John Isaacs

NIHR Manchester Biomedical Research Center, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Center, Manchester, M13 9WL, UK.

View Article and Find Full Text PDF

November 2020

Correction to: Characterization of Creatine Kinase Levels in Tofacitinib‑Treated Patients with Ulcerative Colitis: Results from Clinical Trials.

Authors:

Remo Panaccione John D Isaacs Lea Ann Chen Wenjin Wang Amy Marren Kenneth Kwok Lisy Wang Gary Chan Chinyu Su

Dig Dis Sci 2020 Oct 10. Epub 2020 Oct 10.

Inflammation and Immunology, Pfizer Inc, Collegeville, PA, USA.

View Article and Find Full Text PDF

October 2020

Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors.

Authors:

Yezi Zhu Susan L Dalrymple Ilsa Coleman S Lilly Zheng Jianfeng Xu Jody E Hooper Emmanuel S Antonarakis Angelo M De Marzo Alan K Meeker Peter S Nelson William B Isaacs Samuel R Denmeade Jun Luo W Nathaniel Brennen John T Isaacs

Oncogene 2020 11 28;39(45):6935-6949. Epub 2020 Sep 28.

Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

View Article and Find Full Text PDF

November 2020

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.

Nat Commun 2020 09 21;11(1):4767. Epub 2020 Sep 21.

Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.

View Article and Find Full Text PDF

September 2020

Microparticle Encapsulation of a Prostate-Targeted Biologic for the Treatment of Liver Metastases in a Preclinical Model of Castration-Resistant Prostate Cancer.

Authors:

Oliver C Rogers Lizamma Antony Oren Levy Nitin Joshi Brian W Simons Susan Dalrymple Marc Rosen Andrew Pickering Haoyue Lan Heidi Kuang Sudhir H Ranganath Lei Zheng Jeffrey M Karp S Peter Howard Samuel R Denmeade John T Isaacs W Nathaniel Brennen

Mol Cancer Ther 2020 Sep 17. Epub 2020 Sep 17.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University

View Article and Find Full Text PDF

September 2020

Characterization of Creatine Kinase Levels in Tofacitinib-Treated Patients with Ulcerative Colitis: Results from Clinical Trials.

Authors:

Remo Panaccione John D Isaacs Lea Ann Chen Wenjin Wang Amy Marren Kenneth Kwok Lisy Wang Gary Chan Chinyu Su

Dig Dis Sci 2020 Aug 20. Epub 2020 Aug 20.

Inflammation and Immunology, Pfizer Inc, Collegeville, PA, USA.

View Article and Find Full Text PDF

August 2020

Basic Mechanisms of JAK Inhibition.

Authors:

Chung Ma Lin Faye Ah Cooles John D Isaacs

Mediterr J Rheumatol 2020 Jun 11;31(Suppl 1):100-104. Epub 2020 Jun 11.

Translational and Clinical Research Institute, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.

View Article and Find Full Text PDF

June 2020

Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition: An early phase trial.

Authors:

Stefan Siebert Arthur G Pratt Deborah D Stocken Miranda Morton Amy Cranston Michael Cole Sheelagh Frame Christopher D Buckley Wan-Fai Ng Andrew Filer Iain B McInnes John D Isaacs

Medicine (Baltimore) 2020 Jun;99(26):e20458

Translational and Experimental Medicine Institute, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne.

View Article and Find Full Text PDF

June 2020

Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities.

Authors:

Puja Mehta Joanna C Porter Jessica J Manson John D Isaacs Peter J M Openshaw Iain B McInnes Charlotte Summers Rachel C Chambers

Lancet Respir Med 2020 08 16;8(8):822-830. Epub 2020 Jun 16.

Centre for Inflammation and Tissue Repair, Division of Medicine, University College London, London, UK. Electronic address:

View Article and Find Full Text PDF

August 2020

Smart battles: immunosuppression versus immunomodulation in the inflammatory RMDs.

Authors:

John D Isaacs Gerd R Burmester

Ann Rheum Dis 2020 08 11;79(8):991-993. Epub 2020 Jun 11.

Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany.

View Article and Find Full Text PDF

August 2020

Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission.

Authors:

Kenneth F Baker Ben Thompson Dennis W Lendrem Adam Scadeng Arthur G Pratt John D Isaacs

Ther Adv Musculoskelet Dis 2020 11;12:1759720X20915322. Epub 2020 May 11.

Musculoskeletal Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

View Article and Find Full Text PDF

May 2020

EULAR provisional recommendations for the management of rheumatic and musculoskeletal diseases in the context of SARS-CoV-2.

Authors:

Robert Bm Landewé Pedro M Machado Féline Kroon Hans Wj Bijlsma Gerd R Burmester Loreto Carmona Bernard Combe Massimo Galli Laure Gossec Annamaria Iagnocco John D Isaacs Xavier Mariette Iain McInnes Ulf Mueller-Ladner Peter Openshaw Josef S Smolen Tanja A Stamm Dieter Wiek Hendrik Schulze-Koops

Ann Rheum Dis 2020 07 5;79(7):851-858. Epub 2020 Jun 5.

Division of Rheumatology and Clinical Immunology, Department of Medicine IV, Ludwig Maximilian University of Munich, Munich, Germany.

View Article and Find Full Text PDF

July 2020

Latent Class Trajectory Modeling of 2-Component Disease Activity Score in 28 Joints Identifies Multiple Rheumatoid Arthritis Phenotypes of Response to Biologic Disease-Modifying Antirheumatic Drugs.

Authors:

Arianna Dagliati Darren Plant Nisha Nair Meghna Jani Beatrice Amico Niels Peek Ann W Morgan John Isaacs Anthony G Wilson Kimme L Hyrich Nophar Geifman Anne Barton

Arthritis Rheumatol 2020 10 6;72(10):1632-1642. Epub 2020 Sep 6.

Versus Arthritis Centre for Genetics and Genomics, University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, and Manchester Academic Health Science Centre, Manchester, UK.

View Article and Find Full Text PDF

October 2020

Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress.

Authors:

Michael D Nyquist Alexandra Corella Ilsa Coleman Navonil De Sarkar Arja Kaipainen Gavin Ha Roman Gulati Lisa Ang Payel Chatterjee Jared Lucas Colin Pritchard Gail Risbridger John Isaacs Bruce Montgomery Colm Morrissey Eva Corey Peter S Nelson

Cell Rep 2020 05;31(8):107669

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Urology, University of Washington, Seattle, WA 98195, USA. Electronic address:

View Article and Find Full Text PDF

May 2020

In search of pathobiological endotypes: a systems approach to early rheumatoid arthritis.

Authors:

Jessica R Tarn Dennis W Lendrem John D Isaacs

Expert Rev Clin Immunol 2020 06 27;16(6):621-630. Epub 2020 May 27.

Translational and Clinical Research Institute, Newcastle University Medical School , Newcastle, UK.

View Article and Find Full Text PDF

June 2020

Publications by authors named "John Isaacs"

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors: