John Hiscott

John Hiscott

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John Hiscott

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Cytokines 2017 in Kanazawa: Looking beyond the horizon of integrated cytokine research from the sea of Japan.

Cytokine Growth Factor Rev 2019 Dec 4;50:75-82. Epub 2018 Feb 4.

Pasteur Laboratories, Istituto Pasteur-Fondazione Cenci Bolognetti, 00161 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2018.01.008DOI Listing
December 2019

Evaluation of Innate Immune Gene Expression Following HDAC Inhibitor Treatment by High Throughput qPCR and PhosFlow Cytometry.

Methods Mol Biol 2017 ;1510:245-255

Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1007/978-1-4939-6527-4_18DOI Listing
January 2018

Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities.

J Enzyme Inhib Med Chem 2017 Dec;32(1):1091-1101

a Department of Drug Chemistry and Technologies , Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti , Roma , Italy.

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http://dx.doi.org/10.1080/14756366.2017.1355791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010079PMC
December 2017

Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity.

Mol Ther 2017 08 17;25(8):1900-1916. Epub 2017 May 17.

Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada; Division of Experimental Medicine, McGill University, Montreal, QC H4A 3J1, Canada; Department of Microbiology & Immunology, McGill University, Montreal, QC H3A 2B4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542709PMC
August 2017

Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways.

Trends Immunol 2017 03 7;38(3):194-205. Epub 2017 Jan 7.

Istituto Pasteur - Italia, Istituto Pasteur - Fondazione Cenci Bolognetti, Rome, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714906163020
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http://dx.doi.org/10.1016/j.it.2016.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329138PMC
March 2017

HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal Degradation.

mBio 2016 10 18;7(5). Epub 2016 Oct 18.

Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy

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http://dx.doi.org/10.1128/mBio.01528-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082900PMC
October 2016

Dengue Virus Immunopathogenesis: Lessons Applicable to the Emergence of Zika Virus.

J Mol Biol 2016 08 27;428(17):3429-48. Epub 2016 Apr 27.

Istituto Pasteur-Fondazione Cenci Bolognetti, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.04.024DOI Listing
August 2016

Mechanisms of Zika Virus Infection and Neuropathogenesis.

DNA Cell Biol 2016 Aug 27;35(8):367-72. Epub 2016 Jun 27.

2 Istituto Pasteur-Fondazione Cenci Bolognetti , Rome, Italy .

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http://dx.doi.org/10.1089/dna.2016.3404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971419PMC
August 2016

Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.

Eur J Immunol 2015 12 12;45(12):3386-403. Epub 2015 Oct 12.

Immunobiology Laboratory, The Francis Crick Institute, Lincoln's Inn Fields Laboratory, 44 Lincoln's Inn Fields, London, UK.

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http://dx.doi.org/10.1002/eji.201545794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833184PMC
December 2015

Crosstalk between the TNF and IGF pathways enhances NF-κB activation and signaling in cancer cells.

Growth Horm IGF Res 2015 Oct 20;25(5):253-61. Epub 2015 Jul 20.

Dept of Medicine, McGill University and the McGill University Health Center, Canada; Dept of Surgery, McGill University and the McGill University Health Center, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ghir.2015.07.008DOI Listing
October 2015

Defining New Therapeutics Using a More Immunocompetent Mouse Model of Antibody-Enhanced Dengue Virus Infection.

mBio 2015 Sep 15;6(5):e01316-15. Epub 2015 Sep 15.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, Missouri, USA

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http://dx.doi.org/10.1128/mBio.01316-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600115PMC
September 2015

Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation.

PLoS One 2014 23;9(4):e95927. Epub 2014 Apr 23.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095927PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997492PMC
June 2015

Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon.

J Biol Chem 2015 Jun 24;290(23):14729-39. Epub 2015 Apr 24.

the Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21287,

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http://www.jbc.org/content/290/23/14729.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.633065
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http://dx.doi.org/10.1074/jbc.M114.633065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505538PMC
June 2015

Paula Pitha-Rowe, PhD (1938-2015).

Authors:
John Hiscott

J Interferon Cytokine Res 2015 May 9;35(5):325-6. Epub 2015 Apr 9.

Vaccine & Gene Therapy Institute , Port St. Lucie, Florida.

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http://dx.doi.org/10.1089/jir.2015.1501DOI Listing
May 2015

Innate immune sensing of HIV-1 infection.

Curr Opin HIV AIDS 2015 Mar;10(2):96-102

aInstitute of Biomedicine, Faculty of Health, Aarhus University bAarhus Research Centre of Innate Immunology, Aarhus, Denmark cVaccine and Gene Therapy Institute of Florida, Port Saint Lucie, Florida, USA.

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http://pdfs.journals.lww.com/co-hivandaids/2015/03000/Innate
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/COH.0000000000000129DOI Listing
March 2015

Unmasking immune sensing of retroviruses: interplay between innate sensors and host effectors.

Cytokine Growth Factor Rev 2014 Dec 3;25(6):657-68. Epub 2014 Sep 3.

Vaccine & Gene Therapy Institute of Florida, 9801 Discovery Way, Port Saint Lucie, FL 34987, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2014.08.006DOI Listing
December 2014

Introduction to innate sensing and response to pathogens (part 2).

Authors:
John Hiscott

Cytokine Growth Factor Rev 2014 Dec 19;25(6):629-30. Epub 2014 Nov 19.

West Palm Beach, FL, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13596101140014
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http://dx.doi.org/10.1016/j.cytogfr.2014.11.001DOI Listing
December 2014

HTLV-1 Tax-mediated inhibition of FOXO3a activity is critical for the persistence of terminally differentiated CD4+ T cells.

PLoS Pathog 2014 Dec 18;10(12):e1004575. Epub 2014 Dec 18.

Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Quebec, Canada; VGTI Florida, Port St. Lucie, Florida, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270795PMC
December 2014

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma.

Proc Natl Acad Sci U S A 2014 Oct 6;111(42):E4513-22. Epub 2014 Oct 6.

Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany; Hematology, Oncology, and Tumor Immunology, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;

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http://dx.doi.org/10.1073/pnas.1406985111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210307PMC
October 2014

Introduction to innate sensing and response to pathogens.

Authors:
John Hiscott

Cytokine Growth Factor Rev 2014 Oct 28;25(5):489-90. Epub 2014 Oct 28.

West Palm Beach, FL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2014.09.004DOI Listing
October 2014

Type I and type III interferon-induced immune response: it's a matter of kinetics and magnitude.

Hepatology 2014 Apr 28;59(4):1225-8. Epub 2014 Feb 28.

Viral Pathogenesis Program, Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, FL.

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http://dx.doi.org/10.1002/hep.26959DOI Listing
April 2014

Intact type I Interferon production and IRF7 function in sooty mangabeys.

PLoS Pathog 2013 29;9(8):e1003597. Epub 2013 Aug 29.

Divison of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757038PMC
March 2014

Conference highlights of the 16th International Conference on Human Retrovirology: HTLV and related retroviruses, 26-30 June 2013, Montreal, Canada.

Retrovirology 2014 Feb 24;11:19. Epub 2014 Feb 24.

Département des sciences biologiques and BioMed Research Center, Université du Québec à Montréal, Room SB-3335, 2080 St-Urbain, Montréal, Québec, Canada.

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http://dx.doi.org/10.1186/1742-4690-11-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939404PMC
February 2014

SAMHD1 host restriction factor: a link with innate immune sensing of retrovirus infection.

J Mol Biol 2013 Dec 23;425(24):4981-94. Epub 2013 Oct 23.

Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada H3T 1E2.

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http://dx.doi.org/10.1016/j.jmb.2013.10.022DOI Listing
December 2013

Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis.

Mol Ther 2013 Nov 28;21(11):2043-53. Epub 2013 Aug 28.

Department of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/mt.2013.187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831042PMC
November 2013

Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis.

Cell Host Microbe 2013 Oct;14(4):422-34

Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada.

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http://dx.doi.org/10.1016/j.chom.2013.09.009DOI Listing
October 2013

Cytokine networks during HIV infection: shifting the balance.

Cytokine Growth Factor Rev 2012 Aug-Oct;23(4-5):139-41. Epub 2012 Jul 4.

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http://dx.doi.org/10.1016/j.cytogfr.2012.05.012DOI Listing
January 2013

HCV NS5A and IRF9 compete for CypA binding.

J Hepatol 2013 Jan 15;58(1):16-23. Epub 2012 Aug 15.

Department of Immunology & Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.jhep.2012.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527675PMC
January 2013

Recruitment of histone deacetylase 3 to the interferon-A gene promoters attenuates interferon expression.

PLoS One 2012 7;7(6):e38336. Epub 2012 Jun 7.

Centre National de la Recherche Scientifique-FRE3235, Paris Descartes University, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038336PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369917PMC
December 2012

The use of oncolytic viruses to overcome lung cancer drug resistance.

Curr Opin Virol 2012 Oct 19;2(5):629-35. Epub 2012 Aug 19.

Vaccine and Gene Therapy Institute of Florida, 9801 Discovery Way, Port Saint Lucie, FL 34987, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S18796257120012
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http://dx.doi.org/10.1016/j.coviro.2012.07.006DOI Listing
October 2012

Breaking the barrier: membrane fusion triggers innate antiviral immunity.

Nat Immunol 2012 Jul 19;13(8):713-5. Epub 2012 Jul 19.

Division of Infectious Diseases, Vaccine & Gene Therapy Institute of Florida, Port St. Lucie, FL, USA.

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http://www.nature.com/articles/ni.2373
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http://dx.doi.org/10.1038/ni.2373DOI Listing
July 2012

IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis.

J Virol 2012 Jan 9;86(2):726-37. Epub 2011 Nov 9.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Canada.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.05989-11
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http://dx.doi.org/10.1128/JVI.05989-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255812PMC
January 2012

Vesicular stomatitis virus oncolytic treatment interferes with tumor-associated dendritic cell functions and abrogates tumor antigen presentation.

J Virol 2011 Dec 14;85(23):12160-9. Epub 2011 Sep 14.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1128/JVI.05703-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209377PMC
December 2011

Suppression of IRF4 by IRF1, 3, and 7 in Noxa expression is a necessary event for IFN-γ-mediated tumor elimination.

Mol Cancer Res 2011 Oct 4;9(10):1356-65. Epub 2011 Aug 4.

Department of Biochemistry, Chosun University School of Medicine, Dong-Gu, Gwang-ju 501-759, Korea.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-11
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http://dx.doi.org/10.1158/1541-7786.MCR-11-0185DOI Listing
October 2011

Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter.

Curr Opin Immunol 2011 Oct 22;23(5):564-72. Epub 2011 Aug 22.

Terry Fox Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, Canada.

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http://dx.doi.org/10.1016/j.coi.2011.08.001DOI Listing
October 2011

Cytokines.

Curr Opin Immunol 2011 Oct;23(5):561-3

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http://dx.doi.org/10.1016/j.coi.2011.09.001DOI Listing
October 2011

Modulation of innate immune responses during human T-cell leukemia virus (HTLV-1) pathogenesis.

Cytokine Growth Factor Rev 2011 Aug 15;22(4):197-210. Epub 2011 Sep 15.

Molecular Oncology Group, Lady Davis Institute-Jewish General Hospital, and Department of Microbiology, McGill University, Montreal, Canada H3T 1E2.

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http://dx.doi.org/10.1016/j.cytogfr.2011.08.002DOI Listing
August 2011

The interface between the innate interferon response and expression of host retroviral restriction factors.

Cytokine 2010 Oct-Nov;52(1-2):108-15. Epub 2010 Jun 2.

Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, 3999 Côte Ste-Catherine, Dept. of Microbiology and Medicine, McGill University, Montreal, Quebec, Canada H3T 1E2.

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http://dx.doi.org/10.1016/j.cyto.2010.04.010DOI Listing
December 2010

VSV oncolysis in combination with the BCL-2 inhibitor obatoclax overcomes apoptosis resistance in chronic lymphocytic leukemia.

Mol Ther 2010 Dec 14;18(12):2094-103. Epub 2010 Sep 14.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/mt.2010.188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997588PMC
December 2010

CuRTAiling interferon regulatory factor signaling with the E3 ligase RAUL.

Immunity 2010 Dec;33(6):833-5

Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, H3T 1E2, Canada.

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http://dx.doi.org/10.1016/j.immuni.2010.12.006DOI Listing
December 2010

MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR.

FASEB J 2010 Oct 19;24(10):4068-77. Epub 2010 May 19.

Institute of Molecular Virology, Westfälische-Wilhelms-University, D-48149 Münster, Germany.

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http://dx.doi.org/10.1096/fj.10-158766DOI Listing
October 2010

Oncolytic viruses and histone deacetylase inhibitors--a multi-pronged strategy to target tumor cells.

Cytokine Growth Factor Rev 2010 Apr-Jun;21(2-3):153-9. Epub 2010 Apr 14.

Molecular Oncology Group, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Quebec, Canada H3T 1E2.

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http://dx.doi.org/10.1016/j.cytogfr.2010.03.002DOI Listing
September 2010

Tom70 imports antiviral immunity to the mitochondria.

Cell Res 2010 Sep 13;20(9):971-3. Epub 2010 Jul 13.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1038/cr.2010.113DOI Listing
September 2010

STING-ing the antiviral pathway.

J Mol Cell Biol 2010 Jun 18;2(3):110-2. Epub 2009 Dec 18.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, QC, Canada.

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http://dx.doi.org/10.1093/jmcb/mjp048DOI Listing
June 2010

Functional analysis of a dominant negative mutation of interferon regulatory factor 5.

PLoS One 2009 11;4(5):e5500. Epub 2009 May 11.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005500PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677155PMC
September 2009

RIG-I-like receptors: sensing and responding to RNA virus infection.

Semin Immunol 2009 Aug 17;21(4):215-22. Epub 2009 Jun 17.

The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Quebec, Canada.

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http://dx.doi.org/10.1016/j.smim.2009.05.001DOI Listing
August 2009

Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS.

J Biol Chem 2009 Aug 22;284(33):21797-809. Epub 2009 Jun 22.

Unit of Hepacivirus and Innate Immunity, Laboratory of Viral Genomics and Vaccination, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1074/jbc.M109.018275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755906PMC
August 2009

Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7.

Mol Cell Biol 2009 Jun 6;29(12):3435-50. Epub 2009 Apr 6.

UPR 2228-CNRS, Laboratoire de Régulation Transcriptionnelle et Maladies Génétiques, UFR Biomédicale des Saints-Pères, Université Paris Descartes, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France.

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http://dx.doi.org/10.1128/MCB.01805-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698742PMC
June 2009

Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter.

Mol Cell Biol 2009 Jun 20;29(12):3401-12. Epub 2009 Apr 20.

Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste. Catherine, Montreal, Quebec, Canada H3T 1E2.

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http://dx.doi.org/10.1128/MCB.00880-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698723PMC
June 2009

The emergence of combinatorial strategies in the development of RNA oncolytic virus therapies.

Cell Microbiol 2009 Jun 20;11(6):889-97. Epub 2009 Apr 20.

Terry Fox Molecular Oncology Group, Lady Davis Institute - Jewish General Hospital, Montreal, Quebec, Canada H3T1E2.

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http://dx.doi.org/10.1111/j.1462-5822.2009.01317.xDOI Listing
June 2009

Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis.

J Virol 2008 Sep 25;82(17):8487-99. Epub 2008 Jun 25.

Department of Microbiology and Immunology, Molecular Oncology Group, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1128/JVI.00851-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519628PMC
September 2008

Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation.

J Virol 2008 Jun 16;82(12):5735-49. Epub 2008 Apr 16.

Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Canada H3T 1E2.

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http://dx.doi.org/10.1128/JVI.02601-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395143PMC
June 2008

Targeting dendritic cell signaling to regulate the response to immunization.

Blood 2008 Mar 7;111(6):3050-61. Epub 2008 Jan 7.

Infection and Immunity, University College London, London, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-11-12
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http://dx.doi.org/10.1182/blood-2007-11-122408DOI Listing
March 2008

Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response.

Authors:
John Hiscott

Cytokine Growth Factor Rev 2007 Oct-Dec;18(5-6):483-90. Epub 2007 Aug 13.

Lady Davis Institute for Medical Research - Jewish General Hospital, Departments of Microbiology & Immunology, Medicine and Oncology, McGill University, Montreal, Canada H3T 1E2.

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http://dx.doi.org/10.1016/j.cytogfr.2007.06.002DOI Listing
January 2008

RIG-I has guts: identification of a role for RIG-I in colitis development.

Cell Res 2007 Dec;17(12):974-5

Lady Davis Institute for Medical Research - Jewish General Hospital, Department of Microbiology & Immunology, McGill University, Montreal, Canada.

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http://www.nature.com/articles/cr2007107
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http://dx.doi.org/10.1038/cr.2007.107DOI Listing
December 2007

Ub surprised: viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates.

Cell Host Microbe 2007 Dec;2(6):367-9

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal H3T 1E2, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S193131280700285
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http://dx.doi.org/10.1016/j.chom.2007.11.005DOI Listing
December 2007

Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients.

Blood 2007 Nov 23;110(10):3722-8. Epub 2007 Aug 23.

Laboratoire de Virologie-Immunologie and Jeune Equipe (JE) 2503, Centre Hospitalier Universitaire de Fort-de-France, Fort-de-France, Martinique, France.

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http://dx.doi.org/10.1182/blood-2007-04-085076DOI Listing
November 2007

Bax-dependent mitochondrial membrane permeabilization enhances IRF3-mediated innate immune response during VSV infection.

Virology 2007 Aug 23;365(1):20-33. Epub 2007 Apr 23.

Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.virol.2007.03.011DOI Listing
August 2007

Uncoating reo: uncovering the steps critical for oncolysis.

Mol Ther 2007 Aug;15(8):1406-7

Département de microbiologie et immunologie, Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/sj.mt.6300242DOI Listing
August 2007

The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.

Nat Immunol 2007 Jun 29;8(6):592-600. Epub 2007 Apr 29.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Canada.

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http://dx.doi.org/10.1038/ni1465DOI Listing
June 2007

Triggering the innate antiviral response through IRF-3 activation.

Authors:
John Hiscott

J Biol Chem 2007 May 29;282(21):15325-9. Epub 2007 Mar 29.

Lady Davis Institute for Medical Research-Jewish General Hospital, Departments of Microbiology & Immunology, Medicine, and Oncology, McGill University, Montreal H3T 1E2, Canada.

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http://dx.doi.org/10.1074/jbc.R700002200DOI Listing
May 2007

Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells.

J Immunol 2007 Jan;178(1):253-61

Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland.

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http://dx.doi.org/10.4049/jimmunol.178.1.253DOI Listing
January 2007

Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease.

Biochem Pharmacol 2006 Nov 31;72(11):1477-84. Epub 2006 Jul 31.

Lady Davis Institute for Medical Research-Jewish General Hospital, Department of Microbiology & Immunology, McGill University, Montreal, Canada H3T 1E2.

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http://linkinghub.elsevier.com/retrieve/pii/S000629520600390
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http://dx.doi.org/10.1016/j.bcp.2006.06.030DOI Listing
November 2006

Distinct roles for IFN regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophages.

Cancer Res 2006 Nov;66(21):10576-85

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1279DOI Listing
November 2006

Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.

J Immunol 2006 Aug;177(4):2527-35

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, 3755 chemin de la Cote Sainte Catherine, Montréal, Québec, Canada.

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http://dx.doi.org/10.4049/jimmunol.177.4.2527DOI Listing
August 2006