John Inge Johnsen

John Inge Johnsen

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John Inge Johnsen

Publications by authors named "John Inge Johnsen"

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Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma.

Oncogene 2019 04 12;38(15):2800-2813. Epub 2018 Dec 12.

Department of Pediatrics, Division of Child and Adolescent Health, UNN - University Hospital of North-Norway, NO-9038, Tromsø, Norway.

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http://www.nature.com/articles/s41388-018-0611-7
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http://dx.doi.org/10.1038/s41388-018-0611-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484764PMC
April 2019

RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism.

Cancer Lett 2019 02 14;442:341-350. Epub 2018 Nov 14.

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183066
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http://dx.doi.org/10.1016/j.canlet.2018.11.005DOI Listing
February 2019

SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro.

Cancers (Basel) 2019 Feb 10;11(2). Epub 2019 Feb 10.

Molecular Inflammation Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Hansine Hansens veg 18, 9019 Tromsø, Norway.

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http://dx.doi.org/10.3390/cancers11020202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406899PMC
February 2019

Neuroblastoma-A Neural Crest Derived Embryonal Malignancy.

Front Mol Neurosci 2019 29;12. Epub 2019 Jan 29.

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet (KI), Stockholm, Sweden.

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http://dx.doi.org/10.3389/fnmol.2019.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361784PMC
January 2019

Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth.

EBioMedicine 2018 Jun 24;32:84-92. Epub 2018 May 24.

Childhood Cancer Research Unit, Dep. of Children's and Women's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021299PMC
June 2018

Molecular mechanisms and therapeutic targets in neuroblastoma.

Pharmacol Res 2018 05 18;131:164-176. Epub 2018 Feb 18.

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital Solna, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.phrs.2018.02.023DOI Listing
May 2018

Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability and impairs tumor growth .

Oncotarget 2017 Nov 27;8(56):95135-95151. Epub 2017 Jul 27.

Molecular Inflammation Research Group, Department of Medical Biology, Faculty of Health Science, University of Tromsø, Tromsø, Norway.

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http://www.oncotarget.com/fulltext/19619
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http://dx.doi.org/10.18632/oncotarget.19619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707011PMC
November 2017

Rho-associated kinase is a therapeutic target in neuroblastoma.

Proc Natl Acad Sci U S A 2017 08 24;114(32):E6603-E6612. Epub 2017 Jul 24.

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, 171 76 Stockholm, Sweden;

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http://dx.doi.org/10.1073/pnas.1706011114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559038PMC
August 2017

Regulation of myeloid cells by activated T cells determines the efficacy of PD-1 blockade.

Oncoimmunology 2016 9;5(12):e1232222. Epub 2016 Sep 9.

Childhood Cancer Research Unit, Q6:05, Department of Women's and Children's Health, Karolinska Institutet , Stockholm, Sweden.

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http://dx.doi.org/10.1080/2162402X.2016.1232222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214950PMC
September 2016

Targeting Suppressive Myeloid Cells Potentiates Checkpoint Inhibitors to Control Spontaneous Neuroblastoma.

Clin Cancer Res 2016 08 8;22(15):3849-59. Epub 2016 Mar 8.

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1912DOI Listing
August 2016

The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis.

BMC Cancer 2016 07 18;16:490. Epub 2016 Jul 18.

Molecular Inflammation Research Group, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.

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http://dx.doi.org/10.1186/s12885-016-2545-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950242PMC
July 2016

Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma.

BMC Cancer 2016 Mar 31;16:259. Epub 2016 Mar 31.

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital Q6:05, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s12885-016-2293-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818482PMC
March 2016

Wingless/β-catenin signaling as a modulator of chemoresistance in cancer.

Mol Cell Oncol 2016 Mar 19;3(2):e1131356. Epub 2016 Jan 19.

Department of Stem and Regenerative Biology, Harvard University, Cambridge, MA, USA; Center for Regenerative Medicine and the Cancer Center, Massachusetts General Hospital, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA.

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http://dx.doi.org/10.1080/23723556.2015.1131356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905426PMC
March 2016

The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis.

Dev Cell 2016 Jan;36(2):164-78

Ludwig Institute for Cancer Research Ltd., 17177 Stockholm, Sweden; Department of Microbiology and Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.12.029DOI Listing
January 2016

Cytomegalovirus in human brain tumors: Role in pathogenesis and potential treatment options.

World J Exp Med 2015 Feb 20;5(1):1-10. Epub 2015 Feb 20.

Cecilia Söderberg-Nauclér, Experimental Cardiovascular Research Unit, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.5493/wjem.v5.i1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308527PMC
February 2015

Sunitinib suppress neuroblastoma growth through degradation of MYCN and inhibition of angiogenesis.

PLoS One 2014 23;9(4):e95628. Epub 2014 Apr 23.

AECC-CHUA Cancer Research Unit, Albacete University Hospital, Albacete, Spain; Castilla La Mancha University, Toledo, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095628PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997473PMC
January 2015

Effects of epigenetic modificators in combination with small molecule inhibitors of receptor tyrosine kinases on medulloblastoma growth.

Biochem Biophys Res Commun 2014 Aug 12;450(4):1600-5. Epub 2014 Jul 12.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2014.07.042DOI Listing
August 2014

Frequent detection of human cytomegalovirus in neuroblastoma: a novel therapeutic target?

Int J Cancer 2013 Nov 13;133(10):2351-61. Epub 2013 Jul 13.

Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ijc.28265DOI Listing
November 2013

Expression of TWEAK/Fn14 in neuroblastoma: implications in tumorigenesis.

Int J Oncol 2013 Apr 29;42(4):1239-48. Epub 2013 Jan 29.

Translational Cancer Research Group, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.

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http://dx.doi.org/10.3892/ijo.2013.1800DOI Listing
April 2013

Cytomegalovirus infection in brain tumors: A potential new target for therapy?

Oncoimmunology 2012 Aug;1(5):739-740

Department of Medicine, Solna; Center for Molecular Medicine and Childhood; Stockholm, Sweden.

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http://dx.doi.org/10.4161/onci.19441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429578PMC
August 2012

Effects of small molecule inhibitors of PI3K/Akt/mTOR signaling on neuroblastoma growth in vitro and in vivo.

Int J Cancer 2011 Dec 29;129(12):2958-65. Epub 2011 Aug 29.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ijc.26268DOI Listing
December 2011

Is human cytomegalovirus a target in cancer therapy?

Oncotarget 2011 Dec;2(12):1329-38

Childhood Cancer Research Unit, Department of Women´s and Children´s Health, Karolinska Institute, 171 76 Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282090PMC
http://dx.doi.org/10.18632/oncotarget.383DOI Listing
December 2011

Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models.

Biochem Biophys Res Commun 2011 Jul 25;411(1):208-12. Epub 2011 Jun 25.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2011.06.141DOI Listing
July 2011

Omega-3 fatty acid supplementation delays the progression of neuroblastoma in vivo.

Int J Cancer 2011 Apr 24;128(7):1703-11. Epub 2010 May 24.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

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http://doi.wiley.com/10.1002/ijc.25473
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http://dx.doi.org/10.1002/ijc.25473DOI Listing
April 2011

Differential forms of p53 in medulloblastoma primary tumors, cell lines and xenografts.

Int J Oncol 2011 Mar 23;38(3):843-9. Epub 2010 Dec 23.

Department of Clinical Neuroscience, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.3892/ijo.2010.884DOI Listing
March 2011

Medulloblastoma: a disease with disorganized developmental signaling cascades.

Cell Cycle 2010 Jul;9(13):2548-54

Childhood Cancer Research Unit, Department of Women’s and Children’s Health, Karolinska Institutet, Astrid Lindgren Children’s Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.4161/cc.9.13.12170DOI Listing
July 2010

Omega-3 fatty acids in cancer, the protectors of good and the killers of evil?

Exp Cell Res 2010 May 6;316(8):1365-73. Epub 2010 Mar 6.

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, S-171 76, Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S00144827100010
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http://dx.doi.org/10.1016/j.yexcr.2010.02.039DOI Listing
May 2010

MYC in oncogenesis and as a target for cancer therapies.

Adv Cancer Res 2010 ;107:163-224

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/S0065-230X(10)07006-5DOI Listing
April 2010

Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates.

FASEB J 2010 Mar 4;24(3):906-15. Epub 2009 Nov 4.

Childhood Cancer Research Unit, Q6:05, Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1096/fj.09-137919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830131PMC
March 2010

Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth.

Cancer Res 2010 Jan 22;70(1):266-76. Epub 2009 Dec 22.

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0578DOI Listing
January 2010

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.

Proc Natl Acad Sci U S A 2009 Nov 21;106(44):18757-62. Epub 2009 Oct 21.

Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1073/pnas.0910218106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768589PMC
November 2009

Embryonal neural tumours and cell death.

Apoptosis 2009 Apr;14(4):424-38

Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Childhood Cancer Research Unit, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s10495-009-0325-yDOI Listing
April 2009

The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo.

Mol Cancer Ther 2007 Sep;6(9):2409-17

Division of Clinical Pharmacology, Department of Medical Sciences, Entrance 61, 4th Floor Uppsala University Hospital, 75185 Uppsala, Sweden.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-07
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http://dx.doi.org/10.1158/1535-7163.MCT-07-0156DOI Listing
September 2007

The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo.

Int J Cancer 2006 Aug;119(3):493-500

Department of Biochemistry, Faculty of Medicine, University of Tromsø, Tromsø, Norway, and Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden.

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http://doi.wiley.com/10.1002/ijc.21886
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http://dx.doi.org/10.1002/ijc.21886DOI Listing
August 2006

Neuroblastoma cell death in response to docosahexaenoic acid: sensitization to chemotherapy and arsenic-induced oxidative stress.

Int J Cancer 2006 May;118(10):2584-93

Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ijc.21555DOI Listing
May 2006

Proton magnetic resonance spectroscopy in neuroblastoma: current status, prospects and limitations.

Cancer Lett 2005 Oct;228(1-2):247-55

Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Karolinska Hospital, S-17176 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.canlet.2004.12.055DOI Listing
October 2005

Identification of a unique BK virus variant in the CNS of a patient with AIDS.

J Med Virol 2003 May;70(1):14-9

Department of Pediatrics, Faculty of Medicine, University of Tromsø, Tromsø, Norway.

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http://dx.doi.org/10.1002/jmv.10370DOI Listing
May 2003

The synthetic retinoid RO 13-6307 induces neuroblastoma differentiation in vitro and inhibits neuroblastoma tumour growth in vivo.

Int J Cancer 2003 Apr;104(4):418-24

Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ijc.10954DOI Listing
April 2003