John J P Kastelein

John J P Kastelein

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John J P Kastelein

Publications by authors named "John J P Kastelein"

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Moving Targets: Recent Advances in Lipid-Lowering Therapies

Arterioscler Thromb Vasc Biol 2019 03;39(3):349-359

From the Department of Vascular Medicine, Amsterdam University Medical Center, The Netherlands.

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http://dx.doi.org/10.1161/ATVBAHA.118.312028DOI Listing
March 2019

Mendelian Randomization Study of and Cardiovascular Disease.

N Engl J Med 2019 03;380(11):1033-1042

From the Centre for Naturally Randomized Trials (B.A.F., T.B.F.), Medical Research Council, British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (B.A.F., S.B., C.O.-W., A.M.W., A.S.B., E.D.A., J.D.), Medical Research Council Biostatistics Unit (S.B.), and NIHR Blood and Transplant Research Unit in Donor Health and Genomics (A.S.B., E.D.A., J.D.), University of Cambridge, Cambridge, and Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, School of Public Health, Imperial College London, London (K.K.R.) - all in the United Kingdom; the Department of Pharmacologic and Biomolecular Sciences, University of Milan and Multimedica IRCCS, Milan (A.L.C.); Michigan State University, East Lansing (D.R.N.); the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (J.J.P.K.); and Monash University, Clayton, VIC, Australia (S.J.N.).

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http://www.nejm.org/doi/10.1056/NEJMoa1806747
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http://dx.doi.org/10.1056/NEJMoa1806747DOI Listing
March 2019

FISHing for the Miracle of Eicosapentaenoic Acid.

N Engl J Med 2019 01 16;380(1):89-90. Epub 2018 Nov 16.

From the Academic Medical Center, University of Amsterdam, Amsterdam.

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http://www.nejm.org/doi/10.1056/NEJMe1814004
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http://dx.doi.org/10.1056/NEJMe1814004DOI Listing
January 2019

Inclisiran Lowers LDL-C and PCSK9 Irrespective of Diabetes Status: The ORION-1 Randomized Clinical Trial.

Diabetes Care 2019 01 28;42(1):173-176. Epub 2018 Nov 28.

Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, Imperial College London, London, U.K.

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http://dx.doi.org/10.2337/dc18-1491DOI Listing
January 2019

Safety and efficacy of mipomersen in patients with heterozygous familial hypercholesterolemia.

Atherosclerosis 2019 Jan 10;280:109-117. Epub 2018 Nov 10.

Sections of Cardiology and Cardiovascular Research, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.11.017DOI Listing
January 2019

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC).

Atherosclerosis 2018 10;277:234-255

Imperial Centre for Cardiovascular Disease Prevention (ICCP), Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.08.051DOI Listing
October 2018

Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins.

Circulation 2018 Sep;138(13):1304-1316

Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, the Netherlands (R.M.S., J.J.P.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034710DOI Listing
September 2018

Relationship of lipoprotein-associated apolipoprotein C-III with lipid variables and coronary artery disease risk: The EPIC-Norfolk prospective population study.

J Clin Lipidol 2018 Nov - Dec;12(6):1493-1501.e11. Epub 2018 Aug 29.

Vascular Medicine Program, Sulpizio Cardiovascular Center, Division of Cardiology, Department of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2018.08.010DOI Listing
August 2018

Efficacy of alirocumab in 1191 patients with a wide spectrum of mutations in genes causative for familial hypercholesterolemia.

J Clin Lipidol 2017 Nov - Dec;11(6):1338-1346.e7. Epub 2017 Sep 4.

Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2017.08.016DOI Listing
July 2018

Proprotein convertase subtilisin/kexin type 9: from genetics to clinical trials.

Curr Opin Cardiol 2018 05;33(3):269-275

Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/HCO.0000000000000517DOI Listing
May 2018

Homozygous familial hypercholesterolaemia: light at the end of the tunnel.

Eur Heart J 2018 Apr;39(14):1169-1171

Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/eurheartj/ehx438DOI Listing
April 2018

Icosabutate, a Structurally Engineered Fatty Acid, Improves the Cardiovascular Risk Profile in Statin-Treated Patients with Residual Hypertriglyceridemia.

Cardiology 2016 4;135(1):3-12. Epub 2016 May 4.

Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000445047DOI Listing
January 2018

Plasma lipoprotein(a) levels in patients with homozygous autosomal dominant hypercholesterolemia.

J Clin Lipidol 2017 Mar - Apr;11(2):507-514. Epub 2017 Feb 27.

Department of Internal Medicine, Erasmus Medical Centre, Erasmus University of Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jacl.2017.02.010DOI Listing
January 2018

Alirocumab efficacy in patients with double heterozygous, compound heterozygous, or homozygous familial hypercholesterolemia.

J Clin Lipidol 2018 Mar - Apr;12(2):390-396.e8. Epub 2017 Dec 28.

Department of Molecular Medicine, 'Sapienza' University of Rome, Umberto I Hospital, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2017.12.008DOI Listing
December 2017

Children with hypercholesterolemia of unknown cause: Value of genetic risk scores.

J Clin Lipidol 2016 Jul-Aug;10(4):851-859. Epub 2016 Mar 21.

Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.jacl.2016.02.017DOI Listing
October 2017

Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia.

J Clin Lipidol 2016 Jul-Aug;10(4):1011-1021. Epub 2016 May 9.

London School of Hygiene & Tropical Medicine, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2016.04.013DOI Listing
October 2017

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.

N Engl J Med 2017 09 27;377(12):1119-1131. Epub 2017 Aug 27.

From the Center for Cardiovascular Disease Prevention (P.M.R., B.M.E., J.G.M., R.J.G.) and the Cardiovascular Division (P.M.R., B.M.E., P.L.), Brigham and Women's Hospital, Harvard Medical School, Boston; Novartis, East Hanover, NJ, and Basel, Switzerland (T.T., W.H.C.); Baylor College of Medicine, Houston (C.B.); Federal University of São Paulo (F.F.) and the Heart Institute (InCor), University of São Paulo Medical School (J.N.), São Paulo, and Faculdade Evangelica de Medicina do Parana, Curitiba (P.R.F.R.) - all in Brazil; Deutsches Herzzentrum München, Technische Universität München, German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich (W.K.), and the Department of Cardiology and Berlin-Brandenburg Center for Regenerative Therapies, Charité Campus Virchow Klinikum, Universitätsmedizin Berlin, Berlin (S.D.A.) - both in Germany; Academic Medical Center of the University of Amsterdam, Amsterdam (J.J.P.K.), Alkmaar Medical Center, Alkmaar (J.H.C.), and VieCuri Medical Center for Northern Limburg, Venlo (R.P.T.T.) - all in the Netherlands; Manipal Hospital, St. John's Research Institute, Bangalore, India (P.P.); Pavol Jozef Safarik University, Kosice, Slovakia (D.P.); McGill University, Montreal (J.G.); First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic (R.C.); Cordoba Hospital, Cordoba, Argentina (A.L.); University of Szeged, Szeged, Hungary (T.F.); City Hospital No. 64, Medical Institute RUDN University, Moscow (Z.K.); Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania (L.V.-S.); University of East Anglia, Norwich Medical School, Norwich, United Kingdom (M.F.); Tohoku University Hospital, Sendai (H.S.), and National Cerebral and Cardiovascular Center, Osaka (H.O.) - both in Japan; and Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden (M.D.).

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http://dx.doi.org/10.1056/NEJMoa1707914DOI Listing
September 2017

Novel lipid modifying drugs to lower LDL cholesterol.

Curr Opin Lipidol 2017 Aug;28(4):367-373

Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/MOL.0000000000000428DOI Listing
August 2017

Dyslipidaemia: Statin-associated muscle symptoms - really all in the mind?

Nat Rev Cardiol 2017 08 15;14(8):445-446. Epub 2017 Jun 15.

Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nrcardio.2017.92DOI Listing
August 2017

Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children With Heterozygous Familial Hypercholesterolemia: The CHARON Study (Hypercholesterolemia in Children and Adolescents Taking Rosuvastatin Open Label).

Circulation 2017 Jul 7;136(4):359-366. Epub 2017 Jun 7.

From Department of Vascular Medicine (M.J.A.M.B., D.M.K., J.J.P.K.), Department of Pediatrics (M.J.A.M.B., A.W.), and Department of Clinical Epidemiology, Biostatistics and Bioinformatics (B.A.H.), Academic Medical Center, Amsterdam, the Netherlands; Lipid Clinic, Medical Department, Oslo University Hospital, Norway (G.L.); Department of Pediatrics, University of Toronto, Labatt Family Health Center, The Hospital for Sick Children, Ontario, Canada (B.W.M.); Department of Hepatology and Metabolic Center, University Hospitals Leuven, Belgium (D.C.); Healthy Heart Program Prevention Clinic, St. Paul's Hospital, Vancouver, British Columbia, Canada (G.A.F.); Department of Medicine, University of British Columbia, Vancouver, Canada (G.A.F.); Clinique des Maladies Lipidiques de Québec Inc, Québec, QC, Canada (C.G.); Department of Medicine, Université de Montréal, Montréal, Québec, Canada (D.G.); Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada (K.M.M.); Metabolic & Atherosclerosis Research Center, Cincinnati, OH (T.T., E.A.S.); AstraZeneca Pharmaceuticals LP, Wilmington, DE (E.M., J.S.R.); and AstraZeneca, Macclesfield, Cheshire, United Kingdom (P.D.M.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.025158DOI Listing
July 2017

Can we afford not to screen for FH?

Eur Heart J 2017 06;38(23):1840-1842

Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/eurheartj/ehx197DOI Listing
June 2017

Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study.

Arterioscler Thromb Vasc Biol 2017 06 4;37(6):1206-1212. Epub 2017 May 4.

From the Department of Vascular Medicine (J.C.v.C., S.J.B.M., J.J.P.K., E.S.G.S., G.K.H.), Department of Clinical Epidemiology and Biostatistics (A.H.Z.), and Department of Cardiology (S.M.B.), Academic Medical Center, Amsterdam, The Netherlands; Vascular Medicine Program, Division of Cardiology (X.Y., S.T.) and Division of Endocrinology and Metabolism (J.L.W.), Department of Medicine, University of California San Diego, La Jolla; Medical Research Council Epidemiology Unit, Cambridge, United Kingdom (N.J.W.); and Department of Public Health and Primary Care, University of Cambridge, United Kingdom (K.-T.K.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484077PMC
June 2017

Effect of alirocumab dose increase on LDL lowering and lipid goal attainment in patients with dyslipidemia.

Coron Artery Dis 2017 May;28(3):190-197

aDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands bThe Christ Hospital, Heart and Vascular Center/The Lindner Research Center, Cincinnati, Ohio cHarvard Clinical Research Institute, Boston, Massachusetts dLouisville Metabolic and Atherosclerosis Research Center (L-MARC), Louisville, Kentucky eSanofi, Bridgewater, New Jersey fRegeneron Pharmaceuticals Inc., Tarrytown, New York, USA gBiostatistics and Programming, Sanofi, Chilly-Mazarin hPoint Médical, Dijon, France.

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http://dx.doi.org/10.1097/MCA.0000000000000438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400401PMC
May 2017

Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab.

N Engl J Med 2017 04 17;376(16):1517-1526. Epub 2017 Mar 17.

From Brigham and Women's Hospital, Harvard Medical School, Boston (P.M.R., R.J.G., L.M.R.); Montreal Heart Institute, Université de Montréal, Montreal (J.-C.T.); Pierre et Marie Curie University, Paris (P.A.); Pfizer, New York (W.D., A.M.K., J.R., P.F.S., C.L.S., C.Y.); Leiden University Medical Center, Leiden (J.W.J.), and Academic Medical Center of the University of Amsterdam, Amsterdam (J.J.P.K.) - both in the Netherlands; Deutsches Herzzentrum München, Technische Universität München, DZHK (German Center for Cardiovascular Research), Munich Heart Alliance, Munich, Germany (W.K.); Cleveland Clinic Foundation, Cleveland (S.N.); and the Lipid Clinic Heart Institute, University of São Paulo Medical School Hospital, São Paulo (R.D.S.).

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http://dx.doi.org/10.1056/NEJMoa1614062DOI Listing
April 2017

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.

N Engl J Med 2017 04 17;376(16):1527-1539. Epub 2017 Mar 17.

From Brigham and Women's Hospital and Harvard Medical School, Boston (P.M.R., R.J.G.); Pfizer, New York (J.R., R.B., M.C., U.M., P.F.S., C.Y., C.L.S.); Paris-Diderot, Sorbonne Paris Cité University, Paris (P.A.); Universidad de Zaragoza, IIS Aragon, Zaragoza, Spain (F.C.); University of East Anglia, Norwich (M.F.), and Central Manchester University Hospital, Manchester (H.S.) - both in the United Kingdom; the Montreal Heart Institute, Université de Montréal, Montreal (J.G., J.-C.T.); Leiden University Medical Center, Leiden (J.W.J.), Academic Medical Center of the University of Amsterdam, Amsterdam (J.J.P.K.), and Meander Medical Center, Amersfoort (A.M.) - all in the Netherlands; Russian Cardiology Research and Production Center, Moscow (Y.K.); Deutsches Herzzentrum München, Technische Universität München, Munich Heart Alliance, Munich, Germany (W.K.); Cordoba Hospital, Cordoba, Argentina (A.L.); University of the Witwatersrand, Johannesburg (P.M.); University of Maryland, Baltimore (M.M.); University of Comenius, Bratislava, Slovakia (J.M.); Heart Institute, University of São Paulo Medical School (J.C.N.), and Lipid Clinic Heart Institute, University of São Paulo Medical School Hospital (R.D.S.), São Paulo; Cleveland Clinic Foundation, Cleveland (S.N.); Wroclaw Medical University, Wroclaw, Poland (P.P.); Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand (H.W.); Mayo Clinic, Rochester, MN (R.S.W.); and First Faculty of Medicine, Charles University, Prague, Czech Republic (M.V.).

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http://dx.doi.org/10.1056/NEJMoa1701488DOI Listing
April 2017

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol.

N Engl J Med 2017 04 17;376(15):1430-1440. Epub 2017 Mar 17.

From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.), and Knowle House Surgery, Plymouth (T.H.) - both in the United Kingdom; the Department of Cardiology, Charité-Universitätsmedizin Berlin, Berlin Institute of Health and German Center for Cardiovascular Research, Berlin (U.L.), and University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg (M.K.) - all in Germany; the Division of Endocrinology and Metabolism, Li Ka Shing Knowledge Institute and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, Toronto (L.A.L.); the Medicines Company, Parsippany, NJ (D.K., P.W.); Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal (R.D.); the Department of Cardiology and Interventional Cardiology, VieCuri Medical Center for Northern Limburg, Venlo (R.P.T.T.), University Medical Center, Utrecht (F.L.J.V.), and the Department of Vascular Medicine, Academic Medical Center-University of Amsterdam, Amsterdam (J.J.P.K.) - all in the Netherlands; the Metabolic and Atherosclerosis Research Center, Medpace, Cincinnati (T.T.); and the Department of Cardiology, Mayo Clinic, Rochester, MN (R.S.W.).

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http://dx.doi.org/10.1056/NEJMoa1615758DOI Listing
April 2017

Safety of Very Low Low-Density Lipoprotein Cholesterol Levels With Alirocumab: Pooled Data From Randomized Trials.

J Am Coll Cardiol 2017 Feb;69(5):471-482

Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2016.11.037DOI Listing
February 2017

Molecular basis of familial hypercholesterolemia.

Curr Opin Cardiol 2017 Feb 4. Epub 2017 Feb 4.

Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/HCO.0000000000000385DOI Listing
February 2017

Time to change the SCORE?

Eur Heart J 2017 02;38(8):595-597

Department of Vascular Medicine, Academic Medical Center, University of AmsterdamAmsterdam, The Netherlands.

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http://dx.doi.org/10.1093/eurheartj/ehw428DOI Listing
February 2017

Carriers of the PCSK9 R46L Variant Are Characterized by an Antiatherogenic Lipoprotein Profile Assessed by Nuclear Magnetic Resonance Spectroscopy-Brief Report.

Arterioscler Thromb Vasc Biol 2017 01 17;37(1):43-48. Epub 2016 Nov 17.

From the Department of Vascular Medicine (R.V., G.K.H., J.J.P.K.) and Department of Cardiology (S.M.B.), Academic Medical Centre, Amsterdam, The Netherlands; Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Canada (M.B., B.J.A.); Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada (M.B., B.J.A.); Medical Research Council Epidemiology Unit, Cambridge, United Kingdom (N.W.); and Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom (K.-T.K.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284798PMC
January 2017

LOWER, a registry of lomitapide-treated patients with homozygous familial hypercholesterolemia: Rationale and design.

J Clin Lipidol 2016 Mar-Apr;10(2):273-82. Epub 2015 Dec 1.

Department of Medicine, New York University Langone Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1016/j.jacl.2015.11.011DOI Listing
December 2016

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.

J Med Genet 2016 12 1;53(12):835-845. Epub 2016 Sep 1.

Department of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, California, USA.

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http://dx.doi.org/10.1136/jmedgenet-2016-103966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309131PMC
December 2016

Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial Infarction: The AEGIS-I Trial (ApoA-I Event Reducing in Ischemic Syndromes I).

Circulation 2016 Dec 15;134(24):1918-1930. Epub 2016 Nov 15.

From PERFUSE Study Group, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical, Harvard Medical School, Boston, MA (C.M.G., S.K., Y.D., M.Y., P.J.); Duke Clinical Research Institute, Cardiovascular Division, Department of Medicine, Duke University Health, Durham, NC (P.T., J.H.A.); INSERM-Unité 1148, France Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, France Université Paris-Diderot, Sorbonne- Paris Cité, France National Heart and Lung Institute, Paris, France (P.G.S.); Imperial College London, UK Institute of Cardiovascular Medicine and Science, and Royal Brompton Hospital, London, UK (P.G.S.); Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH (A.M.L.); Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands (J.J.P.K.); Cardiovascular Institute, Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai, New York (R.M.); CSL Behring, LLC, King of Prussia, PA (D.M.D., L.I.D.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Department of Cardiology, Warsaw Medical University, Warsaw, Poland (M.Z.); Department of Cardiology, Canisius Wilhelmina Ziekenhuis, Nijmegen, the Netherlands (T.O.O.); and Department of Medicine, Stanford University, Stanford, CA (R.A.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.025687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147036PMC
December 2016

Determining When to Add Nonstatin Therapy: A Quantitative Approach.

J Am Coll Cardiol 2016 Dec;68(22):2412-2421

Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Chapel Hill, North Carolina.

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https://linkinghub.elsevier.com/retrieve/pii/S07351097163641
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http://dx.doi.org/10.1016/j.jacc.2016.09.928DOI Listing
December 2016

Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration.

Atheroscler Suppl 2016 Dec 7;22:1-32. Epub 2016 Dec 7.

Imperial Centre for Cardiovascular Disease Prevention (ICCP), School of Public Health, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.atherosclerosissup.2016.10.001DOI Listing
December 2016

Icosabutate for the treatment of very high triglycerides: A placebo-controlled, randomized, double-blind, 12-week clinical trial.

J Clin Lipidol 2016 Jan-Feb;10(1):181-91.e1-2. Epub 2015 Nov 14.

Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2015.10.012DOI Listing
November 2016

Distribution of Estimated 10-Year Risk of Recurrent Vascular Events and Residual Risk in a Secondary Prevention Population.

Circulation 2016 Nov 28;134(19):1419-1429. Epub 2016 Sep 28.

From Department of Vascular Medicine (L.K., J.W., F.L.J.V.), Julius Centre for Health Sciences and Primary Care (Y.v.d.G.), Department of Cardiology (M.J.M.C.), Department of Neurology (L.J.K.), and Department of Vascular Surgery (G.J.d.B.), University Medical Centre Utrecht, the Netherlands; Departments of Cardiology (S.M.B., R.J.G.P.) and Vascular Medicine (J.J.P.K.), Academic Medical Centre, Amsterdam, the Netherlands; School of Public Health, Imperial College London, United Kingdom (K.K.R.); Department of Neurology and Stroke Center, Bichat University Hospital, Paris, France (P.A.); and SUNY Health Science Center at Brooklyn, New York, NY (J.C.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.021314DOI Listing
November 2016

Diagnosis and Management of Individuals With Heterozygous Familial Hypercholesterolemia: Too Late and Too Little.

Circulation 2016 Sep;134(10):710-2

From Department of Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023942DOI Listing
September 2016

Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution.

Atherosclerosis 2016 07 23;250:63-8. Epub 2016 Apr 23.

Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907838PMC
July 2016

Statins in Familial Hypercholesterolemia: Consequences for Coronary Artery Disease and All-Cause Mortality.

J Am Coll Cardiol 2016 07;68(3):252-260

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2016.04.054DOI Listing
July 2016

Impact of PCSK9 inhibition on coronary atheroma progression: Rationale and design of Global Assessment of Plaque Regression with a PCSK9 Antibody as Measured by Intravascular Ultrasound (GLAGOV).

Am Heart J 2016 Jun 17;176:83-92. Epub 2016 Feb 17.

Cleveland Clinic Coordinating Center for Clinical Research (C5R), Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH; Department of Medicine, University of Adelaide, Adelaide, Australia; South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ahj.2016.01.019DOI Listing
June 2016

The impact of statin therapy on plasma levels of von Willebrand factor antigen. Systematic review and meta-analysis of randomised placebo-controlled trials.

Thromb Haemost 2016 Mar 3;115(3):520-32. Epub 2015 Dec 3.

Prof. Maciej Banach, MD, PhD, FNLA, FAHA, FESC; FASA, Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, 90-549 Lodz, Poland, Tel.: +48 42 639 37 71, Fax: +48 42 639 37 71, E-mail:

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http://dx.doi.org/10.1160/TH15-08-0620DOI Listing
March 2016

Clinical phenotype in relation to the distance-to-index-patient in familial hypercholesterolemia.

Atherosclerosis 2016 Mar 25;246:1-6. Epub 2015 Dec 25.

Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.12.033DOI Listing
March 2016

Population pharmacokinetics of rosuvastatin in pediatric patients with heterozygous familial hypercholesterolemia.

Eur J Clin Pharmacol 2016 Jan 21;72(1):19-27. Epub 2015 Sep 21.

AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK.

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http://dx.doi.org/10.1007/s00228-015-1946-4DOI Listing
January 2016

Effects of aliskiren in diabetic and non-diabetic patients with coronary artery disease: Insights from AQUARIUS.

Atherosclerosis 2015 Dec 20;243(2):553-9. Epub 2015 Oct 20.

Department of Medicine, University of Adelaide, Adelaide, Australia; South Australian Health and Medical Research Institute, Adelaide, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.10.019DOI Listing
December 2015

What does the future hold for cholesteryl ester transfer protein inhibition?

Curr Opin Lipidol 2015 Dec;26(6):526-35

aCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de QuébecbDepartment of Medicine, Faculty of Medicine, Université Laval, Québec, CanadacDepartment of Vascular Medicine, Academic Medical Center, AmsterdamdDezima Pharma BV, Naarden, the Netherlands.

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http://pdfs.journals.lww.com/co-lipidology/2015/12000/What_d
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MOL.0000000000000248DOI Listing
December 2015

PCSK9 inhibition: the way forward in the treatment of dyslipidemia.

BMC Med 2015 Oct 12;13:258. Epub 2015 Oct 12.

Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, PO Box 22660, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands.

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http://dx.doi.org/10.1186/s12916-015-0503-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601145PMC
October 2015

Association between statin use and plasma D-dimer levels. A systematic review and meta-analysis of randomised controlled trials.

Thromb Haemost 2015 Aug 28;114(3):546-57. Epub 2015 May 28.

Prof. Maciej Banach, MD, PhD, FNLA, FAHA, FESC; FASA, Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113; 90-549 Lodz, Poland, Tel.: +48 42 639 37 71, Fax: +48 42 639 37 71, E-mail:

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http://dx.doi.org/10.1160/TH14-11-0937DOI Listing
August 2015

Efficacy and Safety of Pitavastatin in Children and Adolescents at High Future Cardiovascular Risk.

J Pediatr 2015 Aug 6;167(2):338-43.e5. Epub 2015 Jun 6.

Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jpeds.2015.05.006DOI Listing
August 2015

Gonadal steroids, gonadotropins and DHEAS in young adults with familial hypercholesterolemia who had initiated statin therapy in childhood.

Atherosclerosis 2015 Aug 3;241(2):427-32. Epub 2015 Jun 3.

Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.05.034DOI Listing
August 2015

Screening and treatment of familial hypercholesterolemia - Lessons from the past and opportunities for the future (based on the Anitschkow Lecture 2014).

Atherosclerosis 2015 Aug 9;241(2):597-606. Epub 2015 Jun 9.

Department of Vascular Medicine, Academic Medical Center, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.06.011DOI Listing
August 2015

Is Cholesteryl Ester Transfer Protein Inhibition an Effective Strategy to Reduce Cardiovascular Risk? CETP Inhibition as a Strategy to Reduce Cardiovascular Risk: The Pro Case.

Circulation 2015 Aug;132(5):423-32

From Centre for Vascular Research, University of New South Wales, Sydney, Australia (P.J.B., K.-A.R.); South Australian Health and Medical Research Institute, University of Adelaide, South Australia (S.J.N.); Academic Medical Center, Amsterdam, The Netherlands (J.J.P.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.014025DOI Listing
August 2015

PCSK9 Inhibitors and Cardiovascular Events.

N Engl J Med 2015 08;373(8):774

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http://dx.doi.org/10.1056/NEJMc1508222DOI Listing
August 2015

Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study.

Lancet Diabetes Endocrinol 2015 Jul 27;3(7):507-13. Epub 2015 May 27.

Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22138587150012
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http://dx.doi.org/10.1016/S2213-8587(15)00126-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648056PMC
July 2015

Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia.

N Engl J Med 2015 Jul;373(5):438-47

From the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Chicoutimi, QC, Canada (D.G., D.B., K.T.); Isis Pharmaceuticals, Carlsbad (V.J.A., B.F.B., W.S., R.S.G., S.G.H., N.J.V., M.J.G., R.M.C.), and the Department of Medicine, University of California, San Diego, La Jolla (J.L.W.) - both in California; the Department of Medicine, University of Washington, Seattle (J.D.B.); and the Department of Vascular Medicine, Academic Medical Center, Amsterdam (J.J.P.K.).

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http://dx.doi.org/10.1056/NEJMoa1400283DOI Listing
July 2015

Homozygous autosomal dominant hypercholesterolaemia: prevalence, diagnosis, and current and future treatment perspectives.

Curr Opin Lipidol 2015 Jun;26(3):200-9

aDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands bDepartment of Molecular Medicine, Extracorporeal Therapeutic Techniques Unit - Lipid Clinic and Atherosclerosis Prevention Centre, 'Sapienza' University of Rome, Rome, Italy.

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http://dx.doi.org/10.1097/MOL.0000000000000179DOI Listing
June 2015

Efficacy and safety of alirocumab in reducing lipids and cardiovascular events.

N Engl J Med 2015 Apr 15;372(16):1489-99. Epub 2015 Mar 15.

From the University of Iowa, Iowa City (J.G.R.); Point Médical, Dijon (M.F.), Centre Hospitalier Universitaire de Nantes-Hôpital Nord Laennec, Saint-Herblain (M.K.), University Hospital of Lille, Lille (G. Luc), and Sanofi, Chilly-Mazarin (C.L.) - all in France; Clinique des Maladies Lipidiques de Québec, Quebec, QC, Canada (J.B.); Università di Palermo-Policlinico P. Giaccone, Palermo, Italy (M.A.); the Department of Vascular Medicine, Academic Medical Center, Amsterdam (E.S.S., J.J.P.K.); Lipid Clinic, Oslo University Hospital, Oslo (G. Langslet); University of the Witwatersrand, Johannesburg (F.J.R.); Cardiovascular Center of Sarasota, Sarasota (M.E.S.), and Jacksonville Center for Clinical Research, Jacksonville (M.J.K.) - both in Florida; Westside Medical Associates of Los Angeles, Beverly Hills, CA (N.E.L.); Regeneron Pharmaceuticals, Tarrytown, NY (R.P.); and Sanofi, Bridgewater, NJ (U.C.).

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http://dx.doi.org/10.1056/NEJMoa1501031DOI Listing
April 2015

Association between familial hypercholesterolemia and prevalence of type 2 diabetes mellitus.

JAMA 2015 Mar;313(10):1029-36

Department of Vascular Medicine, Academic Medical Centre, Amsterdam, the Netherlands.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2015.1206DOI Listing
March 2015