John Isaacs

John Isaacs

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John Isaacs

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Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritis.

Authors:
Nisha Nair Darren Plant Suzanne M Verstappen John D Isaacs Ann W Morgan Kimme L Hyrich Anne Barton Anthony G Wilson

Rheumatology (Oxford) 2019 Oct 10. Epub 2019 Oct 10.

University College Dublin School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1093/rheumatology/kez411DOI Listing
October 2019

Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for and CD39.

Authors:
Athina Spiliopoulou Marco Colombo Darren Plant Nisha Nair Jing Cui Marieke Jh Coenen Katsunori Ikari Hisashi Yamanaka Saedis Saevarsdottir Leonid Padyukov S Louis Bridges Robert P Kimberly Yukinori Okada Piet L Cm van Riel Gertjan Wolbink Irene E van der Horst-Bruinsma Niek de Vries Paul P Tak Koichiro Ohmura Helena Canhão Henk-Jan Guchelaar Tom Wj Huizinga Lindsey A Criswell Soumya Raychaudhuri Michael E Weinblatt Anthony G Wilson Xavier Mariette John D Isaacs Ann W Morgan Costantino Pitzalis Anne Barton Paul McKeigue

Ann Rheum Dis 2019 Aug 29;78(8):1055-1061. Epub 2019 Apr 29.

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21487
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http://dx.doi.org/10.1136/annrheumdis-2018-214877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669378PMC
August 2019

Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer.

Authors:
Laura H Porter Mitchell G Lawrence Hong Wang Ashlee K Clark Andrew Bakshi Daisuke Obinata David Goode Melissa Papargiris Mural David Clouston Andrew Ryan Sam Norden Eva Corey Peter S Nelson John T Isaacs Jeremy Grummet John Kourambas Shahneen Sandhu Declan G Murphy David Pook Mark Frydenberg Renea A Taylor Gail P Risbridger

Prostate 2019 Aug 18;79(11):1326-1337. Epub 2019 Jun 18.

Department of Anatomy and Developmental Biology, Monash Partners Comprehensive Cancer Consortium, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1002/pros.23839DOI Listing
August 2019

Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis.

Authors:
Amy E Anderson Nicola J Maney Nisha Nair Dennis W Lendrem Andrew J Skelton Julie Diboll Philip M Brown Graham R Smith Ruaidhrí J Carmody Anne Barton John D Isaacs Arthur G Pratt

Rheumatology (Oxford) 2019 Jul;58(7):1250-1258

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/rheumatology/kez003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587924PMC
July 2019

Routine musculoskeletal ultrasound findings impact diagnostic decisions maximally in autoantibody-seronegative early arthritis patients.

Authors:
Kundan Iqbal Dennis W Lendrem Ben Hargreaves John D Isaacs Ben Thompson Arthur G Pratt

Rheumatology (Oxford) 2019 Jul;58(7):1268-1273

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/rheumatology/kez008DOI Listing
July 2019

Design of experiments and the virtual PCR simulator: An online game for pharmaceutical scientists and biotechnologists.

Authors:
Harold Fellermann Ben Shirt-Ediss Jerzy Kozyra Matt Linsley Dennis Lendrem John Isaacs Thomas Howard

Pharm Stat 2019 Jul 21;18(4):402-406. Epub 2019 Feb 21.

School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/pst.1932DOI Listing
July 2019

In Reply.

Authors:
W Nathaniel Brennen Michael T Schweizer Hao Wang Trinity J Bivalacqua Alan W Partin Su Jin Lim Carolyn Chapman Rehab Abdallah Oren Levy Neil A Bhowmick Jeffrey M Karp Angelo De Marzo John T Isaacs Samuel R Denmeade

Stem Cells Transl Med 2019 Jul 29;8(7):739-740. Epub 2019 Mar 29.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/sctm.19-0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591553PMC
July 2019

Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression.

Authors:
Robert M Hughes Brian W Simons Hamda Khan Rebecca Miller Valentina Kugler Samantha Torquato Debebe Theodros Michael C Haffner Tamara Lotan Jessie Huang Elai Davicioni Steven S An Ryan C Riddle Daniel L J Thorek Isla P Garraway Elana J Fertig John T Isaacs W Nathaniel Brennen Ben H Park Paula J Hurley

Cancer Res 2019 Jul 23;79(14):3636-3650. Epub 2019 May 23.

The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734938PMC
July 2019

Potential Pharmacologic Targets for the Prevention of Rheumatoid Arthritis.

Authors:
John D Isaacs Kundan Iqbal

Clin Ther 2019 Jul 10;41(7):1312-1322. Epub 2019 Jun 10.

Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom; Musculoskeletal Unit, Newcastle Upon Tyne Hospitals National Health Service (NHS) Foundation Trust, Newcastle Upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.clinthera.2019.04.020DOI Listing
July 2019

Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study.

Authors:
Kenneth F Baker Andrew J Skelton Dennis W Lendrem Adam Scadeng Ben Thompson Arthur G Pratt John D Isaacs

J Autoimmun 2019 Jul 4:102298. Epub 2019 Jul 4.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.06.009DOI Listing
July 2019

Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol.

Authors:
Mariam Al-Laith Marianna Jasenecova Sonya Abraham Aisla Bosworth Ian N Bruce Christopher D Buckley Coziana Ciurtin Maria-Antonietta D'Agostino Paul Emery Hill Gaston John D Isaacs Andrew Filer Benjamin A Fisher Thomas W J Huizinga Pauline Ho Clare Jacklin Heidi Lempp Iain B McInnes Arthur G Pratt Andrew Östor Karim Raza Peter C Taylor Dirkjan van Schaardenburg Dharshene Shivapatham Alison J Wright Joana C Vasconcelos Joanna Kelly Caroline Murphy A Toby Prevost Andrew P Cope

Trials 2019 Jul 15;20(1):429. Epub 2019 Jul 15.

Centre for Rheumatic Diseases, Department of Inflammation Biology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, Weston Education Centre, 10 Cutcombe Road, London, SE5 9RJ, UK.

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http://dx.doi.org/10.1186/s13063-019-3403-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633323PMC
July 2019

IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function.

Authors:
Laura A Ridgley Amy E Anderson Nicola J Maney Najib Naamane Andrew J Skelton Catherine A Lawson Paul Emery John D Isaacs Ruaidhrí J Carmody Arthur G Pratt

Front Immunol 2019 3;10:1535. Epub 2019 Jul 3.

Institute of Cellular Medicine (Musculoskeletal Research Group), Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2019.01535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618050PMC
July 2019

Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis.

Authors:
Faye A H Cooles Amy E Anderson Andrew Skelton Arthur G Pratt Mariola S Kurowska-Stolarska Iain McInnes Catharien M U Hilkens John D Isaacs

Front Immunol 2018 9;9:755. Epub 2018 May 9.

Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2018.00755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968398PMC
June 2019

"Living a normal life": a qualitative study of patients' views of medication withdrawal in rheumatoid arthritis.

Authors:
Kenneth F Baker John D Isaacs Ben Thompson

BMC Rheumatol 2019 13;3. Epub 2019 Jun 13.

1Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH UK.

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http://dx.doi.org/10.1186/s41927-019-0070-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567658PMC
June 2019

Between a ROC and a hard place: Teaching prevalence plots to understand real world biomarker performance in the clinic.

Authors:
B Clare Lendrem Dennis W Lendrem Arthur G Pratt Najib Naamane Peter McMeekin Wan-Fai Ng A Joy Allen Michael Power John Dudley Isaacs

Pharm Stat 2019 Jun 23. Epub 2019 Jun 23.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pst.1963
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http://dx.doi.org/10.1002/pst.1963DOI Listing
June 2019

A Phase I Study to Assess the Safety and Cancer-Homing Ability of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Men with Localized Prostate Cancer.

Authors:
Michael T Schweizer Hao Wang Trinity J Bivalacqua Alan W Partin Su Jin Lim Carolyn Chapman Rehab Abdallah Oren Levy Neil A Bhowmick Jeffrey M Karp Angelo De Marzo John T Isaacs W Nathaniel Brennen Samuel R Denmeade

Stem Cells Transl Med 2019 May 8;8(5):441-449. Epub 2019 Feb 8.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://doi.wiley.com/10.1002/sctm.18-0230
Publisher Site
http://dx.doi.org/10.1002/sctm.18-0230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477003PMC
May 2019

Keratinocyte growth factor impairs human thymic recovery from lymphopenia.

Authors:
Alasdair J Coles Laura Azzopardi Onajite Kousin-Ezewu Harpreet Kaur Mullay Sara Aj Thompson Lorna Jarvis Jessica Davies Sarah Howlett Daniel Rainbow Judith Babar Timothy J Sadler J William L Brown Edward Needham Karen May Zoya G Georgieva Adam E Handel Stefano Maio Mary Deadman Ioanna Rota Georg Holländer Sarah Dawson David Jayne Ruth Seggewiss-Bernhardt Daniel C Douek John D Isaacs Joanne L Jones

JCI Insight 2019 May 7;5. Epub 2019 May 7.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1172/jci.insight.125377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629095PMC
May 2019

Efficacy and safety of subcutaneous tocilizumab in rheumatoid arthritis over 1 year: a UK real-world, open-label study.

Authors:
John D Isaacs Abdelrazig Salih Thomas Sheeran Yusuf I Patel Karen Douglas Neil D McKay Barbara Naisbett-Groet Ernest Choy

Rheumatol Adv Pract 2019 19;3(1):rkz010. Epub 2019 Apr 19.

CREATE Centre, Division of Infection and Immunity, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1093/rap/rkz010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649953PMC
April 2019

Tolerising cellular therapies: what is their promise for autoimmune disease?

Authors:
Chijioke H Mosanya John D Isaacs

Ann Rheum Dis 2019 Mar 2;78(3):297-310. Epub 2018 Nov 2.

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21402
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http://dx.doi.org/10.1136/annrheumdis-2018-214024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390030PMC
March 2019

Pharmacologic Exhaustion of Suppressor Cells with Tasquinimod Enhances Bacterial Clearance during Tuberculosis.

Authors:
Shashank Gupta Stefanie Krug Supriya Pokkali Tomas Leanderson John T Isaacs Geetha Srikrishna William R Bishai

Am J Respir Crit Care Med 2019 Feb;199(3):386-389

1 Johns Hopkins University Baltimore, Maryland.

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http://dx.doi.org/10.1164/rccm.201805-0820LEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363972PMC
February 2019

Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

Authors:
Timothy E Krueger Daniel L J Thorek Alan K Meeker John T Isaacs W Nathaniel Brennen

Prostate 2019 Feb 28;79(3):320-330. Epub 2018 Nov 28.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549513PMC
February 2019

Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients.

Authors:
Matthew J Wood Adam Leckenby Gary Reynolds Rachel Spiering Arthur G Pratt Kenneth S Rankin John D Isaacs Muzlifah A Haniffa Simon Milling Catharien Mu Hilkens

JCI Insight 2019 Jan 24;4(2). Epub 2019 Jan 24.

Institute of Cellular Medicine, Newcastle University, United Kingdom.

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https://insight.jci.org/articles/view/125325
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http://dx.doi.org/10.1172/jci.insight.125325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413777PMC
January 2019

Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer.

Authors:
Emmanuel S Akinboye W Nathaniel Brennen Samuel R Denmeade John T Isaacs

Asian J Urol 2019 Jan 28;6(1):99-108. Epub 2018 Nov 28.

Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.ajur.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363604PMC
January 2019

Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient-derived xenograft (PDX) models.

Authors:
Nora M Navone Wytske M van Weerden Robert L Vessella Elizabeth D Williams Yuzhuo Wang John T Isaacs Holly M Nguyen Zoran Culig Gabri van der Pluijm Cyril A Rentsch Rute B Marques Corrina M A de Ridder Lukas Bubendorf George N Thalmann William Nathaniel Brennen Frédéric R Santer Patrizia L Moser Peter Shepherd Eleni Efstathiou Hui Xue Dong Lin Jeroen Buijs Tjalling Bosse Anne Collins Norman Maitland Mark Buzza Michelle Kouspou Ariel Achtman Renea A Taylor Gail Risbridger Eva Corey

Prostate 2018 12 2;78(16):1262-1282. Epub 2018 Aug 2.

University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1002/pros.23701DOI Listing
December 2018

Therapeutic tolerance in autoimmune disease.

Authors:
Fiona Rayner John D Isaacs

Semin Arthritis Rheum 2018 12 28;48(3):558-562. Epub 2018 Sep 28.

Institute of Cellular Medicine, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183059
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http://dx.doi.org/10.1016/j.semarthrit.2018.09.008DOI Listing
December 2018

Mesenchymal stem cells and the embryonic reawakening theory of BPH.

Authors:
W Nathaniel Brennen John T Isaacs

Nat Rev Urol 2018 11;15(11):703-715

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41585-018-0087-9DOI Listing
November 2018

Biologic refractory disease in rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Authors:
Lianne Kearsley-Fleet Rebecca Davies Diederik De Cock Kath D Watson Mark Lunt Maya H Buch John D Isaacs Kimme L Hyrich

Ann Rheum Dis 2018 10 6;77(10):1405-1412. Epub 2018 Jul 6.

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2018-213378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161665PMC
October 2018

Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise.

Authors:
Timothy E G Krueger Daniel L J Thorek Samuel R Denmeade John T Isaacs W Nathaniel Brennen

Stem Cells Transl Med 2018 09 1;7(9):651-663. Epub 2018 Aug 1.

Department of Oncology at the Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/sctm.18-0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127224PMC
September 2018

Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis.

Authors:
Jonathan Massey Darren Plant Kimme Hyrich Ann W Morgan Anthony G Wilson Athina Spiliopoulou Marco Colombo Paul McKeigue John Isaacs Heather Cordell Costantino Pitzalis Anne Barton

Pharmacogenomics J 2018 09 31;18(5):657-664. Epub 2018 Aug 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/s41397-018-0040-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150911PMC
September 2018

Checks and balances occur not only in government, but also in biology.

Authors:
John T Isaacs

Oncotarget 2018 Sep 4;9(69):33054-33055. Epub 2018 Sep 4.

John T. Isaacs: Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA; The Brady Urologic Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.25876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145691PMC
September 2018

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients.

Authors:
John C Taylor Tim Bongartz Jonathan Massey Borbala Mifsud Athina Spiliopoulou Ian C Scott Jianmei Wang Michael Morgan Darren Plant Marco Colombo Peter Orchard Sarah Twigg Iain B McInnes Duncan Porter Jane E Freeston Jackie L Nam Heather J Cordell John D Isaacs Jenna L Strathdee Donna Arnett Maria J H de Hair Paul P Tak Stella Aslibekyan Ronald F van Vollenhoven Leonid Padyukov S Louis Bridges Costantino Pitzalis Andrew P Cope Suzanne M M Verstappen Paul Emery Michael R Barnes Felix Agakov Paul McKeigue Taisei Mushiroda Michiaki Kubo Richard Weinshilboum Anne Barton Ann W Morgan Jennifer H Barrett

Pharmacogenomics J 2018 07 25;18(4):528-538. Epub 2018 May 25.

Leeds Institute of Cancer and Pathology, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

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http://dx.doi.org/10.1038/s41397-018-0025-5DOI Listing
July 2018

Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC).

Authors:
Nefyn H Williams Alison Jenkins Nia Goulden Zoe Hoare Dyfrig A Hughes Eifiona Wood Nadine E Foster David Walsh Dawn Carnes Valerie Sparkes Elaine M Hay John Isaacs Kika Konstantinou Dylan Morrissey Jaro Karppinen Stephane Genevay Clare Wilkinson

Trials 2018 Jul 31;19(1):408. Epub 2018 Jul 31.

School of Healthcare Sciences, Bangor University, Bangor, UK.

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http://dx.doi.org/10.1186/s13063-018-2801-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069989PMC
July 2018

2-fluoro-5-maleimidobenzoic acid-linked albumin drug (MAD) delivery for selective systemic targeting of metastatic prostate cancer.

Authors:
Emmanuel S Akinboye Oliver C Rogers John T Isaacs

Prostate 2018 06 24;78(9):655-663. Epub 2018 Mar 24.

Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404533PMC
June 2018

The what, when, and why of human prostate cancer xenografts.

Authors:
W Nathaniel Brennen John T Isaacs

Prostate 2018 06 24;78(9):646-654. Epub 2018 Mar 24.

Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23510DOI Listing
June 2018

Resolving the Coffey Paradox: what does the androgen receptor do in normal vs. malignant prostate epithelial cells?

Authors:
John T Isaacs

Am J Clin Exp Urol 2018 1;6(2):55-61. Epub 2018 Apr 1.

Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBaltimore, MD 21231, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902723PMC
April 2018

CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis: Implications for Causal Gene Identification.

Authors:
Nishanthi Thalayasingam Nisha Nair Andrew J Skelton Jonathan Massey Amy E Anderson Alexander D Clark Julie Diboll Dennis W Lendrem Louise N Reynard Heather J Cordell Stephen Eyre John D Isaacs Anne Barton Arthur G Pratt

Arthritis Rheumatol 2018 03 30;70(3):361-370. Epub 2018 Jan 30.

NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, and Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/art.40393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888199PMC
March 2018

Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?

Authors:
Kenneth F Baker John D Isaacs

Ann Rheum Dis 2018 02 1;77(2):175-187. Epub 2017 Aug 1.

Musculoskeletal Research Group and Arthritis Research UK Centre of Excellence in Rheumatoid Arthritis Pathogenesis, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2017-211555DOI Listing
February 2018

Targeting of tolerogenic dendritic cells towards heat-shock proteins: a novel therapeutic strategy for autoimmune diseases?

Authors:
Manon A A Jansen Rachel Spiering Femke Broere Jacob M van Laar John D Isaacs Willem van Eden Catharien M U Hilkens

Immunology 2018 01 18;153(1):51-59. Epub 2017 Sep 18.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/imm.12811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721256PMC
January 2018

The interferon gene signature is increased in patients with early treatment-naive rheumatoid arthritis and predicts a poorer response to initial therapy.

Authors:
Faye A H Cooles Amy E Anderson Dennis W Lendrem Julie Norris Arthur G Pratt Catharien M U Hilkens John D Isaacs

J Allergy Clin Immunol 2018 01 5;141(1):445-448.e4. Epub 2017 Oct 5.

Institute of Cellular Medicine, Newcastle University and National Institute for Health Research, Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals, NHS Foundation Trust, and Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2017.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751729PMC
January 2018

The RA-MAP Consortium: a working model for academia-industry collaboration.

Authors:
Andrew P Cope Michael R Barnes Alexandra Belson Michael Binks Sarah Brockbank Francisco Bonachela-Capdevila Claudio Carini Benjamin A Fisher Carl S Goodyear Paul Emery Michael R Ehrenstein Neil Gozzard Ray Harris Sally Hollis Sarah Keidel Marc Levesque Catharina Lindholm Michael F McDermott Iain B McInnes Christopher M Mela Gerry Parker Simon Read Ayako Wakatsuki Pedersen Frederique Ponchel Duncan Porter Ravi Rao Anthony Rowe Peter Schulz-Knappe Matthew A Sleeman Deborah Symmons Peter C Taylor Brian Tom Wayne Tsuji Denny Verbeeck John D Isaacs

Nat Rev Rheumatol 2018 01 7;14(1):53-60. Epub 2017 Dec 7.

Newcastle University, UK.

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http://dx.doi.org/10.1038/nrrheum.2017.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711406PMC
January 2018

Corrigendum: The RA-MAP Consortium: a working model for academia-industry collaboration.

Authors:
Andrew P Cope Michael R Barnes Alexandra Belson Michael Binks Sarah Brockbank Francisco Bonachela-Capdevila Claudio Carini Benjamin A Fisher Carl S Goodyear Paul Emery Michael R Ehrenstein Neil Gozzard Ray Harris Sally Hollis Sarah Keidel Marc Levesque Catharina Lindholm Michael F McDermott Iain B McInnes Christopher M Mela Gerry Parker Simon Read Ayako Wakatsuki Pedersen Frederique Ponchel Duncan Porter Ravi Rao Anthony Rowe Peter Schulze-Knappe Matthew A Sleeman Deborah Symmons Peter C Taylor Brian Tom Wayne Tsuji Denny Verbeeck John D Isaacs

Nat Rev Rheumatol 2018 Jan;14(2):119

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http://dx.doi.org/10.1038/nrrheum.2018.6DOI Listing
January 2018

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.

Authors:
Anke Fuchs Mateusz Gliwiński Nathali Grageda Rachel Spiering Abul K Abbas Silke Appel Rosa Bacchetta Manuela Battaglia David Berglund Bruce Blazar Jeffrey A Bluestone Martin Bornhäuser Anja Ten Brinke Todd M Brusko Nathalie Cools Maria Cristina Cuturi Edward Geissler Nick Giannoukakis Karolina Gołab David A Hafler S Marieke van Ham Joanna Hester Keli Hippen Mauro Di Ianni Natasa Ilic John Isaacs Fadi Issa Dorota Iwaszkiewicz-Grześ Elmar Jaeckel Irma Joosten David Klatzmann Hans Koenen Cees van Kooten Olle Korsgren Karsten Kretschmer Megan Levings Natalia Maria Marek-Trzonkowska Marc Martinez-Llordella Djordje Miljkovic Kingston H G Mills Joana P Miranda Ciriaco A Piccirillo Amy L Putnam Thomas Ritter Maria Grazia Roncarolo Shimon Sakaguchi Silvia Sánchez-Ramón Birgit Sawitzki Ljiljana Sofronic-Milosavljevic Megan Sykes Qizhi Tang Marta Vives-Pi Herman Waldmann Piotr Witkowski Kathryn J Wood Silvia Gregori Catharien M U Hilkens Giovanna Lombardi Phillip Lord Eva M Martinez-Caceres Piotr Trzonkowski

Front Immunol 2017 15;8:1844. Epub 2018 Jan 15.

Department of Clinical Immunology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland.

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http://dx.doi.org/10.3389/fimmu.2017.01844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775516PMC
January 2018

Patient and researcher perspectives on facilitating patient and public involvement in rheumatology research.

Authors:
Judith Pollock Karim Raza Arthur G Pratt Helen Hanson Stefan Siebert Andrew Filer John D Isaacs Christopher D Buckley Iain B McInnes Marie Falahee

Musculoskeletal Care 2017 12 16;15(4):395-399. Epub 2016 Dec 16.

Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1002/msc.1171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808150PMC
December 2017

Proximal Tubal Patency Demonstrated Through Air Infusion During Flexible Office Hysteroscopy Is Predictive of Whole Tubal Patency.

Authors:
J Preston Parry Daniel Riche Justin Aldred John Isaacs Elizabeth Lutz Vicki Butler James Shwayder

J Minim Invasive Gynecol 2017 May - Jun;24(4):646-652. Epub 2017 Feb 16.

Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.

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https://linkinghub.elsevier.com/retrieve/pii/S15534650173013
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http://dx.doi.org/10.1016/j.jmig.2017.02.010DOI Listing
December 2017

The Effect of Person Order on Egress Time: A Simulation Model of Evacuation From a Neolithic Visitor Attraction.

Authors:
Arthur Stewart Eyad Elyan John Isaacs Leah McEwen Lyn Wilson

Hum Factors 2017 12 19;59(8):1222-1232. Epub 2017 Sep 19.

Historic Environment Scotland, The Engine Shed, Stirling, United Kingdom.

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http://dx.doi.org/10.1177/0018720817729608DOI Listing
December 2017

Retrospective cohort study on Angio-Seal closure device safety and effectiveness in antegrade superficial femoral artery punctures: A comparison with antegrade common femoral artery punctures.

Authors:
Tarig Adlan Yousef Shahin Peter Kember John Isaacs Richard Seymour

Int J Surg 2017 Dec 13;48:225-227. Epub 2017 Nov 13.

Department of Radiology, Torbay Hospital NHS, Torquay, United Kingdom.

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http://dx.doi.org/10.1016/j.ijsu.2017.11.003DOI Listing
December 2017

Corrigendum: Synovial tissue research: a state-of-the-art review.

Authors:
Carl Orr Elsa Vieira-Sousa David L Boyle Maya H Buch Christopher D Buckley Juan D Cañete Anca I Catrina Ernest H S Choy Paul Emery Ursula Fearon Andrew Filer Danielle Gerlag Frances Humby John D Isaacs Søren A Just Bernard R Lauwerys Benoit Le Goff Antonio Manzo Trudy McGarry Iain B McInnes Aurélie Najm Constantino Pitzalis Arthur Pratt Malcolm Smith Paul P Tak Sander W Tas Rogier Thurlings João E Fonseca Douglas J Veale

Nat Rev Rheumatol 2017 Dec;14(1):60

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http://dx.doi.org/10.1038/nrrheum.2017.206DOI Listing
December 2017

Cellular Origin of Androgen Receptor Pathway-Independent Prostate Cancer and Implications for Therapy.

Authors:
W Nathaniel Brennen John T Isaacs

Cancer Cell 2017 10;32(4):399-401

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center (SKCCC), The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; The Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.09.011DOI Listing
October 2017

Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica.

Authors:
Nefyn H Williams Alison Jenkins Nia Goulden Zoe Hoare Dyfrig A Hughes Eifiona Wood Nadine E Foster David A Walsh Dawn Carnes Valerie Sparkes Elaine M Hay John Isaacs Kika Konstantinou Dylan Morrissey Jaro Karppinen Stephane Genevay Clare Wilkinson

Health Technol Assess 2017 10;21(60):1-180

School of Healthcare Sciences, Bangor University, Bangor, UK.

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http://dx.doi.org/10.3310/hta21600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672499PMC
October 2017

Traceless Cleavage of Protein-Biotin Conjugates under Biologically Compatible Conditions.

Authors:
Joseph Cowell Matthew Buck Ali H Essa Rebecca Clarke Waldemar Vollmer Daniela Vollmer Catharien M Hilkens John D Isaacs Michael J Hall Joe Gray

Chembiochem 2017 09 19;18(17):1688-1691. Epub 2017 Jul 19.

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1002/cbic.201700214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708275PMC
September 2017

Rationale for bipolar androgen therapy (BAT) for metastatic prostate cancer.

Authors:
John T Isaacs W Nathaniel Brennen Samuel R Denmeade

Cell Cycle 2017 09 18;16(18):1639-1640. Epub 2017 Aug 18.

a The Prostate Cancer Program, The Department of Oncology at the Sidney Kimmel Comprehensive Cancer Center and Brady Urological Institute, The Department of Urology , The Johns Hopkins School of Medicine , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/15384101.2017.1360645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602292PMC
September 2017

Synovial tissue research: a state-of-the-art review.

Authors:
Carl Orr Elsa Vieira-Sousa David L Boyle Maya H Buch Christopher D Buckley Juan D Cañete Anca I Catrina Ernest H S Choy Paul Emery Ursula Fearon Andrew Filer Danielle Gerlag Frances Humby John D Isaacs Søren A Just Bernard R Lauwerys Benoit Le Goff Antonio Manzo Trudy McGarry Iain B McInnes Aurélie Najm Constantino Pitzalis Arthur Pratt Malcolm Smith Paul P Tak Rogier Thurlings João E Fonseca Douglas J Veale

Nat Rev Rheumatol 2017 Sep;13(10):630

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http://dx.doi.org/10.1038/nrrheum.2017.161DOI Listing
September 2017

Synovial tissue research: a state-of-the-art review.

Authors:
Carl Orr Elsa Vieira-Sousa David L Boyle Maya H Buch Christopher D Buckley Juan D Cañete Anca I Catrina Ernest H S Choy Paul Emery Ursula Fearon Andrew Filer Danielle Gerlag Frances Humby John D Isaacs Søren A Just Bernard R Lauwerys Benoit Le Goff Antonio Manzo Trudy McGarry Iain B McInnes Aurélie Najm Constantino Pitzalis Arthur Pratt Malcolm Smith Paul P Tak Rogier Thurlings João E Fonseca Douglas J Veale Sander W Tas

Nat Rev Rheumatol 2017 08 13;13(8):463-475. Epub 2017 Jul 13.

Department of Clinical Immunology &Rheumatology, Amsterdam Rheumatology and Immunology Centre, Academic Medical Centre, University of Amsterdam, Room F4-105, POBox 22700, 1100 DE, Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/nrrheum.2017.115DOI Listing
August 2017

Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate.

Authors:
W Nathaniel Brennen Baohui Zhang Ibrahim Kulac L Nelleke Kisteman Lizamma Antony Hao Wang Alan K Meeker Angelo M De Marzo Isla P Garraway Samuel R Denmeade John T Isaacs

Oncotarget 2017 Jul;8(29):46710-46727

Department of Oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.17362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564518PMC
July 2017

Let's not fool ourselves. In RA, the ACR/EULAR remission criteria are not perfect!

Authors:
Kenneth F Baker Arthur G Pratt Ben Thompson John D Isaacs

Ann Rheum Dis 2017 06 1;76(6):e12. Epub 2016 Dec 1.

Musculoskeletal Research Group, NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2016-210797DOI Listing
June 2017

The predictive value of serum S100A9 and response to etanercept is not confirmed in a large UK rheumatoid arthritis cohort.

Authors:
Samantha Louise Smith Darren Plant Stephen Eyre Kimme Hyrich Ann W Morgan Anthony G Wilson John D Isaacs Anne Barton

Rheumatology (Oxford) 2017 06;56(6):1019-1024

Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, The University of Manchester.

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http://dx.doi.org/10.1093/rheumatology/kew387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445600PMC
June 2017

I Can't Help the Way I Feel.

Authors:
John Isaacs

Acad Med 2017 May;92(5):660

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http://dx.doi.org/10.1097/ACM.0000000000001646DOI Listing
May 2017

Drug breakthrough offers hope to arthritis sufferers: qualitative analysis of medical research in UK newspapers.

Authors:
Helen Hanson Nicola O'Brien Paul Whybrow John D Isaacs Tim Rapley

Health Expect 2017 04 4;20(2):309-320. Epub 2016 May 4.

Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/hex.12460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354054PMC
April 2017

Achieving consensus on minimum data items (including core outcome domains) for a longitudinal observational cohort study in rheumatoid arthritis.

Authors:
Elena Nikiphorou Sarah L Mackie John Kirwan Martin Boers John Isaacs Ann W Morgan Adam Young

Rheumatology (Oxford) 2017 04;56(4):550-555

Rheumatology Department, St Albans City Hospital, St. Albans, UK.

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https://academic.oup.com/rheumatology/article-lookup/doi/10.
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http://dx.doi.org/10.1093/rheumatology/kew416DOI Listing
April 2017

Low p16 Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone.

Authors:
Mindy Kim Graham Lorenzo Principessa Lizamma Antony Alan K Meeker John T Isaacs

Prostate 2017 03 8;77(4):374-384. Epub 2016 Nov 8.

Chemical Therapeutic Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548187PMC
March 2017

The novel use of combined IL-1 and IL-6 inhibition in a patient with severe, aggressive, erosive, systemic-onset juvenile idiopathic arthritis.

Authors:
Martin Lee John Isaacs

Eur J Rheumatol 2017 Mar 1;4(1):68-69. Epub 2017 Mar 1.

Freeman Hospital, Newcastle-Upon-Tyne Hospitals NHS Foundation Trust, Newcastle-Upon-Tyne.

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http://dx.doi.org/10.5152/eurjrheum.2016.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335892PMC
March 2017

Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis.

Authors:
G M Bell A E Anderson J Diboll R Reece O Eltherington R A Harry T Fouweather C MacDonald T Chadwick E McColl J Dunn A M Dickinson C M U Hilkens John D Isaacs

Ann Rheum Dis 2017 Jan 26;76(1):227-234. Epub 2016 Apr 26.

Arthritis Research UK Rheumatoid Arthritis Pathogenesis Centre of Excellence (RACE), Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264217PMC
January 2017

High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort.

Authors:
Meghna Jani John D Isaacs Ann W Morgan Anthony G Wilson Darren Plant Kimme L Hyrich Hector Chinoy Anne Barton

Ann Rheum Dis 2017 Jan 31;76(1):208-213. Epub 2016 May 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264213PMC
January 2017

Clinical trials of biosimilars should become more similar.

Authors:
Jonathan Kay John D Isaacs

Ann Rheum Dis 2017 01 25;76(1):4-6. Epub 2016 Aug 25.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and National Institute of Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208113DOI Listing
January 2017

Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.

Authors:
Philip M Brown Arthur G Pratt John D Isaacs

Nat Rev Rheumatol 2016 12 27;12(12):731-742. Epub 2016 Oct 27.

Institute of Cellular Medicine, Faculty of Medical Sciences, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrrheum.2016.175DOI Listing
December 2016

Immune reconstitution 20 years after treatment with alemtuzumab in a rheumatoid arthritis cohort: implications for lymphocyte depleting therapies.

Authors:
Faye A H Cooles Amy E Anderson Tracey Drayton Rachel A Harry Julie Diboll Lee Munro Nishanthi Thalayasingham Andrew J K Östör John D Isaacs

Arthritis Res Ther 2016 12 20;18(1):302. Epub 2016 Dec 20.

Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1186/s13075-016-1188-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170892PMC
December 2016

Assessing angiogenic responses induced by primary human prostate stromal cells in a three-dimensional fibrin matrix assay.

Authors:
W Nathaniel Brennen Huong Nguyen Susan L Dalrymple Stephanie Reppert-Gerber Jeesun Kim John T Isaacs Hans Hammers

Oncotarget 2016 11;7(44):71298-71308

Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.11347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342079PMC
November 2016

Detection of anti-drug antibodies using a bridging ELISA compared with radioimmunoassay in adalimumab-treated rheumatoid arthritis patients with random drug levels.

Authors:
Meghna Jani John D Isaacs Ann W Morgan Anthony G Wilson Darren Plant Kimme L Hyrich Hector Chinoy Anne Barton

Rheumatology (Oxford) 2016 Nov 25;55(11):2050-2055. Epub 2016 Aug 25.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

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http://dx.doi.org/10.1093/rheumatology/kew299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088626PMC
November 2016

Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.

Authors:
Amanda McGovern Stefan Schoenfelder Paul Martin Jonathan Massey Kate Duffus Darren Plant Annie Yarwood Arthur G Pratt Amy E Anderson John D Isaacs Julie Diboll Nishanthi Thalayasingam Caroline Ospelt Anne Barton Jane Worthington Peter Fraser Stephen Eyre Gisela Orozco

Genome Biol 2016 11 1;17(1):212. Epub 2016 Nov 1.

Arthritis Research UK Centre for Genetics and Genomics, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1186/s13059-016-1078-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088679PMC
November 2016

Teaching examples for the design of experiments: geographical sensitivity and the self-fulfilling prophecy.

Authors:
Dennis W Lendrem B Clare Lendrem Ruth Rowland-Jones Fabio D'Agostino Matt Linsley Martin R Owen John D Isaacs

Pharm Stat 2016 Jan-Feb;15(1):90-2. Epub 2015 Nov 12.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/pst.1723DOI Listing
October 2016

Components of treatment delay in rheumatoid arthritis differ according to autoantibody status: validation of a single-centre observation using national audit data.

Authors:
Arthur G Pratt Dennis Lendrem Ben Hargreaves Osman Aslam James B Galloway John D Isaacs

Rheumatology (Oxford) 2016 Oct 3;55(10):1843-8. Epub 2016 Jul 3.

National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne.

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http://dx.doi.org/10.1093/rheumatology/kew261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034219PMC
October 2016

Analytic Validation of RNA In Situ Hybridization (RISH) for AR and AR-V7 Expression in Human Prostate Cancer.

Authors:
Liana B Guedes Carlos L Morais Fawaz Almutairi Michael C Haffner Qizhi Zheng John T Isaacs Emmanuel S Antonarakis Changxue Lu Harrison Tsai Jun Luo Angelo M De Marzo Tamara L Lotan

Clin Cancer Res 2016 Sep 10;22(18):4651-63. Epub 2016 May 10.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026571PMC
September 2016

Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies.

Authors:
Phillip Lord Rachel Spiering Juan C Aguillon Amy E Anderson Silke Appel Daniel Benitez-Ribas Anja Ten Brinke Femke Broere Nathalie Cools Maria Cristina Cuturi Julie Diboll Edward K Geissler Nick Giannoukakis Silvia Gregori S Marieke van Ham Staci Lattimer Lindsay Marshall Rachel A Harry James A Hutchinson John D Isaacs Irma Joosten Cees van Kooten Ascension Lopez Diaz de Cerio Tatjana Nikolic Haluk Barbaros Oral Ljiljana Sofronic-Milosavljevic Thomas Ritter Paloma Riquelme Angus W Thomson Massimo Trucco Marta Vives-Pi Eva M Martinez-Caceres Catharien M U Hilkens

PeerJ 2016 30;4:e2300. Epub 2016 Aug 30.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.7717/peerj.2300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012269PMC
September 2016

Pregnancy Outcomes in the Tofacitinib Safety Databases for Rheumatoid Arthritis and Psoriasis.

Authors:
Megan E B Clowse Steven R Feldman John D Isaacs Alexandra B Kimball Vibeke Strand Richard B Warren Daniel Xibillé Yan Chen Donald Frazier Jamie Geier James Proulx Amy Marren

Drug Saf 2016 08;39(8):755-62

Pfizer Inc, 500 Arcola Rd, Collegeville, PA, 19426, USA.

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http://dx.doi.org/10.1007/s40264-016-0431-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933738PMC
August 2016

Androgen Deprivation Followed by Acute Androgen Stimulation Selectively Sensitizes AR-Positive Prostate Cancer Cells to Ionizing Radiation.

Authors:
Mohammad Hedayati Michael C Haffner Jonathan B Coulter Raju R Raval Yonggang Zhang Haoming Zhou Omar Mian Emma J Knight Nina Razavi Susan Dalrymple John T Isaacs Aileen Santos Russell Hales William G Nelson Srinivasan Yegnasubramanian Theodore L DeWeese

Clin Cancer Res 2016 07 1;22(13):3310-3319. Epub 2016 Feb 1.

Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930695PMC
July 2016

A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren's Syndrome.

Authors:
Katherine James Shereen Al-Ali Jessica Tarn Simon J Cockell Colin S Gillespie Victoria Hindmarsh James Locke Sheryl Mitchell Dennis Lendrem Simon Bowman Elizabeth Price Colin T Pease Paul Emery Peter Lanyon John A Hunter Monica Gupta Michele Bombardieri Nurhan Sutcliffe Costantino Pitzalis John McLaren Annie Cooper Marian Regan Ian Giles David Isenberg Vadivelu Saravanan David Coady Bhaskar Dasgupta Neil McHugh Steven Young-Min Robert Moots Nagui Gendi Mohammed Akil Bridget Griffiths Anil Wipat Julia Newton David E Jones John Isaacs Jennifer Hallinan Wan-Fai Ng

PLoS One 2015 22;10(12):e0143970. Epub 2015 Dec 22.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143970PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687914PMC
June 2016

Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis.

Authors:
Darren Plant Amy Webster Nisha Nair James Oliver Samantha L Smith Steven Eyre Kimme L Hyrich Anthony G Wilson Ann W Morgan John D Isaacs Jane Worthington Anne Barton

Arthritis Rheumatol 2016 06 21;68(6):1353-60. Epub 2016 Apr 21.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, and Central Manchester NHS Trust, and Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/art.39590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914881PMC
June 2016

A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer.

Authors:
Oren Levy W Nathaniel Brennen Edward Han David Marc Rosen Juliet Musabeyezu Helia Safaee Sudhir Ranganath Jessica Ngai Martina Heinelt Yuka Milton Hao Wang Sachin H Bhagchandani Nitin Joshi Neil Bhowmick Samuel R Denmeade John T Isaacs Jeffrey M Karp

Biomaterials 2016 Jun 17;91:140-150. Epub 2016 Mar 17.

Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital, United States; Harvard Medical School, United States; Harvard Stem Cell Institute, United States; Harvard - MIT Division of Health Sciences and Technology, United States. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824400PMC
June 2016

Rheumatoid arthritis: an evolutionary force in biologics.

Authors:
Philip M Brown John D Isaacs

Curr Pharm Des 2015 ;21(17):2170-8

NIHR Newcastle Biomedical Research Centre, Institute of Cellular Medicine, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.2174/1381612821666150310141827DOI Listing
May 2016

Rapid selection of mesenchymal stem and progenitor cells in primary prostate stromal cultures.

Authors:
W Nathaniel Brennen L Nelleke Kisteman John T Isaacs

Prostate 2016 May 6;76(6):552-64. Epub 2016 Jan 6.

Department of Oncology, Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://doi.wiley.com/10.1002/pros.23145
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http://dx.doi.org/10.1002/pros.23145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856028PMC
May 2016

Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort.

Authors:
Samantha Louise Smith Darren Plant Xiu Hue Lee Jonathan Massey Kimme Hyrich Ann W Morgan Anthony G Wilson John Isaacs Anne Barton

Pharmacogenomics 2016 05 16;17(7):715-20. Epub 2016 May 16.

Arthritis Research UK, Centre for Genetics & Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.2217/pgs.16.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996314PMC
May 2016

CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study.

Authors:
Ioakim Spyridopoulos Carmen Martin-Ruiz Catharien Hilkens Mohammad E Yadegarfar John Isaacs Carol Jagger Tom Kirkwood Thomas von Zglinicki

Aging Cell 2016 Apr 22;15(2):389-92. Epub 2015 Dec 22.

Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.

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http://dx.doi.org/10.1111/acel.12430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783336PMC
April 2016

Bcl-3 in CD4+ T Cell-Mediated Rheumatoid Arthritis Pathogenesis: Comment on the Article by Meguro et al.

Authors:
Arthur G Pratt Amy E Anderson Ruaidhri J Carmody John D Isaacs

Arthritis Rheumatol 2016 Mar;68(3):770-1

NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/art.39509DOI Listing
March 2016

IL-6-driven STAT signalling in circulating CD4+ lymphocytes is a marker for early anticitrullinated peptide antibody-negative rheumatoid arthritis.

Authors:
Amy E Anderson Arthur G Pratt Mamdouh A K Sedhom John Paul Doran Christine Routledge Ben Hargreaves Philip M Brown Kim-Anh Lê Cao John D Isaacs Ranjeny Thomas

Ann Rheum Dis 2016 Feb 3;75(2):466-73. Epub 2015 Feb 3.

The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Queensland, Australia.

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http://dx.doi.org/10.1136/annrheumdis-2014-205850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752669PMC
February 2016

Cytokines in rheumatoid arthritis - shaping the immunological landscape.

Authors:
Iain B McInnes Christopher D Buckley John D Isaacs

Nat Rev Rheumatol 2016 Jan 10;12(1):63-8. Epub 2015 Dec 10.

NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Institute of Cellular Medicine, Newcastle University, William Leech Building, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrrheum.2015.171DOI Listing
January 2016

The Online Dissemination of Nature-Health Concepts: Lessons from Sentiment Analysis of Social Media Relating to "Nature-Deficit Disorder".

Authors:
Marco Palomino Tim Taylor Ayse Göker John Isaacs Sara Warber

Int J Environ Res Public Health 2016 Jan 19;13(1). Epub 2016 Jan 19.

European Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall TR1 3HD, UK.

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http://dx.doi.org/10.3390/ijerph13010142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730533PMC
January 2016

Investigating CD11c expression as a potential genomic biomarker of response to TNF inhibitor biologics in whole blood rheumatoid arthritis samples.

Authors:
Samantha Louise Smith Stephen Eyre Annie Yarwood Kimme Hyrich Ann W Morgan A G Wilson John Isaacs Darren Plant Anne Barton

Arthritis Res Ther 2015 Dec 14;17:359. Epub 2015 Dec 14.

Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, the University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s13075-015-0868-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704535PMC
December 2015

Decade in review-clinical rheumatology: 10 years of therapeutic advances in the rheumatic diseases.

Authors:
John D Isaacs

Nat Rev Rheumatol 2015 Nov 13;11(11):628-30. Epub 2015 Oct 13.

Newcastle University, Institute of Cellular Medicine, William Leech Building, Framlington Place, Newcastle-Upon-Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrrheum.2015.138DOI Listing
November 2015

Lost in space: design of experiments and scientific exploration in a Hogarth Universe.

Authors:
Dennis W Lendrem B Clare Lendrem David Woods Ruth Rowland-Jones Matthew Burke Marion Chatfield John D Isaacs Martin R Owen

Drug Discov Today 2015 Nov 23;20(11):1365-71. Epub 2015 Oct 23.

Centre for Medicines Research, GlaxoSmithKline, Stevenage, UK.

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http://dx.doi.org/10.1016/j.drudis.2015.09.015DOI Listing
November 2015

Why is it hard to terminate failing projects in pharmaceutical R&D?

Authors:
Richard W Peck Dennis W Lendrem Iain Grant B Clare Lendrem John D Isaacs

Nat Rev Drug Discov 2015 Oct 21;14(10):663-4. Epub 2015 Aug 21.

Institute of Cellular Medicine, Framlington Place, Newcastle University NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrd4725DOI Listing
October 2015

RITPBC: B-cell depleting therapy (rituximab) as a treatment for fatigue in primary biliary cirrhosis: study protocol for a randomised controlled trial.

Authors:
Laura Jopson Julia L Newton Jeremy Palmer Achilleas Floudas John Isaacs Jessica Qian Jennifer Wilkinson Mike Trenell Andrew Blamire Denise Howel David E Jones

BMJ Open 2015 Aug 20;5(8):e007985. Epub 2015 Aug 20.

Institute of Cellular Medicine, Medical School, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/bmjopen-2015-007985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550715PMC
August 2015

Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis.

Authors:
Meghna Jani Hector Chinoy Richard B Warren Christopher E M Griffiths Darren Plant Bo Fu Ann W Morgan Anthony G Wilson John D Isaacs KimmeL Hyrich Anne Barton

Arthritis Rheumatol 2015 May;67(8):2011-9

Darren Plant, PhD, Anne Barton, MBChB, PhD, FRCP: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, UK.

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http://doi.wiley.com/10.1002/art.39169
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http://dx.doi.org/10.1002/art.39169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843946PMC
May 2015

Evaluation of the effect of tofacitinib on measured glomerular filtration rate in patients with active rheumatoid arthritis: results from a randomised controlled trial.

Authors:
Joel M Kremer Alan J Kivitz Jesus A Simon-Campos Evgeny L Nasonov Hans-Peter Tony Soo-Kon Lee Bonnie Vlahos Constance Hammond Jack Bukowski Huihua Li Seth L Schulman Susan Raber Andrea Zuckerman John D Isaacs

Arthritis Res Ther 2015 Apr 6;17:95. Epub 2015 Apr 6.

National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1186/s13075-015-0612-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445792PMC
April 2015

Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.

Authors:
Sebastien Viatte Darren Plant Buhm Han Bo Fu Annie Yarwood Wendy Thomson Deborah P M Symmons Jane Worthington Adam Young Kimme L Hyrich Ann W Morgan Anthony G Wilson John D Isaacs Soumya Raychaudhuri Anne Barton

JAMA 2015 Apr;313(16):1645-56

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, England2NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manches.

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http://dx.doi.org/10.1001/jama.2015.3435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928097PMC
April 2015

Genotyping in rheumatoid arthritis: a game changer in clinical management?

Authors:
Arthur G Pratt John D Isaacs

Expert Rev Clin Immunol 2015 Mar 2;11(3):303-5. Epub 2015 Feb 2.

Institute of Cellular Medicine (Musculoskeletal Research Group), Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1586/1744666X.2015.1008454DOI Listing
March 2015

Progression-seeking bias and rational optimism in research and development.

Authors:
Dennis W Lendrem B Clare Lendrem Richard W Peck Stephen C Senn Simon Day John D Isaacs

Nat Rev Drug Discov 2015 Mar 6;14(3):219-21. Epub 2015 Feb 6.

Institute of Cellular Medicine, Newcastle University, Newcastle, NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrd4320-c1DOI Listing
March 2015

Lessons learned about prostatic transformation from the age-related methylation of 5α-reductase type 2 gene.

Authors:
John T Isaacs

Am J Pathol 2015 Mar 17;185(3):614-6. Epub 2015 Feb 17.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and The Brady Urologic Institute, The Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348462PMC
March 2015

Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study.

Authors:
Ariana Montes Eva Perez-Pampin Federico Navarro-Sarabia Virginia Moreira Arturo Rodríguez de la Serna Berta Magallares Yiannis Vasilopoulos Theologia Sarafidou Antonio Fernández-Nebro María Del Carmen Ordóñez Javier Narváez Juan D Cañete Ana Marquez Dora Pascual-Salcedo Beatriz Joven Patricia Carreira Manuel J Moreno-Ramos Rafael Caliz Miguel Angel Ferrer Rosa Garcia-Portales Francisco J Blanco Cesar Magro Enrique Raya Lara Valor Juan J Alegre-Sancho Alejandro Balsa Javier Martin Darren Plant John Isaacs Ann W Morgan Anne Barton Anthony G Wilson Juan J Gómez-Reino Antonio Gonzalez

Arthritis Res Ther 2015 Mar 18;17:63. Epub 2015 Mar 18.

Laboratorio de Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria - Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.

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http://dx.doi.org/10.1186/s13075-015-0571-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411723PMC
March 2015

Clinical utility of random anti-tumour necrosis factor drug testing and measurement of anti-drug antibodies on long-term treatment response in rheumatoid arthritis.

Authors:
Meghna Jani Hector Chinoy Richard B Warren Christopher E M Griffiths Darren Plant Ann W Morgan Anthony G Wilson Kimme L Hyrich John Isaacs Anne Barton

Lancet 2015 Feb;385 Suppl 1:S48

Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S014067361560363
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http://dx.doi.org/10.1016/S0140-6736(15)60363-4DOI Listing
February 2015

Effect of bipolar androgen therapy for asymptomatic men with castration-resistant prostate cancer: results from a pilot clinical study.

Authors:
Michael T Schweizer Emmanuel S Antonarakis Hao Wang A Seun Ajiboye Avery Spitz Haiyi Cao Jun Luo Michael C Haffner Srinivasan Yegnasubramanian Michael A Carducci Mario A Eisenberger John T Isaacs Samuel R Denmeade

Sci Transl Med 2015 Jan;7(269):269ra2

The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1126/scitranslmed.3010563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507510PMC
January 2015