John Isaacs

John Isaacs

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John Isaacs

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Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritis.

Rheumatology (Oxford) 2019 Oct 10. Epub 2019 Oct 10.

University College Dublin School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1093/rheumatology/kez411DOI Listing
October 2019

Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer.

Prostate 2019 Aug 18;79(11):1326-1337. Epub 2019 Jun 18.

Department of Anatomy and Developmental Biology, Monash Partners Comprehensive Cancer Consortium, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1002/pros.23839DOI Listing
August 2019

Routine musculoskeletal ultrasound findings impact diagnostic decisions maximally in autoantibody-seronegative early arthritis patients.

Rheumatology (Oxford) 2019 Jul;58(7):1268-1273

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/rheumatology/kez008DOI Listing
July 2019

Design of experiments and the virtual PCR simulator: An online game for pharmaceutical scientists and biotechnologists.

Pharm Stat 2019 Jul 21;18(4):402-406. Epub 2019 Feb 21.

School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/pst.1932DOI Listing
July 2019

In Reply.

Stem Cells Transl Med 2019 Jul 29;8(7):739-740. Epub 2019 Mar 29.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/sctm.19-0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591553PMC
July 2019

Potential Pharmacologic Targets for the Prevention of Rheumatoid Arthritis.

Clin Ther 2019 Jul 10;41(7):1312-1322. Epub 2019 Jun 10.

Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom; Musculoskeletal Unit, Newcastle Upon Tyne Hospitals National Health Service (NHS) Foundation Trust, Newcastle Upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.clinthera.2019.04.020DOI Listing
July 2019

Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study.

J Autoimmun 2019 Jul 4:102298. Epub 2019 Jul 4.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.06.009DOI Listing
July 2019

Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis.

Front Immunol 2018 9;9:755. Epub 2018 May 9.

Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2018.00755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968398PMC
June 2019

"Living a normal life": a qualitative study of patients' views of medication withdrawal in rheumatoid arthritis.

BMC Rheumatol 2019 13;3. Epub 2019 Jun 13.

1Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH UK.

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http://dx.doi.org/10.1186/s41927-019-0070-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567658PMC
June 2019

Tolerising cellular therapies: what is their promise for autoimmune disease?

Ann Rheum Dis 2019 Mar 2;78(3):297-310. Epub 2018 Nov 2.

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21402
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http://dx.doi.org/10.1136/annrheumdis-2018-214024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390030PMC
March 2019

Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

Prostate 2019 Feb 28;79(3):320-330. Epub 2018 Nov 28.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549513PMC
February 2019

Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer.

Asian J Urol 2019 Jan 28;6(1):99-108. Epub 2018 Nov 28.

Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.ajur.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363604PMC
January 2019

Therapeutic tolerance in autoimmune disease.

Semin Arthritis Rheum 2018 12 28;48(3):558-562. Epub 2018 Sep 28.

Institute of Cellular Medicine, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183059
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http://dx.doi.org/10.1016/j.semarthrit.2018.09.008DOI Listing
December 2018

Mesenchymal stem cells and the embryonic reawakening theory of BPH.

Nat Rev Urol 2018 11;15(11):703-715

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41585-018-0087-9DOI Listing
November 2018

Biologic refractory disease in rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Ann Rheum Dis 2018 10 6;77(10):1405-1412. Epub 2018 Jul 6.

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2018-213378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161665PMC
October 2018

Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise.

Stem Cells Transl Med 2018 09 1;7(9):651-663. Epub 2018 Aug 1.

Department of Oncology at the Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/sctm.18-0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127224PMC
September 2018

Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis.

Pharmacogenomics J 2018 09 31;18(5):657-664. Epub 2018 Aug 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/s41397-018-0040-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150911PMC
September 2018

Checks and balances occur not only in government, but also in biology.

Authors:
John T Isaacs

Oncotarget 2018 Sep 4;9(69):33054-33055. Epub 2018 Sep 4.

John T. Isaacs: Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA; The Brady Urologic Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.25876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145691PMC
September 2018

2-fluoro-5-maleimidobenzoic acid-linked albumin drug (MAD) delivery for selective systemic targeting of metastatic prostate cancer.

Prostate 2018 06 24;78(9):655-663. Epub 2018 Mar 24.

Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404533PMC
June 2018

The what, when, and why of human prostate cancer xenografts.

Prostate 2018 06 24;78(9):646-654. Epub 2018 Mar 24.

Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23510DOI Listing
June 2018

Resolving the Coffey Paradox: what does the androgen receptor do in normal vs. malignant prostate epithelial cells?

Authors:
John T Isaacs

Am J Clin Exp Urol 2018 1;6(2):55-61. Epub 2018 Apr 1.

Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBaltimore, MD 21231, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902723PMC
April 2018

Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?

Ann Rheum Dis 2018 02 1;77(2):175-187. Epub 2017 Aug 1.

Musculoskeletal Research Group and Arthritis Research UK Centre of Excellence in Rheumatoid Arthritis Pathogenesis, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2017-211555DOI Listing
February 2018

Targeting of tolerogenic dendritic cells towards heat-shock proteins: a novel therapeutic strategy for autoimmune diseases?

Immunology 2018 01 18;153(1):51-59. Epub 2017 Sep 18.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/imm.12811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721256PMC
January 2018

The interferon gene signature is increased in patients with early treatment-naive rheumatoid arthritis and predicts a poorer response to initial therapy.

J Allergy Clin Immunol 2018 01 5;141(1):445-448.e4. Epub 2017 Oct 5.

Institute of Cellular Medicine, Newcastle University and National Institute for Health Research, Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals, NHS Foundation Trust, and Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2017.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751729PMC
January 2018

Patient and researcher perspectives on facilitating patient and public involvement in rheumatology research.

Musculoskeletal Care 2017 12 16;15(4):395-399. Epub 2016 Dec 16.

Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1002/msc.1171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808150PMC
December 2017

Proximal Tubal Patency Demonstrated Through Air Infusion During Flexible Office Hysteroscopy Is Predictive of Whole Tubal Patency.

J Minim Invasive Gynecol 2017 May - Jun;24(4):646-652. Epub 2017 Feb 16.

Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.

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https://linkinghub.elsevier.com/retrieve/pii/S15534650173013
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http://dx.doi.org/10.1016/j.jmig.2017.02.010DOI Listing
December 2017

The Effect of Person Order on Egress Time: A Simulation Model of Evacuation From a Neolithic Visitor Attraction.

Hum Factors 2017 12 19;59(8):1222-1232. Epub 2017 Sep 19.

Historic Environment Scotland, The Engine Shed, Stirling, United Kingdom.

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http://dx.doi.org/10.1177/0018720817729608DOI Listing
December 2017

Cellular Origin of Androgen Receptor Pathway-Independent Prostate Cancer and Implications for Therapy.

Cancer Cell 2017 10;32(4):399-401

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center (SKCCC), The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; The Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.09.011DOI Listing
October 2017

Traceless Cleavage of Protein-Biotin Conjugates under Biologically Compatible Conditions.

Chembiochem 2017 09 19;18(17):1688-1691. Epub 2017 Jul 19.

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1002/cbic.201700214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708275PMC
September 2017

Rationale for bipolar androgen therapy (BAT) for metastatic prostate cancer.

Cell Cycle 2017 09 18;16(18):1639-1640. Epub 2017 Aug 18.

a The Prostate Cancer Program, The Department of Oncology at the Sidney Kimmel Comprehensive Cancer Center and Brady Urological Institute, The Department of Urology , The Johns Hopkins School of Medicine , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/15384101.2017.1360645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602292PMC
September 2017

Synovial tissue research: a state-of-the-art review.

Nat Rev Rheumatol 2017 08 13;13(8):463-475. Epub 2017 Jul 13.

Department of Clinical Immunology &Rheumatology, Amsterdam Rheumatology and Immunology Centre, Academic Medical Centre, University of Amsterdam, Room F4-105, POBox 22700, 1100 DE, Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/nrrheum.2017.115DOI Listing
August 2017

Let's not fool ourselves. In RA, the ACR/EULAR remission criteria are not perfect!

Ann Rheum Dis 2017 06 1;76(6):e12. Epub 2016 Dec 1.

Musculoskeletal Research Group, NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2016-210797DOI Listing
June 2017

The predictive value of serum S100A9 and response to etanercept is not confirmed in a large UK rheumatoid arthritis cohort.

Rheumatology (Oxford) 2017 06;56(6):1019-1024

Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, The University of Manchester.

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http://dx.doi.org/10.1093/rheumatology/kew387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445600PMC
June 2017

I Can't Help the Way I Feel.

Authors:
John Isaacs

Acad Med 2017 May;92(5):660

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http://dx.doi.org/10.1097/ACM.0000000000001646DOI Listing
May 2017

Drug breakthrough offers hope to arthritis sufferers: qualitative analysis of medical research in UK newspapers.

Health Expect 2017 04 4;20(2):309-320. Epub 2016 May 4.

Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/hex.12460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354054PMC
April 2017

Low p16 Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone.

Prostate 2017 03 8;77(4):374-384. Epub 2016 Nov 8.

Chemical Therapeutic Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548187PMC
March 2017

The novel use of combined IL-1 and IL-6 inhibition in a patient with severe, aggressive, erosive, systemic-onset juvenile idiopathic arthritis.

Eur J Rheumatol 2017 Mar 1;4(1):68-69. Epub 2017 Mar 1.

Freeman Hospital, Newcastle-Upon-Tyne Hospitals NHS Foundation Trust, Newcastle-Upon-Tyne.

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http://dx.doi.org/10.5152/eurjrheum.2016.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335892PMC
March 2017

Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis.

Ann Rheum Dis 2017 Jan 26;76(1):227-234. Epub 2016 Apr 26.

Arthritis Research UK Rheumatoid Arthritis Pathogenesis Centre of Excellence (RACE), Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264217PMC
January 2017

High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort.

Ann Rheum Dis 2017 Jan 31;76(1):208-213. Epub 2016 May 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264213PMC
January 2017

Clinical trials of biosimilars should become more similar.

Ann Rheum Dis 2017 01 25;76(1):4-6. Epub 2016 Aug 25.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and National Institute of Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208113DOI Listing
January 2017

Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.

Nat Rev Rheumatol 2016 12 27;12(12):731-742. Epub 2016 Oct 27.

Institute of Cellular Medicine, Faculty of Medical Sciences, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrrheum.2016.175DOI Listing
December 2016

Immune reconstitution 20 years after treatment with alemtuzumab in a rheumatoid arthritis cohort: implications for lymphocyte depleting therapies.

Arthritis Res Ther 2016 12 20;18(1):302. Epub 2016 Dec 20.

Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1186/s13075-016-1188-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170892PMC
December 2016

Assessing angiogenic responses induced by primary human prostate stromal cells in a three-dimensional fibrin matrix assay.

Oncotarget 2016 11;7(44):71298-71308

Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.11347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342079PMC
November 2016

Detection of anti-drug antibodies using a bridging ELISA compared with radioimmunoassay in adalimumab-treated rheumatoid arthritis patients with random drug levels.

Rheumatology (Oxford) 2016 Nov 25;55(11):2050-2055. Epub 2016 Aug 25.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

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http://dx.doi.org/10.1093/rheumatology/kew299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088626PMC
November 2016

Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.

Genome Biol 2016 11 1;17(1):212. Epub 2016 Nov 1.

Arthritis Research UK Centre for Genetics and Genomics, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1186/s13059-016-1078-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088679PMC
November 2016

Teaching examples for the design of experiments: geographical sensitivity and the self-fulfilling prophecy.

Pharm Stat 2016 Jan-Feb;15(1):90-2. Epub 2015 Nov 12.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/pst.1723DOI Listing
October 2016

Components of treatment delay in rheumatoid arthritis differ according to autoantibody status: validation of a single-centre observation using national audit data.

Rheumatology (Oxford) 2016 Oct 3;55(10):1843-8. Epub 2016 Jul 3.

National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne.

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http://dx.doi.org/10.1093/rheumatology/kew261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034219PMC
October 2016

Analytic Validation of RNA In Situ Hybridization (RISH) for AR and AR-V7 Expression in Human Prostate Cancer.

Clin Cancer Res 2016 Sep 10;22(18):4651-63. Epub 2016 May 10.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026571PMC
September 2016

Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis.

Arthritis Rheumatol 2016 06 21;68(6):1353-60. Epub 2016 Apr 21.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, and Central Manchester NHS Trust, and Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/art.39590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914881PMC
June 2016

A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer.

Biomaterials 2016 Jun 17;91:140-150. Epub 2016 Mar 17.

Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital, United States; Harvard Medical School, United States; Harvard Stem Cell Institute, United States; Harvard - MIT Division of Health Sciences and Technology, United States. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824400PMC
June 2016

Rheumatoid arthritis: an evolutionary force in biologics.

Curr Pharm Des 2015 ;21(17):2170-8

NIHR Newcastle Biomedical Research Centre, Institute of Cellular Medicine, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.2174/1381612821666150310141827DOI Listing
May 2016

Rapid selection of mesenchymal stem and progenitor cells in primary prostate stromal cultures.

Prostate 2016 May 6;76(6):552-64. Epub 2016 Jan 6.

Department of Oncology, Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://www.gismonline.it/images/ML16/ML_02-16.pdf
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http://doi.wiley.com/10.1002/pros.23145
Publisher Site
http://dx.doi.org/10.1002/pros.23145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856028PMC
May 2016

Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort.

Pharmacogenomics 2016 05 16;17(7):715-20. Epub 2016 May 16.

Arthritis Research UK, Centre for Genetics & Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.2217/pgs.16.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996314PMC
May 2016

Bcl-3 in CD4+ T Cell-Mediated Rheumatoid Arthritis Pathogenesis: Comment on the Article by Meguro et al.

Arthritis Rheumatol 2016 Mar;68(3):770-1

NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/art.39509DOI Listing
March 2016

Cytokines in rheumatoid arthritis - shaping the immunological landscape.

Nat Rev Rheumatol 2016 Jan 10;12(1):63-8. Epub 2015 Dec 10.

NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Institute of Cellular Medicine, Newcastle University, William Leech Building, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrrheum.2015.171DOI Listing
January 2016

The Online Dissemination of Nature-Health Concepts: Lessons from Sentiment Analysis of Social Media Relating to "Nature-Deficit Disorder".

Int J Environ Res Public Health 2016 Jan 19;13(1). Epub 2016 Jan 19.

European Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall TR1 3HD, UK.

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http://dx.doi.org/10.3390/ijerph13010142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730533PMC
January 2016

Investigating CD11c expression as a potential genomic biomarker of response to TNF inhibitor biologics in whole blood rheumatoid arthritis samples.

Arthritis Res Ther 2015 Dec 14;17:359. Epub 2015 Dec 14.

Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, the University of Manchester, Manchester, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704535PMC
December 2015

Decade in review-clinical rheumatology: 10 years of therapeutic advances in the rheumatic diseases.

Authors:
John D Isaacs

Nat Rev Rheumatol 2015 Nov 13;11(11):628-30. Epub 2015 Oct 13.

Newcastle University, Institute of Cellular Medicine, William Leech Building, Framlington Place, Newcastle-Upon-Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrrheum.2015.138DOI Listing
November 2015

Lost in space: design of experiments and scientific exploration in a Hogarth Universe.

Drug Discov Today 2015 Nov 23;20(11):1365-71. Epub 2015 Oct 23.

Centre for Medicines Research, GlaxoSmithKline, Stevenage, UK.

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http://dx.doi.org/10.1016/j.drudis.2015.09.015DOI Listing
November 2015

Why is it hard to terminate failing projects in pharmaceutical R&D?

Nat Rev Drug Discov 2015 Oct 21;14(10):663-4. Epub 2015 Aug 21.

Institute of Cellular Medicine, Framlington Place, Newcastle University NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrd4725DOI Listing
October 2015

Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis.

Arthritis Rheumatol 2015 May;67(8):2011-9

Darren Plant, PhD, Anne Barton, MBChB, PhD, FRCP: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843946PMC
May 2015

Evaluation of the effect of tofacitinib on measured glomerular filtration rate in patients with active rheumatoid arthritis: results from a randomised controlled trial.

Arthritis Res Ther 2015 Apr 6;17:95. Epub 2015 Apr 6.

National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1186/s13075-015-0612-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445792PMC
April 2015

Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.

JAMA 2015 Apr;313(16):1645-56

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, England2NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manches.

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http://dx.doi.org/10.1001/jama.2015.3435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928097PMC
April 2015

Genotyping in rheumatoid arthritis: a game changer in clinical management?

Expert Rev Clin Immunol 2015 Mar 2;11(3):303-5. Epub 2015 Feb 2.

Institute of Cellular Medicine (Musculoskeletal Research Group), Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1586/1744666X.2015.1008454DOI Listing
March 2015

Progression-seeking bias and rational optimism in research and development.

Nat Rev Drug Discov 2015 Mar 6;14(3):219-21. Epub 2015 Feb 6.

Institute of Cellular Medicine, Newcastle University, Newcastle, NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrd4320-c1DOI Listing
March 2015

Lessons learned about prostatic transformation from the age-related methylation of 5α-reductase type 2 gene.

Authors:
John T Isaacs

Am J Pathol 2015 Mar 17;185(3):614-6. Epub 2015 Feb 17.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and The Brady Urologic Institute, The Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348462PMC
March 2015

Clinical utility of random anti-tumour necrosis factor drug testing and measurement of anti-drug antibodies on long-term treatment response in rheumatoid arthritis.

Lancet 2015 Feb;385 Suppl 1:S48

Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, UK.

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February 2015