden cardiac death. This case highlights the fact, that autoimmune carditis must be considered when working up the sudden onset of shortness of breath in patients on immune checkpoint blockade. After controlling the acute myocarditis with high-dose steroids, which should be tapered over 6 weeks, further cardiology care is needed, and a defibrillator might have to be implanted. Understanding the pathophysiology of immune-related adverse events could make cancer immunotherapy both more effective and safer.
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http://dx.doi.org/10.1097/CJI.0000000000000282DOI Listing
October 2019

Factor V Leiden thrombophilia dental considerations.

Gen Dent 2019 May-Jun;67(3):21-24

Factor V Leiden thrombophilia, a relatively common inherited type of hypercoagulability resulting from a mutation in the gene for factor V, has received minimal attention in the dental literature. This review examines related demographic information, risk factors, comorbidities, the thrombotic mechanism, clinical features, diagnostic measures, and medical management strategies. In addition, oral and maxillofacial sequelae and management guidelines are provided. If a patient is known to have the mutation, the clinician should review the patient's potential risk factors for development of thrombosis and ascertain whether any coagulation agents are currently being administered. The practitioner should be prepared to manage instances of prolonged bleeding. The dentist also should be aware of an overall increased risk of systemic thromboembolic events, particularly following head and neck trauma. Rarely, the factor V Leiden mutation has been associated with osteonecrosis of the jaw, usually concurrent with intake of sex hormones.
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November 2019

Florid hypercementosis synchronous with periodontitis: a case report.

Quintessence Int 2019 ;50(6):478-485

Excessive cementum formation, referred to as hypercementosis (HC), is an uncommon nonneoplastic process that principally occurs with permanent teeth. Widespread tooth involvement has been confined mostly to Paget disease of bone. Only a limited number of reports of HC coincident with periodontitis has appeared in the literature. The aim of this article is to present the clinical, radiographic, and histopathologic findings of a 44-year-old female with moderate to severe periodontitis synchronous with 22 HC-affected teeth. A list of other etiologies associated with HC is provided.
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http://dx.doi.org/10.3290/j.qi.a42481DOI Listing
November 2019

Botulinum toxin: a review of applications for the head and neck.

Gen Dent 2019 Mar-Apr;67(2):55-58

Botulinum toxin (BTX) is a popular cosmetic therapy administered by both dentists and physicians. The ability of the toxin to locally paralyze muscles has led to the use of BTX as a potential therapy for a variety of medical conditions. This article will discuss the current head and neck applications of BTX. In addition, a brief review of other potential clinical benefits is provided.
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November 2019

What every dentist needs to know about liquid biopsies.

Gen Dent 2019 Mar-Apr;67(2):31-33

Integral components of the examination of the oral and maxillofacial region include the early detection of benign and malignant lesions and recognition of manifestations of systemic disorders. The gold standard for establishing a diagnosis has entailed excision of tissue and submission to a laboratory for histopathologic review or, to a lesser extent, microcollection of cells via a fine-needle aspiration biopsy. A revolutionary technology in the medical and dental fields, referred to as a liquid biopsy, involves the harvesting of fragments of DNA or RNA for surveillance of an array of pathological processes from various body fluids, such as blood, plasma, and saliva. This article provides an overview of this developing diagnostic field.
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November 2019
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