Publications by authors named "John Isaacs"

317Publications

Immunogenicity of biologic agents in rheumatology.

Nat Rev Rheumatol 2020 Dec 14. Epub 2020 Dec 14.

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

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December 2020

Why remission is not enough: underlying disease mechanisms in RA that prevent cure.

Nat Rev Rheumatol 2020 Dec 10. Epub 2020 Dec 10.

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

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December 2020

Overcoming stromal barriers to immuno-oncological responses via fibroblast activation protein-targeted therapy.

Immunotherapy 2021 Feb 5;13(2):155-175. Epub 2020 Nov 5.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University, Baltimore, MD 21287, USA.

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February 2021

Pharmacogenetics of TNF inhibitor response in rheumatoid arthritis utilizing the two-component disease activity score.

Pharmacogenomics 2020 11 30;21(16):1151-1156. Epub 2020 Oct 30.

NIHR Manchester Biomedical Research Center, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Center, Manchester, M13 9WL, UK.

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November 2020

Basic Mechanisms of JAK Inhibition.

Mediterr J Rheumatol 2020 Jun 11;31(Suppl 1):100-104. Epub 2020 Jun 11.

Translational and Clinical Research Institute, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.

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June 2020

Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition: An early phase trial.

Medicine (Baltimore) 2020 Jun;99(26):e20458

Translational and Experimental Medicine Institute, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne.

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June 2020

Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities.

Lancet Respir Med 2020 08 16;8(8):822-830. Epub 2020 Jun 16.

Centre for Inflammation and Tissue Repair, Division of Medicine, University College London, London, UK. Electronic address:

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August 2020

Smart battles: immunosuppression versus immunomodulation in the inflammatory RMDs.

Ann Rheum Dis 2020 08 11;79(8):991-993. Epub 2020 Jun 11.

Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany.

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August 2020

Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission.

Ther Adv Musculoskelet Dis 2020 11;12:1759720X20915322. Epub 2020 May 11.

Musculoskeletal Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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May 2020

Latent Class Trajectory Modeling of 2-Component Disease Activity Score in 28 Joints Identifies Multiple Rheumatoid Arthritis Phenotypes of Response to Biologic Disease-Modifying Antirheumatic Drugs.

Arthritis Rheumatol 2020 10 6;72(10):1632-1642. Epub 2020 Sep 6.

Versus Arthritis Centre for Genetics and Genomics, University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, and Manchester Academic Health Science Centre, Manchester, UK.

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October 2020

Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress.

Cell Rep 2020 05;31(8):107669

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Urology, University of Washington, Seattle, WA 98195, USA. Electronic address:

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May 2020

In search of pathobiological endotypes: a systems approach to early rheumatoid arthritis.

Expert Rev Clin Immunol 2020 06 27;16(6):621-630. Epub 2020 May 27.

Translational and Clinical Research Institute, Newcastle University Medical School , Newcastle, UK.

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June 2020